3rd international congress on maternal hemodynamics · 2018. 4. 12. · pre-eclampsia clinical...

3rd International Congress on Maternal

Hemodynamics12 – 14 April 2018

Robinson College, Cambridge, UK

PROGRAMME BOOK

www.maternal-hemodynamics.org

Bringing Clarity to Managing Pre-eclampsia Elecsys® sFlt-1/PIGF tests Improving management of difficult cases1,2,3

Early identification and timely referral of patients at risk4,5,6

Appropriate resource allocation2,6,7,8

References1. Schnettler, W., et al. (2013). BJOG 120(10), 1224–1232.2. Frusca, T., et al. (2017). J Matern Fetal Neonatal Med 30:18,2166-2173. 3. Hagmann, H., et al. (2012). Clin Chem 58(5), 837-845.4. Verlohren, S., et al. (2012). Am J Obstet Gynecol 206, 58.e1-e8.5. Roberge, S., et al. (2012). Fetal Diagn Ther 31(3), 141–146.6. Schnettler, W., et al. (2013). BJOG 120, 1224-1232. 7. Vatish, M., et al. (2016). Ultrasound Obstet Gynecol 48, 765-771.8. Rana, S., et al. (2012). Circulation 125, 911-919.ELECSYS and HARMONY are trademarks of Roche© 2018 Roche Diagnostics Limited. All rights reserved.

fisherk5

Sticky Note

Marked set by fisherk5

3rd International Congress on Maternal Hemodynamics 3

WELCOMEDear Colleague,

It is our pleasure to welcome you to our 3rd International Congress on Maternal Hemodynamics here in the heart of Cambridge. Our International Working Group (IWGMH) continues to grow and this year’s congress programme follows our successful format of mixing established and new researchers from Europe and further afield, representing the true international nature of the event.

We have planned a very extensive and stimulating programme of keynote presentations and invited lectures from internationally acclaimed leaders in our field. Free communications and poster presentations continue to be a key feature of the programme content and we have allowed time to encourage interaction and dis-cussion of all of these presentations. Please take time to visit the poster presentations in the exhibition hall during the congress breaks.

We invite you to stay for our Welcome Reception on Thursday 18.30 – 19.30 at Robinson College. This will be a great opportunity to catch up with colleagues and make new connections. Our Congress Dinner will be held in the stunning Trinity Hall (just a ten-minute walk from the congress venue ) on Friday 13 April from 19:45 - 23:00. This will be a unique opportunity to enjoy Trinity Hall, the fifth oldest surviving College of the University of Cambridge, founded by Bishop Bateman of Norwich in 1350. The North Court provides a glimpse into the 15th Century with medieval windows and arches still standing.

If you are not a member of our International Working Group, please do speak to us during the meeting to find out how to collaborate. Our members include obstetricians, cardiovascular physicians and researchers with a special interest in maternal hemodynamics. Our mission is to connect international research groups with interest in the normal and abnormal functioning of a pregnant woman’s cardiovascular system and its re-lation to maternal and fetal outcome. The results of our meetings aim to promote translation of our research to improve clinical care.

On behalf of the Congress Committee, we would like to express our thanks to the exhibitors and generous sponsors of the congress, all members of the Working Group, the abstract reviewers, session chairs, the pre-senters who are sharing their research and experience with us and to our delegates who continue to support the Congress. Please take every opportunity over the next few days to learn, familiarise yourself with new ideas and hear about the latest study results. Share your knowledge with others, build new friendships and meet old ac-quaintances. We also hope you find time to enjoy the wonderful city of Cambridge.

Dr Christoph Lees Associate Professor Dr Wilfried GyselaersImperial College London, UK University of Hasselt, Belgium

Christoph Lees, London UKWilfried Gyselaers, Genk Belgium Carmel McEniery, Cambridge UKIan Wilkinson, Cambridge UKHerbert Valensise, Rome Italy

Asma Khalil, London UKFabricio Costa, Melbourne AustraliaJohn Cockcroft, Cardiff UKEnrico Ferrazzi, Milan Italy

ORGANISING COMMITTEE

4 www.maternal-hemodynamics.org

PROGRAMMEThursday 12 April 2018

8.00 Registration

9.00 Pre-Congress Workshop Techniques and measurement in maternal cardiovascular assessment

12.00 Lunch

14.00 Welcome Carmel McEniery, University of Cambridge, United Kingdom and Ian Wilkinson, University

of Cambridge, United Kingdom

Session 1: Hemodynamics - New concepts Chairs: Carmel McEniery and Ian Wilkinson

14.15 Inflammation as the key to vascular dysfunction Attilio Speciani, University of Bologna, Italy

14.30 Obesity, GDM and maternal cardiovascular function. Would one test fit all? Tommy Mousa, University of Leicester, United Kingdom

