dolen & malenka 2013

Kristen DelevichJournal Club 10/15/13

Prairie vole Montane vole

Insel and Shapiro 1992

125I-OTA bindingOTR and pair-bonding

Photo: Todd Ahern/Emory University/via the San Francisco Chronicle

How to make love like a prairie vole??

Kimberly A. Young, Kyle L. Gobrogge, Yan Liu, Zuoxin Wang 2011

Love and other drugs

photograph copyright Jean-Louis Klein and Marie-Luce Hubert

2013

2012

Complex role of Oxytocin signaling

Do OTergic hypothalamic inputs to NAc even exist in male mice?

Male mice receive substantial OTergic input from PVN but not SON

Oxytocin is required for social CPP

NAc delivery of OT-A sufficient to block social CPP

Cocaine-induced CPP doesn’t require Oxytocin

Oxytocin induces LTD onto NAcc MSNs

Allen Brain Atlas

Social housing engages OT-LTD, OT-LTD targets D1 & D2 NAc MSNs

Oxytocin-induced LTD is presynaptic

Selective ablation of OTRs in cOTR mice

AAV-Cre

Rabies-Cre

Presynaptic OTRs are required for social CPP

OTR-expressing cells that project to NAc

Ruling out vSub and ACC

Dorsal-raphe presynaptic OTRs necessary for social CPP and OT-LTD

NAc projecting dorsal raphe neurons are serotonergic

OT-LTD acts through 5HTR1B 5H

T1R

B a

goni

st5H

T1R

B a

ntag

. + O

T

5HT

1R

B a

goni

st +

OT

ant

ag.

5HTR1B antagonist in NAc blocks social CPP

Circuit Summary

Downstream target?

Mechanism?

2009