antihipertensive poisoning
Post on 19-Jan-2016
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Ronald Chrisbianto Gani405090223
Faculty of MedicineTarumanagara University
EMERGENCY MEDICINE BLOCK
ANTIHIPERTENSIVE POISONING
ANTIHYPERTENSIVE AGENTS POISONING (CCB & B-BLOCKER)
CALCIUM CHANNEL BLOCKER (CCB)
• Depress sinus node automaticity and slow AV node conduction
• Reduce CO and BP hypotension• Treatment : – Supportive care– Whole bowel irrigation and Activated Charcoal– Calcium, antidote for depressed cardiac contractility– Other drugs : glucagon, vasopresin, epinephrine,
high-dose insulin plus glucose to maintain euglycemia
Katzung Basic & Clinical Pharmacology 11th Ed
BETA BLOCKERS
• Highest toxicity : Propanolol• Bradycardia and hypotension• Agents with partial agonist activity (pindolol)
tachycardia and hypertension• Seizures and cardiac conduction block
(propanolol overdose)• Treatment : General supportive care, IV fluids
Beta agonist, atropine, Glucagon
Katzung Basic & Clinical Pharmacology 11th Ed
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