5th Annual PERFORM Centre Research Conference

PHYSICAL ACTIVITY AND AGING:

MULTIDISCIPLINARY APPLICATIONS

ABSTRACTS

May 17, 2018

Concordia University Montreal, Canada

Please note abstracts are subject to change

Table of Contents

Poster #Fragmentation of the Rest-Activity Cycle in Young, Sedentary NappersJoanne Abi-Jaoude, Concordia University, Dept of Psychology, PERFORM Sleep Lab; Abi-Jaoude, J.1,3*Mograss, M.1,2,3,4*Lim, A. 5* Frolova, E.1,3*Suliteanu, J.1,3* Ricchiuti, J. 1,3* Dang-Vu, T.1,2,3,4; 1Concordia University, Dept of Psychology,Montreal, QC, CA, 2Dept of Exercise Science, Concordia University, Montreal, QC, CA, 3Concordia PERFORM Centre,Montreal, QC, CA, 4Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montreal, QC CA, 5Division ofNeurology, Dept of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, ON, CA.

1

An amyloid ligand-free optical retinal imaging method to predict cerebral amyloid PET statusJean-Paul Soucy, UdM, McGill, Concordia; Jean-Paul Soucy - PERFORM Centre, Concordia University, & McGill Uiversity;Claudia Chevrefils - Optina Diagnostics; Jean-Philippe Sylvestre - Optina Diagnostics; Jean Daniel Arbour - Cliniqueophtalmologique 2121, ; Marc-André Rhéaume - Clinique ophtalmologique 2121, ; Sylvain Beaulieu - HôpitalMaisonneuve-Rosemont; Alain Robillard - Hôpital Maisonneuve-Rosemont; Céline Chayer - Hôpital Maisonneuve-Rosemont,;Pedro Rosa-Neto - Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging; Sulantha S. Mathotaarachchi- Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging; Ziad S. Nasreddine - MoCA Clinic andInstitute; Serge Gauthier - Alzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging;Frédéric Lesage - École Polytechnique de Montréal

2

Associations between EEG cross-frequency-coupling during sleep and declarative learning in healthy olderadults: A pilot studyOren Weiner, Concordia University, Dept of Psychology; Oren Weiner [1,2,3,4], Jordan O'Byrne [2,3,4,5], Julia Giraud [4,6],Despina Bolanis [1,2,3], Lukia Tarelli [1,2,3], Lea Homer [1,2,3,4], Victoria Yue [1,2,3], Katherine Walker [2,5], RosetteTamaddon [1,2], Roxanne Carbone [1,2,3], Katherine Chhuon [1,2,3], Kenza Eddebbarh [1,2,3], Julia Lumia [1,2,3], DylanSmith [1,2,3,4], Nathan Cross [2,3,4,5], & Thien Thanh Dang-Vu [1,2,3,4,5,6]; ; 1 Department of Psychology, ConcordiaUniversity, Montréal, Canada; 2 PERFORM Center, Concordia University; Montréal, Canada; 3 Center for Studies inBehavioral Neurobiology, (CSBN) Concordia University, Montréal, Canada; 4 Institut Universitaire de Gériatrie de Montréal,Montréal, Canada; 5 Department of Exercise Science, Concordia University, Montréal, Canada; 6 Département deNeurosciences, Université de Montréal, Montréal, Canada

3

Maternal red blood cell 22:5 n-6 may not be a marker of low 22:6 n-3 status in young infantsZahra Farahnak, School of Human Nutrition, McGill University; Ye Maggie Yuan, Sherry Agellon, Catherine A. Vanstone,Hope A. Weiler.; School of Human Nutrition, McGill University

4

Absolute Quantification of Cerebrovascular and Metabolic Effects of Aerobic Fitness: Cross-Sectional andIntervention DataCatherine Foster, PERFORM/Physics; Catherine Foster (1), Jessica Steventon (2), Michael Germuska (2), Hannah Chandler(2), Kevin Murphy (3), Richard Wise (2); ; 1 Dept. of Physics, Concordia University, Montreal, QC, H4B 1R6; 2 CUBRIC,School of Psychology, Cardiff University, Cardiff, CF24, 4HQ; 3 School of Physics, Cardiff University, Cardiff, CF24 3AA

5

Inter-observer reliability of Street View feature in Google Earth for virtual assessment of environmentalobesogenicity .Anna Smyrnova, Department of Mathematics and Statistics, Concordia University; Tracie A. Barnett; INRSe -Institut ArmandFrappier, Centre de recherche du CHU Sainte-Justine,; Andrea Van Hulst; Ingram School of Nursing, McGill University,; LisaKakinami; Department of Mathematics and Statistics, PERFORM Centre, Concordia University

6

How does total sleep deprivation affect brain activity and performance?Florence Pomares, Concordia Unveristy & Centre de Recherche de l'IUGM; Florence B Pomares1,2,3, Aude Jegou2,4, DylanSmith1,2, Ümit Aydin2,4, Christophe Grova2,4,5,6, Thien Thanh Dang-Vu1,2,3,7; ; Affiliations:; 1 Center for Studies inBehavioral Neurobiology and Department of Exercise Science, Concordia University, Montreal, Quebec, Canada; 2PERFORM Centre, Concordia University, Montreal, Quebec, Canada ; 3Centre de Recherche de l'Institut Universitaire deGériatrie de Montréal, Montréal, Quebec, Canada ; 4Multimodal Functional Imaging Lab. Department of Physics, ConcordiaUniversity, Montreal, Quebec, Canada ; 5Department of Biomedical Engineering, McGill University, Montreal, Quebec,Canada ; 6 Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal,Quebec, Canada ; 7 Department of Neurosciences, Université de Montréal, Montreal, Quebec, Canada

7

Are "Serious Games" too stressful to be beneficial for older adults?Kate Li, PERFORM Centre, Concordia University; Atousa Asadi, Mahsa Mir Gholami, Najmeh Khalili-Mahani; PERFORMCentre, Concordia University)

8

Salivary immunoglobulin-A individual response patterns to cold pressor testGhazal Mohammadi, Concordia University; Ghazal Mohammadi1,2, Nhat Phi Pham1,3,4, Marylen Youssef1,2, AzadehGhassemi1,2, Tanya Babiuk-Henry1,2, Catalina Marysol Carvajal Gonczi1,4, Peter J. Darlington1,2,4; 1. The PERFORMCentre, Concordia University, Montreal, Qc, Canada, H4B 1R62 ; 2. Department of Exercise Science, Concordia University,Montreal, Qc, Canada, H4B 1R6; 3. Science College, Concordia University, Montreal, Qc, Canada, H4B 1R6; 4. Departmentof Biology, Concordia University, Montreal, Qc, Canada, H4B 1R6

9

Clothing in the Everyday Life of Persons with a Physical Disability: A Scoping ReviewAlida Esmail, Université de Montréal/ Centre de recherche interdisciplinaire en réadaptation; Frédérique Poncet; Concordia

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University Department of Psychology Centre de recherche interdisciplinaire en réadaptation du Montréal Métropolitain(CRIR); Annie Rochette; Université de Montréal École de réadaptation, CRIR; Claudine Auger; Université de Montréal Écolede réadaptation, CRIR; Christophe Billebaud; Rhizome strategies, La Piscine; Élaine de Guise; Université de Montréaldépartement de psychologie, CRIR; Isabelle Ducharme; Kéroul; Eva Kehayia; McGill University School of Physical andOccupational Therapy, CRIR; Delphine Labbé; University of British Columbia, Department of Occupational Science andOccupational Therapy; Noèmi Dahan-Oliel; Shriner's Hospital for Children ; Isabelle Lessard; Vestechpro; OlivierVermeersch; Groupe CTT, Ste-Hyacinthe; Bonnie Swaine; Université de Montréal École de réadaptation, CRIR

The effect of adulthood- versus childhood-onset obesity on cardiorespiratory fitness and skeletal musclestrength in adultsAbdulrahman Dera, Department of Exercise Science,Concordia University, Montreal, Quebec, Canada.; Abdulrahman Dera1,2,3, Jessica Murphy1,2,5 José A. Morais4 Sylvia Santosa1,2,5; 1Department of Exercise Science,Concordia University,Montreal, Quebec, Canada.; 2Nutrition, Obesity and Metabolism Laboratory, PERFORM Centre, Concordia University,Montreal, Quebec, Canada.; 3Department of Education, Faculty of physical Education, Jeddah University, Jeddah, SaudiArabia.; 4Division of Geriatric Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; 5Centre derecherche - Axe maladies chroniques, Centre intégré universitaire de santé et de services sociaux duNord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada

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Improving the Accuracy of Motor Imagery-Based Brain-Computer Interface for Locked-in PatientsMahsa Mirgholami Mashhad, Concordia University, Electrical & Computer Engineering (ECE); Golnar Kalantar; ConcordiaInstitute for Information Systems Engineering (CIISE); Arash Mohammadi; Concordia Institute for Information SystemsEngineering (CIISE); Amir Asif; Concordia University, Electrical & Computer Engineering (ECE)

12

Variables associated with detection and distraction by food on a clinical sample of people with obesityBarbara Barth, UFRGS; Barbara Mello Barbosa - Undergraduate student at UniRitter; Yasmin Moreira Silva Souza -Undergraduate student at UniRitter; Camila Martins de Azambuja - Undergraduate student at UniRitter; Lisiane Bizarro -Associate professor at UFRGS

13

Momentary assessment of 'stress' using a wearable physiological monitoring systemAtousa Assadi, PERFORM Centre, Department of Electrical Engineering, Concordia University; Kate Li, PERFORM Centre,Department of Psychology, Concordia University; Mahsa MirGholami, PERFORM Centre, Department of ElectricalEngineering, Concordia University; Habib Benali, PERFORM Centre, Department of Electrical Engineering, ConcordiaUniversity; Najmeh Khalili-Mahani, PERFORM Centre, Department of Design and Computation Arts.

14

Mobile augmented reality for neurosurgical navigationÉtienne Léger, Concordia University; Simon Drouin; Montreal Neurological institute; D. Louis Collins; MontrealNeurological Institute; Marta Kersten-Oertel; Concordia University

15

Auditory discourse processing in bilinguals: an ERP analysisMaude Brisson-McKenna, Concordia University; Dr. Natalie Phillips, Department of Psychology, Concordia University ; Dr.Angela Grant, Department of Psychology, Concordia University

16

Weight bias internalization: Sex differences and relationships with mental healthErica Szwimer, Concordia University; Stefanie Marchione: Department of Mathematics and Statistics, Concordia University,Montreal, Quebec, Canada; Lisa Kakinami: Department of Mathematics and Statistics, Concordia University, Montreal,Quebec, Canada ; PERFORM Centre, Concordia University, Montreal, Quebec, Canada ; Angela Alberga: Department ofExercise Science, Concordia University, Montreal, Quebec, Canada

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High resolution atlasing of the venous brain vasculature from 7T quantitative susceptibilityJulia Huck, Concordia University/PERFORM centre, Montreal, Canada; Yvonne Wanner; (1, 2) ;Audrey P. Fan; (3);Anna-Thekla Schmidt; (4) ;Sophia Grahl; (4); Uta Schneider; (4); Arno Villringer; (4); Christopher J. Steele; (4, 5); ChristineL. Tardif; (6, 7); Pierre-Louis Bazin; (4, 8, 9); Claudine J. Gauthier; (1); (1) Concordia University/PERFORM centre,Canada; (2) Universität Stuttgart, Germany; (3) Stanford University, United States; (4) Max Planck Institute for HumanCognitive and Brain Science, Germany; (5) Douglas Mental Health University Institute, Canada; (6) McGill University,Canada; (7) Montreal Neurological Institute, Canada; (8) Spinoza Centre for Neuroimaging, Netherlands; (9) NetherlandsInstitute for Neuroscience, Netherlands

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GRANNIES PREFER TO PLAY FOR FUN NOT FOR THE BRAINMahsa Mirgholami Mashhad, Dept. Electrical and Computer Engineering,Concordia University; Kate Li; Dept.Psychology,Concordia University; Anna Smyrnova; Dept. Mathematics and Statistics, Concordia University; Atousa Assadi;Dept. Electrical and Computer Engineering, Concordia University; Najmeh Khalili-Mahani; Dept. Design and ComputationArts & PERFORM Centre, Concordia University

19

Locomotor skills proficiency in second-grade children: Evaluation of a two-year fundamental movementskills intervention.John Alexander Jimenez Garcia, The Athletic Therapy Research Laboratory, Concordia University, Montreal, Canada;Matthew Miller; The Athletic Therapy Research Laboratory, Department of Exercise Science, Concordia University, Montreal,Canada.; Chang Ki Hong; The Athletic Therapy Research Laboratory, Department of Exercise Science, Concordia University,Montreal, Canada.; Richard DeMont; The Athletic Therapy Research Laboratory, Department of Exercise Science, ConcordiaUniversity, Montreal, Canada.

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COOK TO SUPPORT ELDERY IN MEAL PREPARATION: CLINICIANS PERSPECTIVEAmel Yaddaden, Université de Montréal; Yaddaden, A. 1, 5 Gagnon-Roy, M. 1,2 Couture, M. 3,4 Lussier, M.1, 5, Belchior, P.,

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Bottari, C., Pigot, H., Giroux, S., Bier, N. 1,5; ; 1. Université de Montréal; 2. Centre de recherche interdisciplinaire enréadaptation; 3. CIUSSS Centre-Ouest-de-l 'Île-de-Montréal; 4. Université de Sherbrooke; 5. Centre de recherche de l'institutuniversitaire en gériatrie de l'Université de Montréal.

FACILITATING FACTORS AND BARRIERS TO COMMUNITY LIVING FOR ELDERLY AT RISKOF SELF-NEGLECT: PERCEPTION OF THE IMPLICATED ACTORSAndrée-Anne Phan, Université de Montréal; Bandaly, Soela ; Université de Montréal, Centre de recherche de l'InstitutUniversitaire de gériatrie de Montréal (CRIUGM); ; Couture, Mélanie ; Centre de recherche et d'expertise en gérontologiesociale (CREGÉS), Université de Sherbrooke;; Giroux, Sylvain ; Université de Sherbrooke;; Lussier, Maxime ; Université deMontréal, Centre de recherche de l'Institut Universitaire de gériatrie de Montréal (CRIUGM); ; Bottari, Carolina ; Universitéde Montréal, Centre de recherche interdisciplinaire en réadaptation du Montréal métropolitain (CRIR); ; Pigot, Hélène ;Université de Sherbrooke;; Belchior, Patricia ; Centre de recherche de l'Institut Universitaire de gériatrie de Montréal(CRIUGM), Université McGill;; Bier, Nathalie ; Université de Montréal, Centre de recherche de l'Institut Universitaire degériatrie de Montréal (CRIUGM);

22

Analyzing male and female hockey players during a stop-and-go transition skating taskAiden Hallihan, McGill University; Philippe Renaud; Department of Kinesiology & Physical Education, McGill University;Shawn Robbins; School of Physical and Occupational Therapy, McGill University; David Pearsall; Department of Kinesiology& Physical Education, McGill University

23

Impact of availability of context on speech perception under noisy conditionsJean-Louis Rene, Concordia University; Alexandre Chauvin & Natalie Phillips, Concordia University

24

Association between psychiatric disorders and vulnerability to stress-related asthma attacksClaudia Gemme, Université du Québec à Montréal (UQÀM); Claudia Gemme; Montreal Behavioural Medicine Centre,CIUSSS-NIM, Department of Psychology, Université du Québec à Montréal (UQÀM), Simon L. Bacon; Montreal BehaviouralMedicine Centre, CIUSSS-NIM, Department of Exercise Science, Concordia University, Anda Dragomir; MontrealBehavioural Medicine Centre, CIUSSS-NIM, Department of Psychology, Université du Québec à Montréal (UQÀM), Kim L.Lavoie; Montreal Behavioural Medicine Centre, CIUSSS-NIM, Department of Psychology, Université du Québec à Montréal(UQÀM)

25

Do body composition phenotypes improve cardiometabolic risk prediction above weight status alone?Martha Zaverdinos, Department of Mathematics and Statistics, Concordia University; Jessica Murphy; Department ofExercise Science, Concordia University; Sylvia Santosa; Department of Exercise Science, Concordia University; LisaKakinami; Department of Mathematics and Statistics, Concordia University, and PERFORM Centre, Concordia University

26

Accelerating Reproducibility Estimations with Collaborative FilteringSoudabeh Barghi, Concordia University; Tristan Glatard; Department of Computer Science and Software Engineering,Concordia University, Montréal, Québec, Canada

27

Oxygen metabolism within hubs of resting-state brain functional connectivityFatemeh Razavipour, PERFORM Centre/Department of Physics, Concordia University, Montreal, Canada,; Kangjoo Lee* 2,3;Claudine Joëlle Gauthier1; Christophe Grova1,2,3; ; 1 PERFORM Centre/Department of Physics, Concordia University,Montreal, Canada; fatemeh.razavipour@concordia.ca; 2 Multimodal Functional Imaging Lab, Biomedical EngineeringDepartment, McGill University, Montreal, Canada; ; 3Neurology and Neurosurgery Department, Montreal NeurologicalInstitute, McGill University, Montreal, Canada; ; * Both authors contributed equally

28

Resting state patterns measured with Magnetoencephalograpy: Biomarkers for surgical outcome inepilepsy?Ümit Aydin, Dpt. of Physics and PERFORM Centre, Concordia University; Ümit Aydin; Dpt. of Physics and PERFORMCentre, Concordia University, Montreal, Canada ; Giovanni Pellegrino; Biomedical Engineering Dpt., McGill University;Neurology and Neurosurgery Dpt., Montreal Neurological Institute, McGill University, Montreal, Canada; Obaï Bin Ka'b Ali;Dpt. of Physics and PERFORM Centre, Concordia University, Montreal, Canada; Jean-Marc Lina; Département de GénieElectrique, École de Technologie Supérieure; Centre De Recherches En Mathématiques, Montreal, Canada; ElianeKobayashi; Neurology and Neurosurgery Dpt., Montreal Neurological Institute, McGill University, Montreal, Canada;Christophe Grova; Dpt. of Physics and PERFORM Centre, Concordia University; Biomedical Engineering Dpt., McGillUniversity; Neurology and Neurosurgery Dpt., Montreal Neurological Institute, McGill University, Montreal, Canada

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A MULTIMODAL PREHABILITATION PROGRAM IN HEPATO-PANCREATO-BILIARY CANCERPATIENTS AWAITING SURGERY: PRELIMINARY RESULTSPopi Kasvis, McGill Nutrition and Performance Laboratory; Popi Kasvis; McGill Nutrition and Performance Laboratory,Supportive and Palliative Care Division, McGill University Health Centre, Montreal, Quebec, Canada; Tram Bui; McGillNutrition and Performance Laboratory, McGill University Health Centre, Department of Exercise Science, ConcordiaUniversity, Montreal, Quebec, Canada; Robert D. Kilgour; McGill Nutrition and Performance Laboratory, McGill UniversityHealth Centre, Department of Exercise Science, Concordia University, Montreal, Quebec, Canada; Franco Carli; Departmentof Anesthesia, McGill University Health Centre, Montreal, Quebec, Canada; Anotnio Vigano; McGill Nutrition andPerformance Laboratory, Supportive and Palliative Care Division, McGill University Health Centre, Montreal, Quebec,Canada

30

Incorporating Temporal Priors in Time-Delay Estimation in Ultrasound ElastographyMd Ashikuzzaman, Department of ECE, Concordia University, Montreal, QC, H3G1M8, Canada; Md Ashikuzzaman;Department of Electrical and Computer Engineering, Concordia University, Montreal, QC, H3G 1M8, Canada ; ClaudineGauthier; Department of Physics, Concordia University, Montreal, QC, H4B 1R6, Canada; Hassan Rivaz; Department of

31

Electrical and Computer Engineering, Concordia University, Montreal, QC, H3G 1M8, Canada

Dynamic functional brain connectivity differences between schizophrenia and healthy control subjects usingresting-state fMRIFatemeh Mohammadi, Concordia University; Fatemeh Mohammadi, Concordia University; M.O. Ahmad, ConcordiaUniversity; M.N.S Swamy, Concordia University

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Associations Between Leisure Time Physical Activity And Depressive Symptoms In Patients With AsthmaMélanie Béland, Concordia; Béland, Mélanie, PhD; Concordia University/INRS; Lavoie, Kim L., PhD; UQAM; Bacon, SimonL.; Concordia University

33

Effect of an orthopedic insole on ankle stability in ice skatingÉtienne Marquis, École de technologie supérieure; Stéphanie Bergeron; Centre collégial de transfert de technologie du Cégeprégional de Lanaudière à Terrebonne, INÉDI; Félix Chénier; Université du Québec à Montréal

34

Title: A Postural Paradigm for the Dual Mechanisms of Control ModelLaurence Lai, Concordia University; Kesaan Kandasamy, Concordia University; Dr. Nancy St-Onge, Concordia University ;Dr. Karen Z. H. Li, Concordia University

35

Regional Adipose Tissue Immune Cell Profiles in Childhood-Onset and Adult-Onset ObesityJessica Murphy, Department of Exercise Science, Concordia University, Montreal, QC, Canada; Vi Dam; Department ofExercise Science, Concordia University, Montreal, QC, Canada; Kerri Delaney; Department of Exercise Science, ConcordiaUniversity, Montreal, QC, Canada; José A. Morais; Division of Geriatric Medicine, McGill University, Montreal, QC,Canada; Michael Tsoukas; Division of Endocrinology and Metabolism, Department of Medicine, McGill University HealthCentre, Montreal, QC, Canada; Sylvia Santosa; Department of Exercise Science, Concordia University, Montreal, QC,Canada

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Are Headforms A Poor Surrogate for Helmet Fit?Kristie Liu, McGill University; Daniel I. Aponte; McGill University; David J. Greencorn; McGill University; Shawn M.Robbins; McGill University; David J. Pearsall; McGill University

37

Mind over medication: Using placebo machines and positive suggestion to treat behavioural disordersJay Olson, McGill University; Samuel Veissière; McGill University; Michael Lifshitz; McGill University; Michael Stevens;Intellectual Property Corporation; Amir Raz; McGill University

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Spatial and Temporal Cross-Correlation for Time-delay Estimation in Ultrasound ElastographyMorteza Mirzaei, Department of ECE, Concordia University, Montreal, QC, H3G 1M8, Canada; (Morteza Mirzaei;Department of Electrical and Computer Engineering, Concordia University); (Amir Asif; Department of Electrical andComputer Engineering, Concordia University),; (Maryse Fortin; PERFORM Centre, Concordia University); (HassanRivaz;Department of Electrical and Computer Engineering, Concordia University & PERFORM Centre, ConcordiaUniversity)

39

What are the relationships among cerebrovascular reactivity, grey matter volume and markers of successfulaging?Brittany Intzandt, INDI Department, Concordia University; Dalia Sabra; Département de médecine, Université de Montréal;Laurence Desjardins-Crepeau; Centre de Recherche d l'institut Universitaire de Gériatrie de Montréal and Centre deRecherche de l'Institute de Cardiologie de Montréal; Saïd Mekary; Department of Kinesiology, Acadia University; LouisBherer; Département de médecine, Université de Montréal and PERFORM Centre, Concordia University; Richard D. Hoge;Department of Neurology and Neurosurgery, McGill University; Chris J. Steele; Department of Neurology, Max PlanckInstitute for Human Cognitive and Brain Sciences and Cerebral Imaging Center, and Douglas Mental Health UniversityInstitute, McGill University; Claudine J. Gauthier; PERFORM Centre and Physics Department, Concordia University

