aaren custom iols

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

Generation and In Situ Modification of Customized IOLs

J. F. Bille , R. Sahler , R. Aguilera , S. Zhou, D. J. Schanzlin 1) University of Heidelberg, Germany, 2) Aaren Scientific Inc, USA, 3) Shiley Eye Center, UCSD, USA,

1, 4 1, 2 2 3 2

Prof. Dr. J. F. Bille

•   Aaren Scientific - C, P

•   Heidelberg Engineering – C, P

Ruth Sahler

•   Aaren Scientific - E

Rick Aguilera

•   Aaren Scientific - E, O

Stephen Zhou

•   Aaren Scientific - E

Prof. Dr. D. J. Schanzlin

•   Aaren Scientific - C

Financial Disclosure

4) josef.bille@urz.uni-heidelberg.de

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

Content

•   Motivation •   Refractive Index Shaping (RIS) •   The Instrument •   Phase Wrapping Algorithm •   Aspheric / Toric IOLs

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

Motivation

Reference: Market Scope Report 2010

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

Concept

After:

Before:

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

Refractive Index Shaping (RIS)

Free Electrons (Lucky) are created Electrons can absorb photons

Bond re-structuring Avalanche Effect creating a plasma

Molecules

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

RIS Key Points

•   Refrac've  index  (RI)  of  the  shaped  lens  is  higher  than  the  refrac've  index  of  the  surrounding  IOL  material  

•   The  geometry  of  the  'lens'  is  determined  by  the  pa@ern  of  laser  beams  hiAng  the  targets  

•   The  diopter  change  is  due  to  the  refrac've  index  change  and  the  curvature  of  the  three  dimensional  shaped  'lens'  object  

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

2 Photon Microscope with 500mW Laser

500mW Laser

AOM

(Acousto Optic Modulator)

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

RIS Max and Min Speed

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

Max RIS Speed

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

Refractive Index Change

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

Phase Wrapping Theory I

•   The RIS area is limited to ~200um

•   A traditional convex lens would therefore be limited to that height

•   The power for a 6mm lens with a height of 200um would be 0.44dpt (Δn = 0.01)

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

Phase Wrapping Theory II

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

Toric IOL

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

Aspheric IOLS

Peripheral Ray

Spheric Lens

Aspheric Lens

J.F.  Bille,  R.  Sahler,  R.  Aguilera,  S.  Zhou,  D.J.  Schanzlin    -­‐  03/  28/11  

Summary

•   A novel method for generation and in situ modification of customized IOLs has been developed.

•   Refractive Index Shaping (RIS) can be used to adjust the power of an IOL in situ by focused infrared femtosecond laser pulses.

•   RIS was successfully performed on Aaren‘s hydrophobic acrylic IOLs and modified formulations with enhanced UV absorber.

•   Employing phase wrapping techniques, several diopters of refractive change can be accomplished in a thin layer of approximately 50µm thickness.

•   Using an acousto-optic modulator (AOM) a total processing time of approximately 20 seconds can be achieved.