ibogaine forms and dose regimen
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TRANSCRIPT
Ibogaine Therapy: Forms and Dose
Regimens
Howard S. Lotsof, B.F.A., C.M.A.President
Dora Weiner FoundationStaten Island, NY
http://www.doraweiner.org
Forms in Current Use
• Botanical - root bark
• Total alkaloid extract
• purified ibogaine
Tabernanthe iboga shrub
Roots contain ibogaine
Total Alkaloid Extract
Large piece 2cm x 2cm, approx 4 grams
Estimate 15% ibogaineCourtesy Sara Glatt
Ibogaine HCl
99.4% purity
All forms have multiple treatment applications1.Chemical use disorders
2.Pain management
3.Psychotherapy
4.Initiatory sessions
Each form has
1.Different onset
2.Different duration of action
3.And significant diversity across the patient population
Onset of Effects (min)
020406080
100120140160
HCl Extract
Full EffectOnset
Period of visuaization (hours)
02468
10121416
HCl Extract
Extended
Visualization
Onset
Duration of Action (days)
0123456789
10
HCl Extract
Residual
Principal
Effect on sleep (weeks)
0123456789
10
HCl
Residual
Principal
Dose and Dose Regimen
1.Single dose
2.Multiple
1.Escalating
2.Deescalating
3.Linear
All doses are representative. Doses, including single administration doses are determined on a patient by patient basis. The graphs of dose regimens and information that follow should not be used by persons without experience to self-administer or administer to others any dose of ibogaine or total alkaloid extract of Tabernanthe iboga.
Single dose regimens usually fall between 10mg/kg and 22mg/kg depending on type of therapy offered: opioid dependence, stimulant dependence, psychospiritual, etc. Most doses fall in the 15mg/kg - 20mg/kg dose range to reach full therapeutic effects.
ibogaine HCl (mg/hour)20mg methadonetotal - 1000mg
350
175 175 175125
050
100150200250300350400
0 h1 h2 h3 h4
HCl
ibogaine HCl (mg/kg/hour)stimulant therapy
courtesy Eric Taub
2.5
10
32468
10121416
0 h2 h3
HCl
ibogaine HCl (mg/kg/hour)heroin therapytotal 21.5mg.kg
courtesy Eric Taub
2.5
14
5
2468
10121416
0 1h h12
HCl
ibogaine HCl (mg/kg/hour)methadone therapy
total 36.5 mg/kgcourtesy Eric Taub
2.5 2.5 2.5 2.5 2.5
12
3 3 3 32468
10121416
013 23 30 34 36 59 68 77 89
100
HCl
extract (grams/hour)heroin therapytotal 7 grams
courtesy Sara Glatt
3 3
1
0123456
0 12 36 48
Exract
extract (grams/hour/day)methadone therapy
total 11 gramscourtesy Sara Glatt
3 3
1 1 1 1 1
0123456
0 12 36 d2 d4 d6 d8 d10
Exract
extract (grams/hour)HCl (mg/hour)
methadone 300mg/daytotal extract 9 grams
total HCl 400mgcourtesy Marc Emery
5.2
3.8
0.1 0.1 0.1 0.10123456
0h72 h96h120h168h192
ExractHCl
All doses and dose regimens shown or discussed are representative and are not indicated to be provided to any other patient or subject. All doses and dose regimens are made on a patient by patient basis upon knowledge and prior art.