40

Balance Improvements in Second Grade Children after 2-year Fundamental Movement Skills-DevelopmentProgramChang Ki Hong, Concordia University, Exercise Science department; Chang Ki Hong : Concordia University, ExerciseScience department; Matthew Miller : Concordia University, Exercise Science department; John Alexander Jimenez Garcia :Concordia University, Exercise Science department; Richard DeMont : Concordia University, Exercise Science department

41

Prevalence of Inadequate Nutritional Intake Among Adults Living with ArthritisPrince Kevin Danieles, Department of Mathematics and Statistics, Concordia University; Lisa Kakinami; Department ofMathematics and Statistics in collaboration with the PERFORM Centre, Concordia University; Matthew Parrott; PERFORMCentre, Concordia University; Kim Arrey; Co-founder, Antiinflammatoryfoodcentral.com; Hugues Plourde; School of HumanNutrition, McGill University ; Beth Armour; PEN - Practice-based Evidence in Nutrition®, Dietitians of Canada; GuylaineFerland; Département de nutrition, Faculté de médicine, Université de Montréal; Théa A. Demmers; PERFORM Centre,Concordia University

42

Hierarchical Sparse Autoencoders for Alzheimer's Disease Classification in Amyloid PET ImagingBiomarkerEmimal Jabason, Concordia University; M. Omair Ahmad and M.N.S Swamy; Department of Electrical and ComputerEngineering, Concordia University, Montreal, Quebec, Canada, H3G 1M8

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Ego Network Exploration with Heatmaps: A Case Study on Social Networks and Pediatric Obesity 44

Philippe Boileau, Concordia Universtiy; Philippe Boileau(1), Lea Popovic (1), Tracie A. Barnett (2), Melanie Henderson (3),Lisa Kakinami (1,4); ; (1) Concordia University, (2) Institut national de la recherche scientifique, Institut Armand-Frappier,;(3) Université de Montréal, (4) PERFORM Center Concordia University

Sex Differences in a Process-Based Assessment of Physical LiteracyMatthew Miller, Concordia University; John Alex Jimenez Garcia; Concordia University, Chang Ki Hong; ConcordiaUniversity, Richard DeMont; Concordia University

45

Reciprocal Modulation of Helper Th1 and Th17 Cells by the ß2-Adrenergic Receptor AgonistCatalina Marysol Carvajal Gonczi, Department of Biology, Concordia University and the PERFORM Centre, Montréal, Q;Tabatabaei Shafiei, Mahdieh ;Department of Biology, Concordia University and the PERFORM Centre, Montréal, Québec,Canada; Burchell-Reyes, Kelly; Department of Chemistry and Biochemistry, Concordia University the PERFORM Centre,Montréal, Québec, Canada; Darlington, Peter J; Department of Biology, Department of Exercise Science and the PERFORMCentre, Montréal, Québec, Canada

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Relationship of pure-tone and speech-in-noise measures of hearing to scores on the Montreal CognitiveAssessment Scale (MoCA): Sex differences and relation to other neuropsychological testsFaisal Al-Yawer, Concordia University; Halina Bruce; Concordia University; Centre for Research in Human Development(CRDH); PERFORM Centre; Karen Z. Li; Concordia University; Centre for Research in Human Development (CRDH);PERFORM Centre; M. Kathleen Pichora-Fuller; University of Toronto; Simon Fraser University; Rotman Research Institute;Natalie Phillips; Concordia University; Centre for Research in Human Development (CRDH); Centre for Research on Brain,Language & Music (CRBLM); Lady Davis Institute for Medical Research

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Debugging the Numerical error propagation in the HCP structural pre-processing pipelinesAli Salari, Department of Computer-Science and Software Engineering, Concordia University; Lalet Scaria; Department ofComputer-Science and Software Engineering, Concordia University, Montréal, Québec, Canada; Gregory Kiar; Department ofBiomedical Engineering, Montreal Neurological Institute, McGill University, Montreal, QC, Canada; Tristan Glatard;Department of Computer-Science and Software Engineering, Concordia University, Montréal, Québec, Canada

48

Analysis of female university soccer players' performance in games using GPS and heart rate measuresStephanie Di Lemme, Athletic Therapy Research Laboratory, Concordia University; Dr Geoffrey Dover; Concordia University,PERFORM Centre, Concordia University

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The influence of high plasma lipid on cardiac function and hypertrophyChelsea D'Abreau, Concordia University; Dr. Andreas Bergdahl, Concordia University

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Hemodynamic correlates of transient and stable changes in neuronal excitability: a simultaneousTranscranial Magnetic Stimulation (TMS) / functional Near Infra Red Spectroscopy (fNIRS) studyZhengchen Cai, Physics Department and PERFORM Center, Concordia University, Montreal, Canada; Giovanni Pellegrino;Montreal Neurological Institute, McGill University, Canada.; Amanda Spilkin; Department of Electrical Engineering, Ecole deTechnologie Supérieure, Montréal, Canada.; Thomas Vincent; Centre de médecine préventive et d'activité physique (CentreÉPIC), Montreal Heart Institute and University of Montreal, Montreal, Canada.; Jean-marc Lina; Department of ElectricalEngineering, Ecole de Technologie Supérieure, Montréal, Canada.; Shirley Fecteau; Medical School, Laval University,Montreal, Canada.; Christophe Grova; Multimodal Functional Imaging Laboratory, Biomedical Engineering Department,McGill University, Montreal, Canada; Multimodal Functional Imaging Laboratory, Biomedical Engineering Department,McGill University, Montreal, Canada.

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Childhood BMI trajectories in a longitudinal community cohort and the risk for eating disorder symptomsin adolescenceJessica Di Sante, Concordia University, Sainte Justine Hospital Research Center; Sylvana Côté; Sainte Justine HospitalResearch Center; Stéphane Paquin; Sainte Justine Hospital Research Center, Université Laval à Québec; Frank Vitaro; SainteJustine Hospital Research Center; Michel Boivin; Université Laval à Québec; Richard E. Tremblay; Sainte Justine HospitalResearch Center; Linda Booij; Concordia University, Sainte Justine Hospital Research Center

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Variations in oxygenation levels at birth interact with the dopamine transporter gene network influencinginternalizing problems and cognition in childrenPatricia Miguel, Universidade Federal do Rio Grande do Sul; Miguel PM1,2, Pereira LO1,2, Nguyen TT3, Garg E3,O'Donnell KJ3,4,5,6, Meaney MJ3,4,5,6,7, Silveira PP3,4,5; ; 1) Programa de Pós-Graduação em Neurociências, ICBS,Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; 2) Departamento de Ciências Morfológicas, ICBS,Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; 3) Ludmer Centre for Neuroinformatics and MentalHealth, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada; 4) Department of Psychiatry,Faculty of Medicine, McGill University, Montreal, QC, Canada; 5) Sackler Program for Epigenetics & Psychobiology atMcGill University; 6) Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto,ON, Canada; 7) Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR)

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The effect of whole body and regional adiposity on substrate utilization during incremental exercise intanner stage 1 and 2 children: A QUALITY studyKerri Delaney, Concordia University Department of Exercise Science; Kerri Delaney; 1: Concordia University Department ofExercise Science, 2: PERFORM Center Nutrition Obesity and Metabolism Lab, 3: Centre de recherche - Axe maladieschroniques, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Ile-de-Montréal; Melanie Henderson; 4:Research Center, Sainte-Justine University Hospital Research Centre, 5: Department of Pediatrics, University of Montreal;Marie-Eve Mathieu 4: Research Center, Sainte-Justine University Hospital Research Centre, 6: Department of Kinesiology,University of Montreal; Sylvia Santosa; 1: Concordia University Department of Exercise Science, 2: PERFORM Center

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Nutrition Obesity and Metabolism Lab, 3: Centre de recherche - Axe maladies chroniques, Centre intégré universitaire desanté et de services sociaux du Nord-de-l'Ile-de-Montréal

Illuminating the prefrontal cortex while manipulating cognitive demand: an fNIRS dual task walk study inyounger adultsTabassum Rahman, University of Ottawa; Tabassum Rahman, Nadia Polskaia, Gabrielle St-Amant, Yves Lajoie & SarahFraser; University of Ottawa

55

The relationship between metabolic syndrome, eating behaviors and psychosocial factors: a HEARTYStudyIyoma Edache, Concordia University; Ronald J. Sigal 2,3,5; Glen P. Kenny 3,5; Gary S. Goldfield 6; Denis Prud'homme 5,7;Stasia Hadjiyannakis 6; Steve Doucette 8; Angela S. Alberga 1; 1 Department of Exercise Science, Concordia University,Montreal, Canada ; 2 Departments of Medicine, Cardiac Sciences and Community Health Sciences, University of Calgary,Calgary, Alberta, Canada; 3 Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; 5School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada; 6 Healthy Active Living and Obesity ResearchGroup, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada; 7 Institut du Savoir Montfort,Ottawa, Ontario, Canada; 8 Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia,Canada

56

Do cannabinoids improve appetite and weight in patients with chronic diseases?Marialuisa Vigano, Department of Science, Lower Canada College, Montreal, Canada; M.F. Arboleda, MD; Department ofOncology, McGill University and Sante Cannabis Montreal, Canada. ; E. Prosk MSc; Sante Cannabis Montreal, Canada. ; Y.Drozd; Sante Cannabis Montreal, Canada. ; L.Xuecheng PhD; Sante Cannabis Montreal, Canada.; M. Dworkind MD; SanteCannabis Montreal, Canada.

57

Computing a meaningful change index on the Montreal Cognitive Assessment (MoCA) in healthy olderadultsChelsea Pozzebon, Concordia University; Faisal Al-Yawer; Concordia University. Karen Li; Concordia University. NataliePhillips; Concordia University.

58

Sex difference in physical activity changes to an e-health behaviour change intervention.Prerna Deshpande, Concordia University and CIUSSSM-NIM ( hospital du Sacre Coeur); Prerna Deshpande; ConcordiaUniversity, Canada, Paul Oh; Toronto Rehabilitation Institute, Canada, Kim Lavoie; Université du Québec à Montréal,Canada, Geneviève Szczepanik; Hospital du Sacre Coeur, Canada, Simon L. Bacon; Concordia University, Canada, for theACCELERATION team

59

Fragmentation of the Rest-Activity Cycle in Young, Sedentary Nappers

Joanne Abi-Jaoude, Concordia University, Dept of Psychology, PERFORM Sleep Lab; Abi-Jaoude, J.1,3*Mograss, M.1,2,3,4* Lim, A. 5*Frolova, E.1,3*Suliteanu, J.1,3* Ricchiuti, J. 1,3* Dang-Vu, T.1,2,3,4; 1Concordia University, Dept of Psychology, Montreal, QC, CA,2Dept of Exercise Science, Concordia University, Montreal, QC, CA, 3Concordia PERFORM Centre, Montreal, QC, CA, 4Centre deRecherche de l'Institut Universitaire de Gériatrie de Montréal, Montreal, QC CA, 5Division of Neurology, Dept of Medicine, SunnybrookHealth Sciences Centre, University of Toronto, ON, CA.

Napping has been shown to have a variety of benefits. In some cases, napping has been found to be detrimental.The use of actigraphy provides a cost effective method of providing data on sleep/wake states. Our aims were: Toassess fragmentation of rest-activity patterns in nappers utilizing a novel alogrithm(1) and, To determine ifnapping behaviours (frequency, duration, nap proximity to bedtime) contribute to night-time sleep disruption.

METHODS: We apply a novel algorithm to existing data currently being collected in another study(2). Thepresent study involved 27(9/group) young adults (NoNap=0, Occasional=1-2, Frequent=3+) aged 23.5±4.2yrs.The participants completed questionnaires based on sleep habits, medical and psychological history. For 10 days,participants were asked to wear a motion watch and complete a diary. An algorithm was used to identify runs ofrest and activity. The metrics represent measures of the tendency to fragment sustained runs of rest/sleep andactivity/wake. Separate averages of the metric were obtained over the nights and during the day. The actigraphywas used to derive sleep variables (TotalSleepTime, SleepLatency, Awakenings, SleepEfficiency).

RESULTS: ANOVA revealed a higher rest/sleep fragmentation metric in the frequent vs. non-nappers (p<0.03).The non-nappers compared to the nappers had higher daytime fragmentation activity (p=0.05). Pearsoncorrelations revealed an association between awakenings and fragmentation metric over the rest/sleep periods(r=0.58,p<0.03). Nap proximity of<7hrs to the bedtime, significantly increased total sleep time and awakenings(p=0.01).

CONCLUSION: Frequent nappers displayed a poorer quality night-time sleep. Naps close to bedtime may resultin sleep disruption and longer sleep periods.

References:

1. 1Lim, A. S., Yu, L., Costa, M. D., Buchman, A. S., Bennett, D. A., Leurgans, S. E., & Saper, C.B. (2011). Quantification of the Fragmentation of Rest-Activity Patterns in Elderly Individuals Using a State Transition Analysis.Sleep. p1400

2. 2Mograss M, Crosetta M, Robertson E, Pepin V, & Dang-Vu T-T. Combined acute affects of short-term exercise and sleep ondeclarative memory in young, sedentary adults: A pilot study. (abstract) APSS SLEEP June 2017.

keywords: actigraphy sleep sleep disruption nap

Poster # 1

An amyloid ligand-free optical retinal imaging method to predict cerebral amyloid PET status

Jean-Paul Soucy, UdM, McGill, Concordia; Jean-Paul Soucy - PERFORM Centre, Concordia University, & McGill Uiversity; ClaudiaChevrefils - Optina Diagnostics; Jean-Philippe Sylvestre - Optina Diagnostics; Jean Daniel Arbour - Clinique ophtalmologique 2121, ;Marc-André Rhéaume - Clinique ophtalmologique 2121, ; Sylvain Beaulieu - Hôpital Maisonneuve-Rosemont; Alain Robillard - HôpitalMaisonneuve-Rosemont; Céline Chayer - Hôpital Maisonneuve-Rosemont,; Pedro Rosa-Neto - Translational Neuroimaging Laboratory,McGill Centre for Studies in Aging; Sulantha S. Mathotaarachchi - Translational Neuroimaging Laboratory, McGill Centre for Studies inAging; Ziad S. Nasreddine - MoCA Clinic and Institute; Serge Gauthier - Alzheimer's Disease Research Unit, The McGill UniversityResearch Centre for Studies in Aging; Frédéric Lesage - École Polytechnique de Montréal

A simple, low-cost approach identifying amyloid positive subjects at or before the earliest clinical stages ofAlzheimer's (AD) could dramatically impact clinical trials evaluating disease modifying treatments AD byreducing cerebral PET amyloid imaging expenses, and could also be clinically useful for screening purposes. Inthis pilot study, a non-invasive retina imaging approach with a Hyperspectral Retinal Camera is evaluated as amean to identify biomarkers correlating with the cerebral load of amyloid determined with PET.

The cohort was composed of 40 subjects (15 probable AD, 25 age-matched controls) without retinaldiseases/ocular media opacity. Hyperspectral measurements were obtained at 450-900 nm. Image analysis basedon texture of the spatial/spectral dimensions in retinal vascular areas yielded 16 different parameters. A classifierwas trained using 102 datasets (1-3/subject) to establish the predictive value of those texture parameters, based onthe cerebral amyloid status determined from 18F-Florbetaben PET studies. A leave-one-out approach determinedsensitivity and specificity values.

At least one good quality hyperspectral dataset was acquired in 40/42 participants enrolled (n=42). Excellentretinal scanning correspondence with PET amyloid status was achieved, independently of cognition, when texturefeatures extracted from the principal retinal vessels were used, with sensitivity and specificity values of 85 and 93respectively.

The developed machine learning approach, based on direct hyperspectral retinal imaging, shows promise inpredicting cerebral amyloid PET status and could serve as a screening tool to identify subjects in the early stagesof the AD continuum, for instance in a drug development context.

keywords: amyloid early detection retinal scanning

Poster # 2

Associations between EEG cross-frequency-coupling during sleep and declarative learning inhealthy older adults: A pilot study

Oren Weiner, Concordia University, Dept of Psychology; Oren Weiner [1,2,3,4], Jordan O'Byrne [2,3,4,5], Julia Giraud [4,6], DespinaBolanis [1,2,3], Lukia Tarelli [1,2,3], Lea Homer [1,2,3,4], Victoria Yue [1,2,3], Katherine Walker [2,5], Rosette Tamaddon [1,2],Roxanne Carbone [1,2,3], Katherine Chhuon [1,2,3], Kenza Eddebbarh [1,2,3], Julia Lumia [1,2,3], Dylan Smith [1,2,3,4], Nathan Cross[2,3,4,5], & Thien Thanh Dang-Vu [1,2,3,4,5,6]; ; 1 Department of Psychology, Concordia University, Montréal, Canada; 2 PERFORMCenter, Concordia University; Montréal, Canada; 3 Center for Studies in Behavioral Neurobiology, (CSBN) Concordia University,Montréal, Canada; 4 Institut Universitaire de Gériatrie de Montréal, Montréal, Canada; 5 Department of Exercise Science, ConcordiaUniversity, Montréal, Canada; 6 Département de Neurosciences, Université de Montréal, Montréal, Canada

Memory consolidation processes may be mediated by a spontaneous synchronization of neuronal oscillationsknown as cross-frequency coupling (CFC)[1,2]. Associations between increased CFC during sleep (especiallyREM sleep) and learning are found among animals and young adult humans, but similar studies have rarely beenconducted in older adults. The current pilot study tested a hypothesis that greater CFC during sleep is positivelyassociated with better declarative memory performance in older adults. Sixteen healthy older adults (M(SD)age=67.7 (5.59) years; 13 female) completed two overnight polysomnography sleep recordings, separated by atleast one week. The second overnight included a word-pair associates task (40 word-pairs), with immediate(pre-sleep) and delayed (post-sleep) recall periods. Phase-amplitude CFC was quantified using the modulationindex[3] from frontal (Fz) and central (Cz or C3) EEG data between delta (1-4Hz) and sigma (11-16Hz; adapted)bands during the first NREM sleep cycle (NREM2, NREM3, NREM2/3), and between delta (1.5-3Hz) [or theta(4-7Hz)] and gamma (50-100Hz) bands during total REM sleep. Better delayed word-pair performance waspositively associated with greater CFC in NREM2/3 sleep on the second overnight. Better delayed word-pairperformance was also positively associated with greater relative increases in CFC between overnight recordingsduring NREM2/3, and during REM sleep. Moreover, greater performance stability between immediate anddelayed recall conditions was positively associated with greater relative increases in REM-CFC betweenovernight recordings. Findings contribute novel evidence to suggest that CFC during sleep may reflect a neuralmechanism underlying offline memory consolidation for newly learned declarative information in healthy olderadults.

References:

1. Jensen, O & Colgin, L.L (2007). Cross-frequency coupling between neuronal oscillations. TRENDS in Cognitive Science, 11(7),267-269.

2. Park, J.Y., Jhung, K., Lee, J., & An, S.K. (2013). Theta-gamma coupling during a working memory task as compared to a simplevigilance task. Neuroscience Letters, 532, 39-43.

3. Tort, A.B., Komorowski, R., Eichenbaum, H., & Kopell, N. (2010). Measuring phase-amplitude coupling between neuronaloscillations of different frequencies. Journal of Neurophysiology, 104(2), 1195-1210.

keywords: sleep brain oscillations cross frequency

Poster # 3

Maternal red blood cell 22:5 n-6 may not be a marker of low 22:6 n-3 status in young infants

Zahra Farahnak, School of Human Nutrition, McGill University; Ye Maggie Yuan, Sherry Agellon, Catherine A. Vanstone, Hope A.Weiler.; School of Human Nutrition, McGill University

Introduction: Maternal n-3 polyunsaturated fatty acid (PUFA) status is a determinant of infant n-3 PUFA profilewith known effects on growth.

Objective: Explore 22:5n-6 as a biomarker to reflect maternal n-3 status and test for associations with infant n-3status and growth.

Methods: Healthy lactating mothers and their singleton infants (n=69) were studied within 1 month postpartumfor anthropometry measurements, body composition assessment using dual-energy x-ray absorptiometry, andblood sampling. Maternal demographic data were surveyed and pregnancy history obtained from medical charts.Maternal and infant red blood cells (RBC) were directly methylated to measure PUFA profiles using gaschromatography and expressed as of total fatty acids. Maternal RBC 22:5n-6 data were divided into lowest(LOWER) and highest (HIGHER) tertile groups; then tested for differences in n-3 status and anthropometry ofmothers and infants. Pearson's correlations and mixed model ANOVA were tested, p<0.05.

Results: Mothers were 31.6±4.8 y (Mean±SD) at delivery and gained 13.3±5.7 kg during pregnancy. Infants (57male) were born at 39.7±1.0 wk gestation. Women in the HIGHER group had higher RBC 22:5n-6 by design, inaddition to lower 18:2n-6, 20:5n-3 and 22:6n-3/22:5n-6 ratio. Infants of mothers in the HIGHER group had lower20:5n-3, but not 22:6n-3. Positive relationships were observed between maternal RBC 22:6n-3/22:5n-6 ratio andinfant RBC 22:6n-3 (r=0.31,p=0.01), and 22:6n-3+20:5n-3 percentages (r=0.37,p=0.002). Infant RBC 22:6n-3was only related to infant whole body lean mass (r=0.25,p=0.04), before adjustment for covariates.

Conclusion: No differences in infant 22:6n-3 were observed despite higher maternal 22:5n-6, suggesting adequatematernal-infant transfer.

References:

1. Otto, SJ, van Houwelingen AC, Badart-Smook A, Hornstra G. Comparison of the peripartum and postpartum phospholipidpolyunsaturated fatty acid profiles of lactating and nonlactating women. The American journal of clinical nutrition.2001;73(6):1074-9.

2. Innis, SM, Vaghri Z, King DJ. n- 6 Docosapentaenoic acid is not a predictor of low docosahexaenoic acid status in Canadianpreschool children. The American journal of clinical nutrition. 2004;80(3):768-73.

3. Donahue, S, Rifas-Shiman S, Olsen S, Gold D, Gillman M, Oken E. Associations of maternal prenatal dietary intake of n-3 and n-6fatty acids with maternal and umbilical cord blood levels. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2009;80(5):2

keywords: rbc maternal infant transfer

Poster # 4

Absolute Quantification of Cerebrovascular and Metabolic Effects of Aerobic Fitness:Cross-Sectional and Intervention Data

Catherine Foster, PERFORM/Physics; Catherine Foster (1), Jessica Steventon (2), Michael Germuska (2), Hannah Chandler (2), KevinMurphy (3), Richard Wise (2); ; 1 Dept. of Physics, Concordia University, Montreal, QC, H4B 1R6; 2 CUBRIC, School of Psychology,Cardiff University, Cardiff, CF24, 4HQ; 3 School of Physics, Cardiff University, Cardiff, CF24 3AA

Introduction: To investigate effects of aerobic fitness on cerebrovascular function, cross-sectional andinterventional studies are necessary. This study investigated associations between VO2max and cerebral bloodflow (CBF), cerebrovascular reactivity (CVR), capillary blood volume (CBVcap), oxygen extraction fraction(OEF0), and the cerebral metabolic rate of oxygen consumption (CMRO2). A 1-week exercise trainingintervention was also conducted to assess whether rapid cerebrovascular and metabolic adaptations occur withexercise training.

