6choice based credit system structure - · pdf filenano and green chemistry ... fries and...

354

6CHOICE BASED CREDIT SYSTEM – STRUCTURE

FOR THOSE WHO HAVE JOINED FROM THE ACADEMIC YEAR 2014–15 ONWARDS

M.Sc CHEMISTRY

Sem Subject Hrs. Cr. Adl.

Cr.

Exam

(Hrs)

Marks

Allotted

Int. Ext.

I

01 Part – III

Core Organic Chemistry – I 4 4 3 25 75

02 Core Inorganic Chemistry – I 4 4 3 25 75

03 Core Physical Chemistry – I 4 4 3 25 75

04 Core

Lab

Organic Chemistry

Practical – I 5 – – – –

Core

Lab

Inorganic Chemistry


Core

Lab

Physical Chemistry


05 Elective

Major Analytical Chemistry 3 3 3 25 75

06 SLC In Plant Training

*Report;@Viva – 3 –

40

[*30:@10]

60

[*50:@10]

II

01 Part – III

Core Organic Chemistry – II 4 4 3 25 75

02 Core Inorganic Chemistry – II 5 4 3 25 75

03 Core

Lab

Organic Chemistry

Practical – I 5 4 6 40 60

04 Core

Lab

Inorganic Chemistry


05 Core

Lab

Physical Chemistry


06 NME Applied Chemistry 6 4 3 25 75

07 SLC

Computer Applications in

Chemistry

3 3 – 100

355

Sem Subject Hrs. Cr. Adl.

Cr.

Exam

(Hrs)

Marks

Allotted

Int. Ext.

III

01 Part – III

Core Organic Chemistry– III 4 4 3 25 75

02 Core Inorganic Chemistry – III 4 4 3 25 75

03 Core Physical Chemistry – II 4 4 3 25 75

04 Core

Lab

Organic Chemistry

Practical – II 5 – – – –

05 Core

Lab

Inorganic Chemistry


06 Core

Lab

Physical Chemistry


07 Elective

Major

Nano and Green

Chemistry 3 3 3 25 75

08 SLC Fundamentals of

Biochemistry – – 3 3 – 100

IV

01 Part – III

Core Organic Chemistry– IV 4 4 3 25 75

02 Core Inorganic Chemistry – IV 4 4 3 25 75

03 Core Physical Chemistry – III 4 4 3 25 75

04 Core

Lab

Organic Chemistry

Practical – II 5 5 6 40 60

05 Core

Lab

Inorganic Chemistry


06 Core

Lab

Physical Chemistry


07 Electives

Major Pharmaceutical Chemistry 3 3 3 25 75

08 Elective

Major

Project

*Report;@Viva 6 –

40

[*30:@10]

60

[*50:@10]

09 SLC Cheminformatics 3 3 – 100

TOTAL 120 90 12

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M.Sc CHEMISTRY: Those Who Have Joined From The

Academic Year 2014-15 Onwards Under CBCS System

Core Subject ORGANIC CHEMISTRY – III Code: 14224301

SEMESTER III

4 Hrs/Week

Credits 4

Objectives:

To have a knowledge of Molecular requirements .

To know the details of Terpenoids, Organic Photo chemistry.

UNIT – I: [12 Hrs]

Reactions and Rearrangements: Mechanism of the following

rearrangements: Wagner – Meerwin, Dienone –phenol rearrangement,

Demjanov, Curtius, Wolff, Baeyer – Villiger, Stevens, Favorski, Cope,

Fries and Di–pi methane rearrangement. Mechanism of sommelet

reaction – vilsmeir haak reaction – Arndt – Eistert reaction.

UNIT – II: [12 Hrs]

Addition to multiple bond: Electrophilic, Nucleophilic and

free radical additions – Addition to Conjugated Systems – Orientation

of the addendum – Sharpless asymmetric epoxidation, Addition to ,

– unsaturated Carbonyl groups.

Michael addition – Addition of Grignard reagent to , –

unsaturated carbonyl groups. Diels – Alder reaction – Addition of

Carbenes and Carbenoids to double and triple bonds.

Addition to Carbonyl Group: Mechanism of – Mannich

reaction – Claisen ester condensation, Darzen’s reaction, Reformatsky

reaction, wittig reaction, Shapiro reaction.

Esterification of acids and hydrolysis of esters – Decarboxylation

of Carboxylic acids.

UNIT – III: [12 Hrs]

Terpenoids and Antibiotics: Terpenoids: Classification of

terpenoids, structure, and synthesis of –pinene, Camphor,

Zingiberene, Cadinene and abietic acid – Biosynthesis of terpenoids.

Antibiotics: Structure and synthesis of penicillins,

Chloramphenicol and tetracyclins.

