healthy ageing through technoculture

Healthy Ageing through Technoculture

Marios Kyriazis

ELPIs Foundation for Indefinite Lifespans

www.elpisfil.org

How to conquer ageing

• Biotechnology?

• Drugs and supplements?

• Nanotechnology?

• Stem cells?

• Artificial Intelligence?

The fallacy of the longevity elixir

PROBLEMS:

• Stem cells: harvesting, delivery, compatibility, bone marrow transplants

• Tissue engineering: harvesting, surgical transplants

• Genetic therapies: technical issues, delivery, integration in the body

• Nano-medicine: unknown results, side effects

• Pharmacological therapies: compliance, interactions, polypharmacy

BIOLOGY OF AGEING

CELLS

DNA

LYSOSOMES

ABNORMAL PROTEINS

FREE RADICALS

MITOCHONDRIA

CROSS LINKS

A wider view of ageing

ELIMINATION OF AGEING

BIOLOGY

EPIGENETICS

LIFESTYLE

REPAIR

BIOMEDICINEREPRODUCTION

GENDER

EVOLUTION

CULTURE

ETHICS

CONFLICT RESOLUTION

RISKS

TECHNOLOGY

HYPER CONNECTION

GLOBAL BRAIN

COMPLEXITY SCIENCE

CYBERNETICS

SOCIETY

ENVIRONMENT

SMART CITIES

POLITICS

I concentrate on Technology and Culture

Technology Culture

Both concepts are based on INFORMATION

A meaningful set of data or patterns which influence the formation or transformation of other data or patterns, in order to reduce uncertainty

and help achieve a goal

Information

+ Complexity Functionality Fitness Survival

Organisation

How to increase information content

1. Enriched environment, hormetic challenges

2. Social hyper-connectivity (real and virtual/online)

3. Behavioural models: goal-seeking behavior, search for excellence, a bias for action

4. The pursuit of innovation, diversification, creativity, novelty, and the avoidance of routine.

HormesisAn adaptive response of cells and organisms to a moderate, intermittent, challenge.

Hormesis describes phenomena where there is low dose stimulation, high dose inhibition.

Nutritional, physical, mental and chemical challenges may result in mild damage which upregulates repair mechanisms. In an attempt to repair this damage, age-related damage is also repaired.

Examples of hormesisNutritional

Physical

Sexual

Social

Environmental Enrichment

Experimental animals are exposed to an enriched environment- a habitat augmentation. This has several positive effects on health, specifically on brain and immune function.

ChallengeHere, a challenge is defined as a situation that potentially carries

biological value for an organism, so that the organism is inclined to act. A challenge provokes action because it represents a situation in which

not acting will lead to an overall lower fitness than acting.

The balance between age-related degeneration and health depends on:

A. How well our repair processes are maintained through artificial (item-based) pharmacological, genetic, cellular, biotechnological and other physical interventions.

B. Through utilising challenging exposure to information with consequent improvement of function.

Use of internet and longevity

Global Brain

Internet connections

An Irregular, Useful Guest

Second, usefulness

• Humanity is not going to improve if its members don't make an effort to achieve something higher.

Third, quest

• Always seek novelty, never be satisfied, never sit quiet and 'relax' for long periods. Be inquisitive, always ask 'why' and don't take anything at face value.

• Try to get to the top but don't stop there. There is always something higher.

• Come up with new ideas, and then try to achieve them.

First, irregularity

We thrive on change, challenges and unexpected events.

A ‘power-law’ lifestyle: frequent low level activities, some medium level ones, and rare intense activities.

Ever-changing, imaginative and unpredictable activities improve immunity, reduce inflammation, improve nerve-growth factors, and many others.

The end?

ELPIs Foundation for Indefinite Lifespans

www.elpisfil.org

drmarios@live.it

Meeting to discuss these concepts: 3rd

Symposium ‘Pathways to Indefinite Lifespans’

0n Saturday 23 May 2015, In Larnaca, Cyprus