conventional radiotherapy vs. flash-radiotherapy cancer ... · with flash-rt prototype, chuv...

Departement für Kleintiere Abteilung für Radio-Onkologie Universität Zürich Departement für Kleintiere Winterthurerstrasse 260 CH-8057 Zürich

Conventional Radiotherapy vs. FLASH-Radiotherapy Cancer research project

Cats with squamous cell carcinoma of the nasal planum

For more details and questions don`t hesitate to ask us. Thank you for your trust! Team Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich (in cooperation with CHUV Lausanne) contact: onkologie@vetclinics.uzh.ch

What is the study duration? What are the costs of participation?

• 5 days total hospital stay at the Small Animal Clinic, University of Zurich

• Follow-up: after 2, 4, 6 weeks • Follow-up: after 3, 6, 9, 12, 18 months

• Cost participation for therapy: CHF 650.- (instead of CHF 3'500.-)

• Follow-up: free of cost

Possible advantages of participation?

Possible disadvantages of participation?

• You`re supporting cancer research • Your cat will be treated with the

standard treatment therapy (10 sessions) or with an experimental treatment (1 session)

• Lower costs

• Maybe more side effects with FLASH-Radiotherapy, because it`s still experimental

• General anesthesia- and radiotherapy-risks (discussed individually)

Treatment schedule

Conventional Radiotherapy FLASH-Radiotherapy

Treatment will be allocated randomly (by chance)

5 days total hospital stay at the Tierspital Zurich • Radiotherapy with the linear accelerator

at the Tierspital Zurich • Radiotherapy duration 1-2 Min;

2x daily, 5 consecutive days

• Ultra-high dose rate radiotherapy (100x faster) with FLASH-RT prototype, CHUV Lausanne

• Radiotherapy duration <1 Sec; only 1 unit of radiotherapy

Follow-ups: after 2, 4, 6 weeks and after 3, 6, 9, 12, 18 months

Goals of the project

• Compare treatment outcome after 10 conventional vs. 1 FLASH-session • Future improvement of radiotherapy with fewer treatments / anesthesias • Comparability of the side effects of both treatments • Cancer research – translation to human medicine

Division of R

adiation Oncology

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