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Immune Escape Mechanisms Immune Escape Mechanisms in Leishmaniasis in Leishmaniasis Nancy Noben-Trauth, Ph.D. Nancy Noben-Trauth, Ph.D. Assistant Professor Assistant Professor Department of Microbiology, Immunology & Tropical Medicine The George Washington University Medical Center [email protected] , 994-0531

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Immune Escape Mechanisms in Leishmaniasis. Nancy Noben-Trauth, Ph.D. Assistant Professor Department of Microbiology, Immunology & Tropical Medicine The George Washington University Medical Center [email protected] , 994-0531. Visceral Leishmaniasis. Cutaneous Leishmaniasis. Self-healing ulcer. - PowerPoint PPT Presentation

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Page 1: Immune Escape Mechanisms in Leishmaniasis

Immune Escape Mechanisms Immune Escape Mechanisms in Leishmaniasisin Leishmaniasis

Nancy Noben-Trauth, Ph.D.Nancy Noben-Trauth, Ph.D.Assistant ProfessorAssistant Professor

Department of Microbiology, Immunology & Tropical Medicine

The George Washington University Medical Center

[email protected], 994-0531

mailto:[email protected]
Page 2: Immune Escape Mechanisms in Leishmaniasis

Visceral Visceral LeishmaniasisLeishmaniasis

Cutaneous Cutaneous LeishmaniasisLeishmaniasis

Self-healing ulcer

“Leishmanization” with live leishmania

Page 3: Immune Escape Mechanisms in Leishmaniasis

The Th1/Th2 Paradigm in Immunology The Th1/Th2 Paradigm in Immunology

Susceptible ResistantIL-4 IL-13 IL-10 IFN TNF IL-2

Th2 Th1AutoimmunityInflammation

AllergyInfections

Th2 Th1IL-4IL-13

IFN

Th2=BAD(Infection)

Th1=GOOD(Cure)

LeishmaniaLeishmania

Page 4: Immune Escape Mechanisms in Leishmaniasis

Susceptible ResistantIL-4 IL-13 IL-10 IFN TNF IL-2

Th2 Th1

Th2 IL-10A New Immune EscapeMechanism

The The NEWNEW Paradigm in Paradigm in LeishmaniaLeishmania

IL-4R KO mice are defective in Th2 responses, but remain susceptible to Leishmania major infection

Page 5: Immune Escape Mechanisms in Leishmaniasis

Susceptible ResistantIL-4 IL-13 IL-10 IFN TNF IL-2

Th2 Th1

Th2

Possible GWU CollaborationsPossible GWU Collaborations

IL-4R KO mice to studyModels of InflammationIL-10 gene analysis

Macrophages from IL-4RKO mice produce IL-10


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