UNIT – IV: [12 Hrs]

Synthetic Methods: Planning a synthesis – relay approach and

convergent approach to total synthesis – Retro synthetic analysis of

simple organic compounds – Functional group interconversions – use

of activation and blocking groups in synthesis – stereoselective

357

problems of geometrical and optical isomerism – steric crowding –

Transition metal complexes in organic chemistry – Homogeneous

hydrogenation – Regioselectivity – Diastereoselectivity –

Enantioselectivity, Umpolung synthesis – Robinson annelation – A

schematic analysis of total synthesis of the following compounds: 2, 4

– dimethyl–2–hydroxypentanoic acid, Trans–9–methyl–1–decalone.

UNIT – V:

Organic Photochemistry: Thermal Vs Photochemical reactions,

n * and * transistions – Allowed and forbidden

transitions – Fluorescence – Internal conversion – Intersystem crossing

– Jablonski diagram.

Photochemical reactions of Ketones – photosensitization –

Norrish type I and Norrish type –II reactions – Paterno – Buchi reaction

– Photo oxidation – photo reduction.

Pericyclic reactions: conservation of orbital symmetry –

Electrocyclic reactions – cycloaddition reactions and sigmatropic

rearrangements – applications of correlation approach, Frontier

Molecular orbital approach.

TEXT BOOKS:

01. Finar I.L., Organic Chemistry Vol.–II., ELBS, England, 1975.

02. Ireland R.E., Organic Synthesis, Prentice – Hall of India (P) Ltd,

New Delhi, 1975.

03. March J., Advanced Organic Chemistry, Wiley, 4th Edition, New

York, 1992.

REFERENCES:

UNIT – I:

01. DeMayo P., Molecular Rearrangements, Academic Press,

London.

UNIT – II:

01. Gould E.S., Mechanisms and Structure in Organic Chemistry,

Henry Holt and Co., New York, 1959.

02. Harris J.M., and Wamser C.C., Fundamentals of Organic

Reaction Mechanisms, John Wiley and Sons Inc., New York,

1976.

03. Mukerji S.M., and Singh S.P., Reaction Mechanisms in Organic

Chemistry, McMilan India Ltd, 1978.

UNIT – III:

01. Agarwal O.P., Natural Products, Vol. I and II, Goel Publication,

Meerut.

02. De Mayo P., Chemistry of Terpenoids, Vol. I and II, Academic

Press, London.

UNIT – IV:

01. Morrison R.T., and Boyd R.N., Organic Chemistry, Prentice –

Hall, 6th Edition, New Delhi, 1995.

358

UNIT – V:

01. Bellamy A.J., An introduction to Conversation of Orbital

Symmetry, Longman, England, 1974.

02. Depuy C.H., and Chapman O.L., Molecular Reactions and Photo

Chemistry, Prentice – Hall, New Delhi, 1972.

Core Subject INORGANIC CHEMISTRY – III Code: 14224302

SEMESTER III

4 Hrs/Week

Credits 4 Objectives:

Advanced study of Inorganic photo chemistry and ESR, photo electron

Spectroscoy.


Complexes of П – acceptor ligands: Synthesis, structure and

bonding in metal carbonyls, nitrosyls, Dioxygen complexes and

Dinitrogen complexes – Applications of EAN rule, synthesis, properties,

structure and bonding in Ferrocene, arene, Olefin, acetylene and allyl

complexes.

Catalysis using organometallics, Homogeneous catalysis

involving organometallics – oxidative addition – reductive elimination –

insertion reaction – Wilkinson’s catalyst - Wacker process and

hydroformylation. Heterogeneous catalysis – Zieglar – Natta

polymerisation – cyclo oligomerisation of acetylenes – Reppe’s and

Wilker’s catalysis.


Inorganic Photochemistry: Laws of photochemistry – Quantum

yield – electronic spectra of transition metal complexes – selection

rules – splitting of terms – Orgel and Tanabaesugano diagram –

Detailed spectral study of Cr(III), Co(III) and Ni(II) complexes – charge

transfer spectra – photochemistry of complexes of I row transition

elements – properties of excited states – photoredox, photosubstitution

and photoracemization reactions – Ruthenium – bipyridyls in the

conversion of Solar energy.


Spectroscopy – I: Application of IR and Raman spectra in the

study of Co–ordination compounds – Application to metal carbonyls

and nitrosyls – Geometrical and linkage isomerism – Detection of inter

and intramolecular H–bonding – stretching mode analysis of metal

carbonyls.

Mossbauer spectroscopy:

Mossbauer effect, Resonance absorption, Doppler effect –

Doppler velocity – Experimental technique of measuring resonance

359

absorption – Isomer shift – Magnetic hyperfine splitting – Application

of Mossbauer spectroscopy in the study of iron and tin complexes.


Spectroscopy – II: NMR : Application of spin – spin splitting and

coupling constants in the study of P.F. and B compounds, 1H – NMR of

metal hydrides – chemical exchange and other factors affecting the line

widths – Evaluation of rate constants – hindered rotation – NMR of

fluxional molecules – NMR of paramagnetic complexes – contact shift,

pseudo contact shift – use of shift reagents in NMR.

