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HOPE A YEAR OF HOPE AND HEALING AT THE BARBARA ANN KARMANOS CANCER INSTITUTE 2009 Calendar

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A Y e A r o f H o p e A n d H e A L I n G A t t H e B A r B A r A A n n K A r M A n o S C A n C e r I n S t I t U t e

2009 Calendar

CanCer. I’ve spent a good part of my life raising money, giving money and working in various ways to end this disease in our lifetime.I do this for literally thousands of families who face their fear of cancer and turn to Barbara Ann Karmanos Cancer Institute (KCI) because of its reputation as one of the best treatment centers in the world with a team of experts that helps in every aspect of the disease.

I didn’t think I would ever get cancer. But when my wife Danialle and I found out that I did, like all cancer patients, we were scared. However, we had an advantage: we knew exactly where to go.

KCI is the only hospital in Michigan solely dedicated to treating cancer–all types of cancer. It ranks number one as southeastern Michigan’s most preferred hospital for cancer care, according to research conducted by the National Research Corporation in 2007 and 2008, and is one of only 41 National Cancer Institute-designated comprehensive cancer centers in the United States.

The experts at KCI quickly pinpointed my problem: a cancerous tumor within one of my kidneys. The diagnosis was quick, but more importantly was 100 percent accurate. My wife and I were surrounded by a team of the best doctors, nurses and administrators in the world. They told us what to expect and left nothing to the imagination. The surgery was perfect, and in less than one week this 65-year old CEO was back to work. That same week I was playing golf as a cancer-free duffer.

After it became public that I had had cancer treatment, someone asked me where I had the surgery performed. I looked at the person with that “are you kidding?” expression. I was almost uncharacteristically speechless. Finally, I replied, “Where do you think? My last name is KARMANOS!”

What I thought was a stupid question, later gave me pause. If it’s not a “no-brainer” that KCI is the first and best place everyone should go when cancer becomes their reality, then our work at making this known is obviously not yet complete. This is why Danialle and I will continue to support KCI in any way we can until we can finally and forever eradicate the disease of cancer.

We hope you will join us in this effort.

Sincerely,

Peter Karmanos, Jr.Chairman and CEOCompuware Corporation

1-800-Karmanoskarmanos.org

Hear cancer. Think Karmanos.

January2009S u n d ay M o n d ay T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org 1-800-Karmanos

January is Cervical Cancer Screening Awareness Month. To learn more about cervical cancer treatment or prevention, please visit karmanos.org.

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Martin Luther King, Jr. Day

For many cancer patients, eliminating stress is crucial to healing. For Brian Tomczyk, a 23-year-old patient from Big Rapids, creat-ing mental barriers against anxiety has been essential in his three-year battle against Primary Central Nervous System Lymphoma (PCNSL).

“Adversity does not define who you are – how you react to adversity does,” Tomczyk says. “You have to train your mind to reduce negativity and stress no matter what you’re going through.”

When Tomczyk first showed symptoms of the disease in 2006, his professors at Ferris State University initially attributed his erratic behavior to drugs. Normally an excellent student, Tomczyk suddenly began exhibiting slurred speech and manic behavior.

A subsequent CT scan and biopsy revealed PCNSL as the true cause of Tomczyk’s behavior. Originating in the brain, PCNSL is a rare cancer that can cause headaches, forgetfulness, confusion and limb weakness. Possible treatments include chemotherapy, radiation therapy and stem cell transplants. Tomczyk chose to be treated by the Karmanos Cancer Center’s team of hematology experts, led by Charles Schiffer, M.D.

“Karmanos is the only hospital in Michigan dedicated solely to cancer research and treatment,” Tomczyk says. “When I learned that, I decided there was no better place for me. Dr. Schiffer and all the doctors and nurses have been wonderful to me. I cannot thank them enough for their care and compassion.”

Tomczyk began treatment with chemotherapy to break down his immune system, followed by a stem cell transplant. The treatment initially appeared successful but the cancer returned.

Subsequent treatments diminished the tumor, but it returned again just before his wedding last June. Tomczyk and his bride, Katie, took the news in stride. When he returned to Karmanos for radiation therapy shortly after the wedding, he and Katie hung a “Just Married” sign on his hospital room door.

“During my three years with cancer, Katie has been my best friend, girlfriend, fiancée and now my wife,” Tomczyk says. “Her sacrifices, dedication and nurturing love give me strength. My parents, family, friends and other acquaintances also help carry me through this. The greatest part about my cancer battle has been the love I have felt from other people.”

Another source of inspiration to Tomczyk is his aunt, Janet DiFelice, who received treatment at Karmanos for ovarian cancer while Tomczyk went through radiation therapy.

“I cherish my Aunt Janet,” Tomczyk says. “Before she was diagnosed with cancer she did a cancer walk in my honor. She also has a special needs daughter who requires a lot of attention. My aunt has taught me a lot about grace and compassion.”

