a1/b1: surviving sepsis kevin rooney...2013/07/01 · and without shock, there was a decrease in...
TRANSCRIPT
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A1/B1: Surviving Sepsis
Kevin Rooney A1 Moderator: Abdulbadi Abu Samra
B1 Moderator: Ghada Al Sulaiti
Saturday 26th April
A1: 11:00 – 12:15
B1: 13:30 – 14:45
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Agenda 11:00-12:15pm
•What is Sepsis and why is it important? •Variations in Sepsis care •Why Sepsis care is difficult? •Sepsis change package •Corroborating evidence •Top tips in Sepsis care •Questions and discussion
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Learning Objectives
•Discuss the challenges related to reducing Sepsis mortality •Build a system to enhance early identification of patients with Sepsis •Describe the role of caregivers in delivering appropriate and timely treatment
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What is Sepsis?
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Diagnostic Criteria for Sepsis:
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Severe Sepsis
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Surviving Sepsis Guidelines 2012
“Similar to polytrauma, acute myocardial infarction, speed and appropriateness of therapy stroke, the or
administered in the initial hours after severe sepsis .”develops are likely to influence outcome
for the appropriate of these recommendations are “Most
.”settingsICU -severe sepsis patient in the ICU and non
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Surviving Sepsis Guidelines 2012 greatest outcome committee believes that the he T“
through education and improvement can be madeprocess change for those caring for severe sepsis patients
and across the spectrum of acute ICU setting -in the noncare.”
best recommendations are intended to be “These (the committee considers this a goal for clinical practice
.”not created to represent standard of carepractice) and
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Lung1 Colon2 Breast3 Sepsis4
Cancers
Annual
UK mortality
(2003),
thousands
1,2,3 www.statistics.gov.uk,
4 Intensive Care National Audit Research Centre (2006)
A U.K. Perspective
0
20
30
40
10
© Ron Daniels 2010
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Discharges with a Main Diagnosis of Sepsis (A40/A41)
0500
100015002000250030003500400045005000
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012No
. of
dis
char
ges
/ ye
ar
Patients
Stays in hospital
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Copyright 2010 by the American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use. American Medical Association, 515 N. State St, Chicago, IL 60610. Published by American Medical Association. 2
Sepsis in General Surgery: The 2005-2007 National Surgical Quality Improvement Program Perspective. Moore, Laura; Moore, Frederick; Todd, S; Jones, Stephen; Turner, Krista; Bass, Barbara Archives of Surgery. 145(7):695-700, July 2010.
Surgical Sepsis
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Acute MI & Trauma 3% Mortality 5% Mortality
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Equal Opportunities Killer
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The Lingering Consequences of Sepsis A Hidden Public Health Disaster D Angus JAMA 2010
•Cohort study of 27,000 older Americans with detailed information on physical &neurocognitive performance •Identified episodes of Sepsis in hospital from Medicare data •Showed incidence of moderate to severe cognitive impairment increasing 3x – from 6.1% to 16.7% i.e. possibly 20,000 new cases per year in US
Iwashyna et al JAMA 2010
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Interventions: Variation In Sepsis Care
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15,022 Patients
165 Hospitals
Median of 14
Months
Mortality Decreased from
37 to 30.8 Percent
6.2% Absolute
16% Relative
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STAG Sepsis Management in Scotland
•Signs of sepsis < 2 days •2% of emergency admissions (~5000) •71% had a EWS •34% had severe sepsis •21% blood cultures •32% IV Antibiotics •70% IV fluids
Scottish Defect Rate was 18-74%
Gray et al Emerg Med J (2012) doi:10.1136/emermed-2012-201361
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Why is implementation so difficult?
•Too many elements in the bundle •Some are controversial •Time Sensitive Process •Difficult To Diagnosis Sepsis Early •Human Factors Get In The Way •Invasive procedures needed •ICU stuff??
