AHNS 2010 RESEARCH WORKSHOPon The Biology, Prevention and Treatment of Head & Neck Cancer

ADVANCE PROGRAMWHEN: October 28-30, 2010

WHERE: Hyatt Regency Crystal City 2799JeffersonDavisHighway•Arlington,VA22202

Early Registration & Housing Deadline: September 24, 2010

WHO SHOULD ATTENDHead and Neck SurgeonsResidents and FellowsClinical InvestigatorsGeneticistsImmunologistsMolecular and Cellular BiologistsAllied Health Professionals

Visit www.ahns.info for more information.

2 AHNS 2010 RESEARCH WORKSHOP

YOU’RE iNViTED!

TABLE OF CONTENTS 2 General Information4 About the AHNS4 Workshop Leadership5 Scientific Program7 Social Events10 Exhibit Hall11 Accommodations11 Registration Instructions12 Registration Form

iNViTATiON FROM THE PROGRAM CHAiRSDearColleagues,

OnbehalfoftheAmericanHeadandNeckSociety,itisourpleasuretoinviteyoutoattendthe2010ResearchWorkshopontheBiology,PreventionandTreatmentofHeadandNeckCancer,October28-30,2010,inArlington,Virginia.

Thisyearmarkstheeighthtimethiscornerstonemeetinghasbeenheld.Convenedeveryfouryears,theResearchWorkshopservesasaplatformforAHNS’smissionandprovidesaninternationalforumforthepresentationanddiscussionofnewresearchdevelopmentsinallscientificfieldsrelatedtoheadandneckcancer.Wehavecarefullydesignedtheprogramaroundidentifyingthenationalresearchprioritiesinheadandneckcancerforthenextfiveyears.TheprogramfeaturestwokeynotelecturesfromDrs.WilliamPaoandLeviGarraway,avarietyofconcurrentsessions–bothpanelsandscientificsessionstocomplementthedifferentdisciplineswhoseresearchaddressestheproblemsofheadandneckcancers,anexhibithallwiththelatestscientificproductsandservices,andseveralsocialopportunitiesfornetworkingandcollaboration.

Throughincreasedinteractionsbetweenscientistsandcliniciansinthefield,the2010ResearchWorkshopoffersauniqueopportunitytodisseminatenewresearchfindings,stimulatenewresearchinitiatives,anddiscussandimplementtranslationalresearchobjectivesandgoals.

WehopeyouandyourcolleagueswilljoinusthisOctoberinArlingtonforthefutureofheadandneckcancerresearch.

CarolR.Bradford,MD JenniferR.Grandis,MDProgram Chair Program Co-Chair

ARLiNGTON, ViRGiNiA Neighbor To The NaTioN’s CapiTol!VeryfewregionsintheUnitedStatescanboastalocalhistorythatisinextricablytiedtoourNationalstory.Arlington,Virginiaisoneofthoseregions-locatedacrossthePotomacRiverfromWashington,D.C.,ArlingtonwasoncepartoftheoriginalFederalCity.Fromitsverybeginningstothepresentday,Arlington’sgeography,buildings,andcitizenshaveplayedaleadingroleintheformationoftheWashingtonD.C.area,andourrichnationalhistory.

Arlington,Virginia,isthebestplacefromwhichtoexperienceournation’scapital.OnelookatourfamousviewofWashington,D.C.saysitall.IntheheartofArlington,visitArlingtonNationalCemetery,finalrestingplaceofAmericanwarheroes,orfeelyournationalpridestirredbythechangingoftheguardattheTomboftheUnknowns.CivilWarbuffswillenjoyatourofArlingtonHouse,formerresidenceofRobertE.Lee.

CrystalCityhasArlington’slargestdowntownarea,with10millionsquarefeetofofficespace,5,000rooms,5,000residences,andagrowing“restaurantrow”.ItisalllocatedjustminutesfromReaganNationalAirport.

EDUCATiONAL OBJECTiVESAt the conclusion of this activity, participants will be able to:

Discuss• theroleofsurgery,radiationtherapy,chemoradiation,andcombinedmodalitytherapyinthetreatmentofheadandneckcancerandtheeffectofeachtreatmentmodalityonclinicalandfunctionaloutcomes.Understand• theclinicalusesofnewnovelmolecularagentsinthemanagementofheadandneckcancer.Be familiar with• theadvantagesanddisadvantagesofultrasound,PETandPET-CTintheevaluationofpatientswithheadandneckcancer.Understand• theimpactoftreatmentonfunctionaloutcomeofheadandneckcancerpatients.Describe• significantadvancesinthefieldofheadandneckcancerresearchthathaveoccurredsincethelastresearchworkshopwasconducted.

Registeron-linetodayatwww.ahns.info/registration 3

GENERAL iNFORMATiON

WHO: The American Head & Neck Society

WHAT: Research Workshop on the Biology, Prevention and Treatment of Head & Neck Cancer

WHEN: October 28-30, 2010

WHERE: Hyatt Regency Crystal City 2799JeffersonDavisHighway•Arlington,VA22202

CONTACT: The American Head and Neck Society (AHNS) 11300W.OlympicBlvd.,Suite600 LosAngeles,CA90064 Phone:+1-310-437-0559 Fax: +1-310-437-0585 Email: registration@ahns.info www.ahns.info

AHNS Accreditation StatementTheAmericanHead&NeckSociety(AHNS)isaccreditedbytheAccreditationCouncilforContinuingMedicalEducation(ACCME)tosponsorContinuingMedicalEducationforphysicians.TheAHNSdesignatesthisactivityforamaximumof 18.5 AMA PRA Category1 Credit(s)™.Physiciansshouldonlyclaimcreditcommensuratewiththeextentoftheirparticipationintheactivity.

Shuttle ServiceNoshuttleservicewillbeprovidedtootherareahotels.ComplimentaryshuttleserviceisavailabledailytoandfromtheCrystalCityMetrostopandtheReganNationalAirport.TheshuttlerotatesfromReaganNationalAirporttothehotelevery20minutes.Gotothehotelcourtesyshuttlestandneargroundtransportationuponarrival.Valetparkingisavailableatthehotelforapproximately$25perdaywithin/outprivileges.

