ac valproic

8/16/2019 AC Valproic

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Generic Name: valproic acid

(val proe‘ ik)

valproic acid: Apo-Valproic Acid (CAN), Gen-Valproic

(CAN), Novo-Valproic (CAN), Nu-Valprox (CAN), ratio-

Valproic (CAN)

Capsules: Depakene

sodium valproate

!rup:

Depakene

valproate acid

"n#ection: Depacon, $pi#ect (CAN), divalproex sodium

%a&lets, enteric coated: Depakote, Depakote $',

Depakote prinkle, Divalproex, $pival (CAN)

renanc! Cateor! D

Dru class - Antiepileptic

Therapeutic actions

*ec+anism o action not understood: antiepileptic

activit! ma! &e related to t+e meta&olism o t+e

in+i&itor! neurotransmitter, GAA. divalproex sodium

is a compound containin e/ual proportions o valproic

acid and sodium valproate0

Indications

ole and ad#unctive t+erap! in simple (petit mal) and

complex a&sence seiures

Depakote $': %reatment o epileps! in c+ildren 2 13

!r. treatment o acute manic or mixed episodes

associated 4it+ &ipolar disorder, 4it+ or 4it+out

ps!c+otic eatures

Ad#unctive t+erap! 4it+ multiple seiure t!pes,

includin a&sence seiures

Depakote ER: Treatment of bipolar mania

Depakote, Depacote $': rop+!laxis o miraine

+eadac+es

Divalproex, sodium valproate in#ection: %reatment o

complex partial seiures as monot+erap! or 4it+ ot+er

antiepileptics

5nla&eled uses: Ad#unct in s!mptom manaement o

sc+iop+renia, treatment o aressive out&ursts in

c+ildren 4it+ attention-de6cit +!peractivit! disorder,

oranic &rain s!ndrome

Contraindications and cautions

Contraindicated 4it+ +!persensitivit! to valproic acid,

+epatic disease or sini6cant +epatic impairment0


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5se cautiousl! 4it+ c+ildren 8 19 mo. c+ildren 8 7 !r,

especiall! 4it+ multiple antiepileptics, conenital

meta&olic disorders, severe seiures accompanied &!

severe mental retardation, oranic &rain disorders

(+i+er risk o developin atal +epatotoxicit!).prenanc! (etal neural tu&e deects. do not

discontinue to prevent ma#or seiures. discontinuin

suc+ medication is likel! to precipitate status

epilepticus, +!poxia and risk to &ot+ mot+er and

etus). lactation0

Available forms

Capsules7;3 m. s!rup7;3 mI +r

"V 'apid 1 +r


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"nusion: Administer over 3 min, not more t+an 73

m


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KA'N"NG: 'educe dosae, discontinue, or su&stitute

ot+er antiepileptics raduall!. a&rupt discontinuation

o all antiepileptics ma! precipitate a&sence seiures0

=ACM ? KA'N"NG: Arrane or re/uent =%s.

discontinue dru immediatel! 4it+ sini6cant +epatic

impairment, suspected or apparent sini6cant +epatic

impairment. continue =%s to determine i +epatic

impairment proresses in spite o dru discontinuation0

KA'N"NG: Arrane or patient to +ave platelet counts,

&leedin time determination &eore t+erap!,

periodicall! durin t+erap!, and prior to surer!0

*onitor patient careull! or clottin deects (&ruisin,

&lood-tined toot+&rus+)0 Discontinue i t+ere isevidence o +emorr+ae, &ruisin, or disorder

o+emostasis0

*onitor ammonia levels, and discontinue i t+ere is

clinicall! sini6cant elevation in level0

*onitor serum levels o valproic acid and ot+er

antiepileptic drus iven concomitantl!, especiall!

durin t+e 6rst e4 4eeks o t+erap!0 Ad#ust dosae on

t+e &asis o t+ese data and clinical response0

=ACM ? KA'N"NG: Arrane or counselin or

4omen o c+ild&earin ae 4+o 4is+ to &ecome

prenant. dru ma! &e teratoenic0

=ACM ? KA'N"NG: Discontinue dru at an! sin o

pancreatitis0

KA'N"NG: $valuate or t+erapeutic serum levels

usuall! ;3>133 mc


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alertness. take at &edtime). G" upset (take 4it+ ood or

milk, eat re/uent small meals. i pro&lem persists,

su&stitute enteric-coated dru). transient increase in

+air loss0

'eport &ruisin, pink stain on t+e toot+&rus+,

!ello4in o t+e skin or e!es, pale eces, ras+,

prenanc!. a&dominal pain 4it+ nausea, vomitin,

anorexia0

ac valproic

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