2-bromo-2-nitropropane-1,3-
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116,254,710 searches since 2004home > ingredient: 2-BROMO-2-NITROPROPANE-1,3-DIOL
2-BROMO-2-NITROPROPANE-1,3-DIOL
Preservative
This ingredient:
Cancer
Developmental/reproductive toxicity
Violations, restrictions & warnings
Allergies/immunotoxicity
Contamination concerns - FORMALDEHYDE, NITROSAMINES
Other strong concerns for this ingredient:
Organ system toxicity (non-reproductive), Irritation (skin,
eyes, or lungs), Occupational hazards
Other moderate concerns for this ingredient:
Neurotoxicity
Lesser or emerging concerns for this ingredient:
Endocrine disruption, Ecotoxicology
See products containing 2-BROMO-2-NITROPROPANE-
1,3-DIOL
About 2-BROMO-2-NITROPROPANE-1,3-DIOL: 2-Bromo-2-Nitropropane-1,3-Diol is a substituted aliphatic diol.
2-BROMO-2-NITROPROPANE-1,3-DIOL has reported used in the following
product types: conditioner (20); baby wipes (16); facial moisturizer/treatment
(13); moisturizer (12); facial cleanser (8); body wash/cleanser (8); makeup
remover (4); exfoliant/scrub (4); hand cream (3); personal cleansing (3)
ALLERGIES/IMMUNOTOXICITY
type of concern product conditions reference
Known human immune system toxicant National Library of
Medicine HazMap
Human skin toxicant - strong evidence
VIOLATIONS, RESTRICTIONS & WARNINGS
type of concern product conditions reference
Restricted in cosmetics (recommendations or
requirements) - use, concentration, or manufacturing
restrictions - Use is restricted in Canadian cosmetics
Canada - Prohibited and
Restricted Cosmetics
Ingredients
Determined safe for use in cosmetics, subject to
concentration or use limitations - Safe for use in
cosmetics with some qualifications
Cosmetic Ingredient
Review Assessments
10 high hazard
49% data gap
(why scores have changed)
BRONOPOL; 1,3-PROPANEDIOL,
2-BROMO-2-NITRO-; 2-BROMO-
2-NITRO- 1,3-PROPANEDIOL;
1,3PROPANEDIOL, 2BROMO2NITRO
SCORE
ALSO LISTED AS
ROMO-2-NITROPROPANE-1,3-DIOL || Skin Deep: Cosmetic Safe... http://www.cosmeticsdatabase.com/ingredient.php?ingred06=70001
6 16/6/2009 10:23 µµ
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ORGAN SYSTEM TOXICITY (NON-REPRODUCTIVE)
type of concern product conditions reference
Known human lung and skin toxicant products that may be
aerosolized (airborne);
products for use on skin
European Union -
Classification & Labelling
One or more animal studies show gastrointestinal
effects at very low doses
RTECS®- "Vrednie
chemichescie veshestva,
galogen I kislorod
sodergashie organicheskie
soedinenia" 1994
One or more animal studies show broad systemic
effects at very low doses
RTECS®- Khimiko-
Farmatsevticheskii
Zhurnal 1977
show more
NEUROTOXICITY
type of concern product conditions reference
One or more animal studies show brain and nervous
system effects at low doses
RTECS®- Kiso to Rinsho
1974
OCCUPATIONAL HAZARDS
type of concern product conditions reference
Allowed workplace exposures restricted to low doses European Union -
Classification & Labelling
IRRITATION (SKIN, EYES, OR LUNGS)
type of concern product conditions reference
Classified as lung and skin irritant products that may be
aerosolized (airborne);
products for use on skin
European Union -
Classification & Labelling
show more
ENDOCRINE DISRUPTION
type of concern product conditions reference
One or more animal studies show endocrine system
disruption at high doses
RTECS®- Federal Register
2002
DEVELOPMENTAL/REPRODUCTIVE TOXICITY
type of concern product conditions reference
ROMO-2-NITROPROPANE-1,3-DIOL || Skin Deep: Cosmetic Safe... http://www.cosmeticsdatabase.com/ingredient.php?ingred06=70001
6 16/6/2009 10:23 µµ
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One or more animal studies show reproductive effects
at high doses
RTECS®- Federal Register
2002
ECOTOXICOLOGY
type of concern product conditions reference
Wildlife and environmental toxicity European Union -Classification & Labelling
show more
PERSISTENCE AND BIOACCUMULATION
type of concern product conditions reference
Not known to bioaccumulative in wildlife or humans Environmental Canada
Domestic Substance List
show more
DATA GAPS
type of concern product conditions reference