Special Services TheAHNSwishestoensurethatnoindividualwithadisabilityisexcluded,deniedservices,segregatedorotherwisetreateddifferentlybecauseoftheabsenceofauxiliaryaidsandservices.Ifyourequireauxiliaryaidsorservices,pleaseindicateyourneedsontheregistrationformenclosedinthisprogram.

Important Visa Information for International AttendeesFormorethan50years,theUnitedStatesofAmericahasrequiredvisastobeissuedtothosewishingtostudy,visit,orconductbusinessintheU.S.Whilechangeshavebeenmaderecentlytovisalaw,manyproceduresremainthesame.Moreimportantly,youmustAPPLYEARLYforavisa,asprocessingtimehasincreasedinsomeinstances.Forinformationaboutobtainingavisa,pleasevisitthefollowingwebsite:www.travel.state.gov.

Ifyouneedawritteninvitationtoassistyouwithyourvisa,pleasecontacttheMeetingRegistraratregistration@ahns.info.

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4 AHNS 2010 RESEARCH WORKSHOP

ABOUT AHNS

HiSTORY OF THE SOCiETYOnMay13,1998,TheAmericanHeadandNeckSociety(AHNS)becamethesinglelargestorganizationinNorthAmericafortheadvancementofresearchandeducationinheadandneckoncology.Themergeroftwosocieties,theAmericanSocietyforHeadandNeckSurgeryandtheSocietyofHeadandNeckSurgeons,formedtheAmericanHeadandNeckSociety.

ThecontributionsmadebythetwosocietiesformingtheAHNSaresignificantinthehistoryofsurgeryintheUnitedStates.Dr.HayesMartinconceivedtheSocietyofHeadandNeckSurgeonsin1954,asurgeonconsideredbymanytobethe“fatherofmodernheadandnecktumorsurgery.”Thepurposeofthesocietywastoexchangeandadvancethescientificknowledgerelevanttothesurgeryofheadandnecktumors(exclusiveofbrainsurgery)withanemphasisoncanceroftheheadandneck.Twoyearslater,TheAmericanSocietyforHeadandNeckSurgerywasorganizedwiththegoalto“facilitateandadvanceknowledgerelevanttosurgicaltreatmentofdiseasesoftheheadandneck,includingreconstructionandrehabilitation;promoteadvancementofthehighestprofessionalandethicalstandardsastheypertaintothepracticeofmajorheadandnecksurgery;andtohonorthosewhohavemademajorcontributionsinthefieldofheadandnecksurgery,orhaveaidedinitsadvancement”.

ThenewSocietyremainsdedicatedtothecommongoalsofitsparentalorganizations.

Mission Statement Thepurposeofthissocietyistopromoteandadvancetheknowledgeofprevention,diagnosis,treatmentandrehabilitationofneoplasmsandotherdiseasesoftheheadandneck,topromoteandadvanceresearchindiseasesoftheheadandneck,andtopromoteandadvancethehighestprofessionalandethicalstandards.

Why Join the AHNS? TheAmericanHeadandNeckSocietyisanorganizationofphysicians,scientistsandalliedhealthprofessionalsdedicatedtoimprovingtheunderstandingofHeadandNeckCancerandthecareofpatientsafflictedwiththatdisease.Membershipisopentoawidevarietyofinterestedindividualsinseveralcategoriesthatdifferbothintermsofresponsibilityandlevelofinvolvementinthesociety.

FormoreinformationaboutAHNSmembershipandtoapplyon-line,pleasevisit www.ahns.info/membercentral orcall+1 310-437-0559,ext.110.

RESEARCH WORKSHOP PROGRAM COMMiTTEE CarolR.Bradford,MD Program Chair

JenniferR.Granids,MD Program Co-Chair

CarolM.Bier-Laning,MD

RuudH.Brakenhoff,MD

JosephA.Califano,MD

AndreL.Carvalho,MD

AmyChen,MD

EzraW.Cohen,MD

TerryA.Day,MD

JamesA.Fagin,MD

RobertL.Ferris,MD,PhD

NeilGross,MD

Quynh-ThuLe,MD

MarkPrince,MD

JamesRocco,MD,PhD

DuaneA.Sewell,MD

RichardJ.Shaw,BDS,FDS, MBChB,FRCS

ErichM.Sturgis,MD

TheodorosN.Teknos,MD

MarileneB.Wang,MD

JohanWennerberg,MD,PhD

RichardJ.Wong,MD

WendellG.Yarbrough,MD

BevanYueh,MD

Registeron-linetodayatwww.ahns.info/registration 5

SCiENTiFiC PROGRAM

Dr. Pao

THURSDAY, OCTOBER 28, 20107:45am-8:10am Welcome and Overview of Workshop - Carol R. Bradford, MD & Jennifer R. Grandis, MD8:10am-9:00am KEYNOTE LECTURE: “Genotype-Driven Cancer Medicine”� William Pao, PhD, Associate Professor of Medicine; Ingram Associate Professor of Cancer Research; Assistant Director, Personalized Cancer Medicine, Vanderbilt University, Nashville, TN9:00am-10:30am Concurrent Sessions

PANEL: Molecular Pathogenesis/Markers of Tumor Progression Co-Chairs: NishaJ.D’Silva,BDS,MSD,PhD&WayneM.Koch,MD

Description: Thissessionwilladdressgenomicpredictorsofpremalignancyprogression,biomarkersofHNCprogression,molecularmarkersofresponsetotreatmentandmarginanalyses andHNCprognosis.

9:00am Epigenomic Salivary Markers for HNC Detection Joseph A. Califano, MD9:15am Molecular Biomarkers in HNC Progression Nisha J. D’Silva, BDS, MSD, PhD9:30am Molecular Signatures of Response to Targeted Therapy - Christine H. Chung, MD9:45am Margin Analyses and HNC Prognosis Wayne M. Koch, MD10:00amAbstract Presentations

At the conclusion of this session, participants will be able to: Assessthevalueofmolecularvs.histologicmarginanalysisfor•adequacyofsurgicalresection.List3biomarkersthatpredictHNCprogression.•ListpotentialpredictorsofresponsetoEGFRtargetedtherapy.•Applymolecularmarkerdetectionforcancersurveillance.•

ABSTRACTS: Cell Cycle Regulation/Apoptosis/Autophagy Co-Chairs: JamesW.Rocco,MD,PhD&WendellG.Yarbrough,MD

Description: Abstractsrelevanttothissessionwillbeselectedfromthescoredabstracts.Inaddition,DrsRocco,YarbroughandYuhaveexpertiseinthisareaandwillpresentrelatedworkfromtheirrespectivelaboratories.