Though Tomczyk’s graduation has been delayed a couple years, earning his degree remains one of his highest goals.

“I also want to write at least one book and do some motivational speaking about what I’ve learned in fighting cancer,” he says. “I believe that all humans face hardships and joys in life. I want to make positive contributions to the world and help others deal with their suffering. Life is a gift, not an entitlement. Our response to adversity reveals all we can be.”

on HealingPATienT’S CourAgeouS ATTiTude reveAlS greAT inner STrengTh

An Insight

Katie and Brian tomCzyK

February2009S u n d ay M o n d ay T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org 1-800-Karmanos

February is national Cancer Prevention Month. Adopt a healthy lifestyle and follow a diet that contains more nutrient-rich foods, such as vegetables, grains and fruit. exercise daily and undergo routine health screenings. Be sure and tell your doctor if you have a family history of cancer.

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Ash Wednesday

Valentine’s Day

Groundhog Day

President’s Day

Use your Visa, MasterCard, Discover or American Express to make a convenient, secure donation online now at Karmanos.org.

Sign up for the latest Karmanos Cancer Institute information. Visit www.karmanos.org/efriends

The Barbara Ann Karmanos Cancer Institute Needs Your Continued Support

maKe a differenCeThere are many ways to support cancer care and research. Please join us in the fight against cancer.

AnnuAl dinner MAy 2009

PArTnerS golF ClASSiC And nighT FAll 2009

Philanthropic employers such as Crain Communications offer employees the opportunity to support the Karmanos Cancer Institute. A partnership with Karmanos also helps enhance your corporate image, while fostering customer and employee loyalty.

Call Maureen Bender at [email protected]

Our Friends Raising Funds program is dedicated to individuals, community organizations and businesses that seek ways to get involved. From golf outings and walks, to bake sales and private dinners, hosting your own event offers a great opportunity to support Karmanos and get creative.

Contact Lauren Miller at [email protected]

Launch an employee pledge drive for Karmanos

Host a fundraiser

Donate online

Sandy Schwartz (left), Karmanos board member Nettie H. Seabrooks and Karmanos Chairman of the Board Alan S. Schwartz enjoy Partners Night where $1.2 million was raised for cancer research. Photo by Patricia A. Ellis

LEFT: A sold out crowd attended the Michigan Design Center’s CatWalk event benefitting Karmanos.Designers: Jill Schumacher & Michele Mio, Rariden, Schumacher Mio & Co. Showroom: Rozmallin

Contact Stephanie Schwager at [email protected]

Sponsor or attend one of our signature events

March2009T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org 1-800-Karmanos

S u n d ay M o n d ay

March is national Colorectal Cancer Awareness Month. To learn more about colorectal cancer treatment or prevention, please visit karmanos.org.

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Birthday Purim

For the second consecutive year, the Karmanos Cancer Center has been designated the most preferred hospital for cancer care among 12 hospitals in southeast Michigan, according to the 2008 Cancer Treatment Preference Profile Survey conducted by the National Research Corporation.

This annual survey, conducted via an Internet questionnaire, was sent to nearly 200,000 households throughout the United States, including 3,504 homes in Wayne, Oakland, Macomb, Washtenaw, Livingston, St. Clair and Monroe counties. The respondent was the individual in the household who is the primary health care decision-maker. Respondents who preferred Karmanos for cancer care also preferred its personalized care, advanced technology and equipment, expert doctors, overall quality and image or reputation.

“We have an exceptional staff made up of brilliant researchers and physicians, compassionate and caring nurses, technicians and other professionals who are committed to providing cancer patients with the highest quality care, the latest treatment options and education, and innovative state-of-the-science research,” says John C. Ruckdeschel, M.D., Karmanos president and chief executive officer. “We’ve only been an independent cancer center since December 2005 and we realize there

are many choices when it comes to health care services. We’re honored to be selected the most preferred hospital for cancer care again. We will continue to do all we can to uphold our high standard of care and vigilance to eradicating this disease.”

Karmanos also earned high rankings from Detroit- area publications in 2008. HOUR Detroit designated Karmanos the number one hospital for cancer and named 52 physicians to its Top Docs list. Crain’s Detroit Business

also named Karmanos one of Detroit’s Most Admired Companies. The dedicated physicians, nurses, scientists and staff at Karmanos who are focused on fighting and winning the battle against cancer have contributed to these distinct honors.

For more information on cancer care and services call 1-800-Karmanos.

Karmanos Ranked Most Preferred Cancer Care Hospital

We’re #1 AgainBrilliant physicians

and researchers, compassionate

and caring nurses, cancer survivors

and dedicated volunteers and

supporters represent the Karmanos

Cancer Center.

April2009S u n d ay M o n d ay T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org 1-800-Karmanos

April is national Cancer Control Month. To learn more about cancer treatment or prevention, please visit karmanos.org.