EPR: Principles – presentation of the spectrum – hyperfine

splitting – evaluation of G and A tensors – Factors affecting the

magnitude of g values – Zero field splitting – Kramer’s degeneracy –

EPR of d3 octahedral complexes – anisotropy and hyperfine coupling

constant – application of EPR in the study of transition metal

complexes – Jahn – Teller distortion studies in Cu(II) complexes –

evaluation of spin orbit coupling.

UNIT – V: [12 Hrs]

Photoelectron Spectroscopy: Theory – XPES – UV – PES –

instrumentation – evaluation of ionization potential – chemical

identification of elements – Koopman’s theorem – chemical shift – UPS

– XPES of N2, O2 and HCl – evaluation of vibrational constants from

UPS – spin orbit coupling, Auger spectroscopy – Principle and its

application.

TEXT BOOKS:

01. Drago R.S., Physical Method in Chemistry, W.B.Saunders Co.,

London, 1977.

02. Huheey J.E., Keiter E.A., and Keiter R.L., Inorganic Chemistry,

Principles of Structure and reactivity, 4th Edition, Addison –

Wesley Publishing Company, New York, 1993.

03. Lee J.D., Concise Inorganic Chemistry, 5th Edition, ELBS,

Chapman and Hall, London, 1996.

REFERENCES:

01. Adamson A.W., and Fleischer F.D., Concepts of Inorganic Photochemistry, John Wiley, Interscience, New York.

02. Basolo F., and Pearson R.G., Mechanisms of Inorganic reactions,

a Study of Metal Complexes in Solution, Wiley Eastern, New Delhi, 1984.

03. Cotton F.A., and Wilkinson G., Advanced Inorganic Chemistry, 4th Edition, John Wiley and Sons, New York, 1988.

04. Drago R.B., Physical Methods in Inorganic Chemistry, Van

Nostrand Rein hold Co., New York, 1965. 05. Ebsworth E.A.V., Rankin D.W.H., and Gadock S., Structural

Methods in Inorganic Chemistry, ELBS, London, 1988.

06. Jackman L.M., and Cotton F.A., Dynamic Nuclear Magnetic Resonance Spectroscopy, Academic Press, London.

07. Kettle S.F.A., Co–ordination Compounds, ELBS, London, 1973. 08. Purcell K.F., and Kotz J.C., Inorganic Chemistry, W.B.Saunders

Company, London, 1997.

360

Core Subject PHYSICAL CHEMISTRY – II Code: 14224303

SEMESTER III 4 Hrs/Week


To have a knowledge of Group theory and Molecular spectroscopy.


Group Theory: Molecular symmetry elements and symmetry

operations vector and matrix Algebra, symmetry operations and

transformation matrices: Group theory, definition and properties of a

group symmetry point groups, representation of a group – reducible

and irreducible representations, Great orthogonality theorem,

characters, construction of character tables (C2V, C3V, C4V and D2d

only) direct product.


Application of Group Theory to Spectroscopy and Molecular

Problem: Symmetry of normal modes of vibrations, symmetry

properties of integrals, application for spectral selection rules of

vibration spectra – IR and Raman active fundamentals. Symmetry of

molecular orbitals and symmetry selection rule for electronic

transitions in simple molecules (ethylene and formaldehyde)

Group theory applies to hybridization, HMO theory HMO

calculation and delocalization energy for cyclopropenyl and butadiene.


Molecular Spectroscopy – I: Microwave and IR spectroscopy of

diatomic molecules – determination of molecular parameters,

vibrational spectra of polyatomic molecules, overtone and combination

bands – concept of group frequencies, coupling interaction, Fermi

resonance, Basic concepts of FT–IR.

Classical Raman Spectroscopy – rotational and vibrational

Raman spectra – LASER Raman spectroscopy and structure

determination. Electronic spectra of diatomic and polyatomic

molecules – break down of Born – oppenheimer approximation, Frank

– Condon principle dissociation energy, predissocation spectra,

rotational fine structure and Fortrat diagram.


Molecular Spectroscopy – II: 1H NMR – Chemical shift–spin–spin

– splitting, relaxation times, experimental technique – double

resonance techniques, ENDOR, overhauser effect, FT – NMR

spectroscopy; chemical shift, coupling constant, Lanthanide shift

reagent, ESR principles – hyperfine splitting, factors affecting the

361

magnitude of the ‘g’ value – fine structures and hyperfine structures –

Zerofield splitting in ESR and applications.


Electrochemistry: Theory of electrolyte conductance – Debye –

Huckel – Onsager equation; Wien’s effect, FalkenHagen effect, ionic

activity and activity coefficient – Debye – Huckel models and the

corresponding theoretical expression for activity coefficient.

Electrodics – origin of different types of potential – Nernst

Equation and significance. EMF of cells, their determination and

applications. Determination of equilibrium constants and dissociation

constant, solubility product, potentiometric titrations – kinetics of

electrode processes, Butler – Volmer equation, over–voltage,

voltammetry.

Electrochemical energy conversion – storage and fuel cells, solar

cells and batteries.

TEXT BOOKS:

01. Atkins P.W., Physical Chemistry, 6th Edition, ELBS and Oxford

University Press, London, 1996.