14.45 Maternal hemodynamics and computerised CTG in the identification of risk during labour Herbert Valensise, University of Rome, Italy

15.00 Clinical use of nitric oxide donors: Latest insights Dietmar Schlembach, University of Berlin, Germany

15.15 Discussion

15.30 OS 1: Free Communications on new developments and links with other medical disciplines

1.1 Cardiac adaptation to pregnancy in morbidly obese mothers at term Bigna Buddeberg, University Hospital Basel, Switzerland

1.2 Nitric oxide donors in women affected by fetal growth restriction: the importance of cardiac dysfunction in non-responder patients Damiano Lo Presti, University of Rome Tor Vergata, Italy

1.3 A pilot study of fetal growth, maternal hemodynamics and plasma and placental expression of epidermal growth factor like domain 7 in pregnancies complicated by fetal growth restriction treated with nitric oxide donors Grazia Maria Tiralongo, Policlinico Casilino Hospital, Rome, Italy

1.4 A pilot study of the effects of metformin on maternal hemodynamics in gestational diabetes mellitus Mohamed Waseem Osman, University Hospitals of Leicester, United Kingdom


1.5 Monocyte subsets and arterial elastance at 13 weeks gestation and the effects of prior hypertension in pregnancy James Castleman, Sandwell and West Birmingham Hospitals NHS Trust, United Kingdom

1.6 A cross sectional study to examine maternal haemodynamic changes, in pregnant women with a body mass index ≥35 Kg/M2 Francesca Maria Teresita Leone, University Hospitals of Leicester, United Kingdom

1.7 Maternal hemodynamic changes amongst women who were screened for gestational diabetes in comparison to healthy controls Mohamed Waseem Osman, University Hospitals of Leicester, United Kingdom

1.8 Maternal cardiovascular changes secondary to sildenafil intake in pregnancies complicated by severe fetal growth restriction: STRIDER trial Asma Khalil, St George’s, University of London, United Kingdom

16.30 Afternoon Tea

Session 2: Hemodynamic changes and clinical management Chairs: Christoph Lees and Wilfried Gyselaers

17.15 What physicians learned from obstetricians Valerie Luyckx, University of Zurich, Switzerland

17.30 How adult antihypertension can teach us lessons Ian Wilkinson, University of Cambridge, United Kingdom

17.45 Home monitoring of hypertension in pregnancy Asma Khalil, St George’s, University of London, United Kingdom

18.00 Discussion

18.15 Closure Day 1

18.20 Talking point and proposals: The future of maternal hemodynamics and of IWGMH (business session of the IWGMH) Christoph Lees, Imperial College London, United Kingdom, Wilfried Gyselaers, University of Hasselt, Belgium and Herbert Valensise, University of Rome Tor Vergata, Italy

18.30 - 19.30 Welcome Reception


Friday 13 April 2018

Session 3: Non-invasive technologies for maternal hemodynamic assessment Chairs: Enrico Ferrazzi and Marc Spaanderman

8.00 Registration

9.00 Blood pressure measurement: which method and thresholds? Andrew Shennan, Kings College London, United Kingdom

9.15 FMD: Endothelium dependent and independent mechanisms Charlotte Iacobaeus, Danderyd Hospital, Sweden

9.30 Is the microcirculation relevant? Andreas Brückmann, University of Jena, Germany

9.45 Skin microvascular function Thomas Kahan, Danderyd Hospital, Sweden

10.00 Discussion

10.15 OS 2: Free Communications on non-invasive technologies and their clinical applications

2.1 Cardiac maladaptation in term preeclampsia - A speckle tracking study Bigna Buddeberg, University Hospital Basel, Switzerland

2.2 Flow-mediated constriction reveals maternal endothelial dysfunction in preeclampsia Dominique Mannaerts, University of Antwerp, Belgium

2.3 Central and uterine haemodynamics in healthy and pathological pregnancies Helen Perry, St George’s, University of London, United Kingdom

2.4 Atrial phase characteristics in the jugular venous doppler waveform during uncomplicated pregnancy Inge Dierickx, University of Hasselt, Belgium

2.5 Central aortic pressure in the first trimester of pregnancy in terms of body mass Maria Evsevyeva, Stavropol State Medical University, Russia