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National Minority Cancer

Awareness Week

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Oral, Head & Neck Cancer

Awareness Week

Palm Sunday

Easter

Good Friday

There are many reasons why patients from across Michigan and around the country choose the Karmanos Cancer Center for care and treatment. One is because Karmanos is among 41 National Cancer Institute-designated comprehensive cancer centers in the United States. Earning and maintaining this designation since 1978 follows a highly competitive process every five years and places Karmanos among the nation’s best.

An NCI-designated comprehensive cancer center must commit to higher standards of combining research, education and patient care. Comprehensive cancer centers are expected to initiate and conduct early phase, innovative clinical trials and to participate in the NCI’s cooperative groups by providing leadership and recruiting patients for trials. Comprehensive cancer centers are known for exceptional cancer care and treatment and must also conduct cancer outreach and educational activities for both health care professionals and the public.

For anyone facing a cancer diagnosis, John C. Ruckdeschel, M.D., president and chief executive officer at the Karmanos Cancer Institute, highly recommends selecting an elite hospital like Karmanos with an NCI designation. “We know there are many choices when it comes to hospitals in southeast Michigan,” says Dr. Ruckdeschel. “What distinguishes us from other health care providers is our NCI designation and total focus on cancer care and research. Lots of places can do a good job at taking care of cancer patients. But it’s integrating research into that care that makes Karmanos special.”

Research breakthroughs at Karmanos helped Terry Fornwall beat pancreatic cancer.

“I was diagnosed at another hospital in September 2004,” Fornwall says. “They sent an oncologist in who told me that most patients normally succumb to this disease. My husband and I were given no hope. We decided to come to Karmanos because we learned that they were running a clinical trial that might help.”

Clinical trials provide critical information about how new cancer-fighting drugs affect patients. Fornwall participated in an FDA-approved trial at Karmanos under the care of Philip A. Philip, M.D., Ph.D., FRCP, professor of medicine and oncology and leader of the Gastrointestinal Multidisciplinary Team, whose research interests include finding novel therapies to treat gastrointestinal cancers.

“When we came to see Dr. Philip, he informed me that the disease had spread to my liver,” Fornwall says. “I started chemotherapy and began taking some medication that was very new. About four or five months into the trial, the cancer in my liver had disappeared and my tumor was gone. I’ve been in remission since August 2005. Karmanos offered me all the hope in the world and saved my life.”

Dr. Ruckdeschel says leading edge research efforts underscore the importance of being treated at an NCI-designated comprehensive cancer center. “It’s very exciting to offer patients the latest advances in fighting cancer,” he says. “Research, integral to an NCI designation, helps lengthen patient’s lives and make them better. It’s what makes us come to work every day.”

terry fornWall

An Honorable Karmanos Maintains Prestigious NCI Designation

Distinction

May2009S u n d ay M o n d ay T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org 1-800-Karmanos

May is Skin Cancer detection and Prevention Month. To learn more about skin cancer treament or prevention, please visit karmanos.org.

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Jordan Maier, M.D., was just beginning his medical education at Wayne State University School of Medicine when his father was diagnosed with cancer at the base of his tongue. Watching his father fight this disease with chemotherapy and radiation helped shape Dr. Maier’s eventual career path.

“That experience gave me perspective on what patients and their families go through when diagnosed with cancer,” says Dr. Maier who became board certified in radiation oncology after completing his residency at the Karmanos Cancer Center. “I was impressed and appreciative of the care he received at Karmanos, both the technical skills of his treating physicians and their bedside manner. Becoming a radiation oncologist and providing this same level of compassion and care to others at the most difficult time in their lives was my way of giving back for the care my father received.”

After completing his residency, Dr. Maier practiced at the Cancer Centers of Florida in Winter Park. He returned to Karmanos last September as Medical Director of the Lawrence and Idell Weisberg Cancer Treatment Center in Farmington Hills.

“I could not pass up the opportunity to be back home with my family and work with the Karmanos physicians and researchers with whom I trained as a resident,” says Dr. Maier. “I was excited about becoming part of the Karmanos team and I hope to further enhance the quality of care patients receive at Weisberg.”

Weisberg, which opened in 2001, offers patients in Oakland County convenient access to chemotherapy, radiation oncology and other sophisticated cancer treatments in an atmosphere designed to provide comfort and healing. The home-like environment includes patient amenities such as a fireplace, individual changing rooms, kitchenettes, and a soothing waterfall. On-site cancer and nutritional counseling services, access to national and local clinical trials and massage therapy are also available.

“Patients who come to our Weisberg facility have access to the same amenities as those patients at our downtown Karmanos facility — compassionate care, opportunities for clinical trials, and a multidisciplinary approach to treatment decision making.”

To set up an appointment with Dr. Maier at the Weisberg Cancer Treatment Center, call 248-538-4701. After connecting, press 1 for a receptionist. Jordan maier, m.d.,

and SHeri madaK, r.n.