Methods: Dual-calibrated arterial spin labelling (ASL) MRI and VO2max testing was performed at baseline. andfollowing the intervention in 15 untrained healthy males. ASL was repeated following the intervention whereparticipants completed 5 supervised sessions of stationary cycling at 55-75 of the age-predicted maximum heartrate for 25 minutes as well as 3 sets of 5 resistance exercises on 3 of the 5 days.

Results: In grey matter, CBVcap, CMRO2 and OEF0 were negatively correlated with VO2max before statisticalcorrections. Follow-up voxelwise analysis showed that CBVcap was negatively correlated with VO2max in leftM1, precuneous, intracalcarine cortex, left lateral occipital cortex and bilateral anterior and posterior cingulategyrus. OEF, and VO2max were inversely correlated in left M1 and supplementary motor areas. The interventiondid not result in cerebrovascular changes.

Discussion: Aerobic fitness was associated with lower CBVcap and OEF0 in multiple cortical regions. However,further investigations are needed to rule out confounding relationships between capillary transit timeheterogeneity or the oxygen tension of tissue and aerobic fitness. The intervention data show that 1 week is notsufficient to induce cerebrovascular adaptations.

keywords: max asl exercise cerebrovascular

Poster # 5

Inter-observer reliability of Street View feature in Google Earth for virtual assessment ofenvironmental obesogenicity .

Anna Smyrnova, Department of Mathematics and Statistics, Concordia University; Tracie A. Barnett; INRSe -Institut Armand Frappier,Centre de recherche du CHU Sainte-Justine,; Andrea Van Hulst; Ingram School of Nursing, McGill University,; Lisa Kakinami;Department of Mathematics and Statistics, PERFORM Centre, Concordia University

Objective: Features of the neighborhood environment are associated with physical activity in children and may bea key determinant for obesity risk. However, epidemiological studies that involve in-person audits of theenvironment are labor-intensive and costly. In this study we aimed to examine the inter- and intra- rater reliabilityof a virtual built environment audit tool.

Methods: Data from 349 street segments in 40 neighbourhoods in Montreal were evaluated as part of theQUALITY study. Two independent observers assessed 50 items per street segment using the Street View featurein Google Earth. Percentage agreement and Cohen's Kappa as measures of inter- and intra-rater reliability werecalculated. Data are reported by categories: Walking and Cycling, Street characteristics, Transport, Safety, Visualaesthetics and Land Use.

Results: The overall inter-observer reliability was high (94 agreement, k=0.78). Most categories of features (suchas Walking and Cycling, Street characteristics and Visual aesthetics) had high inter-observer agreement (91 -97agreement and Kappa scores 0.72-0.87). However, within-category variation was noted, with lowest agreementfor individual items which were more subjective such as road condition (k=0.68) and sufficient lightening(k=0.28). Intra-rater reliability was high (98 agreement, k=0.92).

Conclusion: Results suggest that using Street View for a virtual audit of the built environment is a reliabledesk-based tool to define environmental characteristics related to physical activity in children. However, variationwithin categories were noted, with lowest agreement in items that are more subjective in nature. Results can beimproved through revision in the assessment tool and additional training of observers.

References:

1. Cohen, J. (1960). A coefficient of agreement for nominal scales. Educational and Psychological Measurement, 20, 37-46.2. Landis, J., & Koch, G. (1977). The Measurement of Observer Agreement for Categorical Data. Biometrics, 33(1), 159-174.

keywords: built environment virtual audit tool

Poster # 6

How does total sleep deprivation affect brain activity and performance?

Florence Pomares, Concordia Unveristy & Centre de Recherche de l'IUGM; Florence B Pomares1,2,3, Aude Jegou2,4, Dylan Smith1,2,Ümit Aydin2,4, Christophe Grova2,4,5,6, Thien Thanh Dang-Vu1,2,3,7; ; Affiliations:; 1 Center for Studies in Behavioral Neurobiologyand Department of Exercise Science, Concordia University, Montreal, Quebec, Canada; 2 PERFORM Centre, Concordia University,Montreal, Quebec, Canada ; 3Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Quebec, Canada ;4Multimodal Functional Imaging Lab. Department of Physics, Concordia University, Montreal, Quebec, Canada ; 5Department ofBiomedical Engineering, McGill University, Montreal, Quebec, Canada ; 6 Montreal Neurological Institute, Department of Neurology andNeurosurgery, McGill University, Montreal, Quebec, Canada ; 7 Department of Neurosciences, Université de Montréal, Montreal,Quebec, Canada

Sleep deprivation has negative consequences on mental and physical health. Alertness and attention areparticularly affected and are associated with alterations of brain activity [1]. We investigated the immediateeffects of a recovery nap on brain functions, after total sleep deprivation.

16 young good sleepers (mean age 21, 10 female) underwent two sessions of simultaneous high-densityEEG/fMRI at the PERFORM Centre, separated by one week and counterbalanced across participants. One sessioncomprised acquisitions before (SDpre-nap) and after a recovery nap (SDpost-nap), in the morning following anight of total sleep deprivation. The other session comprised acquisitions in the morning after a night of regularsleep (NN). Both nights were controlled in a sleep laboratory. A total of 3 runs were acquired for each participant,comprising an anatomical image and a set of fMRI images acquired during working memory, attention, andpsychomotor vigilance tasks.

After sleep deprivation, performance on all tasks decreased and reaction times increased significantly (SDpre-napvs. SDpost-nap and SDpre-nap nap vs. NN p<0.05). The 30-minute nap allowed recovery of performance andreaction times (SDpost-nap vs. NN p>0.05). When compared to brain activity patterns following a normal night ofsleep, task-elicited activity was lower after sleep deprivation, but partially recovered after the nap.

Sleep deprivation affects cognitive performance and associated brain activity in psychomotor, working memoryand attention domains. A 30-minute nap has immediate effects as it permits cognitive performance recovery tonormal, however, the recovery of brain responses is only partial after the nap following sleep deprivation.

References:

1. Dang-Vu T.T. (2014) Imaging Sleep and Sleep Deprivation. In: Bianchi M. (eds) Sleep Deprivation and Disease. Springer, NewYork, NY

keywords: sleep fmri eeg attention memory

Poster # 7

Are "Serious Games" too stressful to be beneficial for older adults?

Kate Li, PERFORM Centre, Concordia University; Atousa Asadi, Mahsa Mir Gholami, Najmeh Khalili-Mahani; PERFORM Centre,Concordia University)

Serious Games may provide positive effects on cognitive and emotional wellness of older adults (Colzato et al.,2013). However, there are different genres of games that can produce positive effects and there are notcomparative studies to evaluate the psychophysiological impact of different game modalities. We aimed tocompare the effects of playful cognitive testing on older adults in terms of cognitive and physiological response todifferent computer games. Seventeen healthy volunteers (66-79) participated in a repeated-measures study toevaluate three different games (G1: brain training, G2: Car racing, and G3: Exergaming). Identical sessionsincluded the following epochs Introduction, Picture-Encode, Play, Picture-Recall and Stroop. The picture-recalltest is sensitive to stress (Khalili-Mahani et al., 2010). Heart-rate was continuously monitored. The sample wassplit based on Montreal Cognitive Assessment test (MOCA) scores, >27=High. We found that only in the firstvisit (G1), the low-MOCA group (N=7) had higher heart-rate in all epochs (tdf=15's>2.5, p's<.05), and lowerpicture recall performance (higher false flags) in G1 (tdf=15>3.2, p's<.005). Subjective ratings of the G1 sessionindicate that low- MOCA group rated G1 session significantly less fun. No differences were observed in G2session. Both recall and stroop accuracy rates were lower in low-MOCA group after G3 (p<.05). It is plausiblethat the low-MOCA group perceived the G1 and G3 (with explicit scoring of performance) more stressful than G2which had no scoring elements and was played for fun. Future longitudinal studies are needed to confirm thatplayful-cognitive training is more beneficial than "serious" gaming.

References:

1. Colzato, L., Wildenberg, W., Zmigrod, S., & Hommel, B. (2013). Action video gaming and cognitive control: playing first personshooter games is associated with improvement in working memory but not action inhibition. Psychological Research, 77(2), 234

2. Khalili-Mahani, N., Dedovic, K., Engert, V., Pruessner, M., & Pruessner, J. C. (2010). Hippocampal activation during a cognitivetask is associated with subsequent neuroendocrine and cognitive responses to psychological stress. Hippocampus, 20(2), 323

keywords: older adults gaming moca cognitive

Poster # 8

Salivary immunoglobulin-A individual response patterns to cold pressor test

Ghazal Mohammadi, Concordia University; Ghazal Mohammadi1,2, Nhat Phi Pham1,3,4, Marylen Youssef1,2, Azadeh Ghassemi1,2,Tanya Babiuk-Henry1,2, Catalina Marysol Carvajal Gonczi1,4, Peter J. Darlington1,2,4; 1. The PERFORM Centre, ConcordiaUniversity, Montreal, Qc, Canada, H4B 1R62 ; 2. Department of Exercise Science, Concordia University, Montreal, Qc, Canada, H4B1R6; 3. Science College, Concordia University, Montreal, Qc, Canada, H4B 1R6; 4. Department of Biology, Concordia University,Montreal, Qc, Canada, H4B 1R6

This study investigated the response of salivary immunoglobin-A (SIg-A) to a cold pressor test (CPT). Acutephysical stressors trigger the activation of the sympathetic nervous system, which may influence an immuneresponse (i). However, inter-individual differences in autonomic responses to acute stressors make it difficult todraw conclusions on immune system responses (ii, iii). Our hypothesis was that the CPT causes an increase inSIg-A and salivary alpha amylase (SaA) concentrations with direct correlation to the changes in cardiovascularand hemodynamic parameters indicative of sympathetic activity. The secondary purpose was to determine if thelaw of initial values can be applied to the SIg-A pattern of response.

Twenty participants completed a 5-min CPT, with cardiovascular parameters and saliva samples measured. TheCPT caused the SaA, HR, BP to increase (p< 0.05). The effect of CPT on SIg-A was variable in individuals. Theoverall trend was that SIg-A was lower post CPT, without significance. Our Regression analysis showed aninverse correlation between the SIg-A magnitude of change and its baseline value (r = -0.89, p= 0.01). Therefore,the CPT caused an increased SIg-A in participants with a low baseline, and a decreased SIg-A in participants witha high baseline. The approximate cross-over point for these patterns was at 60?g/mL of baseline SIg-A. Inconclusion, an acute sympathetic stimulus caused the SIg-A to change according to its baseline in accordancewith the law of initial values. These results will help interpret SIg-A studies, and to understand the interindividualvariations in SIg-A responses.

References:

1. Ring, C., Harrison, L. K., Winzer, A., Carroll, D., Drayson, M., & Kendall, M. (2000). Secretory immunoglobulin A andcardiovascular reactions to mental arithmetic, cold pressor, and exercise: Effects of alpha-adrenergic blockade.Psychophysiology,

2. Willemsen, G., Ring, C., Carroll, D., Evans, P., Clow, A., & Hucklebridge, F. (1998). Secretory immunoglobulin A andcardiovascular reactions to mental arithmetic and cold pressor. Psychophysiology, 35(3), 252-259.

3. Winzer, A., Ring, C., Carroll, D., Willemsen, G., Drayson, M., & Kendall, M. (1999). Secretory immunoglobulin A andcardiovascular reactions to mental arithmetic, cold pressor, and exercise: Effects of beta-adrenergic blockade. Psychophysiology,

keywords: immunoglobulin cold pressor test

Poster # 9

Clothing in the Everyday Life of Persons with a Physical Disability: A Scoping Review

Alida Esmail, Université de Montréal/ Centre de recherche interdisciplinaire en réadaptation; Frédérique Poncet; Concordia UniversityDepartment of Psychology Centre de recherche interdisciplinaire en réadaptation du Montréal Métropolitain (CRIR); Annie Rochette;Université de Montréal École de réadaptation, CRIR; Claudine Auger; Université de Montréal École de réadaptation, CRIR; ChristopheBillebaud; Rhizome strategies, La Piscine; Élaine de Guise; Université de Montréal département de psychologie, CRIR; IsabelleDucharme; Kéroul; Eva Kehayia; McGill University School of Physical and Occupational Therapy, CRIR; Delphine Labbé; University ofBritish Columbia, Department of Occupational Science and Occupational Therapy; Noèmi Dahan-Oliel; Shriner's Hospital for Children ;Isabelle Lessard; Vestechpro; Olivier Vermeersch; Groupe CTT, Ste-Hyacinthe; Bonnie Swaine; Université de Montréal École deréadaptation, CRIR

Background: Clothing is important in everyday life. The act of dressing and other clothing-related activities canbe challenging for persons with a physical disability (PWD) and can have altering effects on their participation(daily activities, fulfillment of social roles). Clothing design and wearable technologies are growing industries,however, their potential impact on participation of PWD is understudied. The objective of this scoping review isto map the state of the literature on the role of clothing on participation of PWD. Methods: Using a six-stepapproach [1, 2], peer-reviewed literature published since 1990 was searched in six databases (MEDLINE,Embase, CINAHL, ERIC, PsycINFO, Sociological Abstracts), resulting in 2099 references. Three authorsreviewed references in iterative stages to obtain high inter-rater agreements (?>.75). The InternationalClassification of Functioning, Disability and Health [3] is used as a framework for data extraction of retainedarticles (n=131). A consultation group from different relevant fields (e.g. rehabilitation, technology, fashion) willvalidate the extracted data. Results: Quantitative and qualitative findings indicate a variety of patient populationsand apparel studied (predominantly shoes (n=74)). Clothing can affect body functions (e.g. of the skin,temperature regulation) and structures (e.g. genitourinary), which may positively or negatively influence activitiesand participation (e.g. mobility and community life) of PWD. Conclusion: Understanding how clothingcontributes to enabling PWD to participate fully in meaningful work, school, and leisure activities will informrecommendations for future innovations (e.g. clothing design) and practice (e.g. information clinicians give topatients/caregivers), ultimately supporting the development of an inclusive society.

References:

1. Arksey, H., & O'Malley, L. (2005). Scoping studies: towards a methodological framework. International Journal of SocialResearch, 19-32.

2. Levac, D., Colquhoun, H., O'Brien, K. (2010). Scoping studies: advancing the methodology. Implementation Science, 5(69).3. World Health Organization, W. (2001). International Classification of Functioning, Disability and Health (ICF). Geneva: World

Health Organization.

keywords: rehabilitation clothing participation scoping review

Poster # 10

The effect of adulthood- versus childhood-onset obesity on cardiorespiratory fitness andskeletal muscle strength in adults

Abdulrahman Dera, Department of Exercise Science,Concordia University, Montreal, Quebec, Canada.; Abdulrahman Dera 1,2,3, JessicaMurphy1,2,5 José A. Morais4 Sylvia Santosa1,2,5; 1Department of Exercise Science,Concordia University, Montreal, Quebec, Canada.;2Nutrition, Obesity and Metabolism Laboratory, PERFORM Centre, Concordia University, Montreal, Quebec, Canada.; 3Department ofEducation, Faculty of physical Education, Jeddah University, Jeddah, Saudi Arabia.; 4Division of Geriatric Medicine, Faculty ofMedicine, McGill University, Montreal, Quebec, Canada.; 5Centre de recherche - Axe maladies chroniques, Centre intégré universitairede santé et de services sociaux du Nord-de-l'Ile-de-Montréal, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada

Background: Obesity is associated with metabolic and functional impairments that can affect cardiorespiratoryfitness (CRF) and skeletal muscle strength (SMS). However, it remains unknown whether lifelong obesity, andhence early and prolonged exposure to excess adiposity, impacts elements of fitness. We therefore aimed todetermine whether the timing of obesity onset (childhood- versus adult-onset) affects CRF and SMS in obeseadults. Methods: We recruited 20 adults (BMI: 30 - 39 kg/m2; age: 25 - 39 years) with obesity acquired eitherpre-/peri-puberty (childhood-onset [CO]; n = 11) or after the age of 18 (adult-onset [AO]; n = 9). We measuredtheir CRF using the YMCA submaximal bike test (estimated VO2 max); and their SMS using hand-gripdynamometry. Result: Mean SMS (± SD) was significantly lower in adults with childhood-onset obesity versusadult-onset obesity (CO: 56.5 ± 11.3 vs. AO: 79.7 ± 19.4 kg; p = 0.04). In contrast, CRF was not differentbetween groups (CO: 30.7 ± 6.4 vs. AO: 33.0 ± 4.8 mL/kg/min; p = 0.38) with the majority of participants havinga poor rating. These results persisted when adjusting for age and sex. Conclusion: Our results show that persistentobesity since childhood impairs muscle strength, but not cardiorespiratory fitness, compared to adult-onsetobesity. These results suggest that maintaining a healthy body weight early in life may delay the loss of musclestrength later in life and help prevent future diseases. Our current research is exploring whether differences inadipose tissue and skeletal muscle characteristics are implicated in these findings.

References:

1. Rantanen T, Harris T, Leveille SG, et al. Muscle strength and body mass index as long-term predictors of mortality in initiallyhealthy men. J Gerontol A Biol Sci Med Sci. 2000;55A:M168-M173.

2. Ferrucci L, Penninx BWJH, Volpato S, et al. Change in muscle strength explains accelerated decline of physical function in olderwomen with high interleukin-6 serum levels. J Am Geriatr Soc. 2002;50:1947-1954.

3. Schmidt MD, Magnussen CG, Rees E et al. Childhood fitness reduces the long-term cardiometabolic risks associated withchildhood obesity. Int J Obes (Lond)2016; 40(7):1134-1140.5

keywords: cardio respiratory fitness muscle strength

Poster # 11

Improving the Accuracy of Motor Imagery-Based Brain-Computer Interface for Locked-inPatients

Mahsa Mirgholami Mashhad, Concordia University, Electrical & Computer Engineering (ECE); Golnar Kalantar; Concordia Institute forInformation Systems Engineering (CIISE); Arash Mohammadi; Concordia Institute for Information Systems Engineering (CIISE); AmirAsif; Concordia University, Electrical & Computer Engineering (ECE)

Background

Recently, more efficient and advanced life-support and intensive-care systems are being developed in an ongoingbasis aiding patients with motor disabilities. In particular, there is an urgent need for development of analternative communication channel for Locked-in patients to improve the quality of their lives, possibly withoutpresence of a caregiver.

Brain-computer Interfaces (BCIs) are interpreters of thoughts into commands for external devices, which need tobe highly accurate and capable of well-interpretation by the quickest pace possible [1]. Motor-imagery (MI), oneof the most popular and commonly used techniques in BCIs, is defined as merely imagination of a limbmovement, with no actual movement or peripheral (muscle) activation [2]. MI, although outlining a promisingframework for motor-disabled patients, brings about a critical challenge: different comprehensions amongsubjects from "Imagination of the movement". Some subjects imagine repeating the movement during each epoch,while some others might execute the mental imagination of the activity only once, and not necessarily consistentlywithin equal time intervals after the stimulus is shown. The mentioned challenge causes irrelevant time intervalswithin each trial's signal of MI task.

Contribution

Since training of locked-in patients regarding the MI task might be frustrating, we aim to systematically capturethe most informative part of each trial's signal via employing an adaptive window over each epoch, in order toincrease the accuracy of interpretation.

The proposed method was applied to available EEG datasets retrieved from public online data bases.Effectiveness of the proposed solutions are evaluated by KAPPA value.

References:

1. Chaudhary, U., Birbaumer, N., & Ramos-Murguialday, A. (2016). Brain-computer interfaces for communication andrehabilitation. Nature Reviews Neurology, 12(9), 513.

2. Edelman, B. J., Baxter, B., & He, B. (2016). EEG source imaging enhances the decoding of complex right-hand motor imagerytasks. IEEE Transactions on Biomedical Engineering, 63(1), 4-14

3. Kim, J., Lee, B., Lee, H. S., Shin, K. H., Kim, M. J., & Son, E. (2014). Differences in brain waves of normal persons and strokepatients during action observation and motor imagery. Journal of physical therapy science, 26(2), 215-218.

keywords: brain computer interfaces motor imagery

Poster # 12

Variables associated with detection and distraction by food on a clinical sample of people withobesity

Barbara Barth, UFRGS; Barbara Mello Barbosa - Undergraduate student at UniRitter; Yasmin Moreira Silva Souza - Undergraduatestudent at UniRitter; Camila Martins de Azambuja - Undergraduate student at UniRitter; Lisiane Bizarro - Associate professor at UFRGS

Reactivity to food cues, defined as a conditional response to food cues, can contribute to the onset andmaintenance of obesity. Attentional bias to food has been used as a measure. We aimed to observe the associationbetween attentional bias to food and binge eating, food addiction, impulsivity, BMI and emotional symptoms in aclinical sample of patients with obesity. 29 adults with ages varying between 24 and 58 (M=41.59; SD=9.7) andmean BMI of 44.15kg/m2 (SD=8.31) participated in this study. A Visual Search Task - Reaction Time onDetection and Distraction, Binge Eating Scale, Barratt Impulsivity Scale, Yale Food Addiction Scale, DASS-21and sociodemographic scale were used. Most of the sample had presence of attentional bias for detection but notfor distraction of high and low caloric food, being able to faster detect food than neutral stimuli. No differencewas found between the two types of food stimuli. There was an association between faster detection of highcaloric food stimuli and binge eating symptoms (r=-.336, p<0.05), impulsivity symptoms (r=-.331, p<0.05),depression Scores (r=-.634, p<.001) and anxiety Scores (r=-.634, p<.001). Individuals with a family history ofobesity were able to faster detect high (t(27)=2,147, p<0,05) and low (t(27)=2,345, p<0,05) caloric food stimuli.There was no significant association between attentional bias to food and food addiction and BMI. Having familyhistory of obesity and symptoms of binge eating, impulsivity, depression and anxiety may put obese people ingreater risk for development of higher reactivity to food cues.

References:

1. Boswell, R. G., & Kober, H. (2016). Food cue reactivity and craving predict eating and weight gain: a meta-analytic review.obesity reviews, 17(2), 159-177.

2. Bongers, P., van de Giessen, E., Roefs, A., Nederkoorn, C., Booij, J., van den Brink, W., & Jansen, A. (2015). Being impulsive andobese increases susceptibility to speeded detection of high-calorie foods. Health Psychology, 34(6), 677.

3. Deluchi, M., Costa, F. S., Friedman, R., Gonçalves, R., & Bizarro, L. (2017). Attentional bias to unhealthy food in individuals withsevere obesity and binge eating. Appetite, 108, 471-476.

4. Davis, C., Curtis, C., Levitan, R. D., Carter, J. C., Kaplan, A. S., & Kennedy, J. L. (2011). Evidence that 'food addiction'is a validphenotype of obesity. Appetite, 57(3), 711-717.

keywords: obesity attentional bias impulsivity binge

Poster # 13

Momentary assessment of 'stress' using a wearable physiological monitoring system

Atousa Assadi, PERFORM Centre, Department of Electrical Engineering, Concordia University; Kate Li, PERFORM Centre, Departmentof Psychology, Concordia University; Mahsa MirGholami, PERFORM Centre, Department of Electrical Engineering, ConcordiaUniversity; Habib Benali, PERFORM Centre, Department of Electrical Engineering, Concordia University; Najmeh Khalili-Mahani,PERFORM Centre, Department of Design and Computation Arts.