02. Banwell C.N., and MCCash E.M., Molecular Spectroscopy, 4th

Edition, Tata McGraw – Hill , New Delhi, 1996.

03. Cotton F.A., Chemical Applications of Group Theory, Wiley

Eastern Ltd., New Delhi.

04. Crow D.R., Principles and Applications of Electrochemistry,

Chapman and Hall, London, 1988.

05. Rama Krishnan V., and Gopinath, Group Theory in Chemistry,

2nd Edition, Vishal Publication, New Delhi, 1991.

REFERENCES:

UNIT – I and II:

01. Barrow G.M., Introduction to Molecular Spectroscopy, McGraw –

Hill , New Delhi.

02. Drago R.S., Physical Methods in Chemistry, W.B.Saunders,

London, 1999.

03. Raman K.V., Group Theory and its Application to Chemistry,

Tata McGraw – Hill, New Delhi, 1990.

UNIT – III and IV:

01. Chang R., Basic Principles of Molecular Spectroscopy, McGraw –

Hill, New Delhi.

02. Straughan B.F., and Walker, Spectroscopy, Vol. 1, 2 and 3,

Chapman and Hall, London.

UNIT –V:

01. Antropov L., Theoretical Electrochemistry, MIR Publication,

Moscow, 1972.

02. Bockris J.O.M., and Reddy A.K.N, Modern Electrochemistry,

New Age Publication, Vol. I and II, Plenum Press, New York,

1978.

03. Glasstone S., An Introduction to Electrochemistry, Van Nostrand

Co., In., New York.

362

Elective Major NANO AND GREEN CHEMISTRY Code: 14224304

SEMESTER III

3 Hrs/Week

Credits 3

Objectives:

To understand the Basic concepts of invisible particles.

UNIT – I: [9 Hrs]

Fundamentals of Nano Chemistry: Preparation and properties of

Nano particles – materials – metals, semi conductors, ceramics

(oxides, Carbides, sulphides, nitrides) – physical methods – physical

vapour deposition (evaporation and sputtering) method – optical

properties, electrical properties and magnetic properties.


Physical Chemistry of Solid: Introduction – Emergence of

Nanotechnology – Bottom–up and Top–down approaches – challenges

in Nanotechnology – surface energy – Electrostatic stabilization – steric

stabilization.


Application of nano technology: Introduction – Nanotechnology

to challenging area - energy producers – medicines - Auto mobile

security construction - Environmental remediation.


Green Chemistry: What is the need for green chemistry? –

solvent free reactions – role of ionic liquids in Green chemistry –

cleaner technology with super critical fluids – catalytic approach to

green chemistry (use of zeolites). Waste water treatment by oxidation

technology at ambient conditions – remediation methods for textile

effluents – Green Chemistry bio catalytic reaction.

UNIT – V: [9 Hrs]

Microwave and Ultrasonic assisted Green Synthesis:

1. Aldol condensation

2. Cannizzaro reaction

3. Diels – Alder reaction

4. Strecker synthesis

TEXT BOOK:

01. C.P.Jr. and Ownes F.J., Introduction to Nano Technology, John

Wiliy and Sons, New Jersly, 2003.

02. Delvim S., Green Chemistry, IVY Pusblishing House, 2006.

REFERENCES:

01. Er. Rakesh Rathi, Nanotechnology, S. Chand and company ltd,

New Delhi -110 -055.

363

02. Nalwa H.S., Nanostructured Materials and Nanotechnology,

Academic Press, Sandiego, 2000.

03. Sanghi R., and Srivastra M.M., Green Chemistry, Narosa, 2003.

04. Srivastara M.M., and Sanghi R., Chemistry for Green

Environment, Narosa, 2005.

Self Learning Course FUNDAMENTALS OF BIOCHEMISTRY

SEMESTER III Code: 14804322

Addl. Credits 3

Objectives:

To have a knowledge of Amino acids and Nuclic acids.

UNIT – I:

Solvent of life, pH and buffers and biochemical units;

Introduction to biochemistry, salient features, scopes; current status

of biochemistry; origin of life; components of biochemistry; chemical

composition and bonding.

UNIT – II:

Carbohydrates: Importance, occurrence, definitions,

classification of carbohydrates; properties of carbohydrates – mono

saccharides, oligosaccharides and poly saccharides (physical, chemical

and biology); structures of carbohydrates; glycosidic linkages,

anomers; epimers; diastereomers; epimerization; stereoisomer; optical

isomers; analysis of carbohydrates (Qualitative and Quantitative).

UNIT – III:

Aminoacids: Structure, importance, different types of

classification of amino acids; physical and chemical properties of

amino acids; analysis of amino acids, biochemistry of peptide bond,

types of peptide bond; Zwitter ion; role of aminoacids; pKa value.

UNIT – IV:

Lipids: Importance, structure of lipids, Nomenclature, fatty acid

and its properties; biological role of lipids; classification of lipids –

simple, compound and derived; Wax properties of fat and oils –

physical and chemical properties, saponification, halogenation,

oxidation and dehydration, quantitative and qualitative analysis of

lipids.