9:00am Novel Protein Regulator of Tumor Suppressor ARF and NF-KB - Wendell G. Yarbrough, MD9:08am Targeting Bcl2 Family Members in HNSCC James W. Rocco, MD, PhD9:16am Role of PUMA in EGFR Targeted Therapy Jian Yu, PhD 9:24am Discussion9:30am Abstract Presentations

At the conclusion of this session, participants will be able to:Listrecentadvancesinthefieldofapoptosis/autophagyandcell•cycleregulationastheyrelatedtoHNSCC.UnderstandhowEGFRtargetingisdependentuponthe•proapoptoticPUMAproteininHNSCC.DescribenovelregulationoftheARFandNF-KBmoleculesin•HNSCC.UnderstandthecomplexapoptoticpathwaysatworkinHNSCC.•

10:30am-11:00am Coffee Break with the Exhibitors11:00am-12:30pm Concurrent Sessions

PANEL: Genetics/Epigenetics Co-Chairs: RichardJ.Shaw,MD&MariaJ.Worsham,PhD

Description: Thissessionsaimstogiveanoverviewoftheglobalandgenespecificplatformsavailableinthegeneticandepigeneticanalysisofheadandneckcancers,tooffersomeinsightinspecificareasofinterestandhowthesemightbedevelopedintoclinicallyusefulbiomarkers.

11:00amMolecular Modeling of HNC Diagnosis and Prognosis Maria J. Worsham, PhD11:15am Next Generation (Massively Parallel) Sequencing and Personalized Medicine for Head & Neck Cancer Ross Sibson, PhD11:30am Patterns of Somatic Gene Alterations Karl T. Kelsey, MD, MOH11:45am DNA Methylation Assays in Head and Neck Cancer Richard J. Shaw, MD12:00pmAbstract Presentations

At the conclusion of this session, participants will be able to:Gainanunderstandingofthegeneticandepigenetictechniques•availableatagenomewidescale.TheapproachesandscaleofNextGenerationMethods&Thelikely•impactofNextGenerationMethodsintermsofdiscoveryandapplication.Gainanunderstandingofthegeneticandepigenetictechniques•availableatasinglegenescale.

Appreciatetheprocessbywhichageneticorepigeneticaberration•mightbedemonstratedtobetumourspecificandfunctionallyrelevanti.e.adriverratherthanapassenger.Insightintohowtheseaberrationsmightbeultimatelydeveloped•intoclinicallyrelevantpredictive,prognosticordiagnosticbiomarkers;orintoproductivedrugtargets.

ABSTRACTS: Developmental Therapeutics for Head & Neck Cancer - Co-Chairs:HamidGhandehari,BS,PhD &RichardJ.Wong,MD

Description: Thesession’sgoalistoreviewnoveltherapeuticagentsandapproachesinthemanagementofheadandneckcancer.Agentsmayincludeviral,antibody,smallmolecule,pharmacologic,polymer,andothertherapeuticagents.

11:00amHerpes Viral Targeting of HNC - Richard J. Wong, MD11:08amEngineering Polymers for HNC Gene Therapy Hamid Ghandehari, BS, PhD11:16am Abstract Presentations

At the conclusion of this session, participants will be able to:Gainanunderstandingofhownovelagents(viral,antibody,small•molecule,pharmacologic,polymer,other)maybedesignedforthetherapyofheadandneckcancer.

6 AHNS 2010 RESEARCH WORKSHOP

SCiENTiFiC PROGRAM

12:30pm-1:30pm Lunch on your own1:30pm-3:00pm Concurrent Sessions

PANEL: NCI Head and Neck Steering Committee - Progress to Date and Future Goals Regarding the Integration of Translational Research Into Clinical Trial Development Co-Chairs: JohnA.Ridge,MD,PhD&AndyTrotti,MD

Description: Dr.SchullerservedasCo-chairfortheNCIH&NSteeringCommittee2008-2010,alongwithDrsForastiereandTrotti.DrTrottiisCo-chairoftheRTOGH&NCommmittee,andservedasCo-chairfortheNCIH&NSteeringCommmittee,alongwithDrsForastiereandSchuller,2008-2010.DrBurtnessisChairoftheECOGH&NCommittee.DrRidgeservedasaNCIH&NTaskForceCo-chairforpreviouslyuntreated/locallyadvanced(PULA)H&Ncancers,2008-2010.

1:30pm Genesis of Steering Committee - David E. Schuller, MD1:50pm Interactions of Steering Committee with RTOG Andy Trotti, MD2:10pm Interactions of Steering Committee with ECOG Barbara A. Burtness, MD2:30pm Role of Head and Neck Society in Steering Committee - John A. Ridge, MD, PhD2:50pm Discussion

At the conclusion of this session, participants will be able to:GainanunderstandingofthestructureandprocessoftheNCI•H&NSteeringCommitteeimplementedin2008.Gainanunderstandingofwhichstudieswereapproved,andhow•NCIhassupporteddevelopmentandconductoftranslationalresearchintheseapprovedclinicaltrialsoverthelast3years.

AppreciatethestrengthsandweaknessesofthenewNCIH&N•governancestructureasassessedbykeyinvestigatorandcooperativegroupleadership.

PANEL: Carcinogenesis/Prevention Co-Chairs: FrankG.Ondrey,MD,PhD&DongMoonShin,MD

Description: Thispanelwillexplorecontemporaryconceptsinheadandneckcancerclinicalpreventionandemergingmolecularanddietaryepidemiologicevidenceofassociatedrisks.