Continuous monitoring of physiological responses to real-life physical or psychological health interventions areimportant in delivering e-health to older adults (1). Stress responses are usually measured from salivary cortisol(2), but recently available wearable devices facilitate momentary assessment of stress from electrodermal activity(EDA) and heart rate (HR) (3). We have examined the sensitivity of a wearable stress-biosensor (E4, EmpaticaInc.) in a three-session study involving continuous biosensing and cortisol sampling while older adults (N=18, age65+) played cognitively beneficial games (G1: brain-training; G2: virtual car-racing; G3: an exergame thattracked the accuracy of player's movements using Kinect camera.). We have developed and validated a MATLABsoftware to metricize the continuous EDA and heart rates measured from E4 at customizable intervals. We aimedto compare the sensitivity of these metrics against the standard salivary cortisol. We established a moderatereliability of Baseline biosensors data over three sessions (ICC=.65). A Generalized estimating equation(exchangeable working model) (4) revealed significant Game x Time effects on EDA, HR and Cortisol(Chi-square (df=1,11) = 313, 746 and 83, respectively, p's<.0001). Interviews, and posthoc analysis showed thatG3 was the most stressful of all activities, also indicated by both cortisol and sympathetic responses. A slow andpossibly circadian decay in cortisol levels was observed in G1 and G2 which was not present in EDA/HR profiles.Further analyses will model the circadian effects, and the shifts in peak-response observed from cortisol andsympathetic response. Wearable biosensors may present an alternative to saliva sampling for stress assessment.

References:

1. Gagnon MP, Beogo I, Buyl R. e-Health Interventions for Healthy Aging: A Systematic Review Protocol. Studies in healthtechnology and informatics. 2016;225:954-5. Epub 2016/06/23. PubMed PMID: 27332428.

2. Dickerson SS, Kemeny ME. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research.Psychological bulletin. 2004;130(3):355-91. doi: 10.1037/0033-2909.130.3.355. PubMed PMID: 15122924.

3. Christie MJ. Electrodermal activity and the stress response. A review. Acta Med Pol. 1973;14(4):343-55. Epub 1973/01/01.PubMed PMID: 4587186.

4. Carr GJ, Chi EM. Analysis of variance for repeated measures. Data: a generalized estimating equations approach. Stat Med.1992;11(8):1033-40. Epub 1992/06/15. PubMed PMID: 1496191

keywords: stress edr wearable technology heart

Poster # 14

Mobile augmented reality for neurosurgical navigation

Étienne Léger, Concordia University; Simon Drouin; Montreal Neurological institute; D. Louis Collins; Montreal Neurological Institute;Marta Kersten-Oertel; Concordia University

We have built a prototype of mobile neuronavigation system running on an iPad tablet. The system presents to theuser the live camera feed augmented with segmented structures extracted from a preoperative MRI scan. The coreadvantages of this type of system is the ability it provides to the user to move around the anatomy of interest toenable him/her to see it from different angles and therefore gain a deeper understanding of its structure in all itscomplexity. The prototype is still in development, but we have already tested it in a clinical environment and havereceived positive feedback. The next steps after further development will be quantification of 3D depth perceptionimprovement over traditional neuronavigation. We expect our system to surpass traditional navigation in thatrespect.

keywords: augmented reality neurosurgery neuronavigation mobile

Poster # 15

Auditory discourse processing in bilinguals: an ERP analysis

Maude Brisson-McKenna, Concordia University; Dr. Natalie Phillips, Department of Psychology, Concordia University ; Dr. AngelaGrant, Department of Psychology, Concordia University

When communicating in a second language (L2), one may feel that producing and comprehending extendeddiscourse is quite challenging. As such, the goal of the current experiment is to contrast two different frameworksof discourse processing in L2. The Capacity Theory of language comprehension (Just & Carpenter, 1992) predictsthat bilinguals are only able to benefit from discourse-level cues in L2, such as semantic and world knowledgeinformation, if they have the sufficient working memory capacities to do so. In contrast, the Noisy Channel Model(Gibson, Bergen, & Piantadosic, 2013) predicts that bilinguals will rely mainly on discourse-level cues in L2 asthey are less familiar with the syntax. In this study, seven English-French bilinguals listened to 3-sentence storiesin English and in French while their brain activity was recorded using electroencephalograms. Target wordswithin the stories were either congruent or incongruent with respect to the discourse context and lexicallyassociated or unassociated with a preceding prime word. We examined whether bilinguals were more sensitive tothe discourse-level or lexical-level manipulation in their L2 compared to in their first language (L1) by looking atthe amplitude and latency of the N400 component. Stimulus-locked analyses revealed greater negativities in L2compared to in L1 (p = .005). We interpret this as reflecting the overall greater processing load in L2. Ourpreliminary results also indicated a significant N400 effect for the discourse-level manipulation (p = 0.022) andno significant effects for the lexical-level manipulation, thus lending support to the Noisy Channel Model.

References:

1. Just, M. A., & Carpenter, P. A. (1992). A capacity theory of comprehension: Individual differences in working memory.Psychological Review, 99(1), 122-149

2. Gibson, E., Bergen, L., & Piantadosi, S. T. (2013). Rational integration of noisy evidence and prior semantic expectations insentence interpretation. PNAS, 110(20), 8051-8056

3. Boudewyn, M. A., et al. (2012). Does discourse congruence influence spoken language comprehension before lexical association?Evidence from event-related potentials. Language and cognitive processes, 27(5), 698-733

4. Kutas, M., & Hillyard, S. A. (1980). Reading senseless sentences: Brain potentials reflect semantic incongruity. Science,207(4427), 203-205. doi:10.1126/science.7350657

5. Futrell, R., & Gibson, E. (2017). L2 processing as noisy channel language comprehension. Bilingualism: Language and Cognition,20(4), 683-684. doi:10.1017/S1366728916001061

keywords: bilingual discourse congruence lexical association

Poster # 16

Weight bias internalization: Sex differences and relationships with mental health

Erica Szwimer, Concordia University; Stefanie Marchione: Department of Mathematics and Statistics, Concordia University, Montreal,Quebec, Canada; Lisa Kakinami: Department of Mathematics and Statistics, Concordia University, Montreal, Quebec, Canada ;PERFORM Centre, Concordia University, Montreal, Quebec, Canada ; Angela Alberga: Department of Exercise Science, ConcordiaUniversity, Montreal, Quebec, Canada

Background: Stigma has been identified as a fundamental public health inequity. Weight bias and stigma haveincreased in frequency and intensity over the last few decades. While adverse health consequences of weight biasare well known, sex differences and mental health consequences of weight bias internalization (i.e. self-stigma orthe belief that the stigma is deserved) warrant further study. Objectives: To explore the relationships betweenweight bias internalization (WBI), sex, and mental health.Methods: A sample (N=99, age 37.49 18.43; 39 male;BMI 25.96 4.29 kg/m2) completed demographic characteristics, WBI and mental health measures (lifesatisfaction, emotional wellbeing and body dissatisfaction) at the PERFORM Center in Montreal. The associationbetween WBI on life satisfaction, emotional wellbeing and body dissatisfaction after adjusting for sex, age, race,and BMI were conducted with separate multiple linear regressions. Results: For every unit increase in mean WBI,life satisfaction, positive emotions and body satisfaction decreased ( : -0.41, -0.27, -0.58 respectively, p<0.001).When stratified by sex, every unit increase in WBI resulted in a decrease in life satisfaction, positive emotionsand body satisfaction in females ( : -0.40, -0.26, -0.70, respectively, p<0.01) whereas only life satisfaction andbody satisfaction decreased in males ( : -0.39, -0.63, respectively, p<0.05). Conclusions: Even when controllingfor BMI, WBI was associated with negative mental health. While men or women who internalize weight bias tendto have less body and life satisfaction, only women's positive emotions were worsened from self-stigma.

keywords: weight bias internalization mental health

Poster # 17

High resolution atlasing of the venous brain vasculature from 7T quantitative susceptibility

Julia Huck, Concordia University/PERFORM centre, Montreal, Canada; Yvonne Wanner; (1, 2) ;Audrey P. Fan; (3) ;Anna-TheklaSchmidt; (4) ;Sophia Grahl; (4); Uta Schneider; (4); Arno Villringer; (4); Christopher J. Steele; (4, 5); Christine L. Tardif; (6, 7);Pierre-Louis Bazin; (4, 8, 9); Claudine J. Gauthier; (1); (1) Concordia University/PERFORM centre, Canada; (2) Universität Stuttgart,Germany; (3) Stanford University, United States; (4) Max Planck Institute for Human Cognitive and Brain Science, Germany; (5) DouglasMental Health University Institute, Canada; (6) McGill University, Canada; (7) Montreal Neurological Institute, Canada; (8) SpinozaCentre for Neuroimaging, Netherlands; (9) Netherlands Institute for Neuroscience, Netherlands

Introduction: The venous vasculature is known to be affected in aging and a variety of diseases, and vascularstructure determines the amplitude of hemodynamic signals. To study the venous vasculature in aging anddisease, a normative venous vascular atlas of young healthy subjects against which these populations can becompared is needed. Between-subject variability in vessel location poses a challenge for the creation of this atlas.

Methods: 16 volunteers were scanned on a 7T MR system using a 0.6mm isotropic gradient echo sequence. Phaseinformation was used to obtain Quantitative Susceptibility Maps (QSM). A multiscale vessel filter [1] was applied[2] to segment veins. Vessel probability and diameter maps were used in a registration pipeline to create the atlas.A skeletonization algorithm was applied to reduce the vein to its centerline. Due to the variability in vessellocation across subjects the resulting centerline was inflated to a 5-30mm radius. Group registration wasperformed using ANTs. To return to the centerline another skeletonization algorithm was applied. This centerlineand average diameter were used to obtain partial volume.

Results & Discussion: This atlas shows the average vessel location and diameter of the group. In this framework,the inflation rate of the level set and the skeletonization parameters are the most important parameters fordetermining which vessels are included in the atlas.

Conclusion: The resulting atlas depicts well the major veins of the brain, but also smaller branches. Thisnormative atlas can be used to study vascular changes in aging and disease.

References:

1. Bazin, P., Plessis, V., Fan, A. P., & Gauthier, C. J. (2016). Vessel segmentation from quantitative susceptibility maps for localoxygenation venography. Isbi, 1-4.

2. Bilgic, B., Fan, A. P., Polimeni, J. R., Cauley, S. F., Bianciardi, M., Adalsteinsson, E.,Wald, L.L., & Setsompop, K. (2014). Fastquantitative susceptibility mapping with L1-regularization and automatic parameter selection. Magnetic Resonance in Medi

keywords: atlas venous vasculature qsm

Poster # 18

GRANNIES PREFER TO PLAY FOR FUN NOT FOR THE BRAIN

Mahsa Mirgholami Mashhad, Dept. Electrical and Computer Engineering,Concordia University; Kate Li; Dept. Psychology,ConcordiaUniversity; Anna Smyrnova; Dept. Mathematics and Statistics, Concordia University; Atousa Assadi; Dept. Electrical and ComputerEngineering, Concordia University; Najmeh Khalili-Mahani; Dept. Design and Computation Arts & PERFORM Centre, ConcordiaUniversity

Playing computer games may be beneficial to the physical, emotional, and cognitive fitness of older adults [1].However, a sustained adoption of games in rehabilitation or preventative strategies for this population must relyon qualitative studies that account their subjective assessments of the benefits of these strategies [2]. In apsychophysiological study to assess the "cognitively beneficial games", we assessed the likelihood of playing"non-beneficial" casual games such as Solitaire, and Dots (block-match puzzle), versus MindGame: Reaction(executive function), Match (short-term memory) and Pattern (executive function+memory). We comparedparticipant's evaluation of the brain training games using the following criteria: Fun (likert scale 1-10),Difficulty(1-10), and the number of times that players chose to play each game. Nineteen seniors (10 women, 70.4(± 4.28) years; 16.8 (± 3.5) years of schooling and high scores of self-efficacy (34.5 (± 2.6), out of 40)participated in the study. ANOVA did not reveal differences in fun F(2,48)=0.011, p>0.8), but differences indifficulty F(2,48)=-0.0006, p<0.0001), with Pattern being the most difficult. Although pre- and post-sessionsurveys indicated positive views of digital-gaming, our sample did not consider playing brain games to beparticularly interesting or beneficial. Instead, they preferred to play digital games for pastime and relaxation. The"non-beneficial" games, Solitaire had the highest number of replays, because it was familiar and relaxing,followed by Dots, because it was moderately challenging and enjoyable. These results indicate that digital gamescan be more beneficial for stress-management than for cognitive training, a design consideration for applicationstargeting this demographic [3].

References:

1. Bleakley, C. M., Charles, D., Porter-Armstrong, A., McNeill, M. D., McDonough, S. M., & McCormack, B. (2015). Gaming forhealth: A systematic review of the physical and cognitive effects . Journal of Applied Gerontology, 34(3), NP166-NP189.

2. Lohse, K., Shirzad, N., Verster, A., Hodges, N., & Van der Loos, H. M. (2013). Video games and rehabilitation: using designprinciples to enhance engagement in physical therapy. Journal of Neurologic Physical Therapy, 37(4), 166-175.

3. Ijsselsteijn, W., Nap, H. H., de Kort, Y., & Poels, K. (2007, November). Digital game design for elderly users. In Proceedings ofthe 2007 conference on Future Play (pp. 17-22). ACM.

keywords: brain training games healthy aging

Poster # 19

Locomotor skills proficiency in second-grade children: Evaluation of a two-year fundamentalmovement skills intervention.

John Alexander Jimenez Garcia, The Athletic Therapy Research Laboratory, Concordia University, Montreal, Canada; Matthew Miller;The Athletic Therapy Research Laboratory, Department of Exercise Science, Concordia University, Montreal, Canada.; Chang Ki Hong;The Athletic Therapy Research Laboratory, Department of Exercise Science, Concordia University, Montreal, Canada.; Richard DeMont;The Athletic Therapy Research Laboratory, Department of Exercise Science, Concordia University, Montreal, Canada.

Background: Fundamental movement skills (FMS) are prerequisite movements for more specialized and complexmovements, which are determinants for lifelong physical activity and sports participation. FMS are classified inlocomotor, balance, and object manipulation skills. FMS proficiency in children is associated with learningexperiences, environmental factors, and has benefits including increased levels of physical activity, avoidingdelays in motor skill development, and obesity prevention. Thus, we are interested in assessing FMS locomotorskills following a targeted activity intervention.

Objective: To assess the locomotor component of FMS between second-grade children who experienced atwo-year FMS intervention, with matched controls.

Study design: Non-randomized trial study design.

Methods: The participants were a convenient sample of second-grade children (n=97). The intervention group(n=48) experienced a two-year FMS intervention, and the control group (n=49) did not experience any FMSintervention. The intervention consisted of a series of games and drills associated FMS programming. Thelocomotor skills assessed were running, skipping, horizontal jump, and one leg hop.

Results: Differences in locomotor skills between the groups were explored by conducting a one-way betweengroups ANOVA. No statically significant differences were found in running, skipping, and horizontal jump (p=0.193, p= 0.248, p= 0.189, respectively); however, one leg hop (F= 23.32, p < 0.05) showed a staticallysignificant difference.

Conclusions: FMS interventions are warranted in early years due to the benefits correlated with FMS proficiency.Sensitive FMS assessment tools should concentrate on avoiding both ceiling and floor effects that may affect theassessment of children's FMS proficiency.

References:

1. Robinson, L. E., Stodden, D. F., Barnett, L. M., Lopes, V. P., Logan, S. W., Rodrigues, L. P., & D'Hondt, E. (2015). Motorcompetence and its effect on positive developmental trajectories of health. Sports Medicine, 45(9), 1273-1284.

2. Barnett, L. M., Stodden, D., Cohen, K. E., Smith, J. J., Lubans, D. R., Lenoir, M., ... & Lander, N. J. (2016). Fundamentalmovement skills: An important focus. Journal of Teaching in Physical Education, 35(3), 219-225.

3. Tompsett, C., Sanders, R., Taylor, C., & Cobley, S. (2017). Pedagogical approaches to and effects of fundamental movement skillinterventions on health outcomes: A systematic review. Sports Medicine, 47(9), 1795-1819. doi:10.1007/s40279-017-0697-z

4. Gallahue, D. L., & Ozmun, J. C. (1998). Understanding motor development: Infants, children, adolescents, adults McGraw-HillHumanities, Social Sciences & World Languages.

5. Burton, A. W., & Miller, D. E. (1998). Movement skill assessment Human Kinetics.

keywords: locomotor skills physical activity children

Poster # 20

COOK TO SUPPORT ELDERY IN MEAL PREPARATION: CLINICIANS PERSPECTIVE

Amel Yaddaden, Université de Montréal; Yaddaden, A. 1, 5 Gagnon-Roy, M. 1,2 Couture, M. 3,4 Lussier, M.1, 5, Belchior, P., Bottari, C.,Pigot, H., Giroux, S., Bier, N. 1,5; ; 1. Université de Montréal; 2. Centre de recherche interdisciplinaire en réadaptation; 3. CIUSSSCentre-Ouest-de-l 'Île-de-Montréal; 4. Université de Sherbrooke; 5. Centre de recherche de l'institut universitaire en gériatrie del'Université de Montréal.

Introduction: Promoting the independence and safety of older adults with cognitive impairment during mealpreparation is a challenge for occupational therapists. Assistive technology, such as COOK, can be a solution forthis problem. Composed of two modules (cognitive assistance and security), COOK offers personalized supporton a touch screen installed at the stove to support autonomy while correcting situations at risk. The purpose of thisstudy is to explore the facilitators and barriers to the use of COOK with elderly people with mild cognitiveimpairment (MCI) or Alzheimer's disease (AD).

Methods: 4 focus groups were conducted with occupational therapists working in psychogeriatric clinical setting(n = 24). The verbatims of these meetings were analyzed according to the qualitative approach of Miles &Huberman .

Results & discussion: Occupational therapists identified different needs and types of intervention according to thediagnosis. The use of COOK would be more beneficial with MCI patients. Occupational therapists identifiedmany barriers for the use of COOK with AD patients, including limited learning abilities and decreased awarenessof deficits. Finally, the integration of this technology as an assessment tool in health care settings was discussed.

Conclusion: The use of COOK to optimize the safety and independence of MCI patients would be achievable. It ishowever necessary to consult the caregivers to be able to adapt it to this clientele.

References:

1. Miles, M. B., & Huberman, M. A. (2014). Analyse des données qualitatives (4 ed.). Paris: De Broeck.

keywords:

Poster # 21

FACILITATING FACTORS AND BARRIERS TO COMMUNITY LIVING FOR ELDERLY AT RISK OFSELF-NEGLECT: PERCEPTION OF THE IMPLICATED ACTORS

Andrée-Anne Phan, Université de Montréal; Bandaly, Soela ; Université de Montréal, Centre de recherche de l'Institut Universitaire degériatrie de Montréal (CRIUGM); ; Couture, Mélanie ; Centre de recherche et d'expertise en gérontologie sociale (CREGÉS), Universitéde Sherbrooke;; Giroux, Sylvain ; Université de Sherbrooke;; Lussier, Maxime ; Université de Montréal, Centre de recherche de l'InstitutUniversitaire de gériatrie de Montréal (CRIUGM); ; Bottari, Carolina ; Université de Montréal, Centre de recherche interdisciplinaire enréadaptation du Montréal métropolitain (CRIR); ; Pigot, Hélène ; Université de Sherbrooke;; Belchior, Patricia ; Centre de recherche del'Institut Universitaire de gériatrie de Montréal (CRIUGM), Université McGill;; Bier, Nathalie ; Université de Montréal, Centre derecherche de l'Institut Universitaire de gériatrie de Montréal (CRIUGM);

Intro: Most of the aging population in a community setting wishes to stay in their homes for the longest timepossible. For the older people at risk of self-neglect, living in the community can be challenging, as theirwellbeing, health and safety can be at stake. The purpose of this study is to explore the facilitators and the barriersto community living for elderly people at risk of self-neglect. Method: Focus groups were conducted with casemanagers (n=2), heads of department (n=6) and professionals (n=8) from the CIUSSSCentre-Sud-de-l'Île-de-Montréal. The verbatims of these meetings were analyzed according to the qualitativeapproach of Miles & Huberman. Results: The principal barriers identified were the social isolation, the presenceof cognitive decline, the fear of being relocated, the attitude of the caregivers and the lack of stability in the careservices and of the knowledge about the services. The identified facilitators are the support of the caregiver andthe trust bond with the professionals. Conclusion: The results of this study will help clinicians and researchers toidentify the factors influencing the home support of community dwelling elderly at risk of self-neglect in order tomaximize their safety and independence at home.

References:

1. Ministère de la santé et des services sociaux. (2003) Chez soi: Le premier choix. La politique de soutien à domicile., Québec,Canada

2. Papaioannou, E.-S. C., Räihä, I., & Kivelä, S.-L. (2012). Self-neglect of the elderly. An overview. The European journal of generalpractice, 18(3), 187-190

3. Miles, M. B. (2014). Qualitative data analysis : a methods sourcebook (Edition 3.. ed.): Los Angeles : SAGE

keywords: self neglect community elderly facilitator

Poster # 22

Analyzing male and female hockey players during a stop-and-go transition skating task

Aiden Hallihan, McGill University; Philippe Renaud; Department of Kinesiology & Physical Education, McGill University; ShawnRobbins; School of Physical and Occupational Therapy, McGill University; David Pearsall; Department of Kinesiology & PhysicalEducation, McGill University

Stop/start movements are fundamental and frequent tasks in ice hockey, yet the mechanisms are poorlyunderstood (Bracko, Fellingham, Hall, Fisher, & Cryer, 1998). Rapid dynamic changes in direction are associatedwith hip and knee non-contact injuries, with greater incidence rate in females than males (Abbott 2014; Agel &Harvey 2010). Sex differences have been seen in other sport contexts (e.g., soccer, basketball) during jumping andrun cutting tasks in strength and movement techniques. Therefore, the goal of this study was to assess lower bodymovement patterns of male and female skaters' during a stop & go transition task. Twenty elite ice hockey players(11 female, 9 male) completed the task performing left and right stops 3 times each. Skaters' full-body kinematic,skate landing forces, and lower body surface electromyography measures were collected while the participantsskated forward and performed a parallel blade stop then accelerated back in the return direction. Preliminaryspatiotemporal results indicate there is a significant main effect (p<0.05) for male and female pre and post peakstop skating velocities. Males have a significantly greater stop distance compared to females (p<0.05); however,the time to complete the stop is non-significant (p>0.05). Visual inspection of video trials indicate medial kneedrop on the outer leg of the stop occur in both sexes. Full analysis of all dependent variables measures will bepursued. Study findings may guide gender specific strength and technique training interventions to improveperformance and reduce hip and/or knee injury risks.

