patho-lab 22nd sept cellular accumulations
Post on 03-Jul-2015
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CELLULAR
ACCUMULATION
PATHOLOGY LAB 22ND SEPT
RAVI A PATEL
GRATITUDE TO NOEL AND BARTESH
FOR COLLECTING SOME GOOD PHOTOS
FROM TODAY’S DEMO
MELANOMA
KEYWORDS
Cancerous skin growth
Hyperpigmentation due to excessive growth of melanoblasts
Brown Melanin pigment
If it is not cancerous then it is called-Nevus
Normally pigmented Skin
Brown melanin pigment
Hyperpigmented area due to excess
Melanin formed by excessive
growth of melanoblasts
LPO
HPO
Anthracosis
Keywords
Black Carbon Deposit in alveolar walls
Some carbon deposits are engulfed in
by the alveolar Macrophages--- so
called DUST CELLS
Characteristic Dust cells
Haemosiderin and
Anthracosis
HaemosiderinAnthracosis
Monckeberg’s Sclerosis
(Medial calcification)
Keywords
Location– Medium sized arteries
Layer- Tunica Media
Type of lesion:- Dystrophic
calcification
Structure at the pointer
Calcium deposits in the
Tunica media– Muscle layer
Atheromatous Aorta
Keywords
Cholesterol cleft
Foam cells-oxidized LDL accumulates in the intimaand forms a plaque..when this LDL is engulfed by the macrophages in that layer now we call them as foam cells
Lesion:- Plaque
PROMINENT FOAM CELL
APART FROM THIS WE SEE THERE
ARE MANY MORE SIMILAR FOAM CELLS
VISIBLE IN THE SLIDE
LPO HPO
Cholesterol cleft
Foam cells
can be see in
this area In HPO
Fibrous cap on the cleft
Along with smooth
Muscles and some
Wbc s
GOUT
KEY WORDS
URIC ACID
HYPERURICEMIA
ACUTE INFLAMMATION--- TOPHUS
CHRONIC INFLAMMATORY LESION
TOPHI SURROUNDED BY
INFLAMMATORY CELLS
SLIDE SHOWN TODAY IN
CLASS- URIC ACID CRYSTALS
ARE LIGHT AND THE INFLAMMATORY
CELLS ARE NUMEROUS
STRUCTURE AT THE POINTER
HOMOGENOUS
URATE CRYSTAL DEPOSITS
Bile Nephosis
Keywords
Excess B2-(Conjugated billirubin)
Bile Cast--- In the lumen of the
tubules
Brownish yellow pigment
Bile cast at the pointer
Bile cast at the pointer
Haemosiderin
Keywords:
Lesion :- CPC– Chronic passive conjestion of lungs
Capillary rupture Release of RBCs
Hemolysis Production of Haemosiderin
Brown pigment
Brown pigment when phagocytosed by the macrophages they are known as
“Heart Failure cells “
Haemosiderin and Anthracosis
comparison
HaemosiderinAnthracosis
THANKING TO THE ENTIRE UNIVERSE
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