acute pancreatitis investigations and treatment
DESCRIPTION
prepared this as a part of my seminar.hope u guys like itTRANSCRIPT
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MODERATOR – Dr.BasavarajCHAIR PERSON – Dr.Rajanna
Presented by Dr.Anuraj
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LAB tests
Diagnosis of AP- clinical findings+ elevation of pancreatic enzyme levels in the plasma
threefold or higher elevation of amylase and lipase levels confirms the diagnosis.
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SERUM AMYLASE
Normal value 23-85U/L
IF >4 times normal levels (>450 U/L)
Normal levels do not exclude AP esp. if patient present 48 hrs later
Less sensitivity and specificity
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SERUM LIPASE
Normal value 0-160 U/L
If elevated (>400 U/L) likely indicate pancreatic damage or pancreatitis
rises 4 to 8 hours from the onset of symptoms and normalizes within 7 to 14 days after treatment
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CBC: neutrophil leucocytosis
Electrolyte abnormalities include hypokaemia, hypocalcemia
Elevated LDH in biliary disease
Glycosuria ( 10% of cases) Blood sugar: hyperglycaemia in severe cases
Serum phosphate
LFTs
RFTs
CRP
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To RULE OUT other conditions, such
as perforated ulcer disease.
Nonspecific findings
-cutoff colon sign gaseous distension seen in proximal colon associated with withnarrowing of the splenic flexure
-Widening of the duodenal C loop caused by severe pancreatic head edema
- complications of lung such as pleural effusion, pulmonary
edema and interstitial inflammation.
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to find an enlarged pancreas, a pseudocyst, ascites, biliary
stone, dilated common bile duct and other pancreatic mass
The usefulness of ultrasound to diagnose pancreatitis is limited by intra-abdominal fat and increased intestinal gas as a result of the ileus.
However USG should be ordered because of high sensitivity in diagnosing gallstones
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Contrast enhanced CT If the patient has…..◦ Signs of severe acute pancreatitis◦ No signs of clinical improvement after several days◦ Diagnostic dilemma◦ Infection suspected
T > 101o F Positive blood cultures
What are you looking for?◦ Necrosis: Lack of enhancement with contrast◦ Fluid Collections◦ Alternate diagnosis
Acute Pancreatitis
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Pancreas◦ Pancreatic enlargement
◦ Decreased density due to edema
◦ Intrapancreatic fluid collections
◦ Blurring of gland margins due to inflammation
Peripancreatic◦ Fluid collections and stranding densities
◦ Thickening of retroperitoneal fat
Acute Pancreatitis
* It may take up to 72h for inflammatory changes to become apparent on CT *
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Acute Pancreatitis
Tail Indistinct
Intraperitoneal fluid
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Acute Pancreatitis
Peripancreatic edemaand inflammation
UnenhancingNecrosis
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Acute Pancreatitis
Normal Pancreas
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useful to evaluate the extent of necrosis, inflammation, and presence
of free fluid.
Cost and availability limits its applicability
Not indicated in the acute setting of AP
unexplained or recurrent pancreatitis - the biliaryand pancreatic duct anatomy.To rule out pancreas divisum, intraductal
papillary mucinous neoplasm (IPMN),
small tumor in the pancreatic duct.
