a teaching strategy to improve students’ perception … · a teaching strategy to improve...

A TEACHING STRATEGY TO IMPROVE STUDENTS’ PERCEPTION OF THE IMPORTANCE OF ORGANIC CHEMISTRY IN PHARMACY STUDIES Esther CABALLERO*, Myriam GONZÁLEZ, Andrea J. CHILIQUINGA and Pilar PUEBLA Dpto. Ciencias Farmacéuticas. University of Salamanca, Spain, [email protected] RESULTS: • 57 students have participated in this experience. • This task counts 5% of the final grade of the subject. • The participation has oscillated between 80-90% of the enrolled ones. • At the end of the tasks a survey has been carried out to the students to know their opinion and improve the process. STUDENTS’ FEEDBACK 1- The different complexity of the structures assigned to each student. Justification: It is because the chosen molecules must contain structural requirements that allow to complete the questions and also assign a different molecule to each student to personalize the work 2- Perform more exercises in class before completing tasks. Justification: Strongly agree but limited by the temporary organization of the classes. 3- Review assignments in class. Justification: As it is an off-hour activity must be done in the personal tutorials of students with the teacher. 4- Complete the task on more than one drug. Justification: Can be proposed as an objective for the next year. 5- It is considered very interesting to apply the chemical concepts about the marketed drugs. AIMS OF THE PROJECT: To help students to appreciate the importance of the Organic Chemistry in their studies, a new teaching strategy has been developed. At the beginning of the course, a drug is assigned to each student by random, on which they will have to apply the knowledge acquired in the academic program of the subject. It is important to emphasize that each student has a different drug to perform personalized work. This objective is considered of great interest, since in it, students must apply the theoretical concepts to aspects related to pharmacy and everyday life. Examples of selected drugs: Acetylcysteine, Dexketoprofen (Enantyum), Diclofenac (Voltaren), Glutamic acid, Glutamine, Ibuprofen, Lidocaine, Methionine, Phenylalanine, Tropicamide, Warfarin,… up to 57. THE PROGRAM OF THIS ACTIVITY IS DIVIDED IN SIX STEPS TO APPLY THE NEXT CONCEPTS: First Goal: Structure, activity and pharmacological or industrial applications, IUPAC formulation, hybridization. Second Goal: Electrostatic Bonds, hydrogen bond, resonance. Third Goal: Acid-Base reactions applied. Fourth Goal: Stereochemistry, recognize the different enantiomers and diastereomers. In the case that the molecule doesn’t have stereogenic centers they have to modify the structure to create a chiral analog. Fifth Goal: Addition, Substitution, Elimination reactions. Electrophilic and Nucleophilic reactions will be done depending on the functional groups. Sixth Goal: Nucleophilic reactions will be applied to different carbonyl groups. In the last two items, the drug structure could be modified if it would necessary. OH O O Cl Cl NH OH O H N O N OH O

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Page 1: A TEACHING STRATEGY TO IMPROVE STUDENTS’ PERCEPTION … · a teaching strategy to improve students’ perception of the importance of organic chemistry in pharmacy studies. esther

A TEACHING STRATEGY TO IMPROVE STUDENTS’ PERCEPTION OF THE IMPORTANCE OF ORGANIC CHEMISTRY IN PHARMACY STUDIES

Esther CABALLERO*, Myriam GONZÁLEZ, Andrea J. CHILIQUINGA and Pilar PUEBLA

Dpto. Ciencias Farmacéuticas. University of Salamanca, Spain, [email protected]

RESULTS:• 57 students have participated in this experience.• This task counts 5% of the final grade of the subject.• The participation has oscillated between 80-90% of the enrolled ones.• At the end of the tasks a survey has been carried out to the students to know their opinion and

improve the process.

STUDENTS’ FEEDBACK1- The different complexity of the structures assigned to each student.Justification: It is because the chosen molecules must contain structural requirements that allow tocomplete the questions and also assign a different molecule to each student to personalize the work2- Perform more exercises in class before completing tasks.Justification: Strongly agree but limited by the temporary organization of the classes.3- Review assignments in class.Justification: As it is an off-hour activity must be done in the personal tutorials of students with theteacher.4- Complete the task on more than one drug.Justification: Can be proposed as an objective for the next year.5- It is considered very interesting to apply the chemical concepts about the marketed drugs.

AIMS OF THE PROJECT:To help students to appreciate the importance of the Organic Chemistry in their studies, a new teachingstrategy has been developed. At the beginning of the course, a drug is assigned to each student byrandom, on which they will have to apply the knowledge acquired in the academic program of thesubject.

It is important to emphasize that each student has a different drug to perform personalized work. Thisobjective is considered of great interest, since in it, students must apply the theoretical concepts toaspects related to pharmacy and everyday life.

Examples of selected drugs: Acetylcysteine, Dexketoprofen (Enantyum), Diclofenac (Voltaren), Glutamicacid, Glutamine, Ibuprofen, Lidocaine, Methionine, Phenylalanine, Tropicamide, Warfarin,… up to 57.

THE PROGRAM OF THIS ACTIVITY IS DIVIDED IN SIX STEPS TO APPLY THE NEXT CONCEPTS:First Goal: Structure, activity and pharmacological or industrial applications, IUPAC formulation,hybridization.Second Goal: Electrostatic Bonds, hydrogen bond, resonance.Third Goal: Acid-Base reactions applied.Fourth Goal: Stereochemistry, recognize the different enantiomers and diastereomers. In the case thatthe molecule doesn’t have stereogenic centers they have to modify the structure to create a chiralanalog.Fifth Goal: Addition, Substitution, Elimination reactions. Electrophilic and Nucleophilic reactions will bedone depending on the functional groups.Sixth Goal: Nucleophilic reactions will be applied to different carbonyl groups.

In the last two items, the drug structure could be modified if it would necessary.

ClNH