References:

1. Abbott, K. (2014). Injuries in women's ice hockey: special considerations. Current Sports Medicine Reports, 13(6), 377-82.2. Agel, J., & Harvey, E. J. (2010). A 7-year review of men's and women's ice hockey injuries in the NCAA. Canadian Journal of

Surgery 53(5), 319-324.3. Bracko, M. R., Fellingham, G. W., Hall, L. T., Fisher, A. G., & Cryer, W. (1998). Performance skating characteristics of

professional ice hockey forwards. Sports Medicine, Training and Rehabilitation, 8(3), 251-263.

keywords: skating emg kinematics injury force

Poster # 23

Impact of availability of context on speech perception under noisy conditions

Jean-Louis Rene, Concordia University; Alexandre Chauvin & Natalie Phillips, Concordia University

Listening to someone speak is a complex task even under the best circumstances. Additionally, ideal listeningenvironments are rare; individuals often listen to speech in noisy environments. Fortunately, compensatorystrategies exist. For example, visual speech cues (e.g. lip movements) are well known to improve speechperception in poor listening conditions. Similarly, listeners can use contextual cues (e.g., lexical and semanticinformation) to disambiguate speech. These compensatory strategies are well documented for native listeners;however, not much is known about their use by non-native listeners. In this study, we investigated how youngbilingual adults benefit from visual speech cues and contextual information in their first and second language(L2). We assessed accuracy in a group of French-English/English-French bilinguals on a speech perception taskin which they had to repeat the terminal word of sentence stimuli with context (e.g., Lionel was planting the tree)or no context (e.g., She was glad to see the tree). The sentences stimuli were presented in noise, in both languagesand in different modalities: visual only, auditory only, and audio-visual. We also assessed the participants' L2proficiency with self-reported measures, a fluency task and a living/non-living task. Preliminary results indicatehigher accuracy when sentence context and visual speech cues are available, suggesting that using visual speechcues and contextual information benefit speech perception in noise in L2; however, there is variability in theextent of this benefit. Upcoming analyses will focus on the impact of proficiency on the ability to use thesecompensatory strategies.

References:

1. Burfin, S., Pascalis, O., Ruiz Tada, E., Costa, A., Savariaux, C., & Kandel, S. (2014). Bilingualism affects audiovisual phonemeidentification. Frontiers in Psychology, 5, 1-9.

2. Golestani, N., Rosen, S., & Scott, S. K. (2009). Native-language benefit for understanding speech-in-noise: The contribution ofsemantics. Bilingualism-Language and Cognition, 12, 385-392.

3. Kaandorp, M. W., De Groot, A. M. B., Festen, J. M., Smits, C., & Goverts, S. T. (2016). The influence of lexical-access ability andvocabulary knowledge on measures of speech recognition in noise. International Journal of Audiology, 55, 157-167.

4. Lecumberri, M. L. G., Cooke, M., & Cutler, A. (2010). Non-native speech perception in adverse conditions: A review. SpeechCommunication, 52, 864-886.

5. Ross, L. A., Saint-Amour, D., Leavitt, V. M., Javitt, D. C., & Foxe, J. J. (2007). Do you see what I am saying? Exploring visualenhancement of speech comprehension in noisy environments. Cerebral Cortex, 17, 1147-1153.

keywords: bilinguilism speech perception everyday environments

Poster # 24

Association between psychiatric disorders and vulnerability to stress-related asthma attacks

Claudia Gemme, Université du Québec à Montréal (UQÀM); Claudia Gemme; Montreal Behavioural Medicine Centre, CIUSSS-NIM,Department of Psychology, Université du Québec à Montréal (UQÀM), Simon L. Bacon; Montreal Behavioural Medicine Centre,CIUSSS-NIM, Department of Exercise Science, Concordia University, Anda Dragomir; Montreal Behavioural Medicine Centre,CIUSSS-NIM, Department of Psychology, Université du Québec à Montréal (UQÀM), Kim L. Lavoie; Montreal Behavioural MedicineCentre, CIUSSS-NIM, Department of Psychology, Université du Québec à Montréal (UQÀM)

Background: Psychiatric disorders (e.g. depressive and anxiety disorders) are common in patients with asthmaand linked to worse asthma control. Understanding whether patients with psychiatric disorders are morevulnerable to "stress-related" asthma exacerbations may help explain part of the mechanism for poorer control.This study explored associations between psychiatric disorders and a tendency to experience "stress-related"asthma attacks in adults with asthma.

Methods: A total of 797 adults with physician-diagnosed asthma participating in the Psychosocial andBehavioural Risk Factors for Asthma Longitudinal (PAL) study underwent medical, psychiatric (PRIME-MD)and socio-demographic interviews at baseline. Odds Ratios were calculated to assess the relationship betweenpsychiatric disorders (mood, anxiety) and reporting stress as an asthma trigger, with age, sex and asthma control(ACQ score) as covariates.

Findings: Significant main effects of mood (OR= 2.1, 95 CIs:1.3-3.3) and anxiety (OR 2.3, 95 CI:1.5-3.7)disorders on the likelihood of reporting stress as a trigger of asthma exacerbations were observed. Havingcomorbid mood and anxiety disorders was also related to a 4.6-fold increase (OR= 4.6, 95 CIs:2.5-8.6) in thelikelihood of reporting stress as a trigger.

Discussion: Findings suggest that mood and anxiety disorders alone and in combination may increasesusceptibility to stress-induced asthma attacks. These findings highlight the need for further studies examiningexplanatory mechanisms including autonomic arousal and bronchoconstriction and to determine ifstress-management interventions in this population could improve outcomes.

References:

1. GINA Dissemination Committee (2003). Dissemination and Implementation of Asthma Guidelines. Global Initiative For Asthma.2. McCoy K, Shade DM, Irvin CG, Mastronarde JG, Hanania NA, Castro M, Anthonisen NR. (2006). Predicting episodes of poor

asthma control in treated patients with asthma. Journal of Allergy and Clinical Immunology. Volume 118 : 1226.3. Chapman KR, Ernst P, Grenville A, Dewland P, Zimmerman S. (2001). Control of asthma in Canada: failure to achieve guideline

targets. Can Resp J. Volume 8 Suppl A:35A-40A.4. Chapman KR, Boulet LP, FitzGerald MJ, McIvor RA, Zimmerman S. (2005). Patient Factors Associated with Suboptimal Asthma

Control in Canada: Results from the Reality of Asthma Control Study. Am J Respir Crit Care Med. Volume 172: A678.5. Lavoie, K. L., Bacon, S. L., Barone, S., Cartier, A., Ditto, B., & Labrecque, M. (2006). What is worse for asthma control and

quality of life: depressive disorders, anxiety disorders, or both?. Chest, 130(4), 1039-1047.

keywords: asthma psychiatric disorders stress

Poster # 25

Do body composition phenotypes improve cardiometabolic risk prediction above weight statusalone?

Martha Zaverdinos, Department of Mathematics and Statistics, Concordia University; Jessica Murphy; Department of Exercise Science,Concordia University; Sylvia Santosa; Department of Exercise Science, Concordia University; Lisa Kakinami; Department of Mathematicsand Statistics, Concordia University, and PERFORM Centre, Concordia University

Background:

Accounting for lean and fat mass via dual-energy X-ray absorptiometry (DXA) is a better health predictor thanbody mass index (BMI). More recently, classifying lean and fat mass proportions into phenotypes based on sex-,age- and weight-status (normal-weight, overweight, obese) specific reference curves have been proposed.

Objectives:

Determine whether phenotypes from (1) sex- and age-stratified, and (2) sex-, age-, and weight status stratifiedreference curves will significantly improve prediction of cardiometabolic risk factors above weight status (frommeasured BMI) alone.

Methods:

Data were from the 1999-2006 NHANES dataset. Following Prado et al.'s methodology, phenotypes wereclassified into one of four quadrants based on high/low muscle/adiposity DXA measures. Dependent variableswere cardiometabolic risk factors (total, HDL, and LDL cholesterol, triglycerides, and insulin sensitivity[HOMA-IR, QUICKI]). Separate multiple regressions were conducted with three models (Model1: weight status;Model2: Model1+ sex- and age- based phenotypes; Model3: Model1+ sex-, age- and weight status basedphenotypes). All models were sex-stratified, (n= 2682 females, 2996 males) and took into account the complexsurvey design alongside weighting. Fit statistics compared the two sets of nested models (Model1 vs. Model2, andModel1 vs. Model3)

Results:

Model fit for Model2 was consistently preferable to Model1 for all outcomes (all p<0.05). Model3 did notsignificantly improve identification of insulin sensitivity outcomes.

Conclusion:

Body composition phenotypes based on sex- and age- reference curves were consistently better in predictingcardiometabolic risk, but phenotypes additionally classified based on weight status reference curves may notimprove identification of insulin sensitivity than BMI alone.

References:

1. Prado, C. M., Siervo, M., Mire, E., Heymsfield, S. B., Stephan, B. C., Broyles, S., . . . Katzmarzyk, P. T. (2014). Population-basedapproach to define body-composition phenotypes, The American Journal of Clinical Nutrition, Volume 99(Issue 6), 1369-1377.

keywords:

Poster # 26

Accelerating Reproducibility Estimations with Collaborative Filtering

Soudabeh Barghi, Concordia University; Tristan Glatard; Department of Computer Science and Software Engineering, ConcordiaUniversity, Montréal, Québec, Canada

We investigate the computational reproducibility of Big Data analyses, which can be disrupted by differentcompilation and execution environments as well as variations in hardware architectures and software versions [1].We aim at reducing the number and duration of executions required to estimate the computational reproducibilityof analysis pipelines on large databases.

We model the problem as a Collaborative Filtering (CF) problem, where underlying utility matrix represents thereproducibility of the files generated during pipeline execution over data acquired in different subjects. We focusin particular on the data and pipelines of the Human Connectome project (HCP), a project that maps human braincircuits and their behavioral connection in a large population of healthy adults [2]. The overall workflow forpreprocessing and data analysis in the HCP consists of structural and functional pipelines [3]. This study used thefiles generated through structural PreFreeSurfer pipeline in three different versions of operating system (CentOS5,CentOS6, CentOS7) for 94 brain subjects.

The results show that among all provided selection methods for determining the training set, random strategieslead to more accurate predictions than deterministic methods. In detail, random-triangular-bias-L method with theaim of fitting training set by applying random triangular distributions, surpasses all other random selectionmethods (with accuracy of 0.98 and training size of 40 ).

References:

1. Glatard, T., Lewis, L. B., Ferreira da Silva, R., Adalat, R., Beck, N., Lepage, C., ... & Khalili-Mahani, N. (2015). Reproducibility ofneuroimaging analyses across operating systems. Frontiers in neuroinformatics, 9, 12.

2. Van Essen, D. C., Smith, S. M., Barch, D. M., Behrens, T. E., Yacoub, E., Ugurbil, K., & Wu-Minn HCP Consortium. (2013). TheWU-Minn human connectome project: an overview. Neuroimage, 80, 62-79.

3. Glasser, M. F., Sotiropoulos, S. N., Wilson, J. A., Coalson, T. S., Fischl, B., Andersson, J. L., ... & Van Essen, D. C. (2013). Theminimal preprocessing pipelines for the Human Connectome Project. Neuroimage, 80, 105-124.

keywords: reproducibility recommender system collaborative filtering

Poster # 27

Oxygen metabolism within hubs of resting-state brain functional connectivity

Fatemeh Razavipour, PERFORM Centre/Department of Physics, Concordia University, Montreal, Canada,; Kangjoo Lee* 2,3; ClaudineJoëlle Gauthier1; Christophe Grova1,2,3; ; 1 PERFORM Centre/Department of Physics, Concordia University, Montreal, Canada;fatemeh.razavipour@concordia.ca; 2 Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University,Montreal, Canada; ; 3Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montreal, Canada; ;* Both authors contributed equally

Connector hubs are highly functionally connected regions of the brain, lying at the core of the brain's mainconnections. Hubs perform a crucial role in maintaining networks robustness and global information integration[1]. In this study, we localized the functional connector hubs from individual resting state functional MRI data;using a method recently developed by our group: Sparsity-based Analysis of Reliable K-hubness (SPARK).SPARK allows estimating the number of functional networks associated to each voxel(K-hubness) as well as theunique possibility to identify what are the networks associated to each hub [2]. On the other hand, we estimatedbaseline cerebral metabolic rate of O2 CMRO2 and the oxygen extraction fraction (OEF) using an Arterial spinlabeling (ASL) method combined with generalized Quantitative O2 imaging (QUO2) MRI technique [3]. ThisMRI-based method using hyperoxic and hypercapnic gas manipulations estimate resting arterial O2 content andresting OEF map, which derived from functional relationships between the resting BOLD signal M, and relativechange of OEF. Multiplying the resting OEF Map, resting arterial O2 content, and the resting CBF map from ASLprovides a map of the resting CMRO2. We are presenting preliminary data obtained on two 25-30 years oldhealthy subjects, for whom SPARK method was applied to extract hubs and baseline CMRO2 and OEF wereestimated. These results showed power law model of the relationship between K-hubness and their correspondingoxygen metabolism, and thus provided for the first time a characterization of resting state oxygen consumptionefficiency of hubs when compared to non-hubs regions.

References:

1. Van den Heuvel, M.P., Sporns, O., 2011. Rich-club organization of the human connectome. The Journal of neuroscience 31,15775-15786.

2. Lee, K., Lina, J. M., Gotman, J., & Grova, C. (2016). SPARK: Sparsity-based analysis of reliable k-hubness and overlappingnetwork structure in brain functional connectivity. NeuroImage, 134, 434-449.

3. Gauthier, C.J., Hoge, R.D., (2012). Magnetic resonance imaging of resting OEF and CMRO2 using a generalized calibrationmodel for hypercapnia and hyperoxia. Neuroimage 60, 1212-1225.

keywords: brain metabolism cerebral metabolic rate

Poster # 28

Resting state patterns measured with Magnetoencephalograpy: Biomarkers for surgicaloutcome in epilepsy?

Ümit Aydin, Dpt. of Physics and PERFORM Centre, Concordia University; Ümit Aydin; Dpt. of Physics and PERFORM Centre,Concordia University, Montreal, Canada ; Giovanni Pellegrino; Biomedical Engineering Dpt., McGill University; Neurology andNeurosurgery Dpt., Montreal Neurological Institute, McGill University, Montreal, Canada; Obaï Bin Ka'b Ali; Dpt. of Physics andPERFORM Centre, Concordia University, Montreal, Canada; Jean-Marc Lina; Département de Génie Electrique, École de TechnologieSupérieure; Centre De Recherches En Mathématiques, Montreal, Canada; Eliane Kobayashi; Neurology and Neurosurgery Dpt., MontrealNeurological Institute, McGill University, Montreal, Canada; Christophe Grova; Dpt. of Physics and PERFORM Centre, ConcordiaUniversity; Biomedical Engineering Dpt., McGill University; Neurology and Neurosurgery Dpt., Montreal Neurological Institute, McGillUniversity, Montreal, Canada

In the present study, we investigated whole brain resting state functional connectivity differences betweenseizure-free (SF) and non-SF epilepsy patients using Magnetoencephalography (MEG) data acquired prior tosurgery.

MEG data from 13 focal epilepsy patients were analyzed. After surgery seven patients became SF and six werenon-SF. For each patient, epileptic discharges were localized using coherent Maximum Entropy on the Mean(cMEM) [1] and a focus region-of-interest (ROIFoc) was identified accordingly. For each patient, an homologouscontralateral ROI (ROIHom) of the same size was drawn manually to serve as reference. For resting stateconnectivity analysis, 20 two-second-long epochs without any epileptic discharges or artifacts were first selected.MEG sources were localized within the alpha-band (8-13Hz) using wavelet-based MEM [2]. Orthogonalamplitude envelope correlation maps (AEC maps) [3] between all vertices on cortical surface and each vertex ofthe selected ROI were calculated and averaged, resulting in a single seed based connectivity map for each ROI.

Whole cortex AEC maps were exhibiting smaller spatial extent for ROIFoc when compared to ROIHom for sixout of seven SF patients. In contrast, for all non-SF patients, AECs for ROIFoc were showing more extendedmaps when compared to ROIHom as a seed.

Our results suggest that an epileptic focus isolated from the rest of the brain, would likely be associated with agood surgical outcome, whereas, an epileptic focus associated with a widespread infiltrating resting state network,would be associated with poor surgical outcome, suggesting the need to develop other therapeutic approachesthan focal resection.

References:

1. Chowdhury RA, Pellegrino G, Aydin Ü, Lina JM, Dubeau F, Kobayashi E, Grova C. Reproducibility of EEG-MEG fusion sourceanalysis of interictal spikes: Relevance in presurgical evaluation of epilepsy. Hum Brain Mapp. 2018 Feb;39(2):880-901.

2. Lina JM, Chowdhury R, Lemay E, Kobayashi E, Grova C. Wavelet-based localization of oscillatory sources frommagnetoencephalography data. IEEE Trans Biomed Eng. 2014 Aug;61(8):2350-64.

3. Hipp JF, Hawellek DJ, Corbetta M, Siegel M, Engel AK. Large-scale cortical correlation structure of spontaneous oscillatoryactivity. Nat Neurosci. 2012 Jun;15(6):884-90.

keywords: resting state functional connectivity meg

Poster # 29

A MULTIMODAL PREHABILITATION PROGRAM IN HEPATO-PANCREATO-BILIARY CANCERPATIENTS AWAITING SURGERY: PRELIMINARY RESULTS

Popi Kasvis, McGill Nutrition and Performance Laboratory; Popi Kasvis; McGill Nutrition and Performance Laboratory, Supportive andPalliative Care Division, McGill University Health Centre, Montreal, Quebec, Canada; Tram Bui; McGill Nutrition and PerformanceLaboratory, McGill University Health Centre, Department of Exercise Science, Concordia University, Montreal, Quebec, Canada; RobertD. Kilgour; McGill Nutrition and Performance Laboratory, McGill University Health Centre, Department of Exercise Science, ConcordiaUniversity, Montreal, Quebec, Canada; Franco Carli; Department of Anesthesia, McGill University Health Centre, Montreal, Quebec,Canada; Anotnio Vigano; McGill Nutrition and Performance Laboratory, Supportive and Palliative Care Division, McGill UniversityHealth Centre, Montreal, Quebec, Canada

Purpose: Multimodal prehabilitation programs have been successful in improving postoperative functionaloutcomes in cancer patients undergoing surgery. To date, little is known about the effect of prehabilitation onhepato-pancreato-biliary cancer (HPBC) patients.

Objectives: To determine postoperative functional outcomes in HPBC patients following a multimodalprehabilitation program.

Methodology: Patients were randomized to either prehabilitation (prehab) or rehabilitation (rehab). Both groupsreceived an exercise, nutrition and relaxation program; the prehab group received these interventions 4-weeksbefore surgery, the rehab group just after surgery. Primary outcome was change in six-minute walk test distance(6MWTD).

Results: To date, 11 patients have completed the program; 5 prehab, 6 rehab. Mean age was 55.3 ± 14.2 y. Sixpatients had a diagnosis of pancreatic cancer, 5 had either primary or metastatic liver cancer. Mean 6MWTD atbaseline was 543.8 ± 90.5 m, with no significant differences between groups (p=0.34). Mean appendicularskeletal muscle index was below cutoffs for both men (7.06 ± 1.40 kg/m2) and women (5.43 ± 0.42 kg/m2), withno significant differences between groups (p=0.14). Four-weeks postoperatively, the average decrease in 6MWTDin the rehab group was almost doubled (prehab: -32.7 ± 17.8 m, rehab: -65.6 ± 17.6 m) and statistically differentfrom baseline (p=0.01). After 8 weeks, the prehab 6MWTD exceeded baseline (4.0 ± 17.8 m). The rehab groupfailed to return to baseline (-14.6 ± 17.6 m).

Conclusion: Our preliminary results suggest HPBC patients awaiting surgery have high function, but low musclemass. Prehabilitation may limit postoperative functional decline in HPBC patients.

References:

1. Minnella, E. M., Bousquet-Dion, G., Awasthi, R., Scheede-Bergdahl, C., & Carli, F. (2017). Multimodal prehabilitation improvesfunctional capacity before and after colorectal surgery for cancer: a five-year research experience. Acta Oncologica, 56(2),

keywords: prehabilitation surgery cancer

Poster # 30

Incorporating Temporal Priors in Time-Delay Estimation in Ultrasound Elastography

Md Ashikuzzaman, Department of ECE, Concordia University, Montreal, QC, H3G1M8, Canada; Md Ashikuzzaman; Department ofElectrical and Computer Engineering, Concordia University, Montreal, QC, H3G 1M8, Canada ; Claudine Gauthier; Department ofPhysics, Concordia University, Montreal, QC, H4B 1R6, Canada; Hassan Rivaz; Department of Electrical and Computer Engineering,Concordia University, Montreal, QC, H3G 1M8, Canada

Objectives: Ultrasound Elastography, a non-invasive imaging technique to infer mechanical properties of tissue isincreasingly being used for diagnosis, image-guided surgery and numerous other clinical applications. Thoughoptimization based elastography methods are less sensitive to signal decorrelation due to spatial regularization,temporal continuity has been little used so far. Here we propose a global optimization-based ultrasoundelastography technique considering spatial and temporal regularization priors to make the elastograms robust tonoise and signal decorrelation. We call this algorithm temporal GLobal Ultrasound Elastography (tGLUE).

Methods: Let, I1, I2 and I3 be three consecutive Radio-Frequency (RF) frames. Displacement prior from frame I1to I2 and I2 to I3 are obtained from Dynamic Programming [1]. To estimate subsample displacement field, weconstruct a cost function including data terms, spatial continuity terms and temporal continuity terms. The dataterm, spatial continuity terms and temporal regularization terms are based on data intensity similarity, similarityof displacement values between adjacent pixels and similarity of displacement of a sample between frames intemporal domain. Subsample displacement field from minimization of this cost function is added up with initialguess and spatial differentiation is performed to generate axial strain map.

Results: Improvement of SNR and CNR in tGLUE from GLUE [2] are 39.82 and 53.04 for simulation data,102.15 and 60.92 for phantom data, 163.49 and 123.93 for in-vivo liver data respectively.

Conclusion: An elastography algorithm is presented which incorporates three RF frames along with spatial andtemporal continuity priors. The proposed algorithm is more robust to signal decorrelation than the previousalgorithms.

References:

1. Rivaz, H., Boctor, E. M., Choti, M.A., & Hager, G. D. (2011). Real-Time Regularized Ultrasound Elastography. IEEETransactions on Medical Imaging, 30(4), 928-945.

2. Hashemi, H. S., & Rivaz, H. (2017). Global Time-Delay Estimation in Ultrasound Elastography. IEEE Transactions onUltrasonics, Ferroelectrics, and Frequency Control, 64(10), 1625-1636.

keywords: elastography temporal prior spatial prior

Poster # 31

Dynamic functional brain connectivity differences between schizophrenia and healthy controlsubjects using resting-state fMRI

Fatemeh Mohammadi, Concordia University; Fatemeh Mohammadi, Concordia University; M.O. Ahmad, Concordia University; M.N.SSwamy, Concordia University

Studying functional brain connectivity using resting-state fMRI has led to finding the differences in the brainfunctionality of healthy people and people affected by some psychiatric brain disorders.

Data-driven methods for analyzing fMRI functional connectivity have attracted more attention in researchcommunity in recent years, since these methods requires no prior selection of the brain region. The mostcommonly used method to achieve such a decomposition is independent component analysis.

Independent component analysis (ICA) method is employed to decompose the fMRI image into maximallyindependent components and their corresponding time courses. Time courses can be analyzed in many ways tocapture the brain connectivity. Correlation between time courses provide information related to brain functionalnetwork.

First investigations based on resting-state functional connectivity assumed the correlations are unchanging or"static" throughout the length of a recording of a few minutes. Hence, it is usually referred to static functionalconnectivity in literatures.