Director Combines Clinical Expertise and Emotional Support

EvEry StEp of thE Way Devoted to Patients,

June2009S u n d ay M o n d ay T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org 1-800-Karmanos

The Karmanos Cancer institute is the only hospital in Michigan

that focuses solely on treating cancer – all types of cancer –

and is committed to a future free of the disease.

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National Cancer Survivors Day

Flag Day

Father’s Day

For Stephen Ethier, Ph.D., associate center director of Basic Research and deputy director at the Karmanos Cancer Institute, battling cancer is a lot like climbing a mountain. And cancer research at the molecular level will one day help oncologists reach the summit.

“Our dedication to molecular cancer research is changing how we detect, diagnose and treat the disease,” Dr. Ethier says. “We’ve been climbing the mountain a while and it becomes steeper as we get higher. We still have a long way to go, but patients are already benefiting from our research. We can cure some cancers today that we weren’t able to in the past.”

The U.S. Army Medical Research and Materiel Command, Telemedicine and Advanced Technol-ogy Research Center recently bolstered the innovative research Karmanos scientists perform at its National Oncogenomics and Molecular Imaging Center (NOMIC) with more than $4.6 million in federal appropriations. NOMIC is developing technology that will help physicians better diagnose cancer by defining gene mutations that characterize cancers in individual patients. The federal funding, to be allocated over the next two years, will be used to purchase state-of-the-art medical equipment to study gene mutations and support new research projects.“We want to be able to make a precise molecular diagnosis of each cancer patient at the most basic level,” Dr. Ethier says. “We know that there are at least 500 different genes that can cause cancer if they are

mutated in a particular way. Every cancer has a different set of mutated genes that work in different combinations, which presents an enormous technical challenge.”

NOMIC scientists are also developing new imaging technologies that will greatly improve the detection of mutated genes and measuring treatment response.

“Rather than wait weeks or months to see the results of a certain therapy, we want to obtain real-time images of tumors to gain more immediate results on how a patient is responding to treatment,” Dr. Ethier says.

This research will one day allow physicians to create highly customized treatment therapies based on the specific gene mutations identified in a patient.

“Patients can look forward to a highly individual-ized diagnosis of their cancer that will have a direct impact on which drugs are used for treatment,” Dr. Ethier says. “The older cancer fighting drugs were basically used on a very broad spectrum of patients. Some worked better on certain patients than others. We’re beginning to move away from this approach and instead giving patients new drugs based on their individual molecular profile.

Dr. Ethier is project director for NOMIC. Karmanos’ John C. Ruckdeschel, M.D., president and chief executive officer, is principal investigator and Anthony Shields, M.D., Ph.D., associate center director, Clinical Research, is the co-investigator.

u.S. deparTMenT oF deFenSe GranT SupporTS CanCer reSearCh aT The MoleCular level

CanCer’S Code

StepHen etHier, ph.d.

Cracking

July2009S u n d ay M o n d ay T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org 1-800-Karmanos

July is Sarcoma Awareness Month. To learn more about sarcoma treatment or prevention, please visit karmanos.org.

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From the time he began studying medicine, George Yoo, M.D., FACS, was always interested in helping patients fighting the deadliest diseases.

Dr. Yoo says, “I really want to benefit patients in terms of their quality of life and want to perform surgeries that improve patient outcomes.”

Dr. Yoo has done just that many times over in his work at the Karmanos Cancer Center. He’s the leader of the Head and Neck Multidisciplinary Team, vice president of Medical Affairs, and an expert in the surgical management of cancers of the mouth and throat. He earned his medical degree at the University of Kansas Medical Center and com-pleted a residency and fellowship in head and neck surgery at the prestigious Johns Hopkins Hospital in Baltimore. Dr. Yoo joined the faculty at Wayne State University School of Medicine in 1996 and joined the staff at Karmanos shortly afterwards.

“I gravitated toward performing head and neck surgeries because I enjoy the technical challenges involved,” Dr. Yoo says. “Of course, surgery isn’t always the best option for every patient. As we move forward in developing new therapies and cancer fighting drugs, we’re creating a wider variety of treatment options, which is very exciting.”

Dr. Yoo took on greater challenges last October when Karmanos promoted him to associate center director of medical affairs and chief medical officer. In this role, Dr. Yoo oversees clinical operations, physicians and Karmanos’ 13 multidisciplinary teams. He also works with senior leadership to recruit the best cancer physicians to Karmanos.

“I’m very enthusiastic about my new position and look forward to helping Karmanos expand its services to meet patients and physician needs,” Dr. Yoo says.

While handling multiple administrative responsibilities, Dr. Yoo continues to maintain a full case load and perform surgeries. He says his best days are those when his most ill patients begin feeling better physically and emotionally.