Vitamins:

Structures functions and biological roles and properties of

Vitamins and their types.

UNIT – V:

Nucleic acids – DNA and RNA definition types, structure,

physical and chemical properties of nucleic acids; base compositions;

364

double helical structures; Denaturation, renaturation of nucleic acids.

Quantitative and qualitative analysis of nucleic acids.

TEXT BOOKS:

01. David L.Melson, Lehninger Prineirles of Biochemistry, CBS

Publisher’s Distributors, New Delhi.

02. Jain J.L., and Sanjay Jain, Fundamentals of Biochemistry,

S.Chand and Company Ltd, New Delhi.

REFERENCES:

01. Dr.Palanivelu P., Laboratory Manual for Analytical Biochemistry,

M.K.University, Madurai – 21.

02. Jain. Fundamentals of Biochemistry, S.Chand and Company

Ltd.

03. Meckee and Meikee, An Introduction of Biochemistry, WCB

McGraw – Hill Companies.

Core Subject ORGANIC CHEMISTRY – IV Code: 14224401

SEMESTER IV 4 Hrs/Week


To study the detailed aspects of supstitution and Elimination

reactions.

Detail study of steroids and vitamins.


Aliphatic Nucleophilic Substitution: Nucleophilicity and basicity

– SN1 and SN

2 mechanism – Effect of substrate structure – effect of

reaction medium – effect of leaving group – ambident nucleophile –

ambident substrates – symphoria – Neighbouring group participation

of n, and electrons – SNi mechanism – Nucleophilic substitution

at allylic carbon and vinyl carbon

Aliphatic Electrophilic Substitution: Electrophilic substitution at

saturated Carbon – SE1, SE

2 and SEi mechanism.

Elimination: – elimination, – elimination – E1, E2 and E1CB

mechanism – stereo chemistry of elimination – orientation of double

bond – effect of changes in the substrate, base, leaving group and

medium on E1, E2 and E1CB reaction – Elimination Vs substitution –

Pyrolytic Cis elimination – Bredt’s rule.


Analytical Techniques: ORD and CD – principle – cotton effect –

type of ORD curves – –haloketone rule – octant rule – applications

to determine the configuration and conformation of simple monocyclic

and bicyclic ketones – comparison of ORD and CD.


Free Radicals: Formation, detection and stability of free radicals,

Free radical reactions – Halogenation, addition – Barton, Pschorr and

Hundsdiecker rections.

365

Amino acids, proteins and enzymes: Classification of amino

acids and proteins – peptides and co peptides– synthesis of peptides

(Bergmann method and solid phase peptide synthesis) – Structure of

Polypeptide – Amino end degradation( Sanger’s method and Edman’s

method), Carboxyl end degradation (Reductive method and

Hydrazinolysis) – Chemistry of glutathione and oxytocin – An

elementary treatment of enzymes, Coenzymes and nucleic acids – RNA

and types of RNA – protein synthesis – Difference between RNA and

DNA.


Steroids: Classification – conformational aspects of A/B Cis

and A/B trans steroids – complete chemistry and stereochemistry of

cholesterol (includes bile acid) and ergosterol.

VitaminD2 – Male sex hormones – Androsterone and

testosterone – female sex hormones – Oestrone and progestrone – A

basic idea about adrenocortical hormones – Cortisone (synthesis only).


Vitamins: Structure and synthesis of Vitamins A, B2, B6, C, E,H.

Prostaglandins: General studies of prostaglandins – structure,

stereochemistry and synthesis of PGE1.

TEXT BOOKS:

01. Finar I.L., Organic Chemistry, Vol. II, ELBS, England, 1975. 02. Morrison R.T., and Boyd R.N., Organic Chemistry, Prentice –

Hall, 6th Edition, New Delhi, 1995.

REFERENCES: UNIT – I:

01. Kalsi P.S., Stereochemistry, Wiley Eastern Ltd., New Delhi, 1990.

UNIT – II:

01. Braithwaite A., and Smith F.J. Chromatographic Methods, Chapman and Hall, 4th Edition, London, 1985.

02. Crabbe P., ORD and CD in Chemistry and Biochemistry, Academic Press, London, 1972.

03. Eliel E.L., Stereo Chemistry of Carbon Compounds, McGraw –

Hill , New York, 1962. 04. Silverstein B.M., Bassler G.C., and Morril T.C., Spectrometric

Identification of Organic Compounds, Wiley, 5th Edition, New

York. UNIT – III:

01. Lehninger L.A., Biochemistry, Wath Publishers, New Delhi. UNIT – IV:

01. Fieser L., and Mary Fieser, Steroids, Rein Hold, New York, 1953.

02. Klyne W., The Chemistry of Steroids, Methuen and Co., New York, 1965.

03. Shoppe, Steroids, Macmillan Publication.

UNIT – V: 01. Burger A., Medicinal Chemistry, Academic Press, London.