1:30pm Chemoprevention with Green Tea - Dong Moon Shin, MD1:45pm PPAR Gamma Strategies and Oral Cancer Prevention - Frank G. Ondrey, MD, PhD2:00pm EGFR Targeting for Chemoprevention Scott M. Lippman, MD2:15pm Chemoprevention Using Controlled Release Polymers Susan Mallery, MD2:30pm Genomic Predictors of Premalignant Progression Xiaofeng Zhou, MD2:45pm Best Prevention & Detection Paper 2:53pm Discussion

At the conclusion of this session, participants will be able to: Understandthenaturalhistoryofcarcinogenesisandmolecular•changesduringtheheadandneckcancerprogression.Understandandupdatethecurrentconceptsofchemoprevention,•biomarkersandepidemiologyoftheheadandneckcancer.

3:00pm-3:30pm Coffee Break with the Exhibitors3:30pm-5:00pm Concurrent Sessions

ABSTRACTS: Immunology/Immunomodulation Moderators: RobertL.Ferris,MD,PhD&JohnH.Lee,MD

Description: Thecurrentstatusofworkinprogresswillbepresented,relevanttoimmunology,immunosppressionandtherapeuticimmunomodulationinpatientswithheadandneckcancer.Invitedtalksfromleadersinthefieldwillbefollowedbyproferredabstractpresentationssubmittedbyattendees.

3:30pm Immune Activation by EGFR-Specific Antibodies in Head and Neck Cancer - Robert L. Ferris, MD, PhD3:38pm Mechanisms of Immune Mediated Clearance for HPV+ HNSCC - John H. Lee, MD3:46pm MAGE-A3/HPV Peptide Vaccines - Duane A. Sewell, MD3:54pm Tadalafil Induced Modulation of Immune Response in HNSCC - Joseph A. Califano, MD4:02pm Therapeutic Strategies for Decreasing the Role of Regulatory T Cells (TREG) in Tumor Escape Theresa L. Whiteside, PhD4:10pm STAT3 Signaling Can Regulate Myeloid Derived Suppressor Cell Function in Head & Neck Cancer Patients - Young Kim, MD, PhD4:18pm Combination Immunomodulation in Head and Neck Cancer - Sara I. Pai, MD, PhD4:26pm Discussion (5 Minutes)4:31pm Abstract Presentations

At the conclusion of this session, participants will be able to: Understandthemechanismsofimmunosuppressioninheadand•neckcancerpatients.Describetheclinicallyavailableimmunotherapeuticagentsand•possiblemechanismsofaction.

ABSTRACTS: Angiogenesis/Tumor Microenvironment Co-Chairs: EzraE.W.Cohen,MD&SeungwonKim,MD

Description: ThissessionwillreviewthelatestdevelopmentsinantiangiogenictherapyinHNC.WewillalsoreviewtheroleofstemcellsinthepathogenesisofHNC.

3:30pm Concurrent Targeting of VEGFR and EGFR in HNC Seungwon Kim, MD3:45pm Role of Angiogenesis Inhibitors in HNC Treatment Ezra E.W. Cohen, MD4:00pm Endothelial and Head and Neck Cancer Stem Cell Cross Talk - Jacques E. Nor, DDS, MS, PhD4:15pm HNC Stem Cells - Mark E. Prince, MD4:30pm Abstract Presentations

At the conclusion of this session, participants will be able to:Understandthecurrentroleofangiogenesisinhibitorsinthe•treatmentofHNSC.Understandrationaleforcombiningantiangiogenictherapywith•anti-EGFRtherapy.UnderstandroleofstemcellinregulatingthemicroenvironmentofHNC.•

Registeron-linetodayatwww.ahns.info/registration 7

SCiENTiFiC PROGRAM

SOCiAL EVENTS

Welcome Reception & Poster Tour #1Thursday,October28,2010,5:00pm-6:30pm

PleasejoinusintheExhibitHallaswewelcomeyoutotheResearchWorkshopontheBiology,PreventionandTreatmentofHeadandNeckCancer.Sponsoredbyourexhibitors,thiseventwillfeaturecocktailsandlighthorsd’oeuvres.Posterswillbesetinsidetheexhibithallforinteractionbetweenthescientificandthetechnicalexhibits.Eventisfreetoallregisteredworkshopattendeesandregisteredaccompanyingpersons.

Poster Tour #2 & Social Event ReceptionFriday,October29,2010,4:30pm-8:00pm

OnFridaywewillbeginagainintheExhibitHallwithanextendedopportunitytodiscussfurtherscientificworkin-depththroughasecondroundofpostertours.(Pleasenotetheexhibitswillbeclosedatthistime.)Wewillthengathertogetherforamorerelaxedsettingofmusic,morefoodandcocktailswithenoughtimeleftintheeveningtodineseparatelywithyourfriendsandcolleagues.Eventisfreetoallregisteredworkshopattendeesandregisteredaccompanyingpersons.

5:00pm-6:30pm Opening Reception in the Exhibit Hall with Poster Tour Session #16:00pm-8:00pm GRANT WRiTiNG WORKSHOP with Mock Study Session (Additional Fee)

Description: Thegoalistoprovideinformationondevelopingahypothesis,do’sanddon’tsoftheresearchplan,haveroundtablemockstudysessionsbysuccessfulgrantwritersandprovideusefulhintsincareerdevelopmentforasurgeon.

6:00pm Workshop Introduction Cherie-Ann O. Nathan, MD6:10pm Choosing the Right Grant and Grant Writing Pearls - Jennifer R. Grandis, MD6:40pm R21 Perseverance and Persistence Robert L. Ferris, MD6:50pm The Stepping Stone to a Successful Surgeon Scientist: Writing a K08 Stephen Y. Lai, MD, PhD7:00pm Mock Study Session Workshop: R01, K08, Core Grant - Thomas E. Carey, PhD, Robert L. Ferris, MD, Jennifer R. Grandis, MD, Wayne M. Koch, MD, Duane A. Sewell, MD. & Scott E. Strome, MD

At the conclusion of this session, participants will be able to:

Beknowledgeableingrantsmanshipandgrant•writingissues.Understandthereviewprocessandhowto•reviseunfundedgrantsforresubmission.