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Complacency, Education & Trying Harder Isn’t Enough
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New Ways of Thinking
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New Ways of Thinking
•Front line engagement •Segmentation •Real Time Data Collection •Early Feed Back of Metrics •Early Case Review and Feedback •Use Level 2 Reliability Tools
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22
Knowledge into Action for Change Package Clinical Knowledge (Evidence
Based Practice):
MEDLINE, Cochrane etc
Improvement Knowledge:
SPSP experience, etc
Know-What
Know-How
Quality
Patient Care
Doing the right thing
Doing it right
Clinical Decisions
Process/System Changes
Adapted from: Glasziou, P et al. Can evidence-based medicine and clinical quality improvement learn from each other? 2011. BMJ QualSaf 20 (suppl 1): i13-i17
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Evidence for the Change Package
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Joint Collaborative –
Sepsis Driver Diagram
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Spreading Ink Blot Strategy
•Based on military tactics - Small area of “Good Practice” - Across site - As expand will join up - MAU /AMU/ Surgical - Hospital At night - Medical Wards - DOME
Acute Medical Unit
Acute Surgical
RAH
ED
Med
Wd
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“He Who Must Not Be Named” or “Homer”
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Type of physiological abnormality at time of ED patient inclusion in audit (first signs of sepsis) n=626 – Median age 73 years
Gray et al Emerg Med J (2012) doi:10.1136/emermed-2012-201361
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Difficult Diagnosis •Not all patients have classic SIRS •Some groups at special risk eg neutropaenia, haemodialysis, diabetes mellitus, alcoholism, lung disease, patients with invasive devices
- Laupland et al Crit Care Med 2004 •Elderly patients (age > 65 years) •Decreased inflammatory response •Often not febrile •More likely to be delirious •Falls may be only evidence of sepsis-induced delirium •More likely to develop septic shock and multiple organ dysfunction syndrome (MODS)
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Reliable Recognition, Assessment & Rescue
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Screening for Sepsis and Performance Improvement
•We recommend routine screening of potentially infected seriously ill patients for severe sepsis to increase the early identification of sepsis and allow implementation of early sepsis therapy (grade 1C).
•Performance improvement efforts in severe sepsis should be used to improve patient outcomes (UG).
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I GOT THREE JOBS TO DO IN SEPSIS!
•RECOGNIZE •RESUSCITATE
•REFER
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Sepsis Screening
•EWS: >95% reliable in pilot wards •Systemic Inflammatory Response Syndrome (SIRS) criteria
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SIRS Criteria
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The Sepsis Six 1. Deliver O2 (94 -98% SpO2 or 88-92% in COPD)
2. Take blood cultures and consider source control
3. Give IV antibiotics according to local protocol
4. Start IV fluid resuscitation (min 500ml) and reassess
5. Check lactate & FBC
6. Commence accurate urine output measurement and consider urinary
catheterisation
All within one hour © Ron Daniels 2010
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Serum Lactate as a Predictor of Mortality in ED Patients with Sepsis
Shapiro et al. Ann EM 2005;45:524
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Howell et al Intensive Care Med 2007
Hypotension and Lactate
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© 2004 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins. Published by Lippincott Williams & Wilkins, Inc.
2
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock *. Nguyen, H; Bryant MD, MS; Rivers, Emanuel; MD, MPH; Knoblich, Bernhard; Jacobsen, Gordon; Muzzin, Alexandria; Ressler, Julie; Tomlanovich, Michael Critical Care Medicine. 32(8):1637-1642, August 2004. DOI: 10.1097/01.CCM.0000132904.35713.A7
Figure 1. Kaplan-Meier survival analysis between patients with lactate clearance =10% at 6 hrs after emergency department presentation.
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock
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© 2006 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins. Published by Lippincott Williams & Wilkins, Inc.
5
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock *. Kumar, Anand; Roberts, Daniel; Wood, Kenneth; Light, Bruce; Parrillo, Joseph; Sharma, Satendra; Suppes, Robert; Feinstein, Daniel; Zanotti, Sergio; Taiberg, Leo; Gurka, David; Kumar, Aseem; Cheang, Mary Critical Care Medicine. 34(6):1589-1596, June 2006. DOI: 10.1097/01.CCM.0000217961.75225.E9
Figure 1. Cumulative effective antimicrobial initiation following onset of septic shock-associated hypotension and associated survival. The x-axis represents time (hrs) following first documentation of septic shock-associated hypotension. Black bars represent the fraction of patients surviving to hospital discharge for effective therapy initiated within the given time interval. The gray bars represent the cumulative fraction of patients having received effective antimicrobials at any given time point.
Why within an hour?
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Sepsis deaths
Courtesy of Dr. I. Roberts
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Lives Saved
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Why all septic patients?
•Sepsis Disease Continuum •15% → 30% → 50%
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When to escalate care?
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Surviving Sepsis 2012: Corroborating Evidence
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Corroborating Evidence 2
Am J Respir Crit Care Med Vol 188, Iss. 1, pp 77–82, Jul 1, 2013
N=4,329 patients
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From: Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia
and New Zealand, 2000-2012
JAMA. 2014;():. doi:10.1001/jama.2014.2637
Mean Annual Mortality in Patients With Severe Sepsis
Error bars indicate 95% CI.
