a new preparative route to substituted dibenzofurans by benzannulation reaction. an application to...

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2004 Benzofuran derivatives Benzofuran derivatives R 0070 A New Preparative Route to Substituted Dibenzofurans by Benzannulation Reac- tion. An Application to the Synthesis of Cannabifuran. — 2-Alkoxyaryl-substitut- ed hexynoic acids, readily available from o-iodoanisoles, undergo a new regioselective ring closing reaction yielding dibenzofurans. The reaction is used as the key step in a new total synthesis of cannabifuran (VI). — (SERRA*, S.; FUGANTI, C.; Synlett 2003, 13, 2005-2008; Ist. Chim. Ric. Mol. Sez., Dep. Chim. Mater. Ing. Chim. Politec., I-20133 Milano, Italy; Eng.) — Mais 08- 088

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Page 1: A New Preparative Route to Substituted Dibenzofurans by Benzannulation Reaction. An Application to the Synthesis of Cannabifuran

2004 Benzofuran derivatives

Benzofuran derivativesR 0070 A New Preparative Route to Substituted Dibenzofurans by Benzannulation Reac-

tion. An Application to the Synthesis of Cannabifuran. — 2-Alkoxyaryl-substitut-ed hexynoic acids, readily available from o-iodoanisoles, undergo a new regioselective ring closing reaction yielding dibenzofurans. The reaction is used as the key step in a new total synthesis of cannabifuran (VI). — (SERRA*, S.; FUGANTI, C.; Synlett 2003, 13, 2005-2008; Ist. Chim. Ric. Mol. Sez., Dep. Chim. Mater. Ing. Chim. Politec., I-20133 Milano, Italy; Eng.) — Mais

08- 088