CELLULAR

ACCUMULATION

PATHOLOGY LAB 22ND SEPT

RAVI A PATEL

GRATITUDE TO NOEL AND BARTESH

FOR COLLECTING SOME GOOD PHOTOS

FROM TODAY’S DEMO

MELANOMA

KEYWORDS

Cancerous skin growth

Hyperpigmentation due to excessive growth of melanoblasts

Brown Melanin pigment

If it is not cancerous then it is called-Nevus

Normally pigmented Skin

Brown melanin pigment

Hyperpigmented area due to excess

Melanin formed by excessive

growth of melanoblasts

LPO

HPO

Anthracosis

Keywords

Black Carbon Deposit in alveolar walls

Some carbon deposits are engulfed in

by the alveolar Macrophages--- so

called DUST CELLS

Characteristic Dust cells

Haemosiderin and

Anthracosis

HaemosiderinAnthracosis

Monckeberg’s Sclerosis

(Medial calcification)

Keywords

Location– Medium sized arteries

Layer- Tunica Media

Type of lesion:- Dystrophic

calcification

Structure at the pointer

Calcium deposits in the

Tunica media– Muscle layer

Atheromatous Aorta

Keywords

Cholesterol cleft

Foam cells-oxidized LDL accumulates in the intimaand forms a plaque..when this LDL is engulfed by the macrophages in that layer now we call them as foam cells

Lesion:- Plaque

PROMINENT FOAM CELL

APART FROM THIS WE SEE THERE

ARE MANY MORE SIMILAR FOAM CELLS

VISIBLE IN THE SLIDE

LPO HPO

Cholesterol cleft

Foam cells

can be see in

this area In HPO

Fibrous cap on the cleft

Along with smooth

Muscles and some

Wbc s

GOUT

KEY WORDS

URIC ACID

HYPERURICEMIA

ACUTE INFLAMMATION--- TOPHUS

CHRONIC INFLAMMATORY LESION

TOPHI SURROUNDED BY

INFLAMMATORY CELLS

SLIDE SHOWN TODAY IN

CLASS- URIC ACID CRYSTALS

ARE LIGHT AND THE INFLAMMATORY

CELLS ARE NUMEROUS

STRUCTURE AT THE POINTER

HOMOGENOUS

URATE CRYSTAL DEPOSITS

Bile Nephosis

Keywords

Excess B2-(Conjugated billirubin)

Bile Cast--- In the lumen of the

tubules

Brownish yellow pigment

Bile cast at the pointer

Bile cast at the pointer

Haemosiderin

Keywords:

Lesion :- CPC– Chronic passive conjestion of lungs

Capillary rupture Release of RBCs

Hemolysis Production of Haemosiderin

Brown pigment

Brown pigment when phagocytosed by the macrophages they are known as

“Heart Failure cells “

Haemosiderin and Anthracosis

comparison

HaemosiderinAnthracosis

THANKING TO THE ENTIRE UNIVERSE