a linear motif atlas for phosphorylation-dependent signaling
DESCRIPTION
Advances in Bioinformatics, Heidelberg, Germany, March 6-8, 2009TRANSCRIPT
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A linear motif atlas for phosphorylation-dependent signaling
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location
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signaling networks
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phosphoproteomics
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Linding, Jensen, Ostheimer et al., Cell, 2007
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in vivo phosphosites
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kinases are unknown
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sequence motifs
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Miller, Jensen et al., Science Signaling, 2008
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sequence specificity
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kinase-specific
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in vitro
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context
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association networks
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Linding, Jensen, Ostheimer et al., Cell, 2007
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NetworKIN
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Linding, Jensen, Ostheimer et al., Cell, 2007
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sequence motifs
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NetPhorest
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Miller, Jensen et al., Science Signaling, 2008
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data organization
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Miller, Jensen et al., Science Signaling, 2008
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automated pipeline
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compilation of datasets
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redundancy reduction
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training and evaluation
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classifier selection
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motif atlas
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179 kinases
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93 SH2 domains
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8 PTB domains
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BRCT domains
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WW domains
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14-3-3 proteins
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phosphatases
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model organisms
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biological applications
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disease-related kinases
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Miller, Jensen et al., Science Signaling, 2008
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cell-cycle kinases
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variation and signaling
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augmented browsing
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Reflect
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Acknowledgments
NetworKIN.info– Rune Linding– Gerard Ostheimer– Francesca Diella– Karen Colwill– Jing Jin– Pavel Metalnikov– Vivian Nguyen– Adrian Pasculescu– Jin Gyoon Park– Leona D. Samson– Rob Russell– Peer Bork– Michael Yaffe– Tony Pawson
Reflect.ws– Sean O’Donoghue– Evangelos Pafilis– Heiko Horn– Michael Kuhn– Nigel Brown– Reinhardt Schneider
NetPhorest.info– Martin Lee Miller– Francesca Diella– Claus Jørgensen– Michele Tinti– Lei Li– Marilyn Hsiung– Sirlester A. Parker– Jennifer Bordeaux– Thomas Sicheritz-Pontén– Marina Olhovsky– Adrian Pasculescu– Jes Alexander– Stefan Knapp– Nikolaj Blom– Peer Bork– Shawn Li– Gianni Cesareni– Tony Pawson– Benjamin E. Turk– Michael B. Yaffe– Søren Brunak
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