a 39 yo man with atypical chest pain general internal medicine primary care conference
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A 39 yo Man with Atypical Chest Pain
General Internal MedicinePrimary Care Conference
K. Mae Hla, M.D.October 11, 2006
The Case
• 39 y.o. healthy epidemiologist with no personal or family history of cardiac or pulmonary disease
• Training for marathon: running 30 mins on treadmill, lifting weights and biking 40 mins.
• Developed sharp right anterior chest pain while walking home from work
I need to see “Dr. Hla”
• History of pain in the upper pectoralis muscle past few days after a hard workout
• Denies trauma to the chest, travel hx, SOB, cough, fever, leg pain or swelling, syncope
• Non-smoker
• PMH: labile hypertension with mild postural dizziness
Exam- in the office
• tall male, mild distress, not dyspneic
• no hyper resonance, normal breath sounds, no subcutaneous emphysema
• no murmurs or rubs, no intra-scapular murmurs, BPs in both arms were normal and equal
• point tenderness right pectoralis muscle
Clinical Course--at home
• Did not follow up with primary MD as advised
• Continued to have pleuritic pain
• Stopped all weight lifting and minimized exertion
• Switched to stationary biking due to notable reduced exercise capacity
Clinical Course--in the ER
• 4 days later, syncopal episode in bathroom
• Was seen in the ER and worked up for possible cardiac syncope
• The admitting resident was surprised when he looked up one of the routine tests obtained
“This was the reason for my muscle pain”
In retrospect…
He realized he had ceased all lifting and exercise on the weekend prior to admission because of shortness of breath
Clinical Course--in the hospital
• A chest tube was inserted in the ER• Patient was admitted for observation and
syncope workup• A TTE and a Holter Monitor showed no
abnormalities• A cardiology consult recommended no further
syncope workup• The pneumothorax was felt to be the cause of
the syncope
“Another Clinical Question”!
How safe is it to fly to the west coast to present the “invited” talk at the meeting 10 days after my discharge?
Objectives
• Describe types and incidence of spontaneous pneumothorax
• Review pathogenesis, clinical presentation
• Evaluate evidence for recurrence risk and treatment options
• Discuss guidelines on air travel safety in patients with recent pneumothorax
Spontaneous Pneumothorax
Definition:
Air in pleural space, between the lung and the chest wall
First coined as “pneumothorax simple” by Itard in 1803
No antecedent traumatic or iatrogenic cause
Types of Spontaneous Pneumothorax
• Primary spontaneous pneumothorax in healthy persons with no apparent
underlying lung abnormalities or underlying conditions
• Secondary spontaneous pneumothorax Clinically apparent underlying lung disease
Global Incidence, Morbidity & Mortality (U.K.)
GenderGender IncidenceIncidence
100,000/yr100,000/yr
PSPPSP
MorbidityMorbidity
100,000/yr100,000/yr
PSP+SSPPSP+SSP
MortalityMortality
Per millionPer million
PSP+SSPPSP+SSP
WomenWomen 1.2-61.2-6 5.85.8 0.620.62
MenMen 18-2818-28 16.716.7 1.261.26
U.S. IncidenceOlmsted County (1950-1974)
318 with diagnosis of pneumothorax Age-adjusted annual incidence of primary
pneumothorax: 7.4 per 100,000 men 1.2 per 100,000 women
Annual incidence of secondary pneumothorax 6.3 per 100,000 men 2.0 per 100,000 women
Pathogenesis of PSP
90% of cases at thoracoscopy or thoracotomy80% of cases on CT showed subpleural blebs
or bullae Etiology of bullous changes in healthy: airway inflammation from smoking lifetime risk in smoking men 12% vs. 0.1% non-smokers tall stature-subpleural blebs in apex
Effect of smoking on PSP recurrence risk
Bense et. al. Chest 1987; 92:1009 No. of No. of
cigarettes/daycigarettes/dayRelative RiskRelative Risk
(men)(men)
Relative RiskRelative Risk
(women)(women)
1-121-12 77 44
13-2213-22 2121 1414
>22>22 102102 6868
Pathogenesis of PSP (cont’d)
Other causes• Marfan’s syndrome• Homocystinuria• Catamenial pneumothorax in thoracic
endometriosis• Familial spontaneous pneumothorax:
autosomal dorminant, recessive, polygenic and X-linked recessive inheritance
Genetic mutation and PSP
Gene for Familial cancer syndrome-chromosome17p11.2
• Birt-Hogg-Dube syndrome: benign skin tumors and renal cancer: high PSP incidence-23% in one study
• Other mutations of FLCN-bullous lung disease and spontaneous pneumothorax only
• Autosomal dorminant inheritance of bullous lung disease with 100% penetrance in a Finnish family
Clinical Presentation
Primary spontaneous pneumothorax• Usually occurs at rest• Peak age is early 20s; rare after 40• Sudden onset of dyspnea and pleuritic chest
pain• Severity of sx related to size of pneumothorax
Secondary spontaneous pneumothorax• More severe sx for same size of pneumothorax
Physical Findings
• Decreased chest excursions • Decreased breath sounds• Hyperresonant percussion• Subcutaneous emphysema• Pleural line on chest radiograph