FRiDAY, OCTOBER 29, 20108:30am-10:00am Concurrent Sessions

PANEL: Role of HPV in HNC, Part I Co-Chairs: DuaneA.Sewell,MD&ErichM.Sturgis,MD

Description: Thissessionisdesignedtoreviewexistingdataand/oremerginddataregardingtheroleofhumanpapillomavirusintheetiology,prognosis,and/ormanagementofheadandneckcancers.Invitedandpeer-reviewedpresentationsrepresentingtheseconceptswillbepresented.

8:30am Sexual Behaviors and Oral HPV Infection Gypsyamber D’Souza, PhD8:45am HPV16 DNA in Peripheral Blood as a Marker of Disease Extent and Recurrence - Erich M. Sturgis, MD9:00am Modulating CD4+CD35+ Tregs in an Animal Model of HPV Associated Head and Neck Cancer Elizabeth Field, MD9:15am Q&A9:20am Abstract Presentations

At the conclusion of this session, participants will be able to: DiscusstheutilityofHPV16DNAinperipheralbloodasa•potentialmarkerofdiseaseextent.DiscusshowTregsmightbemodulatedinHPVassociatedcancers.•

PANEL: Cell Signaling and Targeted Therapies Co-Chairs: Cherie-AnnO.Nathan,MD&CarterVanWaes,MD,PhD

Description: Thesignalnetworkisbeingelucidatedinheadandneckcancer.Emergingmediatorsandtargetsfortherapywillbehighlighted.

8:30am Signal Networks and Targeting HSP90 for Therapy Carter Van Waes, MD, PhD8:45am EGFR Degradation and Cisplatin Sensitivity Mukesh K. Nyati, MD9:00am Growth Factor-Induced Resistance to Targeted Therapy - Mark J. Jameson, MD, PhD9:15am MTOR Signaling as a Therapeutic Target Cherie-Ann O. Nathan, MD9:30am Protein Kinase CK2 as an Emerging Target Zhong Chen, MD, PhD9:45am Discussion

At the conclusion of this session, participants will be able to:List3signalpathways/targetsunderpreclinicalorclinical•investigation.Describe3pathways/targetsthatmediateresistancetocurrent•EGFRtargetedtherapies.Describepotentiallyusefulbiomarkersforselectionandmonitoring•ofpatientresponse.

10:00am-10:30am Coffee Break with the Exhibitors

8 AHNS 2010 RESEARCH WORKSHOP

SCiENTiFiC PROGRAM

12:00pm-1:00pm Lunch on your own1:00pm-2:30pm Concurrent Sessions

PANEL: Imaging Techniques (PET/MRI/Ultrasound) and Their Role in the Diagnosis and Assessment of Response to Therapy in Head and Neck Cancer - Co-Chairs: SureshK.Mukherji,MD &DavidL.Schwartz,MD

Description: Panelistswillreviewthecurrentroleofadvancedfunctionalimagingtechniquesinthemanagementofheadandneckcancer.Theemergingcontributionofnovelimagingoftumorproliferation,bloodsupply,andmetabolismtocurrenttreatmentstrategiesandexperimentaltargetedtherapieswillbeemphasized.

1:00pm Imaging Thymidine Update during HNC Treatment Yusuf Menda, MD1:20pm CT-Perfusion as a Means to Assess Treatment Response - Suresh K. Mukherji, MD1:40pm MR Spectroscopy in Head and Neck Cancer Harish Poptani, PhD2:00pm Functional Image Guidance for Advanced IMRT David L. Schwartz, MD2:20pm Q&A

At the conclusion of this session, participants will be able to: Listcurrentfunctionalimagingmodalitiesavailableforlocalizing•andbiologicallycharacterizingheadandneckcancerinpatients.Applyfunctionalimagingtechniquestorelevantclinicalcasesand•researchquestionsinheadandneckoncology.Identifyapplicationsoffunctionalimagingtowardsadvanced•radiotherapyplanninganddevelopmentofclinicaltherapytrialsforheadandneckcancer.

PANEL: Radiation Biology and Response to Therapy Co-Chairs: AvrahamEisbruch,MD&Quynh-ThuLe,MD

Description: Panelistswilldiscussindividualizingtreatmentofheadandneckcancerpatientsincombinationwithradiationvia(1)targetingthetumormicroenvironment,(2)optimalsequencingandintegrationofradiationwithinhibitorsofEGFRreceptorpathways,(3)individualizeddesignofradiationdeliverywithintensitymodulatedradiationtherapy(IMRT)tominimizelatetoxicityand(4)improvesalivaryglandfunctionafterradiationwithmanipulationofgrowthfactorpathways.

1:00pm Where Are We in Targeting Hypoxia and Tumor Microenvironment in HNSCC - Quynh-Thu Le, MD1:15pm Integration of EGFR Inhibitors with Radiochemotherapy - Mukesh K. Nyati, PhD1:30pm Individualizing IMRT Treatment in HNC Avraham Eisbruch, MD1:45pm Mechanisms of IGF-Mediated Rescue of Radiation Induced Salivary Gland Dysfunction Kirsten H. Limesand, PhD2:00pm Abstract Presentations

At the conclusion of this session, participants will be able to:Discusstheavailablebiomarkersforselectingpatientswith•tumorhypoxiaandthetargetingstrategiesforthetumormicroenvirnonment.UnderstandtheoptimalwaytosequencingEGFRinhibitorswith•radiationandchemotherapy.Listorgantolerancefornormaltissueinheadandneckcancerwhen•usingIMRTandhowbesttoprotectthesestructures.Discussnewstrategiesforrescuingsalivaryfunctionafterirradiation•inpatients.

PANEL: Role of HPV in HNC, Part II Co-Chairs: CaroleFakhry,MD&ErichM.Sturgis,MD

Description: Thissessionisdesignedtoreviewexistingdataand/oremerginddataregardingtheroleofhumanpapillomavirusintheetiology,prognosis,and/ormanagementofheadand neckcancers.Invitedandpeer-reviewedpresentationsrepresentingtheseconceptswillbepresented.