56 studies on toxicity in PubMed see search results -> PubMed
GOVERNMENT, INDUSTRY, ACADEMIC STUDIES AND CLASSIFICATIONS
government/industry list/academicstudy
appears on list as classification(s)
European Union - Classification
& Labelling
BRONOPOL (INN); 2-BROMO-
2-NITROPROPANE-1,3-DIOL
•Harmful
•Irritating to respiratory system and skin
•Very toxic to aquatic organisms
Canada - Prohibited and
Restricted CosmeticsIngredients
2-BROMO-2-NITROPROPANE-
1,3-DIOL
• Restricted
Cosmetic Ingredient Review
Assessments
2-BROMO-2-NITROPROPANE-
1,3-DIOL
•Safe for use in cosmetics with some
qualifications
•Determined safe for use in cosmetics up
to a specified concentration limit
•Nitrosating agent: forms carcinogenic
nitrosamine compounds if mixed with
amines
Environmental Canada
Domestic Substance List
1,3-PROPANEDIOL, 2-BROMO-
2-NITRO-
;N-Persistant;N-Bioaccumulative;Y-
AquaticTox;;;;
National Library of Medicine
HazMap
BRONOPOL •Skin Sensitizer - An agent that can induce
an allergic reaction in the skin or lungs:
ROMO-2-NITROPROPANE-1,3-DIOL || Skin Deep: Cosmetic Safe... http://www.cosmeticsdatabase.com/ingredient.php?ingred06=70001
6 16/6/2009 10:23 µµ
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Yes;
EPA Toxic Release Inventory
PBTs
2BROMO2NITRO1,3PROPANEDIOL • Toxic under the EPA's Toxics Release
Inventory
US EPA, 1788 2-BROMO-2-NITROPROPANE-
1,3-DIOL
• Gastrointestinal or Liver Toxicity
Hazards: suspected
A Relational Database of
Hazardous Chemicals and
Occupational Diseases
2-BROMO-2-NITROPROPANE-
1,3-DIOL
• Skin or Sense Organ Toxicity Hazards:
suspected
RTECS®- "Pesticide Index,"
Frear, E 1976
2-BROMO-2-NITROPROPANE-
1,3-DIOL
• broad systemic - Broad systemic toxicity
(rat LD50)
RTECS®- "Vrednie chemichescie
veshestva, galogen I kislorod
sodergashie organicheskie
soedinenia" 1994
2-BROMO-2-NITROPROPANE-
1,3-DIOL
• gastrointestinal - Gastritis (rabbit LD50)
• respiratory - Other changes (rabbit LD50)
• gastrointestinal - Peritonitis (rat LD50)
RTECS®- "Vrednie chemichescie
veshestva, galogen I kislorod
sodergashie organicheskie
soedinenia" 1994
2-BROMO-2-NITROPROPANE-
1,3-DIOL
• respiratory - Dyspnea (rat TDLo)
• gastrointestinal - Other changes (rat
TDLo)
• skin - Primary skin irritant (rat )
RTECS®- Federal Register 2002 2-BROMO-2-NITROPROPANE-
1,3-DIOL
• gastrointestinal - Changes in structure or
function of salivary glands (rat TDLo)
• endocrine system - Death in the "U" data
type field (rat TDLo)
• reproductive - Other effects (rabbit
TDLo)
• metabolic - Weight loss or decreased
weight gain (rat TDLo)
• kidney or renal system - Changes
primarily in glomeruli (rat TDLo)
• kidney or renal system - Hematuria (rat
TDLo)
• gastrointestinal - Other changes (rat
TDLo)
• respiratory - Respiratory depression (rat
TDLo)
• gastrointestinal - Ulceration or bleeding
from stomach (rat TDLo)
RTECS®- Iyakuhin Kenkyu 1977 2-BROMO-2-NITROPROPANE-1,3-DIOL
• broad systemic - Broad systemic toxicity(rat LD50)
RTECS®- Journal of
Environmental Pathology and
Toxicology 1980
2-BROMO-2-NITROPROPANE-
1,3-DIOL
• skin - Primary skin irritant (rabbit )
RTECS®- Journal of the Society
of Cosmetic Chemists 1978
2-BROMO-2-NITROPROPANE-
1,3-DIOL
• broad systemic - Broad systemic toxicity
(rat LD50)
• sense organ - Primary eye irritant (rabbit
)
• skin - Primary skin irritant ( human )
RTECS®- Khimiko-
Farmatsevticheskii Zhurnal
1977
2-BROMO-2-NITROPROPANE-
1,3-DIOL
• broad systemic - Broad systemic toxicity
(mouse LD50)
ROMO-2-NITROPROPANE-1,3-DIOL || Skin Deep: Cosmetic Safe... http://www.cosmeticsdatabase.com/ingredient.php?ingred06=70001
6 16/6/2009 10:23 µµ
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RTECS®- Kiso to Rinsho 1974 2-BROMO-2-NITROPROPANE-
1,3-DIOL
• skin - Hair (rat LD50)
• brain and nervous system - Somnolence
(general depressed activity) (rat LD50)
RTECS®- Pesticide Manual 1991 2-BROMO-2-NITROPROPANE-
1,3-DIOL
• broad systemic - Broad systemic toxicity
(mouse LD50)
REFERENCES
government/industry list/academicstudy
reference
European Union - Classification
& Labelling
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European
Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex I of
Directive 67/548/EEC through the 31st ATP.
