PATENT ABSTRACTS 359

response. Preferred compositions employ N, N- higher alkyI-N',N'-bis(2- hydroxyethyl)propanediamines, particularly N, N-dioctadecyI-N'.N'-bis(2-hydroxyethyl)- propanediamine in lntralipid.

4394502

I M M U N O T H E R A P E U T I C A G E N T F O R T U M O R S C O M P R I S I N G

L I P O P O L Y S A C C H A R I D E AS AN A C T I V E C O M P O N E N T

ChisatoMaruyama, Mukogaoka, Bunkyo ku, Tokyo to, Japan

Disclosed is a novel immunotherapeutic agent for tumors, which comprises as an active compo- nent a lipopolysaccharide derived from human tubercle bacillus or a lipopolysaccharide formed by chemically modifying said lipopolysac- charide.

4394446

P R O C E S S F O R T H E P R E P A R A T I O N O F T H E

A N T I B I O T I C O X A N O S I N E

Hama Umezawa, Nobuyoshi Shimada, Hiroshi Naganawa, Tomohisa Takita, Masa Hamada, Tomio Takeuchi, Tokyo, Japan assigned to Zaidan Hojin Biscibutsu Kagnku Kenkyu Kai

The novel antibiotic, oxanosine, having the structure See Patent for Chemical Structure in- hibits the growth of Gram-negative bacteria and has antiviral and carcinostatic activity. It is pro- duced by cultivation of an oxanosine-producing microorganism of the genus Streptomyces, pre- ferably Streptomyces capreolus MG265-CF3, ATCC No. 319.63.

4393133

H U M A N H E P A T O M A D E R I V E D C E L L LINE, P R O C E S S F O R

P R E P A R A T I O N T H E R E O F , AND U S E S T H E R E F O R

Barbara B Knowles. David P Aden assigned to The Wistar Institute of Anatomy and Biology

Human hepatoma cell lines, useful for metabolic studies such as screening potential carcinogens and mutagens, for cultivation of viruses, and for preparation of vaccines is obtained by culturing human hepatocarcinoma or hepatoblastoma on lethally irradiated cell feeder layers in the pre- sence of a culture medium.

4393071

M E T H O D O F T R E A T I N G GASTRIC, M A M M A R Y , L U N G

AND U T E R U S T U M O R S

Naoharu Fujii, Noboru Iijim& assigned to Shibuya ku. Tokyo, Japan

A method of treating malignant tumors by daily administering of between 5 and 100 mg of protoporphyrin. Prcferrably the proto- porphyrin is given with a carrier which can be a solid edible material.

4393056

A N T I B I O T I C S T E T R O N O L I D E C O M P O U N D S AND P R O C E S S F O R P R O D U C T I O N T H E R E O F

Fusao Tomita, Tatsuya Tamaoki, Kunikatsu Shirahata, Masaji Kasai, Noriaki Hirayama, Makoto Morimoto, Masanori Fukui, Machida, Japan assigned to Kyowa Hakko Kogyo Co Ltd

New antibacterial tetronolide compounds F-I and F-2 are produced by fermentation of a