ibogaine forms and dose regimen

Ibogaine Therapy: Forms and Dose

Regimens

Howard S. Lotsof, B.F.A., C.M.A.President

Dora Weiner FoundationStaten Island, NY

http://www.doraweiner.org

Forms in Current Use

• Botanical - root bark

• Total alkaloid extract

• purified ibogaine

Tabernanthe iboga shrub

Roots contain ibogaine

Total Alkaloid Extract

Large piece 2cm x 2cm, approx 4 grams

Estimate 15% ibogaineCourtesy Sara Glatt

Ibogaine HCl

99.4% purity

All forms have multiple treatment applications1.Chemical use disorders

2.Pain management

3.Psychotherapy

4.Initiatory sessions

Each form has

1.Different onset

2.Different duration of action

3.And significant diversity across the patient population

Onset of Effects (min)

020406080

100120140160

HCl Extract

Full EffectOnset

Period of visuaization (hours)

02468

10121416

HCl Extract

Extended

Visualization

Onset

Duration of Action (days)

0123456789

10

HCl Extract

Residual

Principal

Effect on sleep (weeks)

0123456789

10

HCl

Residual

Principal

Dose and Dose Regimen

1.Single dose

2.Multiple

1.Escalating

2.Deescalating

3.Linear

All doses are representative. Doses, including single administration doses are determined on a patient by patient basis. The graphs of dose regimens and information that follow should not be used by persons without experience to self-administer or administer to others any dose of ibogaine or total alkaloid extract of Tabernanthe iboga.

Single dose regimens usually fall between 10mg/kg and 22mg/kg depending on type of therapy offered: opioid dependence, stimulant dependence, psychospiritual, etc. Most doses fall in the 15mg/kg - 20mg/kg dose range to reach full therapeutic effects.

ibogaine HCl (mg/hour)20mg methadonetotal - 1000mg

350

175 175 175125

050

100150200250300350400

0 h1 h2 h3 h4

HCl

ibogaine HCl (mg/kg/hour)stimulant therapy

courtesy Eric Taub

2.5

10

32468

10121416

0 h2 h3

HCl

ibogaine HCl (mg/kg/hour)heroin therapytotal 21.5mg.kg

courtesy Eric Taub

2.5

14

5

2468

10121416

0 1h h12

HCl

ibogaine HCl (mg/kg/hour)methadone therapy

total 36.5 mg/kgcourtesy Eric Taub

2.5 2.5 2.5 2.5 2.5

12

3 3 3 32468

10121416

013 23 30 34 36 59 68 77 89

100

HCl

extract (grams/hour)heroin therapytotal 7 grams

courtesy Sara Glatt

3 3

1

0123456

0 12 36 48

Exract

extract (grams/hour/day)methadone therapy

total 11 gramscourtesy Sara Glatt

3 3

1 1 1 1 1

0123456

0 12 36 d2 d4 d6 d8 d10

Exract

extract (grams/hour)HCl (mg/hour)

methadone 300mg/daytotal extract 9 grams

total HCl 400mgcourtesy Marc Emery

5.2

3.8

0.1 0.1 0.1 0.10123456

0h72 h96h120h168h192

ExractHCl

All doses and dose regimens shown or discussed are representative and are not indicated to be provided to any other patient or subject. All doses and dose regimens are made on a patient by patient basis upon knowledge and prior art.