aaren custom iols

J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11

Generation and In Situ Modification of Customized IOLs

J. F. Bille , R. Sahler , R. Aguilera , S. Zhou, D. J. Schanzlin 1) University of Heidelberg, Germany, 2) Aaren Scientific Inc, USA, 3) Shiley Eye Center, UCSD, USA,

1, 4 1, 2 2 3 2

Prof. Dr. J. F. Bille

•   Aaren Scientific - C, P

•   Heidelberg Engineering – C, P

Ruth Sahler

•   Aaren Scientific - E

Rick Aguilera

•   Aaren Scientific - E, O

Stephen Zhou

•   Aaren Scientific - E

Prof. Dr. D. J. Schanzlin

•   Aaren Scientific - C

Financial Disclosure

4) [email protected]


Content

•   Motivation •   Refractive Index Shaping (RIS) •   The Instrument •   Phase Wrapping Algorithm •   Aspheric / Toric IOLs


Motivation

Reference: Market Scope Report 2010


Concept

After:

Before:


Refractive Index Shaping (RIS)

Free Electrons (Lucky) are created Electrons can absorb photons

Bond re-structuring Avalanche Effect creating a plasma

Molecules


RIS Key Points

•   Refrac've index (RI) of the shaped lens is higher than the refrac've index of the surrounding IOL material

•   The geometry of the 'lens' is determined by the pa@ern of laser beams hiAng the targets

•   The diopter change is due to the refrac've index change and the curvature of the three dimensional shaped 'lens' object


2 Photon Microscope with 500mW Laser

500mW Laser

AOM

(Acousto Optic Modulator)


RIS Max and Min Speed


Max RIS Speed


Refractive Index Change


Phase Wrapping Theory I

•   The RIS area is limited to ~200um

•   A traditional convex lens would therefore be limited to that height

•   The power for a 6mm lens with a height of 200um would be 0.44dpt (Δn = 0.01)


Phase Wrapping Theory II


Toric IOL


Aspheric IOLS

Peripheral Ray

Spheric Lens

Aspheric Lens


Summary

•   A novel method for generation and in situ modification of customized IOLs has been developed.

•   Refractive Index Shaping (RIS) can be used to adjust the power of an IOL in situ by focused infrared femtosecond laser pulses.

•   RIS was successfully performed on Aaren‘s hydrophobic acrylic IOLs and modified formulations with enhanced UV absorber.

•   Employing phase wrapping techniques, several diopters of refractive change can be accomplished in a thin layer of approximately 50µm thickness.

•   Using an acousto-optic modulator (AOM) a total processing time of approximately 20 seconds can be achieved.

aaren custom iols

Health & Medicine

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ris max

max ris speedj

refractive index changej

ris free electrons lucky

phase wrapping theory

diopters of refractive

pheidelberg engineering