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ABSTRACT Karti kaning tyas, Diah. 2011. Negati ve Effe ct of Subacut ePeror al of Monoso iu! "luta!ate #MS"$ on Da !a ge of %e &a r 'e ll in (h it e )at #)at tusNover gi cus St ra in (istar$.*hesis, Meical +aculty, niversity of Muha!!aiya Malang, -visors #1$ //.. #2$ // Background :  Monosodium Glutamate  #MS"$ as one of the foos seasoning hich is  &o&ularly knon as vetsin or micin.*he ose of MS" on the foo tens to be un!easure or is only base on sense. n nonesia, MS" &rouction reaches 23.400 tons5yea r ith increas e consu!&tion by a&&ro6i!ately 23.175year . *he li!it of MS" usage on hu!an shall be ranging fro! 2. 8 9. g #for boy eight 08:0 kg$. Objective : *o &rove the negative Effect of Subacute Peroral of Monosoiu! "luta!ate #MS"$ on Da!age of %e&ar 'ell in (hite )at #  Rattusnovergicus strain wistar $. Research Method : *he !etho use in this research as laboratory e6&eri!entation, using *he Post *est ;nly 'ontrol "rou& Design. Sa!&le a&&lie in this rese arch as hite rat #  Rattus  Novergicus Strain Wistar $, hich is categori<e into = grou&s. "rou& serves as control regarless MS" istribution, "rou& ith >0!g MS" istribution, "rou& ith 40 !g, an "r ou& = i th 120 !g. *he a ta as analy<e us ing the folloing te sts nor!al it y, ho!egeneity, -N;=-, avance ith *KE?, correlation an regression. Result and Discussion : *he observation on he&ar eight shos the ecrease he&ar eight in rat if co!&ar e i th the con tr ol le conit ion in li ne i th the increase us age of MS"

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