02. Dyke S.F., Chemistry of Vitamins, Interscience Publishers, 1965. 03. Rame Will P.W., The Prostaglandins. Vol. I, Plenum Press, 1973.

366

Core Subject INORGANIC CHEMISTRY – IV Code: 14224402

SEMESTER – IV

4 Hrs/Week

Credits 4

Objectives:

Advanced learning of Nuclear Chemistry Electro and Thermo analytical

methods.


Nuclear Chemistry: Properties of nucleus, Different types of

nuclear reactions with natural and accelerated particles – spallation –

fission and fusion, characteristics of fission reaction – product

distribution and theories of fission – fissile and fertile isotopes –

nuclear fusion – stellar energy – synthesis of elements – feed materials

production – nuclear reactors – reprocessing on nuclear materials –

radiation protection – waste disposal. Atomic power projects in India.


Actinides and Lanthanides: Chemistry of Lanthanides and

actinides, Lanthanides – occurance, extraction from ores – separation

procedure – ion exchange method – solvent extraction method.

Physical and chemical properties – electronic configuration – common

oxidation state – Lanthanide contraction and its consequences – colour

of lanthanide ions – Magnetic properties of lanthanides – separation of

actinide elements – separation of Pu from fission products – electronic

configuration – oxidation state – comparison of lanthanides and

actinides – position in the periodic table.


Electro – analytical Methods: Electro analytical techniques:

Electrogravimetry: Theory of electrogravimetric analysis – electrolytic

separation and determination of metal ions.

Coulometry: Electrolytic cell – working electrodes – auxillary

electrode and reference electrode – coulometric titrations –

voltammetry: cyclic voltammetry – stripping voltammetry –

chronopotentiometry – amperometry : Amperometric titrations.


Spectroanalytical Methods: Laws of absorption and quantitative

law of luminescence – principles and application of colorimetry and

spectrophotometry, fluorimetry, nephelometry and turbidimetry –

emission spectroscopy and flame spectroscopy – atomic absorption,

atomic emission and atomic fluorescence spectroscopy optical rotatory

dispersion and circular dichroism.

367


Thermo–Analytical Methods: Instrumentation and applications

of thermogravimetry – differential thermal analysis and differential

scanning calorimetry.

Magnetism: Magnetic permeability – magnetic susceptibility –

influence of temperature on Ferro, Para and antiferromagnetic

compounds – Curie’s temperature and Neil’s temperature –

Determination of magnetic susceptibility – Applications of magnetic

susceptibility.

TEXT BOOKS:

01. Dick J.G., Analytical Chemistry, Tata McGraw – Hill , New Delhi,

1973.

02. Satya Prakash, Advanced Chemistry of Rare Elements, S.Chand

and Co., 4th Edition, New Delhi, 1986.

REFERENCES:

01. Arnikar H.J., Essentials of Nuclear Chemistry, 3rd Edition, Wiley

Eastern Ltd., New Delhi, 1990.

02. Basse H.J., Vogel’s, Text Book of Quantitative Inorganic Anlayis,

et – al ., ELBS, England.

03. Glasstone S., Source Book of Atomic Energy, 3rd Edition, East

West Press, New Delhi, 1967.

04. Mare. Latort, Nuclear Chemistry, Von–Nostrand Co., Ltd., New York.

05. Mathur H.D., and Tandion O.P., Chemistry of Rare Elements,

3rd Edition., S.Chand and Company Ltd., New Delhi, 1986. 06. Moeller T., The Chemistry of the Lanthanides, Chapman and

Hall London, 1963. 07. Skoog D.A., and West D.M., Principles of Instrumental Analysis,

2nd Edition, Sounders, New York, 1980.

08. Willard H., Merit and Dean J.A., Instrumental Methods of Analysis, East West Press, New Delhi.

Core Subject PHYSICAL CHEMISTRY – III Code: 14224403

SEMESTER IV

4 Hrs/Week

Credits 4

Objectives:

To have a knowledge of Quantum Chemistry and solid surface

Phenomena.


Advance Concepts in Quantum Chemistry: Rigid rotator, simple

harmonic, oscillator and hydrogen atom problem – radial distribution

probability; spherical harmonics and shapes of various atomic

orbitals.

Need for approximation methods, Schrodinger equation for the

He atom and other many electron atoms: the perturbation theory (First

368

order only), the variation method, secular equation and secular

determinants, Hartree – Fock Self – consistent method of many

electron system, antisymmetric nature of the wave functions – Slater

determinents – electronic configuration of many electron systems – H2+

molecular system.


Chemical Kinetics: Simple collision theory, absolute reaction

rate theory (ARRT), thermodynamic treatment. Study of H2–O2

explosive reactions. Theory of Unimolecular reactions – RRKM and

Slater treatments; Reactions in solution – Factors influencing reaction

rate in solution, ARRT to reactions in solution, significance of volume

of activation, primary salt effect.