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Assessment of severity of disease
RANSON’S CRITERIA
MODIFIED GLASGOW CRITERIA
ATLANTA classification
Acute Physiology and Chronic Health Evaluation (APACHE II)
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For non-gallstone pancreatitis, the parameters are: At admission: Age in years > 55 years White blood cell count > 16000 cells/mm3
Blood glucose> 10 mmol/L (> 200 mg/dL) Serum AST > 250 IU/L Serum LDH > 350 IU/L Within 48 hours: Serum calcium < 2.0 mmol/L (< 8.0 mg/dL) Hematocrit fall > 10% Oxygen (hypoxemia PaO2 < 60 mmHg) BUN increased by 1.8 or more mmol/L (5 or more mg/dL) after IV
fluid hydration Base deficit (negative base excess) > 4 mEq/L Sequestration of fluids > 6 L
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For gallstone pancreatitis, the parameters are: At admission: Age in years > 70 years White blood cell count > 18000 cells/mm3
Blood glucose > 12.2 mmol/L (> 220 mg/dL) Serum AST > 250 IU/L Serum LDH > 400 IU/L Within 48 hours: Serum calcium < 2.0 mmol/L (< 8.0 mg/dL) Hematocrit fall > 10% Oxygen (hypoxemia PaO2 < 60 mmHg) BUN increased by 1.8 or more mmol/L (5 or more mg/dL) after IV
fluid hydration Base deficit (negative base excess) > 5 mEq/L Sequestration of fluids > 4 L
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Acute Pancreatitis
MORTALITY †
MORBIDITY *
† Sn 73%, Sp
77%
* > 7 d in ICU
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Management depends on SEVERITY
MILD ACUTE PANCREATITISAcute pancreatitis
No dysfunction of organ or local complications
Ranson’s score <3
or CT grading: A, B, C or CTSI <2
SEVERE ACUTE PANCREATITIS
Acute pancreatitis
Local complications
or organ failure
or Ranson’s score >3
or CT grading: D, E or CTSI >3.
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Supportive care,fluid resuscitation and electrolyte balance
NPO with i.v. fluids and electrolytes
Analgesia
Morphine
Nutrition
If unable to meet adequate protein and calorie needs within 5 days ->nasoenteric feeding
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Antibiotics
Routine antibiotics not recommendedGeneral recommendations for use:◦ Biliary pancreatitis with signs of cholangitis◦ > 30% necrosis on CT scanOPERATIVE MANAGEMENT◦ Early cholecystectomy once symptoms have
subsided and cholestatic liver enzymes have returned to normal in GALLSTONE PANCREATITIS
◦ If cholestatic enzymes not returned to normal then suspect choledocholithiasis and do ERCP
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Mainstay of management is
Early diagnosis
Aggressive resuscitation
Staging by clinical scoring systems
Radiologic imaging
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Admission to ICU Aggressive fluid resuscitation Analgesia Invasive monitoring of vitals,CVP,urine
output,blood gases Nasogastric aspiration Frequent monitoring of lab investigations Antibiotics - imipenem Supportive therapy for organ failure ERCP if cholangitis
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Timing of cholecystectomy
Should be delayed until patient is stabilised,pseudocyst resolves or if it persists beyond 6 weeks then drained concomitantly at time of cholecystectomy
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Infected necrosis◦ Organisms on gram
stain after aspirate
◦ Surgical drainage
◦ Trans-gastric drainage
◦ Try to delay necrosectomy 2-3wk for demarcation of necrosis
Pancreatic abscess◦ CT or EUS guided
drainage Walled collection of
pus
Similar to management of pseudocyst
Acute Pancreatitis
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Open
Endoscopic transluminal
Once necrosectomy is completed,furthernecrotic tissue may form
-Closed continuous lavage(Beger)
-Closed drainage
-Open packing
-Closure and relaporotomy
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Collection of pancreatic fluid enclosed by wall of granulation tissue
Complicates 5-10% cases of AP
Usually 4 weeks after attack The diagnosis is corroborated with by CT
25-50% resolve spontaneously
Acute Pancreatitis
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Infection - 14%
Rupture - 6.8%
Hemorrhage - 6.5%
Common bile duct obstruction - 6.3%
GI obstruction - 2.6%
Acute Pancreatitis
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Observation for asymptomatic patients
spontaneous regression has been documented in up to 70% of cases
Invasive therapies are indicated for
symptomatic patients or when the differentiation between a cystic neoplasm and pseudocyst is not possible.
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Percutaneous
endoscopic drainage
Surgical drainage is indicated for patients with pancreatic pseudocysts that cannot be treated with endoscopic techniques and patients who fail endoscopic treatment
-cystogastrostomy
-cystoduodenostomy
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Acute Pancreatitis
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Acute Pancreatitis
Open Cystgastrostomy
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Acute Pancreatitis
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Bailey and love’s
Sabiston textbook of surgery
Shackelford’s surgery of alimentary tract
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