2.6 Cardio-ankle vascular index in female students, whose mothers differed problematic pregnancy Maria Evsevyeva, Stavropol State Medical University, Russia

2.7 Oscillometric pulse wave analysis as a method to assess endothelial function: A pilot study Emily Aldridge, University of Adelaide, Australia

2.8 A novel fully-automated technique for measuring carotid intima-media thickness in pregnant women Swina Santhirakumaran, Imperial College London, United Kingdom

2.9 Cardiac alterations caused by pre-eclampsia Kristin Kräker, Max Delbrück Center for Molecular Medicine, Berlin, Germany

11.15 Morning Tea


Session 4: Understanding physiology and pathophysiology Chairs: Herbert Valensise and Carmel McEniery

12.00 Non-invasive monitoring: Lessons from acute medicine Tim Rainer, Cardiff University, Wales, United Kingdom

12.15 The maternal circulation is a circuit with interdependently functioning components Wilfried Gyselaers, University of Hasselt, Belgium

12.30 Phenotype-specific treatment of HT and FGR Enrico Ferrazzi, University of Milan, Italy

12.45 Discussion

13.00 Lunch

Session 5: Preconceptional physiology and strategies Chairs: Chahinda Ghossein-Doha and Hans Duvekot

14.00 Preconceptional CV status of former PE women in relation to outcome of subsequent pregnancy Marc Spaanderman, Maastricht University, The Netherlands

14.15 Preconception functional hemodynamic testing: An insight into pregnancy cardiovascular health Victoria Meah, University of Alberta, Canada

14.30 Pre-pregnancy cardiovascular optimisation in women with a history of PE Ralph Scholten, Radboud University Nijmegen, The Netherlands

14.45 WATCH UK: Why we need a pre-pregnancy population study Carmel McEniery, University of Cambridge, United Kingdom

15.00 Discussion

15.15 OS 3: Free Communications on preconceptional assessment/management and preclinical screening

3.1 Mitochondrial DNA copy number in peripheral blood in the first trimester of pregnancy and different pre-eclampsia clinical phenotypes development: A pilot study Andrea Busnelli, University of Milan, Italy

3.2 Maternal demographics and hemodynamics for the prediction of fetal growth restriction at booking, in pregnancies at high risk for placental insufficiency Daniel Stott, King’s College Hospital, London, United Kingdom

3.3 A novel biomarker for twin-to-twin transfusion syndrome prediction in maternal circulation Berta Lima de Carvalho, University of Porto, Portugal

3.4 Abnormal body fluid volume homeostasis in pregnancies complicated with hypertension or poor fetal growth Pauline Dreesen, University of Hasselt, Belgium

3.5 Phenotypes of pregnant women who develop hypertension in pregnancy Kelsey McLaughlin, University of Toronto, Canada


3.6 Longitudinal study to assess changes in arterial stiffness and cardiac output parameters among low-risk pregnant women Mohamed Waseem Osman, University Hospitals of Leicester, United Kingdom

3.7 Arterial stiffness during controlled ovarian hyperstimulation and early pregnancy in women exposed to assisted reproduction Emma von Wowern, Lund University, Sweden

16.15 Afternoon Tea and Poster Session

Session 6: Hemodynamics of GHD and/or IUGR

Chairs: Wilfried Gyselaers and Basky Thilaganathan

17.15 Hemodynamic characteristics of TTP, HUS and AFLP and their relationship with pre-eclampsia David Williams, University College London Hospital, United Kingdom

17.30 Why early and late PE are the same condition Jasmine Tay, Imperial College London, United Kingdom

17.45 PreMoM: The Belgian project on telemonitoring for women at risk for GHD Dorien Lanssens, University of Hasselt, Belgium

18.00 Doppler changes and maternal cardiovascular function Christoph Lees, Imperial College London, United Kingdom

18.15 Discussion

18.30 Closure Day 2

19.45 - 23.00 Congress Dinner - Trinity Hall

Saturday 14 April 2018

Session 7: Management of GHD and/or IUGR

Chairs: Herbert Valensise and Asma Khalil

8.00 Registration

9.00 Vascular function in women with chronic hypertension Lucy Chappell, Kings College London, United Kingdom

9.15 Monitoring antihypertensive therapy with hemodynamics Daniel Stott, King’s College Hospital London, United Kingdom

9.30 Pre-eclampsia: More than sick pregnant women Basky Thilaganathan, St George’s Hospital, London, United Kingdom

9.45 Discussion


10.00 OS 4: Free Communications on management during disease and postpartum

4.1 Preeclampsia and the risk of later dementia -- A nationwide cohort study Heather Boyd, Copenhagen University, Denmark