10:30amTherapeutic Vaccine for HPV16 Positive HNC and Oral HPV Infection in HIV-Infected Men and Women Carole Fakhry, MD, MPH10:45amGenomic Instability Caused by HPV16 E6 and E7 Dennis McCance, MD11:00amRole of MicroRNAs in HPV-Associated Head and Neck Cancer - Saleem A. Khan, PhD11:15am Q&A11:20amAbstract Presentations

At the conclusion of this session, participants will be able to: DiscusstheutilityofatherapeuticHPV16vaccineinHIV-infected•patientswithHPV16positivehead&neckcancer.DiscusshowTregsmightbemodulatedinHPVassociatedcancers.•DiscusstheroleofmicroRNAsinHPV-associatedheadandneck•cancers.

PANEL: EGFR Targeting and Beyond: New Therapies and Therapeutic Targets - Co-Chairs: BarbaraA.Burtness,MD &NeilD.Gross,MD

Description: DrugsthattargettheEpidermalGrowthFactorReceptor(EGFR)havebeenutilizedextensivelytotreatheadandnecksquamouscellcarcinoma.Yet,theidealclinicalapplicationofEGFRinhibitors,andsimilartargetedmoleculartherapies,hasyettobedetermined.Thissessionwillexaminecontemporaryresearchstrategiesthatutilizetheseagents,particularlyinthesettingofclinicaltrials.

10:30amApplication of Targeted Therapies to Aggressive Cutaneous HNSCC - Neil D. Gross, MD10:45amSRC Family Kinases as Targets in HNC Ann Marie Egloff, PhD, MPH11:00amMolecular Targeting Studies in ECOG Barbara A. Burtness, MD11:15am Use of Novel Therapies in RTOG Studies Stuart J. Wong, MD11:30am Abstract Presentations

At the conclusion of this session, participants will be able to:Discusscurrenttherapeuticstrategiesforaggressivecutaneous•squamouscellcarcinomaoftheheadandneck.Discussnoveldrugtargetsinsquamouscellcarcinoma.•DiscusstheuseofEGFRandsimilartargetedagentsincurrentand•futurecooperativegroupclinicaltrials.

10:30am-12:00pm Concurrent Sessions

2:30pm-3:00pm Coffee Break with the Exhibitors

Registeron-linetodayatwww.ahns.info/registration 9

SCiENTiFiC PROGRAM

Dr. Garraway

3:00pm-4:30pm Concurrent Sessions

PANEL: Proteomics/Genomics Co-Chairs: OleBrinkmann,MD&JosephA.Califano,MD

Description: Highthroughputanalytictechniqueshaveallowedforapplicationofsensitivemolecularassaysfordetectionofanalytesspecifictomalignancy,aswellasanalysisofcomplexpathwaysinvolvedincarcinogenesisandtherapeuticresponse.Thissessionwillexploretheuseofproteomicandgenomicanalysesinassessmentofdiseaseburdenandtherapeuticresponseinheadandnecksquamouscellcarcinoma,aswellasbiomarkersforthedetectionofheadandneckcancers.

3:00pm Redox Modulated Metabolic and Signaling Networks as Molecular Predictors of Response to Radiation Therapy in HNC - Cristina M. Furdui, PhD3:15pm Salivary Soluble Markers for Head and Neck Cancer Elizabeth J. Franzmann, MD3:30pm On-Chip Immunoassays of Tumor Specific Autoantibodies for Head and Neck Cancer Detection - Ho-Sheng Lin, MD3:45pm Epigenetic Artifact in Head and Neck Cancer Cell Lines - Joseph A. Califano, MD4:00pm Salivary Genomics and Proteomics for Oral Cancer Detection - Ole Brinkmann, DMD, PhD4:15pm Discussion

At the conclusion of this session, participants will be able to:Understandthepotentialuseofsalivabasedassaysforassessmentof•diseaseburdeninheadandneckcancerpatients.Understandthepotentialuseofserumandsalivabasedassaysfor•earlydetectionofheadandneckcancerinhighriskpopulation.Understandtheimpactofmetabolicsignalingnetworksandtheir•impactonresponsetoradiationinheadandneckcancer.

Understandtheartifactandepigeneticalterationsinducedby•adherentcellcultureofheadandneckcancer.

ABSTRACTS: Therapies-Clinical Co-Chairs: ArleneA.Forastiere,MD&GregoryT.Wolf,MD

Description: ThissessionwillprovideanoverviewofresearchwithinfourHeadandNeckSPOREsspanningpremalignancytoadvanceddisease.Thesessionwillfocusonnoveltherapies,targetsormulti-disciplinaryapproaches.

Hot Topics From the HN SPoReS:3:00pm Inter-SPORE Trials and Collaborations from the Pittsburgh HN SPORE - Jennifer R. Grandis, MD3:10pm Ligand-Specific Therapeutic Nanoparticles in Head and Neck Cancer - Dong Moon Shin, MD3:20pm Targeted Therapy for Larynx Preservation Gregory T. Wolf, MD3:30pm Gene Expression Profiles and Oral Cancer Risk Scott M. Lippman, MD3:40pm Abstract Presentations

At the conclusion of this session, participants will be able to:Understandthespectrumoftranslationalresearchwithinthe•SPORES.Understandareasofcurrentresearchinterestasrelatedtonovel•therapeutics,andopportunitiesforexpandedparticipation.Understandapproachestocombiningtargetedtherapies•withcytotoxicsandradiotherapyinmultidisciplinarydiseasemanagement.

4:30pm-6:00pm Poster Tour Session #2 with Wine and Cheese6:00pm-8:00pm Social Event Reception

SATURDAY, OCTOBER 30, 20108:00am-8:50am KEYNOTE LECTURE: “Systematic and Functional Genomic Studies of Human Cancer”� LeviA.Garraway,MD,Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute/Brigham and Women’s Hospital9:00am-10:30am Concurrent Sessions

PANEL: So You’re A Head And Neck Cancer Survivor: What’s Next? Co-Chairs: AmyY.Chen,MD,MPH&BevanYueh,MD,MPH

Description: Thispanelwillexploreissuesofsurvivorshipandsymptommanagementinheadandneckcancersurvivors.Panelistswilldiscussareassuchasdepression,substanceabuse,acupuncture,andsexualintimacyinthesettingofHPVrelatedcancers.