Fast reaction techniques – chemical relaxation methods,

temperature and pressure jump methods, ultrasonic absorption

technique, reactions in flow systems, continuous and stopped flow,

shock wave tube method.


Catalysis: Homogeneous catalysis – acid – base caytalysis –

Van’t Hoff and Arrhenius intermediates for protolytic and prototropic

mechanisms catalysis in biological systems – enzyme catalysis –

Michaelis – Menten Kinetics – Heterogeneous catalysis – chemical

reactions on solid surfaces – kinetics and mechanism of unimolecular

and bimolecular reactions – Langmuir – Hinshelwood and Langmuir –

Rideal mechanism, ARRT of surface reaction – NH3 synthesis,

hydrogenation of C2H4, cracking of hydrocarbons.


Solids and Surface Phenomena: Solids: dislocation in solids –

Schottky and Frenkel defect electrical properties – insulation,

semiconductors and super conductors Band theory of solids, solid

state reactions.

Adsorption of liquid surface – surface torsion – Gibbs absorption

isotherm: Adsorption of solids – Langmuir and BET adsorption

isotherms – measurement of surface area – electrokinetic phenomena

at interfaces including electro–osmosis and electrophoresis –

Monolayers, Micelles and reversemicelles, stabilization Micro –

emulsion. Application of Photo electron spectroscopy to the study of

surface.


Photochemistry: Physical properties of the electronically excited

molecules – excited state dipolemoments – pka and redox potentials,

369

photo physical processes in electronically excited molecules –

Fluorescence, phosphorescence and other deactivation process; Stern

– Volmer equation; electronic energy transfer mechanisms,

photosensitizations and chemiluminescence experimental techniques

in photochemistry – light sources, chemical actinometry, flash

photolysis techniques. Photochemical conversion and storage of solar

energy.

TEXT BOOKS:

01. Adamsom A.W., Physical Chemistry of Surfaces, 4th Editions,

John Wiley and Sons, New York.

02. Chandra A.K., Introductory Quantum Chemistry, 3rd Edition,

Tata McGraw – Hill Publishing Co., New Delhi, 1988.

03. Laidler K.J., Theories of Chemistry Reaction Retes, McGraw –

Hill , New Delhi.

04. Laidler K.J., Chemical Kinetics, 3rd Editions, McGraw – Hill ,

New Delhi.

05. Rohatgi Mukherjee K.K., Fundamentals of Photochemistry, Wiley

Eastern, Ltd., New Delhi.

REFERENCES:

UNIT – I:

01. Hanna H.W., Quantum Mechanics in Chemistry, Wake

Fineld:EP Publishing.

UNIT – II and III:

01. Kalidas C., Chemical Kinetics Methods, New Age International,

New Delhi, 1996.

02. Wilkinson F., Chemical Kinetics and Reaction Mechanism, Van

Nostrand Reinhold Co., Ltd., New York, 1980.

UNIT – IV:

01. Chethan A.K., and Day P., Solid State Chemistry, Oxford Science

Publication, London, 1993.

02. Hanny N.B., Solid State Chemistry, Penguin Publication.

03. Laidler K.J., Chemical Kinetics, 3rd Edition, McGraw – Hill, New

Delhi.

UNIT – V:

01. Turro N.J., Modern Molecular Photochemistry, Benjamin /

Cummings, London.

Core Lab ORGANIC CHEMISTRY PRACTICAL – II

SEMESTER III & IV Code: 14224404

5 Hrs/Week

Credits 5

Objectives:

To acquire skill in Qualitative analysis and preparation.

1. Organic Quantitative analysis:

a. Estimation of glucose by Lane and Eynon method and

Bertrand method.

b. Estimation of Ethylmethyl Ketone.

370

c. Estimation of Formaldehyde.

d. Estimation of Glycine.

2. Organic Preparation – II: About five two stage organic

preparations.

Core Lab INORGANIC CHEMISTRY PRACTICAL – II


5 Hrs/Week

Credits 5

Objectives:

To acquire skill in Qualitative analysis and preparation.

1. Inorganic Preparation : Preparation of at least five Inorganic

complexes.

2. Quantitative analysis : Separation and estimation of mixture by

Volumetic and Gravimetic methods.

Some typical recommended mixtures are:

Cu, Ca : Cu, Ni : Cu, Fe, Cu, Zn, Ba, Fe, Bi for volumetric

method (wherever possible).

REFERENCES:

01. Jeffery G.H.J.Basset and others, Vogel’s Text Book of

Quantitative Chemical Analysis, ECBS, 5th Edition.

02. Ramanujam V.V., Inorganic Semi Micro Quantitative Analysis,

The National Publishing Company, 1990.

Core Lab PHYSICAL CHEMISTRY PRACTICAL – II


5 Hrs/Week

Credits 5

Objectives:

To apply the many knowledge laboratory work.

1. Study of kinetics of alkaline hydrolysis of ester by conductivity

method.

2.

* Determination of order with respect to

* Study of primary salt effect and determination of [KNO3]

* Determination of unknown concentration of

3. Determination of dissociation constants of weak acids by

conductivity and potentiometric methods.