Risk of Recurrence
Range 25 - >50%; 54% within first 4 years in one study
Risk factors for recurrence in PSP• smoking• tall stature• female gender• low body weight
Risk factors for recurrence in SSP• age over 60 years• pulmonary fibrosis• emphysema
Cumulative freedom from recurrence
Lippert H et al. Eur Respir J 1991;4:324-31
Types of Treatment Options
1. Observation and supplemental oxygen
2. Aspiration of the pleural space
3. Tube thoracostomy
4. Tube thoracostomy with pleurodesis
5. Thoracoscopy
6. Open thoracotomy
British Thoracic Society (2003) and American College of Chest Physicians guidelines (2001)
Choice of Treatment Options
• Size of pneumothorax• Symptoms • Clinical stability: <24/min resp rate, HR >60-
<120, normal BP, pulse ox >90%, can speak whole sentences in between breaths
• Recurrence risk, underlying conditions• Patient occupation
Size of Pneumothorax
Small< 2cm between lung margin and chest wall
(BTS)< 3 cm apex-to-cupola distance (ACCP)< 15% of the hemithorax (UpToDate)
Large> 2 cm between lung margin and chest wall
(BTS) > 3cm apex-to-cupola distance (ACCP) > 15% of hemithorax (UpToDate)
Treatment Recommendations
based on Size
• Small < 15% SP and stable patients: • observation and supplemental oxygen to facilitate
absorption of pleural air
• Large >15%• Initial simple aspiration of the pleural space• Tube thoracostomy if persistent airleak and no
lung reexpansion
Manual Aspiration vs. Thoracostomy
Meta-analysis of 3 randomized controlled trials (194 patients)• Similar Clinical outcomes at 1 week and 1 year• Manual aspiration group--shorter hospital stay
A randomized controlled trial (137 patients)• Similar rates of immediate success (62% vs. 68% in
1 day and 89% vs. 88% in 1 week)• Aspiration associated with shorter hospital stay
(1.8 vs. 4 days)
Tube Thoracostomy Indications
• PSP that fails aspiration treatment• Recurrent spontaneous pneumothorax• Presents with hemopneumothorax • Small chest tube in most (5.5 or 7.0 French)• Clamp chest tube when no bubbles
emanate from a patent tube in 12 hours• Remove after 24 hours if no clinical or x-ray
evidence of recurrence
Pleurodesis Procedures
• Chemical pleurodesis• Intrapleural instillation of sclerosing agents• Tetracycline, doxycycline, talc, premedicate with
midazolam and an opiate
• Open or surgical pleurodesis• thoracoscopy vs. a limited or full thoracotomy• Indications: lung remains unexpanded after 3
days of chest tube, bronchopleural fistula, recurrence after chemical pleurodesis, bullae resection, patient occupation
Postgrad Med 2005;118(6) (online article)
Back to the Future… Is he safe to fly?
• Safety of air travel following pneumothorax-a subject of debate
• Concerns during air travel (speculative): • ? expansion of trapped air at high altitude • ? pressure change at ascent and descent• ? change in barometric pressure may
open a sealed air leak• lack of appropriate medical care
BTS Air Travel Safety Review and Recommendations
• Airlines recommend 6 week-waiting period-arbitrary• Evidence for timing of maximum risk of a
recurrence (review 37 papers)• Data on recurrence: variable, no data on timing• Recurrence risk >54-72% in first 1-2 yrs, higher in
smokers, COPD• Surgical/pleurodesis intervention makes risk
negligible• Recurrence while flying more likely to suffer serious
consequences especially in patients with pre-existing lung disease
BTS recommendations. Air Travel Working Party-Thorax 2002;57;289-304 (Page 298)
Safety in flying--what’s the evidence?
A small prospective study (n=12) of pts with traumatic pneumothorax in a Level I Trauma Center, Orlando, Fl, 14 day waiting period after resolution in adults
• 10/12 patients flew >14 days (mean 17.5 days) remained asymptomatic
• 2/12 flew in < 14 days: 1 developed sx suggestive of pneumothorax in flight
Cheatham, et al. The Am Surgeon 1999;65:1160-1164
What did the patient do?
• Like a true epidemiologist, decided the data on waiting period and increased recurrence risk during air travel was not supported by good evidence
• Decided to fly 12 days after his re-expansion• Completed an uneventful trip!!!
Bibliography
1. BTS guidelines for the management of spontaneous pneumothorax. Henry M. et al. Thorax 2003;58 (Suppl II):ii39-ii52.
2. Management of spontaneous pneumothorax An AACP delphi concensus statement. Baumann MH, et al. Chest 2001;119:590-602.
3. Air travel following traumatic pneumothorax: when is it safe? Cheatham ML, Safcsak K. Am Surg 1999;65(12):1160-4.
4. Managing passengers with respiratory disease planning air travel BTS recommendations. Air Travel Working Party. Coker RK, et al. Thorax 2002;57:289-304 pp 298.
5. The Intricacies of Pneumothorax Management depends on accurate classification. Dincer HE, Lipchik RJ. Postgrad Med 2005;118(6) (online article).
6. Primary spontaneous pneumothorax in adults. Light RW. 2006 UpToDate
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