Hemodynamic performance characterization of aortic outflow cannula jets for improved neonatal cardiopulmonary

bypassThe cutting edge in computational surgical planning of cardiovascular surgery

A D I V S E RKerem Pekkan, Ph.D : Associate Professor

Biomedical Engineering, Carnegie Mellon University

Pekkan Cardiovascular Fluid Mechanics Lab700 Technology Drive, Pittsburgh, PA:15219, Tel: +1 (412) 259-3031

P r a h l a d G . M e n o n 2011 Dowd-ICES fellow, Ph.D candidate

pgmenon@andrew.cmu.edu

Objectives Device specific hemodynamic evaluation and design optimization: To design hemodynamically efficient aortic outflow cannulae that can provide high blood volume flow rates at low exit force during pediatric or neonatal cardiopulmonary bypass (CPB), using high performance computing computational fluid dynamics (CFD) and in-vitro particle image velocimetry (PIV) testing of confined jet streams exiting device-specific cannula tip geometries.

3D patient-specific surgical planning: To determine optimum low-hemolytic aortic cannula insertion configurations that can significantly reduce risk of post-surgical neurological complications and developmental defects in the young patient, by in-silico surgery.

Simulation-driven medical device design and surgical planning that can improve surgical outcomes in cardiopulmonary bypass

procedures for pediatrics, neonates and adults

2 and 10 cases per 1000 live births are associated with congenital heart defects

Complex biventricular and univentricular repairs require non-traditional patient-specific CPB strategies.

Device associated thrombosis and cannula jet wake hemolysis can lead to post surgical neurological complications and developmental defects.