Recent analysis revealed that the temporal correlations between remote brain regions vary with time. In view ofthis, time-varying approaches using a sliding time window has been exploited for investigating the functionalconnectivity that varies in time. In this work, different brain connectivity patterns, called 'states' in theresting-state fMRI are identified by applying deep learning-based clustering method using convolutionalautoencoder on covariance matrices of all time-course windows. By investigating these states and their dynamicbehavior for each subject, we have shown group difference in dynamic brain connectivity between HC and SCZgroups.

References:

1. V. D. Calhoun, T. Adali, "Time-Varying Brain Connectivity in fMRI Data Whole-brain data-driven approaches for capturing andcharacterizing dynamic states", IEEE Signal Processing Magazine, 2016; vol(33): pp. 52-66.

2. E. A. Allen, E. Damaraju, S. M. Plis, E. B. Erhardt, T. Eichele and V. D. Calhoun, "Tracking whole-brain connectivity dynamics inthe resting state", Cerebral cortex, 2014; vol(24): pp. 663-676.

3. R. M. Hutchison, T. Womelsdorf, E. A. Allen, P. Bandettini, V. D. Calhoun, M. Corbetta, S. D. Penna, J. H. Duyn, "Dynamicfunctional connectivity: Promise issues and interpretations", NeuroImage, 2013; vol(80): pp. 360-378.

4. J. Masci, U. Meier, D. Ciresan, J. Schmidhuber, "Stacked convolutional auto-encoders for hierarchical feature extraction".International Conference on Artificial Neural Networks, 2014, pp. 52-59.

keywords: dynamic brain connectivity ica autoencoder

Poster # 32

Associations Between Leisure Time Physical Activity And Depressive Symptoms In PatientsWith Asthma

Mélanie Béland, Concordia; Béland, Mélanie, PhD; Concordia University/INRS; Lavoie, Kim L., PhD; UQAM; Bacon, Simon L.;Concordia University

Background: Depression is common in asthma patients and can have a negative impact on asthma outcomes, suchas asthma control. Physical activity has been shown to reduce depressive symptoms and asthma symptoms.However, there is limited data on the association between physical activity and depression in adult asthmatics.

Objective: Assess the cross-sectional relationship between leisure time physical activity and depressive symptomsin adult asthmatics.

Methods: A total of 953 adult patients with objectively confirmed asthma from two asthma cohorts (PAL: n=640,mean age (SD)=49 (14) years, 60 women; and RESP: n=513, mean age (SD)=53 (16) years, 64 women) wereincluded. All patients completed the Beck Depression Inventory (BDI) and a physical activity questionnaire toassess leisure time physical activity (LTPA), as well as a measure of asthma control (Asthma ControlQuestionnaire, ACQ).

Results: Engaging in any LTPA was associated with lower levels of depressive symptoms in adult asthmatics(ß=-1.272, p = 0.008). Moreover, in patients with high levels of depressive symptoms, engaging in vigorousLTPA was related to lower levels of depressive symptoms (ß=-0.819, p = .040). These relationships were notstatistically significant after adjustment for inhaled corticosteroid (ICS) dose and asthma control.

Conclusions: Results indicate that engaging in any LTPA is associated with lower levels of depressive symptomsand it seems to have a stronger effect in adult asthmatics who have moderate to severe depressive symptoms.However, future studies are needed to better understand the role of asthma control and ICS in the relationshipbetween physical activity and depression.

References:

1. De Mello, M.T., de Aquino Lemos, V., Antunes, H.K.M., Bittencourt, L., ... Tufik, S. (2013). Relationship between physical activityand depression and anxiety symptoms: a population study. Journal of Affective Disorders, 149(1), 241-246.

2. Dunn, A. L., Trivedi, M. H., Kampert, J. B., Clark, C. G., & Chambliss, H. O. (2005). Exercise treatment for depression: efficacyand dose response. American Journal of Preventive Medicine, 28(1), 1-8.

3. Bacon, S.L., Lemiere, C., Moullec, G., Ninot, G., ... Lavoie, K. L. (2015). Association between patterns of leisure time physicalactivity and asthma control in adult patients. BMJ open respiratory research, 2, e000083. doi:10.1136/bmjresp-2015-000083

keywords: exercise depression asthma depressive symptoms

Poster # 33

Effect of an orthopedic insole on ankle stability in ice skating

Étienne Marquis, École de technologie supérieure; Stéphanie Bergeron; Centre collégial de transfert de technologie du Cégep régional deLanaudière à Terrebonne, INÉDI; Félix Chénier; Université du Québec à Montréal

Postural alignment and stability are important factors contributing to injury prevention in ice skating. However,only a few studies evaluated the biomechanical effect of the foot placement relative to the blade on the stability ofthe ankle. The purpose of the present study was to measure the effect of a newly developed orthopedic insole onankle stability in ice skating. Seven male and three female ice hockey and figure skating athletes, from 20 to 58years old, performed forward on-ice skating with and without the experimental insole. The skaters' center ofpressure (COP) was measured using pressure sensor instrumented insoles (F-Scan, Tekscan Inc.). The root meansquare difference (RMSD) between the COP and the skate's blade was then computed. Optimal stability is relatedto a low RMSD, i.e. when the skater's COP is collinear with the blade of the skate. The use of the experimentalinsole allowed the skaters' COP to be closer to the blade of the skate (RMSD = 3.8 ± 2.0), which is related to ahigher level of ankle stability compared to the usage of the default sole (RMSD = 8.8 ± 4.0). These findingssuggest that the experimental insole could contribute to injury prevention in ice skating.

References:

1. Dingenen, Bart; Malfait, Bart; Nijs, Stefaan; Peers, Koen H.E.; Vereecken, Styn; Verschueren, Sabine M.P.; Janssens, Luc; Staes,Filip F.;. (2016). Postural Stability During Single-Leg Stance: A Preliminary Evaluation of Noncontact Lower Extremity Injury

2. Willson, JD; Dougherty, CP; Ireland, ML; Davis, IM;. (2005, September 13). Core stability and its relationship to lower extremityfunction and injury. Retrieved March 22, 2018, from Pubmed: https: www.ncbi.nlm.nih.gov/pubmed/16148357

keywords: biomechanics orthopedics skating stability prevention

Poster # 34

Title: A Postural Paradigm for the Dual Mechanisms of Control Model

Laurence Lai, Concordia University; Kesaan Kandasamy, Concordia University; Dr. Nancy St-Onge, Concordia University ; Dr. Karen Z.H. Li, Concordia University

Relative to young adults (YA), older adults (OA) show an enhanced fall risk (Studenski, 2011). This fall risk maybe attributable to age-related declines in executive functions (Mirelman et al., 2012). However, the precisemechanisms of executive functions involved in postural control remain to be identified. The literature consistentlyreveals age-related deficits in attention, inhibition, and working memory (WM). These deficits are subsumed inBraver's (2012) Dual Mechanisms of Control (DMC) model, which describes two modes used to manageinterference: proactive control (PC) and reactive control (RC). PC is a cognitively taxing, anticipatory,WM-dependent mode used to preemptively resolve an interference event. On the other hand, RC is a latecorrective response that is reactive to a stimulus. Given pronounced normative decline in working memory, OAtend to exhibit RC more than PC. To apply the DMC model in a gross motor context, the AX ContinuousPerformance Task (AX-CPT; Braver et al., 2001) was adapted to a cued perturbation paradigm in which theX-probe became a platform movement. Using electromyography (peak amplitude), PC and RC were indicated bythe proportion of anticipatory postural responses (APR) to compensatory postural responses (CPR). Adopting amixed subject design, healthy OA and YA (n = 4, 4) were tested. Effect size analyses suggest that, compared toYA, OA exhibit higher CPR than APR in AX trials (R2 = .353, medium ES), replicating past patterns ofresponses in the fine motor AX-CPT on degraded PC in OA.

References:

1. Braver, T. S., Barch, D. M., Keys, B. A., Carter, C. S., Cohen, J. D., Kaye, J. A., & Jagust, W. J. (2001). Context processing inolder adults: evidence for a theory relating cognitive control to neurobiology in healthy aging. Journal of Experimental

2. Braver, T. S. (2012). The variable nature of cognitive control: A dual mechanisms framework. Braver, T. S. (2012). The variablenature of cognitive control: a dual mechanisms framework. Trends in Cognitive Sciences, 16(2), 106-113.

3. Mirelman, A., Herman, T., Brozgol, M., Dorfman, M., Sprecher, E., Schweiger, A., & Hausdorff, J. M. (2012). Executive functionand falls in older adults: new findings from a five-year prospective study link fall risk to cognition. PLoS One, 7(6), e402

4. Studenski, S., Perera, S., Patel, K., Rosano, C., Faulkner, K., Inzitari, M., & Nevitt, M. (2011). Gait speed and survival in olderadults. JAMA, 305(1), 50-58.

keywords: cognitive aging cognitive control gross

Poster # 35

Regional Adipose Tissue Immune Cell Profiles in Childhood-Onset and Adult-Onset Obesity

Jessica Murphy, Department of Exercise Science, Concordia University, Montreal, QC, Canada; Vi Dam; Department of Exercise Science,Concordia University, Montreal, QC, Canada; Kerri Delaney; Department of Exercise Science, Concordia University, Montreal, QC,Canada; José A. Morais; Division of Geriatric Medicine, McGill University, Montreal, QC, Canada; Michael Tsoukas; Division ofEndocrinology and Metabolism, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada; Sylvia Santosa;Department of Exercise Science, Concordia University, Montreal, QC, Canada

Background: We do not understand why individuals who have had obesity since childhood are at increased risk ofmetabolic disease. It is plausible that a pro-inflammatory adipose tissue environment may play a role.

Objective: To examine the effects of obesity onset and adipose tissue region (upper vs. lower body) on theproportion of adipose tissue immune cells.

Methods: We used flow cytometry to quantify the proportion of immune cells in the stromovascular fraction ofabdominal (AB) and femoral (TH) subcutaneous adipose tissue from adults with childhood-onset (n = 16; age =30.5 ± 3.8 years; body mass index = 34.1 ± 3.0 kg/m2) and adult-onset (n = 22; age = 30.2 ± 3.1 years; body massindex = 32.4 ± 2.7 kg/m2) obesity.

Results: The proportion of CD8+CD3+ T-cells was greater in AB than TH in childhood-onset obesity, whilegreater in TH than AB in adult-onset obesity. There was no effect of obesity onset on other immune cell types.However, there was an overall effect of region where the proportion of CD45RA+CD8+CD3+ T-cells was greaterin TH than AB, and the proportion of CD206+CD68+ M2-like macrophages was greater in AB than TH.

Conclusion: Our results show that there are regional differences in the adipose tissue immune cell profilesbetween individuals with childhood-onset and adult-onset obesity. It remains to be seen whether these differencesare implicated in increasing the risk of metabolic disease.

keywords: obesity adipose tissue flow cytometry

Poster # 36

Are Headforms A Poor Surrogate for Helmet Fit?

Kristie Liu, McGill University; Daniel I. Aponte; McGill University; David J. Greencorn; McGill University; Shawn M. Robbins; McGillUniversity; David J. Pearsall; McGill University

International standards organizations require ice hockey helmets to be impact tested while mounted to a surrogateheadform (HF), with anthropometrics of a 50th percentile male [1]. However, human head shapes are notidentical, nor are there consistent guidelines for fitting a helmet to the ordinary user. The interaction of head shapeand helmet fit matters in helmet safety: the contact area between a HF and helmet interior has been identified as acritical determinant of protection afforded by a helmet [2]. The objective of this study was to compare quantitativemeasures of helmet fit between an adult male sample and the three 50th percentile male HFs. 42 adult maleparticipants who wore a medium sized ice hockey helmet were recruited in an attempt to compare theirquantitative helmet fit to those of three 50th percentile adult male HFs. Through 3D modeling, fit was quantifiedby assessing dimensional differences in two transverse planes of the head, and by using Principal ComponentAnalysis (PCA) to determine the largest components of fit variance. Significant differences were found betweenthe HFs and the participant's heads in both anthropometrics and dimensional differences. The HFs were smallerthan the participants' heads, demonstrating average gapping with the interior of the helmet. The principalcomponents of fit included medial-lateral warping, gapping/compression at the rear aspect of the helmet-headinterface, and general congruence of the head shape to the helmet liner. These findings demonstrated dissimilarityin helmet fit between surrogate headforms and ordinary users.

References:

1. Pearsall DJ et al. (2000). ASTM International Vol 3; p.78-92.2. Chang LT et al. (2001). JMSE International Journal Series Vol 44(1); p. 185-192.

keywords: hockey helmet fit headforms

Poster # 37

Mind over medication: Using placebo machines and positive suggestion to treat behaviouraldisorders

Jay Olson, McGill University; Samuel Veissière; McGill University; Michael Lifshitz; McGill University; Michael Stevens; IntellectualProperty Corporation; Amir Raz; McGill University

Placebos are the most studied procedure worldwide and can produce robust healing effects. Although themechanism underlying these effects is unknown, researchers have identified many factors that maximise placeboeffectiveness. Complicated or expensive-looking placebo procedures, for example, work better than simpler orcheaper ones. In this feasibility study, we combined many of these factors - including complicated machinery,celebrity endorsements, and the allure of neuroscience - into a novel treatment for behavioural disorders. Wetested this procedure on 11 children with various co-morbid conditions, including Attention Deficit HyperactivityDisorder (n=9), Tourette Syndrome (n=4), Obsessive Compulsive Disorder (n=1), and migraines (n=1). Topromote positive expectations, children first watched video-taped celebrity endorsements and met a previous childparticipant. The children and their families then visited the Montreal Neurological Institute to meet anothercelebrity as well as a large team of researchers and assistants. Over three sessions, the children entered an inactiveMRI scanner which we introduced as a "placebo machine" that would help their brain heal itself. We gaveparticipants positive suggestions that the procedure would reduce their symptoms and improve their strengths. Atone- and three-week follow-ups, we collected qualitative data from home visits, video-taped interviews, andparent reports. Parents of 10 of the 11 children reported improvements in symptoms and functioning. Twochildren showed near complete remission of symptoms, and none reported any negative side effects. Ourintervention may thus offer a safe and effective complement to standard care for chronic conditions.

References:

1. Thibault, R.T., Veissière, S.P.L., Olson, J.A., Raz, A. (in press). Treating ADHD with suggestion: Neurofeedback and placebotherapeutics. Journal of Attention Disorders.

keywords: placebo effects suggestion adhd

Poster # 38

Spatial and Temporal Cross-Correlation for Time-delay Estimation in Ultrasound Elastography

Morteza Mirzaei, Department of ECE, Concordia University, Montreal, QC, H3G 1M8, Canada; (Morteza Mirzaei; Department ofElectrical and Computer Engineering, Concordia University); (Amir Asif; Department of Electrical and Computer Engineering, ConcordiaUniversity),; (Maryse Fortin; PERFORM Centre, Concordia University); (Hassan Rivaz;Department of Electrical and ComputerEngineering, Concordia University & PERFORM Centre, Concordia University)

Objectives: This paper introduces a novel technique to estimate tissue displacement in quasi-static elastography.A popular technique for strain estimation is maximizing normalized cross correlation (NCC) of ultrasoundradio-frequency (RF) data of the pre-and post-compressed images. In these methods spatial windows are used toestimate NCC, wherein displacement magnitude is assumed to be constant within each window. In this work, weextend this assumption along the temporal domain to exploit neighboring samples in both spatial and temporaldirections. This is important since traditional and ultrafast ultrasound machines can record images at more than 30frame per second (fps) and 1000 fps, respectively. We call our novel method spatial temporal normalized crosscorrelation (STNCC) and demonstrate that it substantially outperforms NCC using simulation, phantom andin-vivo experiments.

Methods: Instead of considering just two images for elastography, two three-dimensional boxes should beconsidered. In this technique one should look for a box in the second sequence that has the maximum NCC withthe box of first sequence and peak of NCC represents displacement of the center of first box.

Results: Improvement of Signal to noise Ration and Contrast to noise ratio in STNCC from NCC are 534.11 and280.78 for simulation, 4556.31 and 527.08 for phantom, 118.35 and 67.15 for in-vivo liver data respectively.

Conclusion: STNCC is more robust to signal de-correlation and can tolerate higher levels of noise compared toNCC. Another advantage of this method pertains to the wealth of previous work on improving displacementestimation techniques with window-based methods.

References:

1. Ophir, J., Céspedes, I., Ponnekanti, H., Yazdi, Y., Li, X.. (1991). Elastography: A quantitative method for imaging the elasticity ofbiological tissues. Ultrasonic Imaging, 13(2), 111-134.

2. Zahiri-Azar R. & Salcudean, S.E.. (2006). Motion estimation in ultrasound images using time domain cross correlation with priorestimates. IEEE Transactions on Biomedical Engineering, 53(10), 1990-2000.

3. Xia R., Tao, G., Thittai, A. K.. (2014). Dynamic frame pairing in real-time freehand elastography. IEEE Transactions onUltrasonics, Ferroelectrics, and Frequency Control, 61(6), 979-985.

4. Rivaz, H., Foroughi, P., Fleming, I., Zellars, R., Boctor, E., Hager, G.. (2009). Tracked regularized ultrasound elastography fortargeting breast radiotherapy. In Medical image computing and computer-assisted intervention - MICCAI. 12, 507-515.

keywords: elastography spatial temporal domain cross

Poster # 39

What are the relationships among cerebrovascular reactivity, grey matter volume and markersof successful aging?

Brittany Intzandt, INDI Department, Concordia University; Dalia Sabra; Département de médecine, Université de Montréal; LaurenceDesjardins-Crepeau; Centre de Recherche d l'institut Universitaire de Gériatrie de Montréal and Centre de Recherche de l'Institute deCardiologie de Montréal; Saïd Mekary; Department of Kinesiology, Acadia University; Louis Bherer; Département de médecine,Université de Montréal and PERFORM Centre, Concordia University; Richard D. Hoge; Department of Neurology and Neurosurgery,McGill University; Chris J. Steele; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences and CerebralImaging Center, and Douglas Mental Health University Institute, McGill University; Claudine J. Gauthier; PERFORM Centre and PhysicsDepartment, Concordia University

Aging is associated with decreased cerebrovascular reactivity (CVR) [1] and cerebral blood flow (CBF) [2].Reductions in CBF likely cause decreased GMV [3] and impaired cognition [2]. Importantly, older adults withhigh compared to low fitness levels show enhanced cognition [3], however, brain data is more ambiguous. Morespecifically, some studies demonstrate increased fitness relates to higher CVR [2] or GMV [4], whereas othersreveal lower [5] or region-dependent changes to CVR [1]. Given this ambiguity, we aimed to disentangle theinteractions between these outcomes in healthy older adults.

Functional MRI (fMRI) acquisitions collected anatomical and CVR (BOLD response to CO2) scans in 51 olderparticipants. Fitness levels (VO2max) and a cognitive test (trail making test part B [TMTB]) were also measuredto identify if relationships existed amongst: i) CVR and VO2max or TMTB; ii) GMV and VO2max or TMTB.

Analyses revealed clusters: of negative relationship between CVR and VO2max; and regions showing a trend fora positive relationship between GMV and VO2max (p=0.055). There was no association between CVR or GMVwith TMTB performance.

Overall, results reveal relationships between CVR and fitness have high complexity in aging and require othermarkers of cerebrovascular health, such as CBF to be interpreted. More specifically, baseline CBF, and changesin CBF during exposure to hypercapnia could help disentangle the mechanisms modulating CVR, since theBOLD signal conflates changes in baseline and reactivity. No associations were found for CVR or GMV withTMTB; a limitation here is the use of a single cognitive measure, therefore a more comprehensive compositemeasure will be utilized to represent overall cognition.

References:

1. Gauthier CJ, Lefort M, Mekary S, et al. (2014) Hearts and minds: linking vascular rigidity and aerobic fitness with cognitiveaging. Neurbiol Aging; 36 (1): 304-14

2. de la Torre JC.(2012) Cerebral hemodynamics and vascular risk factors: setting the stage for Alzheimer's disease. J AlzheimersDis; 32(3): 553-67

3. Colcombe S and Kramer AF. (2003). Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci;14:125-30

4. Barnes JN, Taylor JL, Kluck BN, Johnson CP and Joyner MJ (2013). Cerebrovascular reactivity is associated with maximalaerobic capacity in healthy older adults. J Appl Physiol; 114: 1383-7

5. Thomas BP, Yezhuvath US, Tseng BY, et al (2013). Life-long aerobic exercise preserved baseline cerebral blood flow but reducedvascular reactivity to CO2. J Magn Reson Imaging; 38: 1177-83

keywords: exercise cognition fmri aging

Poster # 40

Balance Improvements in Second Grade Children after 2-year Fundamental MovementSkills-Development Program

Chang Ki Hong, Concordia University, Exercise Science department; Chang Ki Hong : Concordia University, Exercise Sciencedepartment; Matthew Miller : Concordia University, Exercise Science department; John Alexander Jimenez Garcia : ConcordiaUniversity, Exercise Science department; Richard DeMont : Concordia University, Exercise Science department

Background: Fundamental Movement Skills (FMS) are important for a healthy lifestyle for children as these skillsprovide a foundation to physical activity participation. FMS includes locomotion, objective control, and balance.Balance has been found to support the development of other FMS and to prevent musculoskeletal injuries.

Objective: The objective of this study was to determine whether participation in a FMS program could increasebalance ability in children.

Design: Nonrandomized controlled trial.

Method: A total of 96 second grade children from two elementary schools in Montreal area were enrolled in thisstudy. The intervention group participated in the Champions for Life program for two years and the control groupdid not participate in the program. The program is a FMS-Development program through games and activities.Each subject underwent two balance tests: 1) Airplane balance (AB), 2) Single-leg balance (SLB).

Result: There was no significant difference between the intervention group (N=47, mean=3.2553) and the controlgroup (N=49, mean=3.1429) in SLB (p=.504). The score of AB was significantly greater in the intervention group(N=48, mean=3.1042) than the control group (N=48, mean==2.3021) (p=.000).

Conclusion: There may be a ceiling effect for SLB. Previous research demonstrated that a ceiling effect can beseen for SLB after the age of 7. The program had positive effect on AB score. The similarity between AB scoreand SLB score in the intervention group, when AB is considered to be more challenging, may imply that ABbecame easier (a ceiling effect) through the program.

References:

1. Holfelder, B., & Schott, N. (2014). Relationship of fundamental movement skills and physical activity in children and adolescents:A systematic review. Psychology of Sport and Exercise, 15(4), 382-391.

2. Liao, H. F., & Hwang, A. W. (2003). Relations of balance function and gross motor ability for children with cerebral palsy.Perceptual and motor skills, 96(3_suppl), 1173-1184.

3. McLeod, T. C. V., Armstrong, T., Miller, M., & Sauers, J. L. (2009). Balance improvements in female high school basketballplayers after a 6-week neuromuscular-training program. Journal of Sport Rehabilitation, 18(4), 465-481.

4. Condon, C., & Cremin, K. (2014). Static balance norms in children. Physiotherapy Research International, 19(1), 1-7.5. Hsu, Y. S., Kuan, C. C., & Young, Y. H. (2009). Assessing the development of balance function in children using stabilometry.

