am briefings from 9 feb 2016 innovation network event

Innovation Network event 09 February 2016

Jim Pennycook CDE Head of Operations

Military capability

Advantage

Persistent

The aim of CDE

Rapid technology change

Defence

Other markets

Utilisation

CDE evolution

Years

CDE directive

Prove the value of innovative, high-risk, high-potential-benefit research to enable development of cost-effective military capability advantage

Defence White Paper – National Security Through Technology Feb 2012

Defence and security

First point of contact

‘CDE remains our first point of contact for those who wish to submit a research idea to the MOD.’

Defence White Paper – National Security Through Technology Feb 2012

Support to SMEs

Routes to market

CDE operating principles

Engage with innovators

Funded opportunities

Participation costs

Risk

Intellectual property

Managing innovation

Proof of concept Development

Innovation Future capability

CDE MOD + investors

CDE competition space

Technology innovation lifecycle

Original idea Capability

Technology innovation lifecycle

Uptake / commercialisation

Pre-commercial development

TRL 1 TRL 2 TRL 3 TRL 4 TRL 5 TRL 6 TRL 7 TRL8 TRL 9

Experimental research

Technology implementation

Applied research

Curiosity driven

research

CDE competition space

Pre-commercial development

TRL 3 TRL 4 TRL 5 TRL 6

Applied research

Solution exploration Prototyping/test products

Phase 1 Phase 2

Phase 1

TRL 7

TRL 2

CDE competition space

Phase 2

TRL 3

TRL 4

TRL 5

TRL 6

Two routes to funding

Enduring

Themed

Not classified

Enduring competition

Themed competition

£ 7M

Enduring competition

Enduring challenges

Challenge framework

Protection Lethality

Human performance

Mobility

Situational awareness

Communication Data

Power

Lower cost of ownership

Themed competition

Competitions this year Theme Value

Open-source big data insight £2.25M Persistent surveillance from the air £2.25M

Agile, immersive training £2.25M What's inside that building? £1.15M

Understand and interact with cyberspace £1.00M Security for the internet of things £2.00M

Autonomy and big data £4.00M Synthetic biology £1.5M

Identification and treatment of tinnitus £1.0M

Online bid submission

How has CDE performed?

CDE in numbers

6133 proposals received 57%

CDE in numbers

17% of proposals funded

19% 13% E T

CDE in numbers

1018 contracts placed 43%

CDE in numbers

£69.91M invested

1 2 3 4 5 6 7 8

What’s next for CDE?

Innovation Network events

www.gov.uk/dstl/cde

A successful proposal

A successful proposal

Questions

Today’s competition

Detect and treat hearing loss and tinnitus

Detect and treat hearing loss and tinnitus Centre for Defence Enterprise themed competition

9 February 2016

UK OFFICIAL © Crown copyright 2014 Dstl

10 February 2016

Detect and treat hearing loss and tinnitus

UK OFFICIAL © Crown copyright 2013 Dstl

10 February 2016

Introduction Context

• the human component of capability • innovation in defence medicine • MOD’s medical sciences programme

Technology challenges • monitor and diagnose • treat and restore

Exploitation Questions and answers

Noise-induced hearing loss and tinnitus: A Serviceman’s perspective

© Crown copyright 2013 Dstl

10 February 2016

• noise exposure history – Chinook/MAOT (1992 – 1998) • first manifestation – War Operations Centre (2002) • the realisation – MOD (2008) • the impact – service environment

– SF Ops (2006) – briefings/presentations – orientation on exercise/ops – image – war fighter first?

• the impact – at home – noise levels – stress – anxiety – sleep!

