addison elliott , akhila karlapalem amy givan maria ... · addison elliott1, akhila karlapalem1,...

1
RESEARCH POSTER PRESENTATION DESIGN © 2015 www.PosterPresentations.com y = 1.308x - 158.33 R² = 0.7585 0 500 1000 1500 2000 2500 3000 0 1000 2000 3000 Computer Area (mm 2 ) Observer Area (mm 2 ) y = 1.3156x - 154.96 R² = 0.7094 0 500 1000 1500 2000 2500 0 500 1000 1500 2000 2500 Computer Area (mm 2 ) Observer Area (mm 2 ) Figure 4 (3-4) Edge converted polar image with optimal path shown in blue. (5) Cartesian image with optimal path in blue Dice Similarity Coefficient End-Systolic: 0.750±0.074 End-Diastolic: 0.802±0.079 Hausdorff Distance End-Systolic: 9.03±2.71mm End-Diastolic: 9.09±2.37mm 10 female subjects, pre- and post-intervention, 18-40 years old Select end-systolic (ES) and diastolic (ED) frames from scans 2 apex, 7 papillary muscles, 6 mitral valve (randomly chosen) B-mode images created from custom software from IQ files Wavelet’s transform used for speckle reduction Algorithm 1. Smooth image using anisotropic diffusion 2. Convert to polar domain (origin = endocardial center) 3. Robert’s edge detection filter applied to polar image 4. DP Dijkstra’s Algorithm 1. Cost function = inverted edge image 2. Moves from left->right angular dimension (loops back around), stops at start point 5. Convert path back to Cartesian domain METHODS RESULTS DISCUSSION AND CONCLUSIONS Simple validation of algorithm to segment endocardium Limitations Algorithm purely based on image content, messes up for missing or weak boundaries Only one observer, not providing any context of inter- observer variability Future Work Factor in temporal dimension (easier to see with motion) Use shape model or ASMs to segment boundaries Integrate algorithm in one software package to eventually fit a shape model to Coronary heart disease is the #1 leading cause of death globally Echocardiography is the first step in assessing cardiac health Ultrasound is inexpensive, portable and non-invasive compared to MRI Measures such as LVEF, LV mass/volume difficult to measure manually Automatic segmentation allow easy calculation of measures Objective: Create automatic segmentation algorithm to segment the endocardium in PSAX views. Validate to 1 expert tracer Addison Elliott 1 , Akhila Karlapalem 1, Amy Givan 2, Maria Fernandez-del-Valle 2 , Jon Klingensmith 1 1 Department of Electrical and Computer Engineering, Southern Illinois University Edwardsville, Edwardsville, Illinois, 2 Department of Applied Health, Southern Illinois University Edwardsville, Edwardsville, Illinois Endocardium Segmentation in Parasternal Short-axis Echocardiograms using Dynamic Programming Figure 1 Diagram of parasternal short-axis views Figure 5 Left: Subject 8 ED mitral valve PSAX. Right: Plot of computer & observer CSA with black line Hausdorff Dist. INTRODUCTION Figure 2 Apical PSAX view -800 -600 -400 -200 0 200 400 600 800 1000 0 500 1000 1500 2000 Difference in Area (mm 2 ) Mean Area (mm 2 ) -800 -600 -400 -200 0 200 400 600 800 1000 0 500 1000 1500 2000 2500 Difference in Area (mm 2 ) Mean Area (mm 2 ) Figure 6 Bland-Altman charts (bottom) and linear regression (top) shown for ES (left) and ED (right) ACKNOWLEDGEMENTS Funding provided by AHA Grant #17AIREA33670361 (Volumetric assessment of epicardial adipose tissue using echocardiography) IRB ID: #17-0817-1C RESULTS METHODS Figure 3 (1) Smoothed PSAX apical view. (2) Polar image from smoothed image in (1). Endocardial center shown in (1) as red point.