“Karmanos is an incredible place to work,” Dr. Yoo says. “We’re focused solely on treating cancer, but we’re also involved in dealing with all the various emotions our patients experience when battling this disease. Helping patients on both fronts makes our jobs extremely rewarding.”

a neW paTh in a reWardinG Career

Surgeon Accepts Greater Challenges as Chief Medical Officer and Associate

Director of Clinical Affairs

george yoo, m.d., faCS

August2009S u n d ay M o n d ay T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org 1-800-Karmanos

every surgeon at Karmanos is a cancer surgeon. each one is

on the faculty of Wayne State university School of Medicine

giving them access to the latest technology and techniques.

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Manny Rosenbaum’s passion is spreading the word about the importance of frequent cancer screenings – and with good reason.

Because his brother, Irving, had been diagnosed with prostate cancer, Rosenbaum knew he was at higher risk and increased his screenings from once to twice per year. In 2004, the Karmanos Cancer Center doctors confirmed Rosenbaum had a highly aggressive form of prostate cancer. He immediately began an intense radiation and medication treatment at Karmanos’ Weisberg Cancer Treatment Center in Farmington Hills. Today at age 79, Rosenbaum is a cancer survivor, and he tells everyone he can to get tested early and often.

“My brother was diagnosed with prostate cancer in spite of getting tested annually,” says Rosenbaum, a retired microbiologist and computer support specialist. “He died five years after he was diagnosed. I knew that my risk of prostate cancer was higher, so my thought was to not give the disease a chance to get a head start. That’s why I began getting the test twice annually. That decision saved my life.”

Rosenbaum says he was impressed by the care Karmanos cancer specialists provided his brother. “The Karmanos team was the most caring, competent and compassionate medical staff I’ve ever encountered,” Rosenbaum said. “They do everything they can to make patients feel comfortable and at ease, and showed great concern and feeling for me as a person.”

Rosenbaum became a member of the Karmanos Speaker’s Bureau in 1998 to honor his brother and to help raise awareness about prostate health. Besides speaking and handing out cancer awareness literature at health fairs, he also records educational audio books for Recording for the Blind and Dyslexic.

“A cancer diagnosis is not necessarily a death sentence,” Rosenbaum says. “People should not be frightened by cancer, because as long as it is caught early, there are many different treatment methods available. People should not neglect to get regular testing because it can be life saving. I’m proof of that.”

Manny roSEnbauM

Cancer Survivor advocates frequent Screenings

Stopping Prostate Cancerin itS traCKS

Screening for Prostate CancerProstate cancer is the most common cancer among men in the united States. African American men and men with a family history of prostate cancer are at an increased risk for prostate cancer.

The recommended screenings for prostate cancer are:• A Digital Rectal Exam (DRE) annually starting at age 50• A Prostate Specific Antigen (PSA) blood test annually starting at age 50

• If you are African American or your brother, father or son had prostate cancer before age 65, get an annual DRE and PSA blood test at age 45

Like any screening test, prostate screening has its benefits and limita-tions. Make sure you discuss your individual need for prostate cancer screening with a health care provider.

For more information on cancer prevention, screening and diagnostic programs, call 1-800-Karmanos.

2009September

S u n d ay M o n d ay T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org • 1-800-Karmanos

September is national Prostate, ovarian, gynecologic, and leukemia and lymphoma Cancer Awareness Month. To learn more about treatment or prevention of these types of cancer, please visit karmanos.org.

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Labor Day

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Judge Maria L. Oxholm was preparing to launch her campaign for re-election to Wayne County’s Third Circuit Court in 2000 when she learned she had breast cancer. At first she felt overwhelmed and worried about her three young children. Then she decided cancer wouldn’t beat her. She sought treatment at the Karmanos Cancer Center, where she elected to have a mastectomy and chemotherapy.

“I came to Karmanos because they are known throughout the country for providing expert cancer care,” says Judge Oxholm, who won her election and fight against cancer. “I had a lot of confidence in the doctors who treated me and felt very comfortable with my treatment plan. I went through chemo during the week and campaigned on the weekends. I’ve been cancer-free going on nine years. Cancer never stopped me.”

Thankfully, Judge Oxholm sought early treatment and had a successful outcome. Unfortunately, many other women of Hispanic heritage lack the information needed to battle cancer due to language barriers, misconceptions about the disease and other socioeconomic factors. The Centers for Disease Control and Prevention reports that just 38 percent of Latina women have regular mammograms, and breast cancer among Latinas is rising faster than in any other ethnic group.

To address the need for greater awareness about breast cancer within metro Detroit’s Hispanic community, Karmanos launched its Latina Breast Cancer Project in 2005 with grant funds from Susan G. Komen for the Cure®. The program is part of Karmanos’ Latino Cancer Program.