4.2 Haemodynamic assessment and gestational diabetes mellitus: Could we improve the identification of the obstetric risk? Ilaria Pisani, Policlinico Casilino Hospital, Rome, Italy

4.3 Role of maternal hemodynamic evaluation in the definition of fetuses with growth restriction outcome Damiano Lo Presti, University of Rome Tor Vergata, Italy

4.4 Monochorionic twin pregnancy and its “physiological” cardiac dysfunction during 3rd trimester Daniele Farsetti, University of Rome Tor Vergata, Italy

4.5 Some complications of pregnancy and arterial stiffness in the presence of isolated central hypertension Maria Evsevyeva, Stavropol State Medical University, Russia

4.6 Cardiovascular effects of oxytocin and carbetocin at caesarean section, a prospective double-blind randomised study using non-invasive pulse wave analysis Sofus Rabow, University of Lund, Sweden

4.7 Intraoperative haemodynamic monitoring during high-risk caesarean section: A comparison between pressure waveform (lidcorapid®) and bioreactance analysis (nicom®) Juan de Dios Gutierrez Henares, St George’s Hospital, London, United Kingdom

4.8 Placental growth factor as an indicator of maternal cardiovascular risk after pregnancy Laura Benschop, Erasmus University Medical Center, Rotterdam, The Netherlands

4.9 Cardiovascular health after a hypertensive pregnancy disorder: Better or worse? Laura Benschop, Erasmus University Medical Center, Rotterdam, The Netherlands

11.00 Morning Tea

Session 8: Postpartum and long term cardiovascular function after PE

Chairs: Marc Spaanderman and Christoph Lees

11.45 Postpartum and long term cardiovascular function after PE Chahinda Ghossein-Doha, Maastricht University, The Netherlands

12.00 Assisted reproductive technologies induced alteration of the cardiovascular phenotype Théo Meister, University Hospital of Bern, Switzerland

12.15 Public health benefits of maternal hemodynamics assessment during pregnancy and beyond Hans Duvekot, Erasmus University Medical Center, Rotterdam, The Netherlands

12.30 Discussion

12.45 Best Abstract Award

13.00 Closure of Congress Lunch

GENERAL INFORMATION

Abstracts and Invited Speaker Biographies Abstracts and Invited Speaker Biographies are available to download from the ICMH 2018 website www.maternal-hemodynamics.org

Badges Name badges must be worn at all times throughout the meeting. For reasons of security, delegates not wear-ing a name badge will be denied access to scientific sessions.

Lunch and Refreshments Catering stations are located in the exhibition area. Lunch will be provided for all participants on Thursday, Friday and Saturday.

Mobile/Cell Phones and Electronic Devices As a courtesy to speakers and other delegates, please ensure that mobile/cell phones, tablets and other electronic devices are switched to silent during sessions. Photography and filming during sessions is not permitted.

Questions to speakers During discussion periods, delegates who wish to pose a question should raise their hand clearly and wait to be acknowledged by the chairperson. Please do not ask a question until you have been given a microphone.

Registration Desk The conference organisers will be located at the registration desk and will be pleased to assist you with any queries throughout the conference.

Speaker Preview All oral presenters should meet with the audio-visual technician in the speaker preview room at the earliest opportunity and at the very latest, two hours before the start of the session in which the presentation will take place.

Social ProgrammeWelcome Reception

Thursday 12 April

18.30 – 19.30

Robinson College

Congress Dinner

Friday 13 April,

19.45 – 23.00Trinity Hall, Trinity Lane, Cambridge CB2 1TJ. Ticket holders only.



POSTERSP.1 Agreement between blood pressure techniques used in pregnancy Emily Aldridge, University of Adelaide, Australia

P.2 Multivariable evaluation of the maternal hemodynamic profile in high-risk pregnancies complicated by intrauterine growth restriction: A prospective study Daniela Denis Di Martino, University of Milan, Italy

P.3 Maternal hemodynamic profile in hypertensive disorders and intrauterine growth restriction during pregnancy and postpartum Daniela Denis Di Martino, University of Milan, Italy

P.4 Cardiac dysfunction in late-onset pre-eclampsia - the interaction between intrauterine growth restriction and preeclampsia in third trimester hemodynamic profiles Lisa Grange Persson, Statens Serum Institute, Copenhagen, Denmark