© Crown copyright 2013 Dstl

10 February 2016

Detect and treat hearing loss and tinnitus

UK OFFICIAL © Crown copyright 2013 Dstl

10 February 2016

The human component of defence

• the human component is central to delivering military capability

• provision of sufficient, capable and appropriately trained personnel is critical to operational success

• need to sustain capability by protection, treatment and rehabilitation

• high-quality support, care and treatment at all points along the continuum of care

Detect and treat hearing loss and tinnitus

UK OFFICIAL © Crown copyright 2013 Dstl

10 February 2016

Innovation in defence medicine Brigadier Timothy Hodgetts CBE PhD MMEd MBA CMgr FRCP FRCSEd FRCEM FIMCRCSEd

Medical Director, Defence Medical Services Honorary Professor of Emergency Medicine (University of Birmingham)

@DMSMedDir

SG-DMED-MEDD-D@mod.uk

Visit the Royal Centre for Defence Medicine at:

Brigadier Tim Hodgetts CBE PhD MMEd MBA MBBS CMgr FRCP FRCSEd FRCEM FIMC FIHM FRGS

Medical Director Defence Medical Services

Honorary Professor of Emergency Medicine University of Birmingham

Visiting Professor School of Health Sciences City University London

INNOVATION IN DEFENCE MEDICINE

REDUCING THE BURDEN OF HEARING LOSS AND TINNITUS

RSM LONDON 9 FEB 16

Hearing loss and tinnitus REDUCING THE BURDEN

Shifting the problem focus An analogy

The environmental challenges Noise protection vs hearing utility

DMS Research Strategy Where does hearing loss and tinnitus fit?

The CDE call Disruptive ideas that protect quality of life

Hearing loss and tinnitus A UK POLITICAL PRIORITY

“We will work to address hearing loss among veterans.”

US Military BENCHMARK DATA

The most prevalent individual Service-related disability

US DoD estimated compensation costs for FY 2014 = $2.3Bn

Tinnitus & deafness increasing by 13-18% annually

SOURCE: US DoD HCoE

SHIFTING THE PROBLEM FOCUS

Shifting the problem focus ANALOGY—IN-HOSPITAL CARDIAC ARREST

Outcome from in-hospital cardiac arrest is poor …but resources traditionally focused on management

of the arrest after it has occurred

Shifting the problem focus ANALOGY—IN-HOSPITAL CARDIAC ARREST

Early detection of deterioration and timely intervention saves lives …but requires a change in culture and resources

• Warning signs in around 75% of arrests • Warning signs not picked up in 35% • Not acted upon adequately in 56% • Not communicated to senior doctors in 55%

Shifting the NIHL problem focus PREVENTION, EARLY DETECTION & INTERVENTION

Established hearing loss and tinnitus impairs the quality of life and reduces employability …so the Defence research focus should be on

prevention and measures that slow, arrest or reverse early deterioration iot sustain productive Service

CDE

THE ENVIRONMENTAL CHALLENGE

The environmental challenge

protection from impulse noise

The environmental challenge

protection from background noise

The environmental challenge

understanding speech in noise

The environmental challenge

stealth awareness

The environmental challenge

faint noise

perception

The environmental challenge

sound localisation

DMS RESEARCH STRATEGY

Medical

Personnel

NIHL NFCI

NUTRITION

VIBRATION HEAT

MENTAL HEALTH

HUMAN PERFORMANCE

TRAINING

Research MED-PERS INTERFACE

SUBSTANCE ABUSE

Research ADDRESSING KEY PRIORITIES: NIHL

CONSORTIUM

hearWELL COLLABORATION

hearWELL MISSION

Deliver a systematic research programme that provides comprehensive understanding and practical solutions to PREVENT, DETECT and TREAT Service-related noise induced hearing loss in order to PROTECT and SUSTAIN the operational effectiveness of the force

hearWELL CENTRES OF GRAVITY

PROBLEM The critical vulnerability

that provides opportunity to be attacked Prevention through education and culture change

STRENGTH

The component of the clinical system that must be protected

Regular hearing assessment/surveillance

hearWELL MAIN EFFORT

When resources are limited (people, time, money)

where should they be focused? Earlier and better detection

PREVENT?