“Our first step was to learn about the Latina community’s needs so we could develop specific program goals,” says Beatriz Esquivel-Ramos, breast cancer co-survivor and Latina Education and Outreach

Coordinator at Karmanos. “From that we’ve developed advisory boards, support groups and free bilingual breast health education programs that serve the Latina population in southwest Detroit, the downriver area, and in Macomb and Oakland counties. We help Latina women enroll in the Breast and Cervical Cancer Control Program, which is run by the Michigan Department of Community Health and provides low-income women with access to cancer screening services.”

Since the program’s launch, nearly 1,400 Latina women have learned about breast health and life-saving cancer screenings through Karmanos-sponsored programs at community family health agencies, churches, ESL classes and other forums.

“It’s very important that Karmanos offers these types of programs to the Hispanic community, because people need to know that the earlier you get medical attention, the better the outcome will be,” says Judge Oxholm. “Hispanic women cannot live in fear of cancer. They need to know that there are good treatment options and you can continue to live your life.”

bEatriz ESquivEl-raMoS (lEft) and JudgE Maria oxholM

ProgrAM rAiSeS BreAST CAnCer AwAreneSS AMong lATinAS

a Culture

For more information on Karmanos’ Latino Cancer Program, call (313) 576-8164 (Spanish) or (313) 576-9283 (English).

of Good Health

October2009S u n d ay M o n d ay T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org 1-800-Karmanos

october is national Breast Cancer Awareness Month. To learn more about breast cancer treatment or prevention, please visit karmanos.org.

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Thanksgiving (Canada)

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National Mammography Day

At the Karmanos Cancer Center, when a challenge is present, you’ll also likely find Antoinette Wozniak, M.D., FACP.

“Challenges make life interesting,” says Dr. Wozniak, leader of the Thoracic Oncology Multidisciplinary Team at Karmanos and professor of medicine at Wayne State University School of Medicine. “Between caring for patients, teaching and mentoring residents and leading various clinical trials, there are no dull moments.”

Dr. Wozniak’s penchant for pursuing medical challenges began while she was an undergraduate chemistry major at Niagara University near her childhood home of Buffalo, New York. Always intrigued by the sciences, Dr. Wozniak found the lab environment a bit constricting.

“I wanted to pursue a career that would always hold my interest,” Dr. Wozniak says. “Even then, I found the nature of being a physician and taking care of people very appealing. I liked that much better than sitting in a lab with chemicals.”

Although Dr. Wozniak initially wanted to become a pediatrician, the prospect of working in oncology – a field rife with opportunities for advances in treatments and medications – changed her career path. After completing her medical oncology residency and internship, she joined Wayne State as an assistant professor of

medicine in 1983. She continued conducting research while treating patients at the former VA hospital in Allen Park. In 1992, she chose to become a thoracic oncology specialist, thanks to the influence of Manuel Valdivieso, M.D., former chief medical officer and associate director of Clinical Affairs at Karmanos.

“I have to credit Dr. Valdivieso with piquing my interest in thoracic oncology,” Dr. Wozniak says. “He was the one who started the multidisciplinary team approach to treating lung cancer at Karmanos. I found thoracic oncology challenging, and he persuaded me to join his team. I began treating thoracic patients, launched some clinical trials and things just took off from there.”

Today, Dr. Wozniak is leading a number of clinical trials involving the development of new drugs to treat lung cancer. As a clinician-educator in Wayne State’s Division of Hematology and Oncology, she is very involved in helping young residents/fellows learn to become leading oncologists. Above all, Dr. Wozniak remains devoted to treating cancer patients.

“It’s wonderful to see patients who may have been given a grim diagnosis a few years ago, but now are doing quite well,” Dr. Wozniak says. “We’ve made great progress over the last 20 years in developing new drugs to help these patients. It’s very rewarding and exciting to be part of that.”

up CloSE: antoinEttE WozniaK, M.d., faCp

Always Acceptinga ChallEngE

[BIo]antoinette J. WozniaK, m.d., faCp

title: Professor of internal Medicine, wayne State univerity School of Medicine; and leader, Thoracic oncology Multidisciplinary Team. Associate director Fellowship Program. dr. wozniak was elected as President of the Medical Staff by her physician peers at Karmanos.

eduCation: M.d. from the State university of new york at Buffalo School of Medicine; B.S. summa cum laude in Chemistry from niagara University (New York).

training: residency and internship at the State university of new york at Buffalo Affiliated Hospitals; Fellowship in Hematology and Medical Oncology at the university of Florida in gainesville.

November2009S u n d ay M o n d ay T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org 1-800-Karmanos

november is Pancreatic Cancer Awareness and lung Cancer Awareness Month. To learn more about pancreatic and lung cancer treatment or prevention, please visit karmanos.org.

International Brain Tumor

Awareness Week

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Though the pharmacists still wear white lab coats, there are plenty of differences between a typical retail drug store and the specialized care and service provided at the Karmanos Cancer Center Pharmacy. Located within Karmanos in midtown Detroit, pharmacy staff members provide full medication services for Karmanos patients, participate in the research of new cancer fighting drugs and offer training opportunities for future pharmacists.

