Teratogenic potency of drugs and other disadvantages

Drug dosage and the ability to cross the placenta

The stadium of pregnancy

General condition of the mother.

Elimination :

Renal blood flow and GFR increase

“Steady state” only slight declines but the dosage

does not need increase

Drug could damage the fetus :

1. Directly

2. Indirectly

Placental determinants

Area exchange

Thickness of membranes

Enzyme systems

Drug determinants

Molecular weight < 600

Lipid soluble

Non-charged, basic

Death => abortion

Malformation / anomalies

Changing in behavior

Retardation