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Page 1: Addison Elliott , Akhila Karlapalem Amy Givan Maria ... · Addison Elliott1, Akhila Karlapalem1, Amy Givan2, Maria Fernandez-del-Valle2, Jon Klingensmith1 1 Department of Electrical

RESEARCH POSTER PRESENTATION DESIGN © 2015

www.PosterPresentations.com

y = 1.308x - 158.33R² = 0.7585

0

500

1000

1500

2000

2500

3000

0 1000 2000 3000

Co

mp

ute

r A

rea

(mm

2)

Observer Area (mm2)

y = 1.3156x - 154.96R² = 0.7094

0

500

1000

1500

2000

2500

0 500 1000 1500 2000 2500

Co

mp

ute

r A

rea

(mm

2)

Observer Area (mm2)

Figure 4 – (3-4) Edge converted polar image with optimal path

shown in blue. (5) Cartesian image with optimal path in blue

• Dice Similarity Coefficient

• End-Systolic: 0.750±0.074

• End-Diastolic: 0.802±0.079

• Hausdorff Distance

• End-Systolic: 9.03±2.71mm

• End-Diastolic: 9.09±2.37mm

• 10 female subjects, pre- and post-intervention, 18-40 years old

• Select end-systolic (ES) and diastolic (ED) frames from scans

• 2 apex, 7 papillary muscles, 6 mitral valve (randomly chosen)

• B-mode images created from custom software from IQ files

• Wavelet’s transform used for speckle reduction

Algorithm

1. Smooth image using anisotropic diffusion

2. Convert to polar domain (origin = endocardial center)

3. Robert’s edge detection filter applied to polar image

4. DP Dijkstra’s Algorithm

1. Cost function = inverted edge image

2. Moves from left->right angular dimension (loops back

around), stops at start point

5. Convert path back to Cartesian domain

METHODS

RESULTSDISCUSSION AND CONCLUSIONS

• Simple validation of algorithm to segment endocardium

• Limitations

• Algorithm purely based on image content, messes up for

missing or weak boundaries

• Only one observer, not providing any context of inter-

observer variability

• Future Work

• Factor in temporal dimension (easier to see with motion)

• Use shape model or ASMs to segment boundaries

• Integrate algorithm in one software package to eventually

fit a shape model to

• Coronary heart disease is the #1 leading cause of death

globally

• Echocardiography is the first step in assessing cardiac health

• Ultrasound is inexpensive, portable and non-invasive

compared to MRI

• Measures such as LVEF, LV mass/volume difficult to measure

manually

• Automatic segmentation allow easy calculation of measures

• Objective: Create automatic segmentation algorithm to

segment the endocardium in PSAX views. Validate to 1

expert tracer

Addison Elliott1, Akhila Karlapalem1, Amy Givan2, Maria Fernandez-del-Valle2, Jon Klingensmith1

1 Department of Electrical and Computer Engineering, Southern Illinois University Edwardsville, Edwardsville, Illinois, 2 Department of Applied Health, Southern Illinois University Edwardsville, Edwardsville, Illinois

Endocardium Segmentation in Parasternal Short-axis Echocardiograms using Dynamic Programming

Figure 1 – Diagram of parasternal short-axis views

Figure 5 – Left: Subject 8 ED mitral valve PSAX. Right: Plot of

computer & observer CSA with black line Hausdorff Dist.

INTRODUCTION

Figure 2 – Apical PSAX view

-800

-600

-400

-200

0

200

400

600

800

1000

0 500 1000 1500 2000

Dif

fere

nce

in A

rea

(mm

2)

Mean Area (mm2)

-800

-600

-400

-200

0

200

400

600

800

1000

0 500 1000 1500 2000 2500

Dif

fere

nce

in A

rea

(mm

2)

Mean Area (mm2)

Figure 6 – Bland-Altman charts (bottom) and linear regression

(top) shown for ES (left) and ED (right)

ACKNOWLEDGEMENTS

Funding provided by AHA Grant #17AIREA33670361

(Volumetric assessment of epicardial adipose tissue using

echocardiography)

IRB ID: #17-0817-1C

RESULTSMETHODS

Figure 3 – (1) Smoothed PSAX apical view. (2) Polar image from

smoothed image in (1). Endocardial center shown in (1) as red

point.