Canada - Prohibited and
Restricted Cosmetics
Ingredients
Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients.
Canada's Cosmetic Ingredient Hotlist. March 2007.
Cosmetic Ingredient Review
Assessments
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing
abstracts, discussions, and conclusions of CIR cosmetic ingredient safety
assessments. Washington DC.
Environmental Canada Domestic
Substance List
EC (Environment Canada). 2008. Domestic Substances List Categorization.
Canadian Environmental Protection Act (CEPA) Environmental Registry.
National Library of Medicine
HazMap
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure
to Hazardous Agents.
EPA Toxic Release Inventory
PBTs
EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory
Program. PBT Chemical Rule.
Scorecard.org Toxicity
Information
US EPA. Addition of Certain Chemicals; Toxic Chemical Release Reporting;
Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788
(Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized
in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under
Chemical Expansion. http://www.epa.gov/tri/chemical/hazard_cx.htm
Scorecard.org Toxicity
Information
A Relational Database of Hazardous Chemicals and Occupational Diseases.
Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov
/hazmapadv.html - testing a change
RTECS®- "Pesticide Index,"Frear, E 1976
RTECS®- "Pesticide Index," Frear, E.H., ed., State College, PA, College SciencePub., 1969 5,30,1976
RTECS®- "Vrednie chemichescie
veshestva, galogen I kislorod
sodergashie organicheskie
soedinenia" 1994
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie
organicheskie soedinenia". (Hazardous substances. Galogen and oxygen
containing substances), Bandman A.L. et al., Chimia, 1994 -,193,1994
RTECS®- "Vrednie chemichescie
veshestva, galogen I kislorod
sodergashie organicheskie
soedinenia" 1994
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie
organicheskie soedinenia". (Hazardous substances. Galogen and oxygen
containing substances), Bandman A.L. et al., Chimia, 1994 -,194,1994
RTECS®- Federal Register 2002 RTECS®- Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- 67,78459,2002
ROMO-2-NITROPROPANE-1,3-DIOL || Skin Deep: Cosmetic Safe... http://www.cosmeticsdatabase.com/ingredient.php?ingred06=70001
6 16/6/2009 10:23 µµ
8/3/2019 2-BROMO-2-NITROPROPANE-1,3-..
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RTECS®- Iyakuhin Kenkyu 1977 RTECS®- Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai,
12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
8,680,1977
RTECS®- Journal of
Environmental Pathology and
Toxicology 1980
RTECS®- Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
4(4),47,1980
RTECS®- Journal of the Societyof Cosmetic Chemists 1978
RTECS®- Journal of the Society of Cosmetic Chemists. (Soc. of CosmeticChemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
29,3,1978
RTECS®- Khimiko-
Farmatsevticheskii Zhurnal
1977
RTECS®- Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical
Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1967- 11(1),73,1977
RTECS®- Kiso to Rinsho 1974 RTECS®- Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- 8,1029,1974
RTECS®
- Pesticide Manual 1991 RTECS®
- Pesticide Manual. (The British Crop Protection Council, 20 BridportRd., Thornton Heath CR4 7QG, UK) V.1- 1968- 9,103,1991
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and
through MDL Information Systems, Inc.
ROMO-2-NITROPROPANE-1,3-DIOL || Skin Deep: Cosmetic Safe... http://www.cosmeticsdatabase.com/ingredient.php?ingred06=70001
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