2-bromo-2-nitropropane-1,3-

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116,254,710 searches since 2004home > ingredient: 2-BROMO-2-NITROPROPANE-1,3-DIOL

2-BROMO-2-NITROPROPANE-1,3-DIOL

Preservative

This ingredient:

Cancer

Developmental/reproductive toxicity

Violations, restrictions & warnings

Allergies/immunotoxicity

Contamination concerns - FORMALDEHYDE, NITROSAMINES

Other strong concerns for this ingredient:

Organ system toxicity (non-reproductive), Irritation (skin,

eyes, or lungs), Occupational hazards

Other moderate concerns for this ingredient:

Neurotoxicity

Lesser or emerging concerns for this ingredient:

Endocrine disruption, Ecotoxicology

See products containing 2-BROMO-2-NITROPROPANE-

1,3-DIOL

About 2-BROMO-2-NITROPROPANE-1,3-DIOL: 2-Bromo-2-Nitropropane-1,3-Diol is a substituted aliphatic diol.

2-BROMO-2-NITROPROPANE-1,3-DIOL has reported used in the following

product types: conditioner (20); baby wipes (16); facial moisturizer/treatment

(13); moisturizer (12); facial cleanser (8); body wash/cleanser (8); makeup

remover (4); exfoliant/scrub (4); hand cream (3); personal cleansing (3)

ALLERGIES/IMMUNOTOXICITY

type of concern product conditions reference

Known human immune system toxicant National Library of

Medicine HazMap

Human skin toxicant - strong evidence

VIOLATIONS, RESTRICTIONS & WARNINGS


Restricted in cosmetics (recommendations or

requirements) - use, concentration, or manufacturing

restrictions - Use is restricted in Canadian cosmetics

Canada - Prohibited and

Restricted Cosmetics

Ingredients

Determined safe for use in cosmetics, subject to

concentration or use limitations - Safe for use in

cosmetics with some qualifications

Cosmetic Ingredient

Review Assessments

10 high hazard

49% data gap

(why scores have changed)

BRONOPOL; 1,3-PROPANEDIOL,

2-BROMO-2-NITRO-; 2-BROMO-

2-NITRO- 1,3-PROPANEDIOL;

1,3PROPANEDIOL, 2BROMO2NITRO

SCORE

ALSO LISTED AS

ROMO-2-NITROPROPANE-1,3-DIOL || Skin Deep: Cosmetic Safe... http://www.cosmeticsdatabase.com/ingredient.php?ingred06=70001

6 16/6/2009 10:23 µµ



ORGAN SYSTEM TOXICITY (NON-REPRODUCTIVE)


Known human lung and skin toxicant products that may be

aerosolized (airborne);

products for use on skin

European Union -

Classification & Labelling

One or more animal studies show gastrointestinal

effects at very low doses

RTECS®- "Vrednie

chemichescie veshestva,

galogen I kislorod

sodergashie organicheskie

soedinenia" 1994

One or more animal studies show broad systemic

effects at very low doses

RTECS®- Khimiko-

Farmatsevticheskii

Zhurnal 1977

show more

NEUROTOXICITY


One or more animal studies show brain and nervous

system effects at low doses

RTECS®- Kiso to Rinsho

1974

OCCUPATIONAL HAZARDS


Allowed workplace exposures restricted to low doses European Union -


IRRITATION (SKIN, EYES, OR LUNGS)


Classified as lung and skin irritant products that may be

aerosolized (airborne);

products for use on skin

European Union -


show more

ENDOCRINE DISRUPTION


One or more animal studies show endocrine system

disruption at high doses

RTECS®- Federal Register

2002

DEVELOPMENTAL/REPRODUCTIVE TOXICITY



6 16/6/2009 10:23 µµ



One or more animal studies show reproductive effects

at high doses

RTECS®- Federal Register

2002

ECOTOXICOLOGY


Wildlife and environmental toxicity European Union -Classification & Labelling

show more

PERSISTENCE AND BIOACCUMULATION


Not known to bioaccumulative in wildlife or humans Environmental Canada

Domestic Substance List

show more

DATA GAPS


56 studies on toxicity in PubMed see search results -> PubMed

GOVERNMENT, INDUSTRY, ACADEMIC STUDIES AND CLASSIFICATIONS

government/industry list/academicstudy

appears on list as classification(s)

European Union - Classification

& Labelling

BRONOPOL (INN); 2-BROMO-

2-NITROPROPANE-1,3-DIOL

•Harmful

•Irritating to respiratory system and skin

•Very toxic to aquatic organisms


Restricted CosmeticsIngredients

2-BROMO-2-NITROPROPANE-

1,3-DIOL

• Restricted

Cosmetic Ingredient Review

Assessments


1,3-DIOL

•Safe for use in cosmetics with some

qualifications

•Determined safe for use in cosmetics up

to a specified concentration limit

•Nitrosating agent: forms carcinogenic

nitrosamine compounds if mixed with

amines

Environmental Canada

Domestic Substance List

1,3-PROPANEDIOL, 2-BROMO-

2-NITRO-

;N-Persistant;N-Bioaccumulative;Y-

AquaticTox;;;;

National Library of Medicine

HazMap

BRONOPOL •Skin Sensitizer - An agent that can induce

an allergic reaction in the skin or lungs:


6 16/6/2009 10:23 µµ



Yes;

EPA Toxic Release Inventory

PBTs

2BROMO2NITRO1,3PROPANEDIOL • Toxic under the EPA's Toxics Release

Inventory

US EPA, 1788 2-BROMO-2-NITROPROPANE-

1,3-DIOL

• Gastrointestinal or Liver Toxicity

Hazards: suspected

A Relational Database of

Hazardous Chemicals and

Occupational Diseases


1,3-DIOL

• Skin or Sense Organ Toxicity Hazards:

suspected

RTECS®- "Pesticide Index,"