P.5 Comparison of two non-invasive devices measuring arterial stiffness and central blood pressure in pregnancy Helen Perry, St George’s, University of London, United Kingdom

P.6 Maternal haemodynamics in normal pregnancies and in pregnancies affected by pre-eclampsia Daniel Stott, King’s College Hospital, London, United Kingdom

P.7 Prenatal exercise for the prevention of gestational diabetes mellitus and hypertensive disorders of pregnancy: a systematic review and meta-analysis Margie Davenport, University of Alberta, Edmonton, Canada

P.8 New perspective in pre-eclampsia risk assessment: Quantification of endogenous marinobufagin by a specific and very sensitive uplc-ms/ms assay in pregnant women Charline Lenaerts, University of Mons, Belgium

P.9 Is maternal arterial function associated with birth weight? Swina Santhirakumaran, Imperial College London, United Kingdom

P.10 The effect of a raised BMI on surgical morbidity in women undergoing caesarean section - A pilot study Samantha Yeo, KK Women’s and Children’s Hospital, Singapore

P.11 The venous heart-brain axis, intracerebral hypertension and complications of pregnancy: A literature search Inge Dierickx, University of Hasselt, Belgium

P.12 Anticogulation therapy in pregnant women with mechanical heart valves Nguyen Van Thao, Vietnam National Heart Association, Hanoi, Vietnam

P.13 Does metformin prevent preeclampsia? A systematic review and meta-analysis Juan de Dios Gutierrez, St George’s, University of London, United Kingdom

P.14 Characteristics of the obstetric patients admitted in the intensive care unit of Sanglah General Hospital Indonesia in 2014-2017 Stella Kawilarang, Udayana University, Bali, Indonesia

www.maternal-hemodynamics.org

Professional Conference OrganisersThe Conference Collective Ltd.

8 Waldegrave Road, Teddington, Middlesex, TW11 8HT, UKTelephone: +44 (0) 20 8977 7997

www.conferencecollective.co.uk

BPLab company is a leading Russian manufacturer of 24-hour blood pressure monitoring equipment with arterial stiffness and central aortic pressure assessment.

Our ABPMs offer accurate, safe and comfortable blood pressure measurement with no second inflation for expanded parameters (PWV, Augmentation index, SYSao, DIAao, etc).

BPLab devices were validated BHS protocol (A/A class) in three groups of patients: general, pregnant women and children.

BPLab Vasotens is a unique validated diagnostic system which combines a non-invasive estimation of arterial stiffness and central aortic pressure parameters with traditional blood pressure monitoring.

SaaS Vasotens is an open platform which enables assessment of central aortic pressure and arterial stiffness parameters from pulse waves recorded by other manufacturers’ devices.

BPLab is integrated into Italian telemedicine platform “Tholomeus”.

GE Healthcare provides transformational medical technologies and services to meet the demand for increased access, enhanced quality and more affordable healthcare around the world. GE (NYSE: GE) works on things that matter - great people and technologies taking on tough challenges. From medical imaging, software & IT, patient monitoring and diagnostics to drug discovery, biopharmaceutical manufacturing technologies and performance improvement solutions, GE Healthcare helps medical professionals deliver great healthcare to their patients.

Non Invasive screening for early detection of Pre-Eclampsia and hypertensive disorders continues to be a major cause of maternal and fetal concern.

Early prediction of pre-eclampsia would allow for timely intervention of preventive therapy.

BioScan touch i8 is a non-invasive device which provides fast and accurate measurement of Total Body water.

Early diagnosis plays an important role, take control, make a difference and be proactive, understand changes in body composition and fluid balance. The assessment of body composition and fluid volume is important and should be performed in all patients.

BioScan touch i8 provides healthcare professionals with an objective measure of patients, which could improve outcomes.

USCOM 1A- The non-invasive Doppler Monitor for Advanced Hemodynamics.

Preeclampsia is the single greatest cause of maternal and fetal morbidity worldwide. In the US it is estimated to cost $US 2.18 billion in the 12 months following delivery. The USCOM 1A can identify changes in maternal circulation that indicate the onset of preeclampsia from as early as 5 weeks. The Uscom 1A allows for earlier intervention and improved outcomes, and decreased costs for healthcare providers.

Thank you to our exhibitors. Please ensure you take the time to visit and support the companies exhibiting.

3rd international congress on maternal hemodynamics · 2018. 4. 12. · pre-eclampsia clinical...

Documents