DETECT?

TREAT?

NIHL A SYSTEMATIC APPROACH

1. What is the size and nature of

NIHL?

4. How can damage to hearing be quantified more

consistently & reliably?

2. What is the optimal hearing

protection?

5. How can hearing be

assessed more functionally in

relation to role?

3. How can damage to hearing

be detected earlier?

6. How can an accurate staging and prognosis be

determined for NIHL prior to discharge?

7. How do we optimally treat

established hearing loss?

PREVENT DETECT TREAT PRE-EMPLOYMENT

- DETECT genetic predisposing trait. DETECT recreational pre-existing damage.

-

EMPLOYMENT MAINTAIN optimal hearing by protection& avoidance. PREVENT further damage once established

IDENTIFY early loss (optimise test sensitivity; ensure reliability & consistency). DISCRIMINATE between recreational & occupational damage (pre- & post-deployment tests).

TREAT established hearing loss to optimise continued employment. AMELIORATE deterioration.

PRE-DISCHARGE - ESTABLISH final disability with reliable prognosis (relates to compensation)

ESTABLISH & ASSURE referral pathway & commissioning for long term needs

POST-EMPLOYMENT

- MONITOR deterioration in order to INFORM pre-discharge prognosis

SUSTAIN optimal treatment as a benefit of Service acquired disability

NIHL A SYSTEMATIC APPROACH

E

PREVENT PREVENT PREVENT PREVENT

DETECT DETECT DETECT DETECT

TREAT TREAT TREAT TREAT

NIHL A SYSTEMATIC APPROACH

CDE THEMED COMPETITION

active serving personnel Disruptive ideas to prevent or limit harm and thereby sustain employability

Secondary benefit: to protect enduring quality of life

Prevent Passive/active occlusive hearing protection Otoprotectant drugs (pre- or post-exposure)

Detect Earlier detection of hearing loss & tinnitus

Treat Intervention to slow, arrest and reverse established

hearing loss & tinnitus

CDE themed competition HEARING LOSS & TINNITUS

CDE themed competition HEARING LOSS & TINNITUS

The competition relates to disruptive ideas that can be taken through proof of principle

But are their COTS solutions that are not being exploited?

Do you have ideas about occlusive prevention that we can separately exploit?

Summary REDUCING THE NIHL BURDEN

Shifting the problem focus

Understanding the environmental challenges

A DMS Research Strategy priority

Disruptive ideas to protect quality of life

@DMSMedDir

SG-DMED-MEDD-D@mod.uk

Visit the Royal Centre for Defence Medicine at:

Defence medical sciences research programme

10 February 2016 © Dstl 2014

Four research themes • casualty care

• contingent operational medicine

• whole service life care

• medical systems

UK OFFICIAL

Providing research which contributes to an improvement in physical, psychological and social health, to maintain operational

effectiveness and minimise mortality, morbidity and residual disability

Defence medical sciences research programme

10 February 2016

• systems for medics and first responders

• simulated environments in defence medical training

• rehabilitation and regenerative medicine within defence

• fit to deploy • operational health and protection • combat casualty care • Surgical Reconstruction and Microbiology Research Centre

UK OFFICIAL

Delivery and partnerships • Dstl • National Institute of

Health Research (NIHR) Surgical Reconstruction and Microbiology Research Centre

• Defence Human Capability Science and Technology Centre

• industry • academia • small medium enterprises • international collaboration

10 February 2016 UK OFFICIAL

The medic on operations

UK OFFICIAL

Innovation: recent CDE themes The extremes of defence medical capability (2012) • medical operational independence of front line units • rehabilitation support to severely injured service personnel

The medic of the future (2013) • exploring the potential of simulated training • novel systems to help those injured in battle

Future battlefield health surveillance and systems (2014) • technologies for health surveillance • advance medical systems for field care

