immune escape mechanisms in leishmaniasis

Immune Escape Mechanisms Immune Escape Mechanisms in Leishmaniasisin Leishmaniasis

Nancy Noben-Trauth, Ph.D.Nancy Noben-Trauth, Ph.D.Assistant ProfessorAssistant Professor

Department of Microbiology, Immunology & Tropical Medicine

The George Washington University Medical Center

nnoben@gwu.edu, 994-0531

Visceral Visceral LeishmaniasisLeishmaniasis

Cutaneous Cutaneous LeishmaniasisLeishmaniasis

Self-healing ulcer

“Leishmanization” with live leishmania

The Th1/Th2 Paradigm in Immunology The Th1/Th2 Paradigm in Immunology

Susceptible ResistantIL-4 IL-13 IL-10 IFN TNF IL-2

Th2 Th1AutoimmunityInflammation

AllergyInfections

Th2 Th1IL-4IL-13

IFN

Th2=BAD(Infection)

Th1=GOOD(Cure)

LeishmaniaLeishmania

Susceptible ResistantIL-4 IL-13 IL-10 IFN TNF IL-2

Th2 Th1

Th2 IL-10A New Immune EscapeMechanism

The The NEWNEW Paradigm in Paradigm in LeishmaniaLeishmania

IL-4R KO mice are defective in Th2 responses, but remain susceptible to Leishmania major infection

Susceptible ResistantIL-4 IL-13 IL-10 IFN TNF IL-2

Th2 Th1

Th2

Possible GWU CollaborationsPossible GWU Collaborations

IL-4R KO mice to studyModels of InflammationIL-10 gene analysis

Macrophages from IL-4RKO mice produce IL-10