International journal of pediatric otorhinolaryngology, 73(5), 737-740.

keywords: balance fundamental movement skills physical

Poster # 41

Prevalence of Inadequate Nutritional Intake Among Adults Living with Arthritis

Prince Kevin Danieles, Department of Mathematics and Statistics, Concordia University; Lisa Kakinami; Department of Mathematics andStatistics in collaboration with the PERFORM Centre, Concordia University; Matthew Parrott; PERFORM Centre, Concordia University;Kim Arrey; Co-founder, Antiinflammatoryfoodcentral.com; Hugues Plourde; School of Human Nutrition, McGill University ; BethArmour; PEN - Practice-based Evidence in Nutrition®, Dietitians of Canada; Guylaine Ferland; Département de nutrition, Faculté demédicine, Université de Montréal; Théa A. Demmers; PERFORM Centre, Concordia University

Background: Roughly 4.6 million Canadian adults are living with arthritis. While evidence suggests that lifestylefactors (such as diet) can influence arthritis symptoms, nutritional intake among people with arthritis is poorlyunderstood. This cross-sectional study estimated prevalence of inadequate micro- and macronutrient intake amongpeople with arthritis.

Methods: Data are from participants living with arthritis during the 2009-2014 cycles of the National Health andNutrition Examination Survey (NHANES), a representative sample of the US population (n=3,179). Exclusioncriteria included age (<20 y), atypical energy intake (<800 or >5000 kcal) and self-reported digestive disorders.Intake of micronutrients (e.g. vitamin A, zinc) and macronutrients (e.g. protein, fat) were obtained from two24-hour food recalls. Analyses were stratified by age (20-50, >50) and sex. Prevalence of not meeting establishedDietary Reference Intakes (DRIs) were estimated using the National Cancer Institute (NCI) method. The complexsurvey sampling design of NHANES alongside sampling and replicate weights were accounted for in all analyses.

Results: The sample was comprised of 58.45 female; median age was 63 years. High prevalence of inadequateintake of Vitamins A (47-51 ), D (91-99 ), E (73-93 ), and K (40-61 ), choline (87-97 ), potassium (94-99 ), andfiber (85-99 ) was detected across all strata. Similarly, 75 of older females had inadequate intake of calcium.

Conclusion: While the majority of people with arthritis had adequate intake of most nutrients, severalinadequacies (both general and age-sex specific) were found. Further study on improving their intake of thesenutrients (such as through nutritional intervention programs) are needed.

keywords: arthritis diet nutrition nci method

Poster # 42

Hierarchical Sparse Autoencoders for Alzheimer's Disease Classification in Amyloid PETImaging Biomarker

Emimal Jabason, Concordia University; M. Omair Ahmad and M.N.S Swamy; Department of Electrical and Computer Engineering,Concordia University, Montreal, Quebec, Canada, H3G 1M8

Although there is no cure for Alzheimer's disease (AD), an accurate early diagnosis is significant for health andsocial care and will become increasingly important once disease-modifying treatments become available toreverse the course of the disease. However, the absence of a single test and the complexity of AD create delays indiagnosis. Hence, due to the recent advances in noninvasive imaging technology, several structural basedclassification methods have been proposed to automatically discriminate the patients having AD, mild cognitiveimpairment (MCI) which is further categorized as early and late MCI, and cognitively normal (CN). Thesetechniques start with extracting suitable user-defined anatomical features of specific brain regions, which is achallenging task in the classification problem due to the lack of sufficient knowledge in finding and labelingfeatures that completely describe each class. To overcome this challenge, we propose to use deep sparseautoencoders to learn the high-level molecular feature representation by itself from the amyloid imaging data,which is one of the potential hallmarks of AD to investigate biological clues. From the experimental results, it isobserved that the performance of the proposed classification framework is superior to that of the conventionalmethods. This is because the pretrained network effectively learns the salient information in multiple layers whichis more appropriate to predict the probabilities of the different possible outcomes. As a result, it has the potentialto distinguish the four stages of AD progression with less clinical prior information.

References:

1. Villemagne, V. L., Doré, V., Burnham, S. C., Masters, C. L., & Rowe, C. C. (2018). Imaging tau and amyloid-ß proteinopathies inAlzheimer disease and other conditions. Nature Reviews Neurology. doi:10.1038/nrneurol.2018.9.

2. Shi, J., Zheng, X., Li, Y., Zhang, Q., & Ying, S. (2018). Multimodal Neuroimaging Feature Learning With Multimodal StackedDeep Polynomial Networks for Diagnosis of Alzheimers Disease. IEEE Journal of Biomedical and Health Informatics, 22(1),173-183.

3. Liu S, Liu S, Cai W, Che H, Pujol S, Kikinis R, Feng D, Fulham MJ; ADNI. (2015). Multimodal Neuroimaging Feature Learningfor Multiclass Diagnosis of Alzheimers Disease. IEEE Transactions on Biomedical Engineering, 62(4), 1132-1140.

keywords: amyloid pet alzheimer disease

Poster # 43

Ego Network Exploration with Heatmaps: A Case Study on Social Networks and PediatricObesity

Philippe Boileau, Concordia Universtiy; Philippe Boileau(1), Lea Popovic (1), Tracie A. Barnett (2), Melanie Henderson (3), LisaKakinami (1,4); ; (1) Concordia University, (2) Institut national de la recherche scientifique, Institut Armand-Frappier,; (3) Université deMontréal, (4) PERFORM Center Concordia University

The growing complexity of data sets renders traditional exploratory methods like boxplots and scatter plotsincapable of efficiently summarizing the data. Namely, data consisting of multiple social networks pose achallenge due to the quantity of information on the individuals within each network, their relationships and eachnetwork's structure. This research demonstrates the use of heatmaps, produced via hierarchical clustering, as toolsfor identifying potential relationships among the variables and networks in such data sets. Social network datafrom the Québec Adipose and Lifestyle Investigation in Youth (QUALITY)(mean age=16.4) were used tovalidate this novel method. The data consists of 46 networks centered around an individual (ego), each containinga maximum of 10 contacts (alters). Variables of interest included items describing the ego (n=12, e.g. fat mass ),the alters (n=18, e.g. frequency of physical activity) and the network structure (n=12, e.g. density). Both thenetworks and the variables underwent hierarchical clustering. The bootstrap method was applied to the resultingvariable clusters to determine significant groupings. The dendrograms produced with the bootstrap method wereused to organize the heatmaps. The method identified significant relationships (based on p<0.05) between socialbehaviours and pediatric obesity that have been linked in the literature. More precisely, it determined that an ego'sstandardized BMI and fat mass were related to their alters' levels of physical activity and healthy eating habits. Inconclusion, the heatmaps facilitated the exploration of the multiple network data by visualizing the relationshipsamong variables and networks in an interactive graph.

keywords: social networks heatmaps obesity

Poster # 44

Sex Differences in a Process-Based Assessment of Physical Literacy

Matthew Miller, Concordia University; John Alex Jimenez Garcia; Concordia University, Chang Ki Hong; Concordia University, RichardDeMont; Concordia University

Physical literacy (PL) encourages childhood physical activity participation.(1) Measurements assessing children'sPL capacity are predominantly performance-based (quantitative) not process-based (qualitative). Qualitativeinstruction methods are suggested in injury prevention strategies.(2) While females experience injures (i.e. kneeinjuries) at a much higher rate than males, measures of PL have yet to report sex differences in performance.1,2The sex differences in the process-based Champions for Life (C4L) PL program have not been explored. The C4Lprogram involves a qualitative evaluation of eight fundamental movement skills (FMS). The aim of this researchwas to determine if sex differences exist in the C4L movement skills.Ninety-six subjects, aged 7-8 years,participated in a non-randomized control-trial and performed eight FMS. The skills included, single-leg hop,horizontal jump, run, under-hand throw, under-hand catch, airplane balance, single-leg balance and skip. Aone-way between-subjects ANOVA was conducted to compare the effect of sex on each of the FMS. There wereno significant differences between sexes on all skills, except for single-leg balance. Females performed better thanmales in the control [F (1, 47) = 6.854, p = 0.012] and intervention [F (1,45) = 8.648 p = 0.005] groups.Femalesperformed better than males on the single-leg balance skill in both control and intervention; however, this sexdifference is considered an age related norm.(3) The C4L program is the first PL assessment to examine sexdifferences, and use process-based outcomes. Future research should use process-based measures to assess PL andexplore the link between process-based assessments and reducing injury.

References:

1. Longmuir, PE., Boyer, C., Lloyd, M., Yang, Y., Boiarskaia, E., Zhu, W., Tremblay, MS. The Canadian Assessment of PhysicalLiteracy:methods for children in grades 4 to 6 (8 to 12 years). BMC Public Health. 2015;15(767):1-11

2. Padua, DA., DiStefano, LJ., Hewett, TE., Garrett, WE., Marshall, SW., Golden, GM., Shultz, SJ., Sigward, SM. National AthleticTrainers' Association Position Statement: Prevention of Anterior Cruciate Ligament Injury. 2018;53(1):5-19.

3. Condon, C., Cremin, K. Static Balance Norms in Children. Physiotherapy Research International. 2014;19:1-7

keywords: physical literacy injury prevention sex

Poster # 45

Reciprocal Modulation of Helper Th1 and Th17 Cells by the ß2-Adrenergic Receptor Agonist

Catalina Marysol Carvajal Gonczi, Department of Biology, Concordia University and the PERFORM Centre, Montréal, Q; TabatabaeiShafiei, Mahdieh ;Department of Biology, Concordia University and the PERFORM Centre, Montréal, Québec, Canada; Burchell-Reyes,Kelly; Department of Chemistry and Biochemistry, Concordia University the PERFORM Centre, Montréal, Québec, Canada; Darlington,Peter J; Department of Biology, Department of Exercise Science and the PERFORM Centre, Montréal, Québec, Canada

Introduction:

T helper (Th) cells protect the body against infections. One subtype of Th cells is called "Th17 cell" which are ofinterest due to their involvement in host protection as well as its link to various autoimmune diseases. Thebeta2-adrenergic receptor (ß2AR) pathway regulates physiological reactions in response to catecholamineshormones such as epinephrine and norepinephrine. The aim of this study is to determine the effect that thesignaling pathway has on Th17 cell proliferation, cytokine secretion and the balance of Th cells.

Methods:

Blood samples were collected from healthy human subjects. Jurkat T cells and isolated immune cells were treatedwith different pharmacological ligands in an in vitro setting. Proliferation was measured by flow cytometry andcytokines were measured by enzyme assay.

Results:

Th17 cells express ß2AR and the ß2AR-specific agonist terbutaline increased Th17 cell cytokine levels whiledecreasing the Th1 cell cytokine levels (p<0.01), although proliferation was unaltered. Terbutaline effects wereblocked once the Th cells were treated with a ß2AR-specific antagonist. The ß2AR has two operational signalingpathways that converge in the second messenger cAMP. Pathway was targeted by adding cAMP analog(dbcAMP), stimulating Th17 cytokines (p<0.05). The cAMP levels were measured in Jurkat T cells, showing adifferential response with terbutaline and a biased agonist-nebivolol.

Conclusion:

Cell signaling through ß2AR alters the Th17 cytokines. Results show that catecholamines modulate the balance ofTh1 and Th17 cells during an adaptive immune response and can help understand the predisposition forautoimmunity.

References:

1. Felten, D. L., Ackerman, K. D., Wiegand, S. J., & Felten, S. Y. (1987). Noradrenergic sympathetic innervation of the spleen: I.nerve fibers associate with lymphocytes and macrophages in specific compartments of the splenic white pulp. Journal of Neur

2. Kohm, A. P., & Sanders, V. M. (2001). Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and Blymphocyte function in vitro and in vivo. Pharmacological Reviews, 53(4), 487-525.

3. Sanders, V. M., Baker, R. A., Ramer-Quinn, D. S., Kasprowicz, D. J., Fuchs, B. A., & Street, N. E. (1997). Differential expressionof the beta2-adrenergic receptor by Th1 and Th2 clones: Implications for cytokine production and B cell help. Journal of

4. Ramer-Quinn, D. S., Baker, R. A., & Sanders, V. M. (1997). Activated T helper 1 and T helper 2 cells differentially express thebeta-2-adrenergic receptor: A mechanism for selective modulation of T helper 1 cell cytokine production. Journal of Immunol

5. Sanders, V. M. (2012). The beta2-adrenergic receptor on T and B lymphocytes: Do we understand it yet? Brain, Behavior, andImmunity, 26(2), 195-200.

keywords: beta adrenergic receptor helper

Poster # 46

Relationship of pure-tone and speech-in-noise measures of hearing to scores on the MontrealCognitive Assessment Scale (MoCA): Sex differences and relation to other neuropsychologicaltests

Faisal Al-Yawer, Concordia University; Halina Bruce; Concordia University; Centre for Research in Human Development (CRDH);PERFORM Centre; Karen Z. Li; Concordia University; Centre for Research in Human Development (CRDH); PERFORM Centre; M.Kathleen Pichora-Fuller; University of Toronto; Simon Fraser University; Rotman Research Institute; Natalie Phillips; ConcordiaUniversity; Centre for Research in Human Development (CRDH); Centre for Research on Brain, Language & Music (CRBLM); LadyDavis Institute for Medical Research

Research points towards a relationship between hearing loss (HL) and cognitive decline in older adults. Scores onthe Montreal Cognitive Assessment (MoCA), a brief cognitive screening measure, show an association with HL.However, the susceptibility of MoCA scores to HL relative to more comprehensive neuropsychological measuresremains unexplored. Furthermore, while there are sex-differences in the rate/degree of HL, how these differencesaffect testing is unknown. 170 healthy older adults (M=68.94 years) were assessed on hearing using pure toneaudiometry (PTA), and the Words in Noise (WIN) tests and cognition using the MoCA, the Stroop, and theRepeatable Battery for the Assessment of Neuropsychological Status (RBANS).

Most participants had good hearing (66.9 normal hearing, NH, defined as a PTA of 500, 1000, and 2000Hzaveraged between both ears <25dB) and high MoCA scores (M=26.89; 73.8 passing based on score >25). Therewas no difference in proportions of individuals passing the MoCA as a function of hearing (76.5 of NH; 68.4 ofHL). Nevertheless, MoCA scores weakly correlated with PTA (r=-0.176; p=0.027). When the sample wassex-split (61.2 women), the correlation was significant only for women (r=-0.220; p=0.03). This remained evenwhen hearing-dependent subtests were not included (r=-0.223; p=0.028). We observed similar sex-specificcorrelations between women's WIN scores and variables on the Stroop (r=-0.365; p=0.061). PTA in all subjectswas associated with scores on the RBANS memory subtests (r range=0.253-0.335).

The present findings highlight sex-differences in a sample of healthy older adults. Implications for cognitivescreening and sensory-cognitive relationships will be discussed.

keywords: aging audiology cognitive testing sex

Poster # 47

Debugging the Numerical error propagation in the HCP structural pre-processing pipelines

Ali Salari, Department of Computer-Science and Software Engineering, Concordia University; Lalet Scaria; Department ofComputer-Science and Software Engineering, Concordia University, Montréal, Québec, Canada; Gregory Kiar; Department ofBiomedical Engineering, Montreal Neurological Institute, McGill University, Montreal, QC, Canada; Tristan Glatard; Department ofComputer-Science and Software Engineering, Concordia University, Montréal, Québec, Canada

Operating systems are known to have an effect on the results produced by neuroimaging pipelines [1,2],presumably due to the creation, propagation and amplification of small numerical errors across the pipelines. Sucherrors highlight numerical instability which is also likely to appear as a result of other types of small perturbationssuch as acquisition and parametric noise. In the previous studies [3], we showed that pre-processing pipelines ofthe Human Connectome Project [4] were sensitive to operating system variation. However, the precise causes ofsuch instabilities and the path along which they propagate in the pipelines are unclear. We present a technique toidentify the processes in a pipeline that create numerical errors along the execution by capturing all thesystem-call interceptions, and we apply this technique to the HCP structural pre-processing pipelines. The resultsof running PreFreesurfer HCP pipeline on CentOS6 and CentOS7 for 6 different subjects show that Thenumerical instability in the PreFreesurfer arises mainly from linear and non-linear registration processesimplemented in FSL FLIRT and FNIRT. In addition, errors were observed in image mean and standard-deviationcomputations with "fslstats", and in masked image extrapolation with "fslmaths". Besides, transformation formatconversion with "convertwarp" was able to remove errors.

References:

1. Gronenschild, E. H., Habets, P., Jacobs, H. I., Mengelers, R., Rozendaal, N., Van Os, J., & Marcelis, M. (2012). The effects ofFreeSurfer version, workstation type, and Macintosh operating system version on anatomical volume and cortical thickness me

2. Glatard, T., Lewis, L. B., Ferreira da Silva, R., Adalat, R., Beck, N., Lepage, C., ... & Khalili-Mahani, N. (2015). Reproducibility ofneuroimaging analyses across operating systems. Frontiers in neuroinformatics, 9, 12.

3. Scaria, L., Lewis, L.B., Khalili-Mahani, N., Evans, A.C., Glatard, T. (2017). Reproducibility of Human Connectome Projectpipelines across operating systems. Neuroinformatics 2017. doi: 10.12751/incf.ni2017.0058

4. Glasser, M. F., Sotiropoulos, S. N., Wilson, J. A., Coalson, T. S., Fischl, B., Andersson, J. L., ... & Van Essen, D. C. (2013). Theminimal preprocessing pipelines for the Human Connectome Project. Neuroimage, 80, 105-124.

keywords: reproducibility numerical instability neuroimaging

Poster # 48

Analysis of female university soccer players' performance in games using GPS and heart ratemeasures

Stephanie Di Lemme, Athletic Therapy Research Laboratory, Concordia University; Dr Geoffrey Dover; Concordia University,PERFORM Centre, Concordia University

Introduction: Evaluating performance in soccer athletes is challenging.(1,2) Using in-game wearable technologyis a novel measure of on-field performance.(3) The purpose of this study was to measure in-game performance ofsoccer players using global positioning system (GPS) and heart rate (HR) technologies. Methods: Athletes wore aPolar Team Pro device for 14 games. Paired t-tests compared total distance covered, peak HR and average HRbetween the first half and second half of the game. Repeated measures ANOVAs compared total distance coveredin each speed interval and time spent in each HR zone. Results: Players covered an average of 8613.4±758.5meters per game. Players covered significantly less distance and had a lower average HR during the 2nd halfcompared to the 1st half (p=0.003, p=0.005 respectively). Players covered more total distance walking andjogging compared to standing, running and sprinting. Lastly, players spent the most time competing in the 80-90and the second most time in the 90-100 of their max HR compared to the other HR zones. Discussion: Thedecrease in distance and HR in the second half may be due to fatigue or the need to conserve energy.Interestingly, players covered the most distance walking and jogging compared to running but spentapproximately 74 minutes of the 90-minute game in the 80-100 max HR zones. Our GPS and HR data provide ameasure of specific work rate profiles and the physical requirements of soccer players. Wearable technology canbe used to assess function and physiological responses to physical activity.

References:

1. Frick, B. (2011). Performance, Salaries, and Contract Length: Empirical Evidence from German Soccer. International Journal ofSport Finance, 6(2), 87-118.

2. Lockie, R. G., et al. (2017). Yo-Yo Intermittent Recovery Test Level 2 and Its Relationship with Other Typical Soccer Field Tests inFemale Collegiate Soccer Players. Journal of Strength and Conditioning Research, 31(10), 2667-2677.

3. Sapp, R. M., et al. (2017). Laboratory and Match Physiological Data from an Elite Male Collegiate Soccer Athlete. Journal ofStrength and Conditioning Research, 31(10), 2645-2651.

keywords: distance speed interval athlete training

Poster # 49

The influence of high plasma lipid on cardiac function and hypertrophy

Chelsea D'Abreau, Concordia University; Dr. Andreas Bergdahl, Concordia University

Apolipoprotein E (ApoE) is a molecule required for normal lipid metabolism. Deficiency of ApoE (ApoE-/-)leads to an accumulation of fatty acids in the plasma and forces lipids into non-oxidative pathways. Weinvestigate the influence of an increased lipid environment, induced by ApoE-/-, on cardiac size and function. Aslipids are the preferred substrate of cardiomyocytes, we hypothesize that elevated plasma lipid will increase ATPproduction, thus increasing cardiac workload and inducing cardiomyocyte hypertrophy. To analyze mitochondrialfunction in hypertrophic hearts, we compared mitochondrial oxygen consumption in ApoE-/- mice to miceexpressing human apolipoprotein-E4 isoforms (ApoE4). Tissue from the left ventricle of the heart was isolatedand the plasma membrane permeabilized. O2 flux was determined using a polarographic oxygen sensor and asequential titration protocol was utilized to evaluate aerobic ATP production in the electron transport system.Weighing of the hearts revealed higher heart mass to body weight ratio, as well as average heart mass, in ApoE-/-compared to ApoE4. ADP-restricted respiration was higher in the ApoE-/-, whereas ADP-stimulated respirationwas higher in the ApoE4. In ApoE-/-, OXPHOS capacity was reduced, as illustrated by enhanced ADP-restrictedrespiration. This suggests that cardiomyocytes respond less to ADP in a state of decreased substrate availability.Beta-oxidation is unaffected by ApoE-/-, suggesting that only mitochondrial glucose metabolism is disrupted in ahigh plasma lipid context. ApoE-/- affects oxidation and phosphorylation coupling within cardiac mitochondria.Our findings provide insight on altered mitochondrial metabolism in cardiac hypertrophy and may help explainthe mechanisms leading to cardiac growth.

References:

1. Pendse, A. A., Arbones-Mainar, J. M., Johnson, L. A., Altenburg, M. K., & Maeda, N. (2009). Apolipoprotein E knock-out andknock-in mice: Atherosclerosis, metabolic syndrome, and beyond. Journal of Lipid Research, 50 Suppl, S178-82.

2. Harrison, C. M., Pompilius, M., Pinkerton, K. E., & Ballinger, S. W. (2011). Mitochondrial oxidative stress significantly influencesatherogenic risk and cytokine-induced oxidant production. Environmental Health Perspectives, 119(5), 676-681.

keywords: apolipoprotein atp cardiomyocytes hypertrophy

Poster # 50

Hemodynamic correlates of transient and stable changes in neuronal excitability: asimultaneous Transcranial Magnetic Stimulation (TMS) / functional Near Infra Red Spectroscopy(fNIRS) study

Zhengchen Cai, Physics Department and PERFORM Center, Concordia University, Montreal, Canada; Giovanni Pellegrino; MontrealNeurological Institute, McGill University, Canada.; Amanda Spilkin; Department of Electrical Engineering, Ecole de TechnologieSupérieure, Montréal, Canada.; Thomas Vincent; Centre de médecine préventive et d'activité physique (Centre ÉPIC), Montreal HeartInstitute and University of Montreal, Montreal, Canada.; Jean-marc Lina; Department of Electrical Engineering, Ecole de TechnologieSupérieure, Montréal, Canada.; Shirley Fecteau; Medical School, Laval University, Montreal, Canada.; Christophe Grova; MultimodalFunctional Imaging Laboratory, Biomedical Engineering Department, McGill University, Montreal, Canada; Multimodal FunctionalImaging Laboratory, Biomedical Engineering Department, McGill University, Montreal, Canada.

Introduction: Near-infrared spectroscopy (NIRS) tomography reconstructs the measured oxy- anddeoxy-hemoglobin concentration changes on the scalp along the cortical regions [1]. Transcranial MagneticStimulation (TMS) is a non-invasive neurostimulation technique, which allows depolarizing neuronal pools usinga brief and intense magnetic pulse [2]. Paired associative stimulation (TMS), during which a pair of stimulationsconsisting in one electrical median nerve stimulation followed one TMS pulse, could either temporarily increaseor decrease neuronal excitability by tuning the inter-stimulus interval [3]. We propose to combine NIRSreconstruction with TMS and PAS, to characterize the hemodynamic response elicited by stable and phasicchanges of cortical excitability of the healthy brain.