Enduring competition: human performance • resilience, systems interfaces, survivability, sustainment,

training, medical systems

UK OFFICIAL

Detect and treat hearing loss and tinnitus

UK OFFICIAL © Crown copyright 2013 Dstl

10 February 2016

Technology challenge 1: monitor and diagnose Development of technologies to identify those at risk of injury, early diagnosis of hearing loss and an objective measure of tinnitus, for example:

• novel enhancements to current hearing screening methods • solutions to identify individual susceptibility and risk • improvements to standard audiometry surveillance tools • remote monitoring and self-assessment • understanding and assessing tinnitus

Detect and treat hearing loss and tinnitus

UK OFFICIAL © Crown copyright 2013 Dstl

10 February 2016

Technology challenge 2: treat and restore Development of interventions to stop deterioration and/or restore hearing, for example:

• restoration of damaged cells and cell structures • regenerative medicine • rehabilitation • pharmaceutical and therapeutic interventions • gene therapies • tinnitus treatment

What we want

UK OFFICIAL © Crown copyright 2014 Dstl

10 February 2016

• novel and innovative systems • systems which consider full cost of introduction • solutions which can easily be upgraded or updated • details on validation and accreditation • systems which require minimal training or changes to existing

practice • demonstration of proof-of-concept for further investigation

What we don’t want • audiology or screening services • data handling services • consultancy on audiology, hearing loss or tinnitus • demonstrations of existing ‘off-the-shelf’ products • paper-based studies • marginal improvements in capability • technology watch or horizon scanning • roadmaps or technology prediction

© Crown copyright 2013 Dstl

10 February 2016

Exploitation

UK OFFICIAL © Crown copyright 2013 Dstl

10 February 2016

Follow-on activities • stakeholder demonstration • phase 2 competition

Research integration • medical sciences programme

Procurement • refine, trial or purchase

Policy • refinement and implementation • development of doctrine

Important information

• total budget for phase 1 up to £500,000 • projects typically between £40,000 to £80,000 • stakeholder event January 2017 successful phase 1 to

demonstrate their technology • up to an additional £500,000 available for phase 2

funding

© Crown copyright 2013 Dstl

10 February 2016

Important dates • webinar 12:30pm Monday 7 March 2016 • competition closes at 5pm Thursday 21 April 2016 • proposals must be submitted using CDE’s online

submission service • contract placement initiated and feedback provided

mid-June 2016 • phase-1 projects to complete by 31 December 2016

© Crown copyright 2013 Dstl

10 February 2016

Detect and treat hearing loss and tinnitus

UK OFFICIAL © Crown copyright 2014 Dstl

10 February 2016

Technical questions

medicalsciences@dstl.gov.uk

General enquiries

cde@dstl.gov.uk

Proposals submitted via CDE’s online submission service – no later than 5pm Thursday 21 April 2016

© Crown copyright 2013 Dstl

10 February 2016

Detect and treat hearing

loss and tinnitus

How will it work?

Funded opportunities

Awareness

Network

Funding

Intellectual property

Online bid submission

A successful proposal

Assessors

Technical partners

www.gov.uk/dstl/cde

Detect and treat hearing loss and tinnitus

What do we want?

Challenge 1: monitor and diagnose

Challenge 2: treat and restore

Up to £500,000 Typically £40-80,000 Complete by 31 December 2016 Proof of concept Phase 2 proposal

Phase 1

Up to £500,000 available

Longer research projects

Phase 2

What we want

Innovative proof-of-concept

Value for money

Integration

Demonstrations

What we don’t want

Consultancy

Incremental

Mature technologies

Studies

Technical queries

medicalsciences@dstl.gov.uk

Competition dates

Webinar:

7 March 2016

Competition dates

Start to place contracts:

June 2016

Competition dates

Phase 1 research completed by:

31 December 2016

Competition deadline

Competition closes

21 April 2016 at 5pm

Apr

5 21 2016

www.gov.uk/dstl/cde

Questions

Innovation Network event 9 February 2016