drugs used in pregnancy
Post on 15-Apr-2017
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Teratogenic potency of drugs and other disadvantages
Drug dosage and the ability to cross the placenta
The stadium of pregnancy
General condition of the mother.
Elimination :
Renal blood flow and GFR increase
“Steady state” only slight declines but the dosage
does not need increase
Drug could damage the fetus :
1. Directly
2. Indirectly
Placental determinants
Area exchange
Thickness of membranes
Enzyme systems
Drug determinants
Molecular weight < 600
Lipid soluble
Non-charged, basic
Death => abortion
Malformation / anomalies
Changing in behavior
Retardation
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