Method: We first customized subject specific optimal montage [4] for NIRS to probe "hand knob" cortical area.Three experimental sessions were considered, in three different days. In each session, neuronal excitability wasincreased/decreased by PAS or preserved by sham. Before and after each PAS intervention, we performed 1) 75single pulse TMS delivered onto the "hand knob" cortical region, 2) finger tapping task. Maximum Entropy on theMean (MEM) framework [5] was applied to reconstruct the NIRS hemodynamic response along cortical surface.

Results and discussion: Our premilitary results suggest that MEM could provide quite promising NIRSreconstructions during TMS and finger tapping task. For the first time, our protocol allowed us to detect 1)hemodynamic response in the hand knob regions elicited by TMS pulse and 2) a stronger task-relatedhemodynamic response when the brain was in a state of enhanced excitability elicited by PAS and vice versa.

References:

1. Eggebrecht AT, Ferradal SL, Robichaux-Viehoever A, et al. Mapping distributed brain function and networks with diffuse opticaltomography. Nat Photonics. 2014;8(6):448-454.

2. Di Pino G, Pellegrino G, Assenza G, et al. Modulation of brain plasticity in stroke: A novel model for neurorehabilitation. Nat RevNeurol. 2014;10(10):597-608.

3. Stefan K. Induction of plasticity in the human motor cortex by paired associative stimulation. Brain. 2000;123(3):572-584.4. Machado A, Marcotte O, Lina JM, Kobayashi E, Grova C. Optimal optode montage on electroencephalography/functional

near-infrared spectroscopy caps dedicated to study epileptic discharges. J Biomed Opt. 2014;19(2):26010.5. Amblard C, Lapalme E, Lina JM. Biomagnetic Source Detection by Maximum Entropy and Graphical Models. IEEE Trans Biomed

Eng. 2004;51(3):427-442.

keywords: nirs tms tms neuronal excitability

Poster # 51

Childhood BMI trajectories in a longitudinal community cohort and the risk for eating disordersymptoms in adolescence

Jessica Di Sante, Concordia University, Sainte Justine Hospital Research Center; Sylvana Côté; Sainte Justine Hospital Research Center;Stéphane Paquin; Sainte Justine Hospital Research Center, Université Laval à Québec; Frank Vitaro; Sainte Justine Hospital ResearchCenter; Michel Boivin; Université Laval à Québec; Richard E. Tremblay; Sainte Justine Hospital Research Center; Linda Booij;Concordia University, Sainte Justine Hospital Research Center

Background: Recent studies have shown that the average age of first presentation of an Eating Disorder (ED) suchas Bulimia and Anorexia Nervosa is progressively decreasing. A higher BMI in childhood has been shown to be apredictor of ED risk. However, most studies showing such association were retrospective, in clinical samplesand/or only in girls.

Objectives: To investigate the prevalence of ED symptoms in a community sample of adolescent boys and girlsand its associations with childhood BMI trajectories.

Methods: BMI from 6-12 years in 2223 individuals (1138 boys, 1085 girls), and self-reported EDsymptomatology at 15 and 17 years, were extracted from the Quebec Longitudinal Study of Child Developmentdatabase. Group-based BMI trajectories were identified using a semiparametric mixture model in the Proc Trajprocedure in SAS.

Results: Adolescent ED symptoms were higher in girls than in boys, particularly in terms of frequentweight/appearance preoccupation (44 vs. 13 ); body dissatisfaction (11 vs. 1.3 ); fear of losing control (16 vs. 5.4 )and purging behaviours (1 vs. 0.3 ). Three childhood BMI trajectories were identified: (1) normal weight (57 ofboys, 48.3 of girls), (2) late childhood overweight (41 of boys, 47.3 of girls), and (3) chronically obese (2 of boys,4.4 of girls). Higher Childhood BMI Trajectories predicted ED symptom severity at 15 and 17 years of ageirrespective of sex (p<.0001),

Discussion: These findings highlight the need for preventive interventions aimed to reduce ED risk. Regularassessments of BMI in childhood may be informative in identifying individuals at risk.

keywords: bmi trajectories childhood disordered eating

Poster # 52

Variations in oxygenation levels at birth interact with the dopamine transporter gene networkinfluencing internalizing problems and cognition in children

Patricia Miguel, Universidade Federal do Rio Grande do Sul; Miguel PM1,2, Pereira LO1,2, Nguyen TT3, Garg E3, O'Donnell KJ3,4,5,6,Meaney MJ3,4,5,6,7, Silveira PP3,4,5; ; 1) Programa de Pós-Graduação em Neurociências, ICBS, Universidade Federal do Rio Grandedo Sul, Porto Alegre, RS, Brazil; 2) Departamento de Ciências Morfológicas, ICBS, Universidade Federal do Rio Grande do Sul, PortoAlegre, RS, Brazil; 3) Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGillUniversity, Montreal, QC, Canada; 4) Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada; 5)Sackler Program for Epigenetics & Psychobiology at McGill University; 6) Child and Brain Development Program, Canadian Institute forAdvanced Research (CIFAR), Toronto, ON, Canada; 7) Singapore Institute for Clinical Sciences, Agency for Science, Technology andResearch (A*STAR)

Attention-deficit hyperactivity disorder (ADHD) is a developmental disorder resulting from the interplay ofgenetic and environmental factors. Different genetic variants associated with decreased dopamine (DA) signalinghave been described, and perinatal complications associated with poor oxygenation also affect the DA function.The objective of this study is to analyze whether variations in oxygenation levels at birth (1-min APGAR score)interact with a genetic profile associated with dopaminergic signaling, influencing the development of behavioraloutcomes related to ADHD in children (socio-emotional and cognitive flexibility). We created a novel geneticscore based on genes co-expressed with the DA transporter gene (ePRS-DAT1) in the pre-frontal cortex (PFC),and analyzed its interaction with the APGAR score on extradimentional shift (IED, CANTAB) and ChildBehavior Checklist (CBCL) internalizing, externalizing and total problems. In the CBCL at 48 months, there wasan interaction between the ePRS-DAT1 and 1-min APGAR score in the Internalizing problems (p=0.029), inwhich the high ePRS group has more problems as APGAR decreases (p=0.002, b=-0.318). In the IED task at 72months, there was also an ePRS X APGAR interaction in the number of trials (p=0.003), errors (p=0.004) andlatency to respond (p<0.001), in which the high ePRS group demonstrated worse outcomes as APGAR decreases.We demonstrated that the genetic profile related to DA signaling in the PFC interacts with oxygenation levels atbirth predicting worse ADHD-related outcomes in children. The gene network of the DAT gene seems to be animportant player in modulating these effects.

keywords: adhd dopamine apgar cbcl ied

Poster # 53

The effect of whole body and regional adiposity on substrate utilization during incrementalexercise in tanner stage 1 and 2 children: A QUALITY study

Kerri Delaney, Concordia University Department of Exercise Science; Kerri Delaney; 1: Concordia University Department of ExerciseScience, 2: PERFORM Center Nutrition Obesity and Metabolism Lab, 3: Centre de recherche - Axe maladies chroniques, Centre intégréuniversitaire de santé et de services sociaux du Nord-de-l'Ile-de-Montréal; Melanie Henderson; 4: Research Center, Sainte-JustineUniversity Hospital Research Centre, 5: Department of Pediatrics, University of Montreal; Marie-Eve Mathieu 4: Research Center,Sainte-Justine University Hospital Research Centre, 6: Department of Kinesiology, University of Montreal; Sylvia Santosa; 1: ConcordiaUniversity Department of Exercise Science, 2: PERFORM Center Nutrition Obesity and Metabolism Lab, 3: Centre de recherche - Axemaladies chroniques, Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Ile-de-Montréal

Background: Pre-pubertal children favor the oxidation of lipids at higher exercise intensities compared to adults.Our objective was to examine the effect of whole-body and regional adiposity on substrate utilization during anexhaustive cycling test in tanner stage 1 and 2 males and females.

Methods: We included a subset of 320 children (n=188 males) from the Quebec Adipose and LifestyleInvestigation in Youth (QUAILTY) cohort. Children were tanner stage 1 or 2 and completed a minimum of fourstages of the McMaster exhaustive exercise protocol on an upright cycle ergometer. DXA scans provided regionaland whole-body measures of adiposity. Children were classified by weight category according to BMI percentile.

Results: Starting at 65 and 70 VO2 peak, children with obesity (OB) had a significantly lower RER than childrenwith healthy weight (HW) and overweight (OW), respectively (p<0.05). RER was furthermore negativelycorrelated to all regional measures of fat mass (p<0.01). In males and females HW had significantly greater VO2(mL/kg/min) followed by OW then OB children (p<0.01). Throughout exercise lipid oxidation (mg/kg lean bodymass/min) was significantly greater in HW and OB females compared to males (p<0.01). Peak lipid oxidation(mg/kg lean body mass/min ) was significantly higher in HW and OB females than males (p<0.05). Peak fatoxidation occurred latest in OB males at 50 of their VO2 peak (p<0.05).

Conclusion: Exercise capacity and substrate utilization during an exhaustive exercise task differs between weightcategories and sexes in tanner stage 1 and 2 children.

References:

1. Riddell MC, Jamnik VK, Iscoe KE, Timmons BW, Gledhill N. Fat oxidation rate and the exercise intensity that elicits maximal fatoxidation decreases with pubertal status in young male subjects. J Appl Physiol (1985). 2008;105(2):742-8.

2. Isacco L, Duche P, Thivel D, Meddahi-Pelle A, Lemoine-Morel S, Duclos M, et al. Fat mass localization alters fuel oxidationduring exercise in normal weight women. Med Sci Sports Exerc 2013 Oct;45(10):1887-1896.

3. McMurray RG, Hosick PA. The interaction of obesity and puberty on substrate utilization during exercise: a gender comparison.Pediatr Exerc Sci 2011 Aug;23(3):411-431.

4. Zunquin G, Theunynck D, Sesboue B, Arhan P, Bougle D. Comparison of fat oxidation during exercise in lean and obese pubertalboys: clinical implications. Br J Sports Med 2009 Oct;43(11):869-870

keywords: regional adiposity substrate utilization tanner

Poster # 54

Illuminating the prefrontal cortex while manipulating cognitive demand: an fNIRS dual task walkstudy in younger adults

Tabassum Rahman, University of Ottawa; Tabassum Rahman, Nadia Polskaia, Gabrielle St-Amant, Yves Lajoie & Sarah Fraser;University of Ottawa

ABSTRACT

Introduction

Studies have demonstrated that increased prefrontal cortex (PFC) activation is needed to manage dual-taskwalking demands. Understanding how younger adults (YA) manage increased cognitive demands when walkinghelps elucidate the neural mechanisms relevant to dual-task walking abilities.

Objective

This study utilized functional Near Infrared Spectroscopy (fNIRS) to measure cerebral oxygenation in YA (n =20, 18-35 years) dual-task walking. Cognitive demand was manipulated with four tasks: [1] a simple reaction time(SRT), [2] go/no go inhibition (GNG), [3] a 2-back working memory task and [4] double number sequence(DNS).

Methodology

Participants completed counterbalanced runs including blocks of single cognitive (SC), single motor (SM) anddual task (DT; simultaneous SC+SM) with rest periods (15s) and baseline (10s). Cerebral oxygenation (HbO),number of errors and walk speed (m/s) were measured.

Results

Preliminary t-test analyses examined HbO differences between SM and DT for each channel/cognitive task. Onlythe DNS task demonstrated significant differences in 4 of the 8 channels (SM < DT). For the behavioural data,2x4 repeated-measures revealed that error rates were greater in DT vs SC in the NBK (p =.026) and DNS (p =.008). Significantly less meters per second were completed in DT vs SM for SRT and DNS (ps <.001), but moremeters per second DT vs SM (p <.001) in the 2-back.

Conclusions

Cerebral oxygenation contributions increase with increasing cognitive demands and this coincides with increasederror rates and slowed walk speed. fNIRS during dual-task walking can aid our understanding neural mechanismsduring functional dual-tasks.

References:

1. Bherer L. (2015) Cognitive plasticity in older adults: effects of CT and physical exercise.Ann. NY. Acad. Sci. 1337:1-6.2. Mirelman, A., Maidan, I., Bernad-Elazari, H., Nieuwhof, F., Reelick, M., Giladi, N., & Hausdorff, J. M. (2014). Increased frontal

brain activation during walking while dual tasking: an fNIRS study in healthy young adults. Journal of neuroengineering a3. Fraser, S. A., Dupuy, O., Pouliot, P., Lesage, F., & Bherer, L. (2016). Comparable Cerebral Oxygenation Patterns in Younger and

Older Adults during Dual Task Walking with Increasing Load. Frontiers in Aging Neuroscience, 8, 240.

keywords: fnirs dual task cognitive demand

Poster # 55

The relationship between metabolic syndrome, eating behaviors and psychosocial factors: aHEARTY Study

Iyoma Edache, Concordia University; Ronald J. Sigal 2,3,5; Glen P. Kenny 3,5; Gary S. Goldfield 6; Denis Prud'homme 5,7; StasiaHadjiyannakis 6; Steve Doucette 8; Angela S. Alberga 1; 1 Department of Exercise Science, Concordia University, Montreal, Canada ; 2Departments of Medicine, Cardiac Sciences and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; 3 ClinicalEpidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; 5 School of Human Kinetics, University of Ottawa,Ottawa, Ontario, Canada; 6 Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario ResearchInstitute, Ottawa, Ontario, Canada; 7 Institut du Savoir Montfort, Ottawa, Ontario, Canada; 8 Department of Community Health andEpidemiology, Dalhousie University, Halifax, Nova Scotia, Canada

Metabolic syndrome (MetSyn) is characterized by risk factors such as abnormal glucose regulation, abdominaladiposity, hypertension, and high cholesterol. Little research has examined relationships between MetSyn andpsychological health in adolescents with obesity. The purpose of this study was to examine the associationbetween MetSyn, eating behaviours and psychosocial factors (mood, self-esteem, body image) in a sample ofadolescents with obesity aged 14-18 years enrolled in the HEARTY (Healthy, Eating, Aerobic and ResistanceTraining in Youth) trial. A cross-sectional analysis was performed on N= 304 participants at baseline. MetSynwas categorized according to the International Diabetes Federation criteria. Independent sample t-tests were usedto examine differences in eating behaviours and psychosocial factors between participants with (n=62) andwithout MetSyn (n=242). Participants with MetSyn had greater BMI (36.9 3.8 kg/m2 vs. 34.1 4.5 kg/m2; p =0.00) and protein intake compared to non-MetSyn (92.1 29.9g vs. 81.8 26.1g; p = 0.008). Participants withMetSyn had higher scores on the perceptions of an attractive body subscale of the Physical Self-Perception Profile(10.5 3.8 vs. 9.5 3.2; p= 0.042). Participants with MetSyn had lower scores on the appearance orientation subscaleof body image from the Multidimensional Body-Self Relations Questionnaire (3.2 0.75 vs. 3.4 0.74; p= 0.026).These differences did not hold after adjusting for sex and BMI. Compared to adolescents without MetSyn,adolescents with MetSyn consumed more protein, placed significantly less importance on how they looked butalso perceived their bodies to be more attractive.

References:

1. Alberga, A. S., Goldfield, G. S., Kenny, G. P., Hadjiyannakis, S., Phillips, P., Prud'Homme, D., ... & Sigal, R. J. (2012). HealthyEating, Aerobic and Resistance Training in Youth (HEARTY): study rationale, design and methods. Contemporary clinic

2. Alberti, K. G. M. M., Zimmet, P., & Shaw, J. (2006). Metabolic syndrome-a new world-wide definition. A consensus statement fromthe international diabetes federation. Diabetic medicine, 23(5), 469-480.

keywords: obesity adolescents mood self esteem

Poster # 56

Do cannabinoids improve appetite and weight in patients with chronic diseases?

Marialuisa Vigano, Department of Science, Lower Canada College, Montreal, Canada; M.F. Arboleda, MD; Department of Oncology,McGill University and Sante Cannabis Montreal, Canada. ; E. Prosk MSc; Sante Cannabis Montreal, Canada. ; Y. Drozd; Sante CannabisMontreal, Canada. ; L.Xuecheng PhD; Sante Cannabis Montreal, Canada.; M. Dworkind MD; Sante Cannabis Montreal, Canada.

Introduction: Cannabinoids are widely claimed to improve appetite in both cancer and non-cancer patients,however, the evidence for their orexigenic effect is still weak and very few studies have evaluated the impact ofcannabis on weight.

Objectives: To determine the impact of cannabis and nabilone on appetite and weight maintenance.

Methods: We conducted a retrospective chart review of all adult patients who were assessed at Santé CannabisClinic (SCC) between August 2016 and October 2017, and who had "increase of appetite" as a treatment goal.SCC is the only medical cannabinoid clinic in the province of Quebec, Canada. The "lack of appetite" item (0 =no lack of appetite to 10 = complete lack of appetite) from the revised Edmonton Symptom Assessment System(r-ESAS), and weight (kg), were considered our primary outcomes.

Results: Fifty four patients suffering from anorexia from cancer (43 ) and non-cancer (57 ) were analyzed. Ther-ESAS score for lack of appetite significantly improved between baseline (5.07 ± 3.21) and follow up (3.56 ±3.15) (p-value= 0.0026). Weight remained stable between baseline (70.74 ± 14.63) and follow up (71.02 ± 14.76).The use of nabilone (p= 0.0521) along with type of administration (inhaled and oral plus inhaled vs. oral) (p=0.0142) impacted the difference in appetite. Overall, 18.5 of the subjects reported only mild side effects such asanxiety, fatigue, dizziness and dry mouth.

Conclusions: Administration of cannabinoids within an individualized and supportive monitoring program maysafely improve appetite and weight maintenance in patients suffering from chronic diseases.

References:

1. Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, et al. Cannabinoids for Medical Use: A SystematicReview and Meta-analysis. JAMA. 2015 Jun 23;313(24):2456-73.

2. Abrams DI. Integrating cannabis into clinical cancer care. Curr Oncol Tor Ont. 2016 Mar;23(2):S8-14.3. Cannabis-In-Cachexia-Study-Group, Strasser F, Luftner D, Possinger K, Ernst G, Ruhstaller T, et al. Comparison of orally

administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexiasyndrome: a

4. Abrams DI, Guzman M. Cannabis in cancer care. Clin Pharmacol Ther. 2015 Jun;97(6):575-86.5. Turgeman I, Bar-Sela G. Cannabis Use in Palliative Oncology: A Review of the Evidence for Popular Indications. Isr Med Assoc J

IMAJ. 2017 Feb;19(2):85-8.

keywords: anorexia weight cannabinoids complementary chronic

Poster # 57

Computing a meaningful change index on the Montreal Cognitive Assessment (MoCA) inhealthy older adults

Chelsea Pozzebon, Concordia University; Faisal Al-Yawer; Concordia University. Karen Li; Concordia University. Natalie Phillips;Concordia University.

The Montreal Cognitive Assessment scale (MoCA) is a popular screening measure used to test for mild cognitiveimpairment (MCI) among older adults. However, little is known about what constitutes clinically significantchange over multiple MoCA administrations after accounting for random measurement error. We used twoseparate reliable change index (RCI) calculation methods (Modified Practice Adjusted RCI,Gulliksen-Lord-Novick (GLN)) to establish a 95 RCI for MoCA performance over a one-year period in a sampleof healthy Canadian older adults (N=117; age range= 60-75 years). The 95 RCI using the Modified PracticeAdjusted RCI formula was +/-4, while 95 RCI using the GLN formula spanned from -5 to 0 and +4 to +8,depending on MoCA baseline score. Strengths and weaknesses of the two methods will be discussed. Theseresults provide a metric for interpreting test score differences on the MoCA so as to estimate meaningful changesin cognitive functioning in healthy older adults.

References:

1. Chelune, G. J. (2010). Evidence-based research and practice in clinical neuropsychology. The Clinical Neuropsychologist, 24(3),454-467.

2. Cooley, S. A., Heaps, J. M., Bolzenius, J. D., Salminen, L. E., Baker, L. M., Scott S. E., & Paul, R. H. (2015) Longitudinal changein performance on the Montreal Cognitive Assessment in older adults. The Clinical Neuropsychologist, 29(6), 824-835.

3. Nasreddine, Z. S. Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H.(2005). The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment. Journal of the American

4. Kopecek, M., Bezdicek, O., Sulc, Z., Lukavsky, J., & Stepankova, H. (2016). Montreal Cognitive Assessment and Mini-Mental StateExamination reliable change indices in healthy older adults. International Journal of Geriartric Psychiatry, 32(8), 868-875

keywords: aging cognition reliable change index

Poster # 58

Sex difference in physical activity changes to an e-health behaviour change intervention.

Prerna Deshpande, Concordia University and CIUSSSM-NIM ( hospital du Sacre Coeur); Prerna Deshpande; Concordia University,Canada, Paul Oh; Toronto Rehabilitation Institute, Canada, Kim Lavoie; Université du Québec à Montréal, Canada, GenevièveSzczepanik; Hospital du Sacre Coeur, Canada, Simon L. Bacon; Concordia University, Canada, for the ACCELERATION team

Background:

Poor diet and physical inactivity has a negative impact on health. Epidemiological data suggests that, there are sexdifferences in the impact of poor health behaviour on chronic disease development. However, there is limited dataon sex specific responses of behaviour change interventions.

Methods:

A total of 45 men and 94 women participated (mean[SD] age=50.6[11.0]) in the online ACCELERATIONprogram, a 12- week structured behaviour change intervention delivered in 4 sites across Canada. The programfocused on improving physical activity, diet, smoking and alcohol consumption.

Result:

Repeated measures mixed model analyses found trends over 12 weeks for sex specific intervention effects onphysical activity (F=3.25, p=.072 +49min MVPA in women, +11 min in men), Sedentary time (F= 3.06, p=.057;-0.75 hours/week in women, 0.24 hours/week in men), Alcohol consumption (F=3.68, p=.082; -.28 drinks/week inwomen, -1.43 drinks/men).There were no sex-differences in fruit and vegetable intake (F=0.01, p=.903) norsmoking (F=0.82, p=.377).

Conclusion:

There were suggestions of sex specific responses to the online ACCELERATION program. Women had betterphysical activity and sedentary behaviour responses compared to men but lower reductions in alcoholconsumption. These provide importance insights into the potential sex-specific ways in which the onlineACCELERATION platform can be tailored in the future.

References:

1. Johnson, F., & Wardle, J. (2011). The association between weight loss and engagement with a web-based food and exercise diaryin a commercial weight loss programme: a retrospective analysis. International Journal of Behavioral Nutrition and Physical A

2. Kamal, N., & Fels, S. (2012). Determining the determinants of health behaviour change through an online social network.Persuasive Technology. Design for Health and Safety, 1-12

3. McCully, N. S., Don, P. B., & Updegraff, A. J. (2013). Using the Internet to Help With Diet, Weight, and Physical Activity: ResultsFrom the Health Information National Trends Survey (HINTS). Journal of Medical Internet Research, 15(8), e148. doi:10.2

4. Warburton, D. E. R., Nicol, C. W., & Bredin, S. S. D. (2006, 2006/03/14/). Health benefits of physical activity: the evidence.CMAJ: Canadian Medical Association Journal, 174, 801+

keywords: health male female physical

Poster # 59