Frear, E 1976


1,3-DIOL

• broad systemic - Broad systemic toxicity

(rat LD50)

RTECS®- "Vrednie chemichescie

veshestva, galogen I kislorod


soedinenia" 1994


1,3-DIOL

• gastrointestinal - Gastritis (rabbit LD50)

• respiratory - Other changes (rabbit LD50)

• gastrointestinal - Peritonitis (rat LD50)




soedinenia" 1994


1,3-DIOL

• respiratory - Dyspnea (rat TDLo)

• gastrointestinal - Other changes (rat

TDLo)

• skin - Primary skin irritant (rat )

RTECS®- Federal Register 2002 2-BROMO-2-NITROPROPANE-

1,3-DIOL

• gastrointestinal - Changes in structure or

function of salivary glands (rat TDLo)

• endocrine system - Death in the "U" data

type field (rat TDLo)

• reproductive - Other effects (rabbit

TDLo)

• metabolic - Weight loss or decreased

weight gain (rat TDLo)

• kidney or renal system - Changes

primarily in glomeruli (rat TDLo)

• kidney or renal system - Hematuria (rat

TDLo)

• gastrointestinal - Other changes (rat

TDLo)

• respiratory - Respiratory depression (rat

TDLo)

• gastrointestinal - Ulceration or bleeding

from stomach (rat TDLo)

RTECS®- Iyakuhin Kenkyu 1977 2-BROMO-2-NITROPROPANE-1,3-DIOL

• broad systemic - Broad systemic toxicity(rat LD50)

RTECS®- Journal of

Environmental Pathology and

Toxicology 1980


1,3-DIOL

• skin - Primary skin irritant (rabbit )

RTECS®- Journal of the Society

of Cosmetic Chemists 1978


1,3-DIOL


(rat LD50)

• sense organ - Primary eye irritant (rabbit

)

• skin - Primary skin irritant ( human )

RTECS®- Khimiko-

Farmatsevticheskii Zhurnal

1977


1,3-DIOL


(mouse LD50)


6 16/6/2009 10:23 µµ



RTECS®- Kiso to Rinsho 1974 2-BROMO-2-NITROPROPANE-

1,3-DIOL

• skin - Hair (rat LD50)

• brain and nervous system - Somnolence

(general depressed activity) (rat LD50)

RTECS®- Pesticide Manual 1991 2-BROMO-2-NITROPROPANE-

1,3-DIOL


(mouse LD50)

REFERENCES

government/industry list/academicstudy

reference

European Union - Classification

& Labelling

CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European

Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex I of

Directive 67/548/EEC through the 31st ATP.


Restricted Cosmetics

Ingredients

Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients.

Canada's Cosmetic Ingredient Hotlist. March 2007.

Cosmetic Ingredient Review

Assessments

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing

abstracts, discussions, and conclusions of CIR cosmetic ingredient safety

assessments. Washington DC.

Environmental Canada Domestic

Substance List

EC (Environment Canada). 2008. Domestic Substances List Categorization.

Canadian Environmental Protection Act (CEPA) Environmental Registry.

National Library of Medicine

HazMap

NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure

to Hazardous Agents.

EPA Toxic Release Inventory

PBTs

EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory

Program. PBT Chemical Rule.

Scorecard.org Toxicity

Information

US EPA. Addition of Certain Chemicals; Toxic Chemical Release Reporting;

Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788

(Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized

in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under

Chemical Expansion. http://www.epa.gov/tri/chemical/hazard_cx.htm

Scorecard.org Toxicity

Information

A Relational Database of Hazardous Chemicals and Occupational Diseases.

Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov

/hazmapadv.html - testing a change

RTECS®- "Pesticide Index,"Frear, E 1976

RTECS®- "Pesticide Index," Frear, E.H., ed., State College, PA, College SciencePub., 1969 5,30,1976




soedinenia" 1994

RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie

organicheskie soedinenia". (Hazardous substances. Galogen and oxygen

containing substances), Bandman A.L. et al., Chimia, 1994 -,193,1994




soedinenia" 1994

RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie

organicheskie soedinenia". (Hazardous substances. Galogen and oxygen

containing substances), Bandman A.L. et al., Chimia, 1994 -,194,1994

RTECS®- Federal Register 2002 RTECS®- Federal Register. (U.S. Government Printing Office, Supt. of

Documents, Washington, DC 20402) V.1- 1936- 67,78459,2002


6 16/6/2009 10:23 µµ



RTECS®- Iyakuhin Kenkyu 1977 RTECS®- Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai,

12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-

8,680,1977

RTECS®- Journal of

Environmental Pathology and

Toxicology 1980

RTECS®- Journal of Environmental Pathology and Toxicology. (Park Forest

South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.

4(4),47,1980

RTECS®- Journal of the Societyof Cosmetic Chemists 1978

RTECS®- Journal of the Society of Cosmetic Chemists. (Soc. of CosmeticChemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-

29,3,1978

RTECS®- Khimiko-

Farmatsevticheskii Zhurnal

1977

RTECS®- Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical

Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga,

113095 Moscow, USSR) V.1- 1967- 11(1),73,1977

RTECS®- Kiso to Rinsho 1974 RTECS®- Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda

Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- 8,1029,1974

RTECS®

- Pesticide Manual 1991 RTECS®

- Pesticide Manual. (The British Crop Protection Council, 20 BridportRd., Thornton Heath CR4 7QG, UK) V.1- 1968- 9,103,1991

"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and

through MDL Information Systems, Inc.