9:00am What Works in a Smoking Cessation Program - Elba C. Díaz Toro, MD9:15am Relapsed Smoking Cessation - Vani N. Simmons, PhD9:30am Important Aspects of an Effective Smoking Cessation Program Janice A. Blalock, PhD9:45am Prevention and Predictors of Post-Treatment Depression William J. Burke, MD10:00amAcupuncture in Symptom Management - Weidong Lu, MB10:15am Discussion

At the conclusion of this session, participants will be able to: Understandthemultidimensionalfacetsofsmokingcessation.•Appreciatethepotentialadvantagesofpreventingtheemergenceofdepressionduring•treatmentforheadandneckcancer.Appreciatepotentialbenefitsofacupunctureinmanagingfunctionaloutcomessuchas•dysphagia,xerostomiaandpainforpatientswithheadandneckcancer

ABSTRACTS: Correlative Studies in Conjunction with Clinical Trials: Potentials and Pitfalls Co-Chairs: TerryA.Day,MD &JohanP.Wennerberg,MD,PhD

Description: Thissessionwillpresentpeer-reviewedabstractsinrelationtothetopic.

9:00am Abstract Presentations

10 AHNS 2010 RESEARCH WORKSHOP

SCiENTiFiC PROGRAM

12:00pm-12:15pm Closing Comments/Meeting Summary/Future Directions - Carol Bradford, MD & Jennifer Grandis, MD12:15pm Adjourn

PANEL: Invasion/Metastasis: Models and Applications Co-Chairs: ThomasE.Carey,PhD&Ernst-JanM.Speel,PhD

Description: ThispanelwilldiscusscurrentissuesinHeadandneckcancermetastasisandinvasionusingmodelsystemsandclinicaldata.Thesessionwillincludecurrentqualitystandardsforcelllines,earlymetastaticbehaviorofHPV-inducedcancers,theroleofcancerstemcellsininvasionandmetastasis,physiologicstudiesoflymphaticmetastasis,andtheroleofreceptorcrosstalkinHNSCCmetastasis.

10:30amTumor Cell Lines: Current Quality Standards Thomas E. Carey, PhD10:45amEarly Metastatic Behavior of HPV-Induced Oropharyngeal Cancer - Ernst-Jan M. Speel, PhD11:00amPhysiologic Studies of Lymphatic Metastases Vincente Resto, MD, PhD11:15am Receptor Crosstalk in HNSC Metastasis Steven A. Rosenzweig, PhD11:30am Stem cells in Invasive, Migratory and Experimental Metastasis - Samantha J. Davis, MD11:45am Global Methylation and Gene Expression Differences in HPV positive and HPV Negative Squamous Cell Carcinomas - Maureen A. Sartor, PhD

At the conclusion of this session, participants will be able to: Understandtheimportanceofpropercelllinedocumentationanduse•forresearch.Appreciatethecurrentlevelofunderstandingofbiologicalbehaviorof•HPV-inducedoropharyngealcancers.Understandthephysiologyoflymphaticmetastasis.•Understandthecomplexityofreceptorsignalinginthemetastaticprocess.•Appreciatetheroleofcancerstemcellininvasionandmetastasis.•Awarenessofthestrongdifferencesinmethylationandgeneexpression•inHPV+andHPV-cancercells.

PANEL: Salivary Malignancies: Basic and Translational Science Co-Chairs: PatrickHa,MD&ChristopherA.Moskaluk,MD,PhD

Description: Thissessionwillappreciatethecomplexmechanismsunderlyingsalivaryglandmalignancies.Wewillbroadlyhighlightseveralareasofnovelresearch.

10:30amResources for Salivary Gland Tumor Research Yasaman Shirazi, PhD10:40amEpigenetic Alterations in Salivary Gland Tumors Patrick Ha, MD10:55am Expression Analyses and Modeling of Salivary Cancers - Wendell G. Yarbrough, MD11:10am Phosphoproteomic Analysis of Adenoid Cystic Carcinoma - Christopher A. Moskaluk, MD, PhD11:25am Dissecting the Receptor Tyrosine Kinase Signaling Pathways for Potential Therapies in Adenoid Cystic Carcinoma of the Salivary Glands - Osamu Tetsu, MD11:40amDiscussion

At the conclusion of this session, participants will be able to: Appreciatethegoalofresearchdirectedatunderstandingthe•mechanismsunderlyingsalivaryglandmalignancies.Understandthearray-basedexpressionmodelingofsalivarygland•cancers.Understandtheconceptofepigeneticsandtheroleitplaysincancer.•Understandtheroleofkinomeanalysisinadenoidcysticcarcinoma•andhowthismaytranslateintotargetedtherapies.

10:30am-12:00pm Concurrent Sessions

EXHiBiT HALLVisittheExhibitHallforyouropportunitytoupdateyourselfonthelatestsurgicalservicesandproducts.TheExhibitHalloffersyoutheverybestinequipmentandservices,plustheinnovativetoolsforboostingyoursurgicalknowledge.Exhibit Hall HoursThursday, October 28, 2010ExhibitHallOpen 10:30am-6:30pmExhibit Hall Closed 4:00pm - 5:00pmWelcomeReceptionWithPosterTour#1 5:00pm-6:30pmFriday, October 29, 2010ExhibitHallOpen 10:00am-3:30pmExhibit Hall Closed 3:30pm - 4:30pmPosterTour#2* 4:30pm-6:00pm*Friday Poster Tours will be held in the Exhibit Hall, but exhibits will no longer be available for viewing.

Attention Corporate Partners: AreyouinterestedinexhibitingorsupportingtheAHNSResearchWorkshop?Foranexhibitorprospectus,floorplan,orsupportandvisibilityopportunities,pleasecontactDanielle Vannatterat310-437-0559,ext.117.