“Our pharmacy is very different from the traditional retail pharmacy – it’s about more than counting out pills and placing them in a bottle,” says Stephen T. Smith, M.S., FASHP, director of Pharmacy Services at Karmanos. “We have 12 pharmacists and 14 technicians who are responsible for all the medications our patients receive during their hospital stay or clinic visit.”

Pharmacy staff members prepare nearly 2,700 chemotherapy medications per month, which are given to patients either orally or intravenously. Each dose must be prepared according to exact parameters for each individual patient.

“Chemotherapy drugs are not in ‘ready to administer’ form,” Smith explains. “We prepare these medications based on individual patient factors such as height, weight, liver and kidney function. It’s an exact process that must be performed with extreme precision, because very small dosage changes can have an adverse affect on a patient. And because of the highly toxic nature of these drugs, we prepare them under strict sterility and stability standards. Our sterile prep lab is akin to an operating room – it’s an extremely clean environment for medication preparation. These drugs can cause side effects in otherwise healthy people, so we have to use special equipment when transferring the medication to an IV bag. It adds some additional time to the compounding process, but we must have the proper safety measures in place to protect those who prepare, dispense, and administer the medication.”

Karmanos pharmacists also provide services for all research protocols, including investigations centered on dozens of new medications through the Phase I Clinical Trials Program.

“We participate heavily in researching new cancer drugs, Smith says. “The principal investigator is generally a physician, but

Karmanos pharmacists help study how patients respond to different medications.”

Through affiliations with Wayne State University and University of Michigan colleges of pharmacy, Karmanos provides structured educational programs for future pharmacists. Karmanos also offers a 12-month, post-graduate Oncology Specialty Residency Program that provides pharmacists with advanced clinical training and experience working with cancer patients.

Perhaps the biggest difference between the retail setting and the work of a Karmanos pharmacist is the amount of direct interaction with the patient’s physician.

“The pharmacists do more than make sure patients get the right drugs – they’re part of the team that cares for our patients,” Smith says. “They make rounds, make any appropriate medication adjustments and help coordinate patient care with attending physicians, nurses, and other members of the health care team. It’s our carefully coordinated team approach that sets us apart from the retail arena.”

Karmanos Pharmacists Provide More

than Medication

drug StoreThis Isn’t Your Corner

StepHen t. SmitH, m.S., faSHp

December2009S u n d ay M o n d ay T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org

our doctors and teams of experts

offer hope to more than 6,000 new

patients who seek diagnosis and treatment

at Karmanos each year.

1-800-Karmanos

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Entering the Working WorldKarmanos Doctors Recall their Early Job Experiences

Jeffrey Zonder, M.d.Assistant Professor of Medicine and Oncology, Hematology/Oncology

“When I was 15 I got a job for about six months bussing tables at a Bill Knapp’s restaurant in Farmington Hills. I made about two dollars per hour plus a portion of the waitresses’ tips. I would come home from every shift exhausted and jump right into the shower. It was the messiest job I’ve ever had. Bill Knapp’s used to give away free chocolate cakes and a percent-age off the bill equal to your age on your birthday, so people were constantly having birthday parties. There were evenings when it felt like my sole occupational duty was to try to get chocolate cake and frosting off the carpet. Still, I rarely needed to ask my parents for spending money while I was working there.”

PhiliP A. PhiliP, M.d., Ph.d., frCPProfessor of Medicine and Oncology

“My father died when I was 11 and because I was the oldest child, I began learning the family trade by working during the hot Iraqi summers in a Baghdad shoe factory. I cleaned floors, carried things around and learned how to operate some of the machines. I took time to make some little toy gun holsters from leftover leather and designed several myself. By the time I finished medical school I also knew how shoes were made and could run the business. My first ‘paycheck’ was in currency equal to about three dollars. I felt very excited when the accountant called my name and handed me this little brown bag filled with coins.”

Peter J. littruP, M.d.Radiologist

“I put myself through college working in Detroit area tool shops and learned a lot about practical machinery, safety and the benefits of being a ‘wimp.’ Although OSHA (Occupational Safety and Health Administration) established its standards in 1970, some small shops didn’t take exposure to hazardous materials very seriously. I was asked to clean a two-story high stamping press caked with muck and grease. They gave me a spackling knife, a bunch of rags and an open bucket of gasoline. After two hours of scraping, my head felt like it would explode. So I went to the shop foreman and asked him whether this was considered safe according to OSHA. He told me questions like mine reflected that, as a wimp, I should just go sweep the shop. The foreman found a less fortunate kid to clean the press.”

