methods, mathematical models, data quality assessment and result interpretation: solutions developed...

METHODS, MATHEMATICAL MODELS, DATA QUALITY ASSESSMENT AND RESULT

INTERPRETATION: SOLUTIONS DEVELOPED IN THE IFEDH FRAMEWORK

G. Zauner

dwh Simulation ServicesVienna , Austria

1. Decisions have to be made in Austria

2. Advanced data structures, HTA methods and new modeling techniques

3. Interdisciplinary project tasks

4. „Good Practice“ guidelines, limited development duration

The IFEDH project

IFEDH – Framework: Basics

IFEDHNetwork

Decision Makers Provider

Ministry

Provinces

Social Security

Pharmaceutical Industry

Medical Technology

Medical Provider

Informations for Generating Evidence Based Decision on Basis of Models for Possible Strategies

CUSTOMER

Services

The IFEDH Network

IFEDH: Services

IFEDH – Framework: Partner

• Modeling experts (theoretical development and practical solutions)

• HTA experts (Main Association of Austrian Health Security Services, Ludwig Boltzmann Institute - Health Technology Assessment)

• Data structure and DQA experts• Statisticians• Web developer and programmer• Centre for Virtual Reality and Visualization

1. State of the Art detection and guideance for practical use in:

I. Modeling

II. HTA Techniques

III. Visualization

IV. Data Sources and Data Quality Assessment

V. Validatation and Verification

2. Modular and hybrid modeling technique development

3. Data source evaluation and HTA-manager tool

4. Proof of concept

IFEDH – Framework: Structure

IFEDH – Framework: Structure

HTA question

Data structures HTA techniques

Modular models

Hybrid models

DQA Visualization

ValidationVerification

ResultInterpretation

IFEDH – Framework: Structure

IFEDH – Framework: Proof of Concept

Disease ModelSocial Interaction Model

Population Model

Economic Model

1. Seasonal influenza epidemicsAgent based model / modular structure

2. Human papillomavirus (HPV) vaccination and cancer treatmentODE model + Markov structure

3. Abdominal aortic aneurysm (AAA) screeningbottum-up modeling, cost module

Feedback to data structure

internal data (HVB, clinical trials, …)

external data

Pool of Methods- AB- SD, ODEs- couplings- …

Hybrid decom-position

modelcom-parison

EvaluationInsigths for data structureexternal evaluation

Feedback to model pool

Problem classdefinition

economicalpoint of view

modeldemand

Feedback to data structure

Including modeling techniques in HTA

An interdiciplinary process for model based HTA is under development

Modeling and Simulation plays a key role in decision making in advanced HTA questions

Modular structures allow faster decision support and guarantee approved model structures/model assumptions

Knowledge combination of different domains is an import basis for successful solution of socio-economic questions in HTA and EBM

Conclusion

Thank you very much!