4. Solubility product by conductivity and potentiometric methods.

371

5. Stability constants of complexes by the use of pH meter,

Potentiometric method.

6. Potentiometric Titrations.

a. Precipitation titrations

1. AgNO3 Vs Halide mixture.

b. Redox titrations.

1. MnO

4 Vs

2. Cr2O2

7 Vs Fe2+

3. Ce4+ Vs Fe2+

7. Titrations using pH meter – determination of first, second and

third dissociation constants of phosphoric acid.

Elective Major PHARAMACEUTICAL CHEMISTRY Code: 14224407

SEMESTER IV

3 Hrs/Week

Credits 3

Objectives:

To have a knowledge of medicinal chemistry.

UNIT –I : [9 Hrs]

General principles of medicinal Chemistry: Introduction –

progress of drug absorption – distribution of drugs – storage depots –

metabolism and excretion – physico – chemical parameters and drug

action – Ferguson principle – Ionisation – complexation – surface

activity – Hydrogen bonding and Bioisosterism.

UNIT –II : [9 Hrs]

Local Anaesthetics : Site of action – nerve tissues – mode of

action – classification – structure activity relationship. Psychotropic

drugs : Neuroleptics – Therapeutic applications – Anti-depressants –

classification of anti-depressants.

UNIT –III : [9 Hrs]

Hormones and Vitamines: Diabetes mellitus – anti diabetic

drugs – Insulin – sulphonyl ureas – Biguanides – vitamins – sources –

classifications- vitamin A,K, B Group, C

UNIT –IV: [9 Hrs]

Chemotherapy and Antibiotics: Introduction – β- lactum

antibiotics – mechanism of action – mechanism of resistance –

pencillin- Natural,amino pencillin – Adverse effects.

372

UNIT –V : [9 Hrs]

Antifungal Drugs – Amphotercin B, Fluconazole – chemistry and

mechanism of action – absorption, distribution, metabolism and

excretion – clinical uses – adverse effects.

REFERENCES:

01. Kadam. S.S., Mahadik.K.R and Bothara K.G, “Principles of

Medicinal Chemistry” Vol. II Nirali Prakashan, Pune.

02. Gandhi. T.P and Goyal. R.K., “Elements of pharamacology”,

Shah Prakashan, Ahmedabad.

03. Charles. R.Craig, Robert E .Stitzel , “Modern Pharmacology with

clinical applications”, VI edition, Lippincott Williams and

Wilkins, New York.

Elective Major PROJECT Code: 14224408

SEMESTER IV

Credits 6

Post Graduate students of Chemistry will do projects under the

guidance of staff members of chemistry during IV semester.

The projects will be on chemistry and chemistry related fields. The

project diary signed by the project guide and HOD must be submitted

in the month of April. The Viva on Project will be conducted jointly by

the guide, external examiner and the HOD.

Project INTERNAL EXTERNAL

*Report 40; Viva 10

*30:10 *50:10

Self–Learning Course CHEMINFORMATICS Code: 14804422

SEMESTER IV

Addl. Credits 3

Objectives:

To have a knowledge of chemical information.

UNIT – I:

Computer Representation of Molecules in Databases: Molecular

models – Chem draw – Connection table – Linear notation – Canonical

representation – Substructure – Sub graph isomerism based finger

print.

UNIT – II:

Chemical Information – An Introduction: History of Scientific

Information – Periodic table – Homologous series – Concepts in

Chemistry – Internet test servers – Molecular formats and MIME.

373

UNIT – III:

Computer Sources of Chemical Information: Communication –

WWW – URLS – Chemistry on website – Chemical literature –

Secondary literature.

UNIT – IV:

Chemical Information Searches: Searching skills – Strategies –

Advantages and disadvantages – CAS – Keyword search – Chemical

abstract – Flow of chemical information and computer searching.

UNIT – V:

Application of Cheminformatics: Chemical databases – 2D

substructure searching – 3D database searching – Generation and

retrieval – Use of QSAR and combinatorial library in drug design.

TEXT BOOK:

01.Thomas Engel and Gasteiger, Chemoinformatics, Kluwer

Academic Publishers.

REFERENCE:

01. Andrew R.Leach, Molecular Modelling, Principles and

Applications, 2nd Edition, Dorset Press, Dorchester, Dorset,

2001.

374

M.Sc CHEMISTRY : Those who have joined from the

academic year 2014-15 onwards under CBCS System

EVALUATION PATTERN

Internal : 25 Marks

External : 75 Marks

INTERNAL:

Test –15 (average of the better two of the three tests conducted)

Assignment – 5

Seminar – 5

Question Paper Pattern:

INTERNAL EXTERNAL

Part – A : 4 1 = 4

Part – B : 3 4 = 12

(Either/ Or)

Part – C : 2/3 7 = 14

*30

Part – A :5/7 2 = 10

Part – B : 5 7 = 35

(Either /Or)

Part – C : 3/510 = 30

75

* Internal test mark 30 will be converted to 15.

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