3DMDAptiumOncologyAtosMedicalBioformMedical,Inc.Biotene/Laclede,Inc.BostonMedicalProductsBristol-MyersOncologyDivisionBSDMedicalCorporationDNAGenotekEllmanInternationalMfg,Inc.EndocraftLLCEthiconEndo-Surgery,Inc.EUSAPharmacy/CytogenGenzymeCorporationGlaxoSmithKlineOncologyGriffinLaboratoriesGyrusACMIHemostatixMedicalTechnologiesIBAParticleTherapyInHealthTechnologies

IRXTherapeuticsKarlStorzEndoscopy- America,Inc.KayPentaxKLSMartinLPLippincott,Williams&WilkinsLisaLaserUSAMedicalModelingMedtronic,Inc.MerckKGAAMichelsonDiagonosticsMicrosurgeryInstruments,Inc.OlympusSurgicalAmericaOmniGuidesanofi-aventisStrykerEndoscopySynthesCMFVarianMedicalSystemsVioptix,Inc.Xlear,Inc.

Previous AHNS Exhibitors

Registeron-linetodayatwww.ahns.info/registration 11

ACCOMMODATiONS & REGiSTRATiON iNForMaTioN

HOTEL RESERVATiONSHyatt Regency Crystal City2799 Jefferson Davis HighwayArlington,VA22202

TheAHNShasmadespecialarrangementswiththeHyattRegencyCrystalCitytoofferattendeesdiscountedratesonafirst-come,first-servebasis.The Hyatt Regency Crystal City requires a major credit card in order to guarantee your room. All reservations may be canceled without penalty at least twenty-four (24) hours prior to the arrival date by 4:00 pm.Check-inisat3:00pmandcheck-outisat12:00pm.

Special discounted room rates for registered attendees of the Research Workshop:

Single: $185.00USD

Double: $185.00USD

Triple: $210.00USD

Quadruple: $235.00USD

Hotelroomratesaresubjecttoapplicablestateandlocaltaxes(currently12.25%)ineffectatthetimeofcheck-in.

RESERVATIONS MUST BE RECEIVED BY SEPTEMBER 24, 2010 IN ORDER TO RECEIVE THE CONFERENCE DISCOUNT. Rooms may be available after this date, but not necessarily at the discounted rate.

How to Make a Hotel ReservationBook on-line at 1. www.ahns.info/hotelCall the Hyatt’s reservation department at: 2. 1-800-233-1234 or +1-703-418-1234 for attendees outside the United States.

REGiSTRATiON iNSTRUCTiONSRegistrationfeesincludeadmittanceto allsessionsfromThursday,October28,2010throughSaturday,October30,2010,excludingtheGrantWritingWorkshop(additionalfee).Alsoincludedarecontinentalbreakfasts,coffee/beveragebreaks,posterreceptionsaswellasthemainreceptiononFridayevening.

AccompanyingGuestfeesincludeadmittancetotheExhibitHallandtheeveningposterandsocialeventreceptions.

PleasedirectallquestionsconcerningregistrationtotheMeetingRegistrarat+1-310-437-0559,ext.128or registration@ahns.info.

How to Register in AdvanceRegister on-line at: 1. www.ahns.info/registrationFax your completed registration form to the AHNS Office at:2. +1-310-437-0585Mail your completed registration form to the AHNS Office at:3. AHNS Research Workshop Registration 11300W.OlympicBlvd.,Suite600,LosAngeles,CA90064

Paymentmustaccompanyregistrationform.MeetingregistrationisavailableinadvanceofthemeetingthroughSeptember24,2010.AfterSeptember24,2010,attendeesmustregisteron-site.On-siteregistrationissubjecttoanadditionalchargeof$150.

EarlyRegistration&HousingDeadlineis

Sept. 24, 2010

Registeron-linetodayatwww.ahns.info/registration 12

First/GivenName: MI: Last/FamilyName: Degrees:

Institution:

Address:

City: State: Zip:

Country: EmailAddress:

Phone (country code, city/area code, phone #): Fax (country code, city/area code, phone #):

Please indicate your type of practice (check all that apply): Head&NeckSurgeon Otolaryngologist PlasticSurgeon SurgicalOncologist MedicalOncologist Dentist OralSurgeon RadiationOncologist Radiologist Pathologist ClinicalInvestigator Molecular&CellularBiologist AlliedHealthProfessional Other:

Notificationsofcancellationmust be submitted in writing.CancellationsreceivedbeforeSeptember 24, 2010willberefundedlessa$100administrativefee.No refundswillbeavailableafterSeptember24,2010.Substitutionsareallowedatanytimebutmustbesubmittedinwritingandmustbeofthesamememberstatus.PleaseemailtheMeetingRegistraratregistration@ahns.infofortheserequests.

Special Services:

Payment in full must accompany registration:

CheckEnclosed(PayabletotheAmericanHeadandNeckSociety)

CreditCard(AHNSacceptsonlyVisa,Mastercard,andAmericanExpress)

Card#: Exp.: VerificationCode: (Verification Code: Visa/MC 3 Digits on the Back of the card. Amex: 4 Digits on the Front of the card.)

CardHoldersName: Signature:

Mail or fax this form with payment to:Meeting Registrar - The American Head and Neck Society By mail:11300W.OlympicBlvd.,Suite600,LosAngeles,CA90064Via fax: 1-310-437-0585Via email: registration@ahns.info

STEP 1 (required): Register Under the Appropriate Category (circle your registration category)

PHYSICIANS ALLIED HEALTHTOTAL

AHNS Member Non-Member Resident,Fellow Nurse, PA Scientist,

engineer, PhD

$500 $600 $275 $275 $400

STEP 2: Register for Additional Fee Activities

Grant Writing Session (Limited Seating) Thursday,October28,2010,6:00pm-8:00pm

$35

STEP 3: Register Any Accompanying Persons

Guest 1 Name: $125

Guest 2 Name: $125

STEP 4: RSVP for Social Events (no extra charge)

Opening Reception in the Exhibit Hall,Thursday,October28,2010,7:00pm-9:00pm $0

Evening Social Event Reception,Friday,October29,2010,7:00pm-9:00pm $0

STEP 5: Late Registration Fees (if applicable)

Registering after September 24, 2010 and before October 21, 2010 $100

Onsite Registration Fee after October 21, 2010 $150

TOTAL AMOUNT DUE

REGiSTRATiON FORM

AHNS 2010 RESEARCH WORKSHOP October 28-30, 2010, Arlington, Virginia