CAssAn BlAke, M.d., MPhCo-Director, Walt Comprehensive Breast CenterAssistant Professor of Surgery

“When I was in high school I worked as a telemarketer for a company called Schulman, Ronca & Bucuvalas in Man-hattan. I started at age 15 and worked part-time during the evenings for a little extra spending money. It was a fun job. Almost all the surveys took about two or three minutes. If someone hung up on me, I just took it in stride and made the next call. But I recall one survey that was over an hour long – I had to call farmers in Iowa and ask about their fertilizer. I tried to mask my thick Brooklyn accent because I was afraid the farmers would hear it and not want to talk to me.”

January2010S u n d ay M o n d ay T u e S d ay W e d n e S d ay T h u r S d ay F r i d ay S aT u r d ay

karmanos.org 1-800-Karmanos

January is Cervical Cancer Screening awareness Month.

regular pap tests can help identify the disease in

its early stages, when cancer is the most treatable.

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Email: [email protected] . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

MARY ANN SHORT Vice President,

Marketing and Communications

LINDA H. REMINGTON Editor

Director, Marketing and Communications

Associate Editors:

PATRICIA A. ELLISMedia Relations Manager

CHRISTINE PARKERMarketing Coordinator

On the cover: Manny Rosenbaum, prostate cancer survivor.

Read Manny’s story in the month of September. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Feature photos by Stephen Lengnick, Plum Street Studio

Copyright 2008 Barbara Ann Karmanos Cancer Institute

Dear Friends,

As we begin another new year, we are pleased to present our Karmanos Hope 2009 calendar. It showcases the stories of just a few of our remarkable patients who remind us of the true meaning of hope, grace and perseverance.

You’ll also read about our extraordinarily gifted team of scientific researchers, oncologists, pharmacists, technicians and other members of the Karmanos team. During the past year, there has been worldwide attention focused on the work they do to eradicate cancer. With this dedication and commitment, I expect 2009 will be characterized by further scientific, diagnostic and clinical advances.

Thank you for your support and inspiration in our fight against cancer.

Sincerely,

nonproFiT orGu.S. poSTaGe

paiddeTroiT, Mi

perMiT no. 1579

WINTER 2009 • VOLUME 4 | NUMBER 2...................................................

about KarManoS

The Barbara Ann Karmanos Cancer Institute is one of only 41 National Cancer Institute-designated Comprehensive Cancer

Centers in the United States. Federal designation as a Comprehensive Cancer Center is the pinnacle of translational oncology research.

...................................................ExECutivE Staff

JOHN C. RUCKDESCHEL, M.D.President & Chief Executive Officer

CYNTHIA K. SIKINASenior Vice President/Chief Financial Officer

NICK KARMANOS Vice President, Development

...................................................

KarManoS CanCEr inStitutE board of dirECtorS

Mail Code: NCO 6MC

4100 JOHN R DETROIT, MI 48201

Charles E. Becker, ChairTimothy Monahan, Vice Chair

Jonathan S. AaronChristina Balian Mehren

Leslie C. BowmanArmando R. CavazosKenneth Eisenberg

Nathan ForbesThomas A. Goss

Denise IlitchMelvin A. Lester, M.D.

Robert H. MarcinRobert M. Mentzer, Jr., M.D. (ex officio)

J. Edson Pontes, M.D.John C. Ruckdeschel, M.D. (ex officio)

Anthony J. RuscianoAlan S. Schwartz (ex officio)

Nettie H. SeabrooksMaureen L. StapletonJane R. Thomas, Ph.D.

Antoinette J. Wozniak, M.D. (ex officio)George Yoo, M.D. (ex officio)

Alan S. Schwartz, ChairRandolph J. Agley, Vice Chair

Charles E. Becker, Lead Vice ChairRichard M. Gabrys, Vice ChairW. James Prowse, Vice Chair

Eugene ApplebaumNancy Barrett, Ph.D. (ex officio)

Paul BormanArmando R. Cavazos

Lillian ErdeljanJeremiah E. Farrell

Nathan ForbesStanley FrankelMyron Frasier

Bruce A. GershensonStephen Grand

Adnan Hammad, Ph.D.Patricia Hartmann

David JacobEleanor M. Josaitis

Peter Karmanos, Jr.C. Michael Kojaian

Melvin A. Lester, M.D.Edward C. Levy, Jr.

Mervyn H. ManningMary Matuja

Robert M. Mentzer, Jr., M.D. (ex officio)Timothy Monahan

Paul L. NineThomas D. Ogden

Fred D. OlsonJ. Edson Pontes, M.D.

Eunice RingRichard F. Roth

John C. Ruckdeschel, M.D. (ex officio)Nettie H. SeabrooksNedda N. ShayotaRobert A. Stone

Vainutis K. Vaitkevicius, M.D.Nancy Yaw

John C. Ruckdeschel, M.D.

PRESIDENT AND CHIEF EXECUTIVE OFFICERBARBARA ANN KARMANOS CANCER INSTITUTE

KarManoS CanCEr CEntEr board of dirECtorS

As of November 21, 2008