Copyright © 2014 American Medical Association.
All rights reserved.
In critically ill patients in Australia and New Zealand with severe sepsis with and without shock, there was a decrease in mortality from 2000 to 2012. These findings were accompanied by changes in the patterns of discharge to home, rehabilitation, and other hospitals.
N=101,064 patients
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“..compelling evidence… about changes in severe sepsis mortality.”
“Critical care is improving for patients with severe sepsis and throughout the ICU.”
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Protocolized Care for Early Septic Shock (ProCESS) trial
N=1,341 patients
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ProCESS Trial …. identifies early recognition of sepsis, early administration of antibiotics, early adequate volume resuscitation, and clinical assessment of the adequacy of circulation as the elements we should focus on to save lives.
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122,323 patients believe in Sepsis bundles & can’t be wrong
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TOP TIPS & RESULTS TO DATE
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Safety Briefings
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Ward Rounds
•Interrupt if necessary •Experiential learning •Improved communication •Competing demands •Multidisciplinary •Checklists
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Rapid Response Teams
•ANP’s / Outreach •Provide technical expertise •ABC’s •Everybody departs •Dual response •Learning opportunity
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Clinical Leadership
•Everyone’s job •Hold people to account •Sepsis terminology •Wording of screening tool •Prompt stickers •Common order sets
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Further Tips
•Brightly coloured paper for screening tool draws attention •Simplify the screening tool •Screening tool in blood culture bags to connect essential elements of the process •Target doctors through induction
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Critical Care Feedback •Presents both positive and negative feedback in an objective, constructive manner
•Acts as an educational tool in its own right
•Allows for a conversation between improvement team and care givers
•Makes sepsis ‘personal’
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Results
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Royal Alexandra Hospital ED Level
UCL
LCL 0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Ap
r-12
Ma
y-1
2
Jun
-12
Au
g-1
2
Se
p-1
2
Oct-
12
Nov-1
2
Dec-1
2
Jan
-13
Fe
b-1
3
Ma
r-1
3
Ap
r-13
Ma
y-1
3
Jun
-13
Jul-
13
Au
g-1
3
Se
p-1
3
Oct-
13
Nov-1
3
Dec-1
3
201
4-M
ar
P Chart Sepsis 6 Percent
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Royal Alexandra Hospital
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0
10
20
30
40
50
60
70
80
90
100
% b
loo
d c
ulu
res
< 1
ho
ut
NHS Scotland % Blood Cultures < 1 hour - acute
min team
average team
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0
10
20
30
40
50
60
70
80
90
100Ja
n-1
2
Feb
-12
Mar
-12
Ap
r-1
2
May
-12
Jun
-12
Jul-
12
Au
g-1
2
Sep
-12
Oct
-12
No
v-1
2
Dec
-12
Jan
-13
Feb
-13
Mar
-13
Ap
r-1
3
May
-13
Jun
-13
Jul-
13
Au
g-1
3
Sep
-13
Oct
-13
No
v-1
3
Dec
-13
% a
chie
ved
< 1
ho
ur
NHS Scotland % antibiotics < 1 hour - acute
min team
average team
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0
10
20
30
40
50
60
70
80
90
100Ja
n-1
2
Feb
-12
Mar
-12
Ap
r-1
2
May
-12
Jun
-12
Jul-
12
Au
g-1
2
Sep
-12
Oct
-12
No
v-1
2
Dec
-12
Jan
-13
Feb
-13
Mar
-13
Ap
r-1
3
May
-13
Jun
-13
Jul-
13
Au
g-1
3
Sep
-13
Oct
-13
No
v-1
3
Dec
-13
% d
eliv
ere
d <
1 h
ou
r
NHS Scotland % delivery of Sepsis Six < 1 hour - acute
min team
average team
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Scottish Sepsis Mortality
0
5
10
15
20
25
30
35
40
2009 2010 2011 2012 2013p
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Surviving Sepsis Caveat
optimum this document is static, the “Although of severe sepsis and septic shock is a dynamic treatment
.”processevolving and
established interventions will be proven and “New .” may need modificationinterventions
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In Summary
•Sepsis is a Medical Emergency •Awareness, Screening, Recognition and Prompt Treatment is the Key to Reliable Rescue
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Any Questions & Discussion?