2/25/08 blood vessels chapter 19 – day 1. 2/25/08 blood vessel structure fig. 19.1
DESCRIPTION
2/25/08 Blood Vessels - Intro Blood vessels are essentially a “pipeline” to: ♦Carry blood TO parts of the body = arteries ♦Carry blood BACK FROM parts of the body = veins Subdivisions ♦Pulmonary blood vessels: blood to the lungs and back ♦Systemic blood vessels: blood to and from the rest of the bodyTRANSCRIPT
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Blood Vessels
Chapter 19 – Day 1
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Blood Vessel Structure
Fig. 19.1
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Blood Vessels - Intro
Blood vessels are essentially a “pipeline” to:♦Carry blood TO parts of the body = arteries♦Carry blood BACK FROM parts of the body = veins
Subdivisions♦Pulmonary blood vessels: blood to the lungs and back♦Systemic blood vessels: blood to and from the rest of the
body
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Blood Vessels - Intro
Veins = mostly deoxygenated – except pulmonary vein & umbilical vein
Arteries = mostly oxygenated – except pulmonary artery & umbilical artery
Capillaries = interconnecting vessels♦Enable gas exchange, etc.
Blood vessel structure and comparison activity in lab
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Blood Vessel Structure
Fig. 19.1
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Arteries vs. Veins - Similarities 3 LayersTunica Externa
♦Connective TissueTunica Media
♦Smooth muscle cells ♦Elastic fibers (arteries)♦Collagen fibers
Tunica Interna♦Elastic layer♦Endothelial cells & connective tissue with elastic fibers
(arteries)
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Arteries vs. VeinsArteries are thick walledLarger arteries have more elastic fibers
♦Tunica media – thicker, concentric & longitudinal♦Tunica interna – internal elastic membrane
ARTERIES♦Elasticity
•Ability to stretch when full = high pressure•Return to their original state when relaxed
♦Contractability•More smooth muscle (than veins)•Vasodilation, Vasoconstriction
Both veins & large arteries need O2 – supplied by vaso vasorum
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Arteries vs. VeinsHierarchy of organization
♦(learn examples from text)Largest vessels coming out of heart or to heartThese carry the most volume
♦If arteries – they have the highest pressureDiagram on board and Fig. 19.2
Be able to work though these – know order and characteristics
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Blood Vessel Hierarchy
Fig. 19.2
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Capillaries
Fig. 19.5
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Arteries vs. VeinsDifferent jobs and different driving forcesArteries
♦Force of contraction pushes blood forward♦Blood pressure = driving force♦Moves downhill to lower extremities - gravity
Veins ♦Lower extremities to heart = against gravity♦Low pressure♦Relies on other driving forces
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VeinsTwo features help to push blood forward:
♦Valves – keep blood from flowing backward (flow is possible in 1 direction only)
♦Skeletal muscle contraction•Helps to push blood forward
♦Breathing action•Pressure in chest helps venous flow
♦All contribute to venous return
Fig. 19.6
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Blood vessel functionUltimately blood delivers O2 & nutrients to tissues as
well as removing wastes How does this happen?Any organ:
♦Blood vessels (in & out): arteries – smallest branch = capillary
♦The organ is infused with capillaries♦Nutrient exchange occurs at this level
In the capillaries – only the endothelial layer is presentSubstances in the capillaries move to the Interstitial
Fluid → then into cells
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O2, Nutrient, and Waste ExchangeWaste products are released into the interstitial fluid
Waste products are then taken up by fenestrated capillaries because they are typically large molecules (recall differences between fenestrated & continuous capillaries)
Fig. 19.4
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O2, Nutrient, and Waste Exchange Exchange between blood and interstitial fluid
1. Simple (& Facilitated) Diffusion:♦In response to a concentration gradient
2. Filtration♦Force pushes out substances – based on pressure
3. Osmosis♦Reabsorption of water
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Diffusion Ions and small organic molecules (glucose, amino
acids, urea – move through pores in fenestrated capillaries or move via diffusion between endothelial cells of adjacent capillaries
Ions (Na+, K, etc.) diffuse across endothelial cells by passing through channels in cell membranes
Large water-soluble compounds can only work enter or leave blood stream via fenestrated capillaries
Lipids (FAs, steroids) and lipid-soluble compounds (esp. CO2, O2) cross capillary walls by diffusion through endothelial cell membranes
Plasma proteins can only diffuse through in sinusoids (such as those in the liver)
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Filtration Driving force =
PRESSURE in capillary = Capillary Hydrostatic Pressure (CHP)
Water is forced across a capillary wall and small solutes travel with the water♦Through endothelial cells
or pores of fenestrated capillaries
Fig. 19.11
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Reabsorption Occurs as a result of osmosis
♦Diffusion of water across selectively permeable membrane•Remember, water molecules move toward soln with higher
solute concentration Process by which dissolved solutes is moved Osmotic pressure = amount of pressure that must be
applied to prevent osmotic movement across a membrane♦BCOP = blood colloid osmotic pressure = osmotic pressure
of blood Remember…hydrostatic pressure forces water OUT
of solution, whereas osmotic pressure draws water INTO a solution
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Pressures have to be balanced so that fluid in and out can be coordinated
Fig. 19.11
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Filtration & Reabsorption If BHP > BOP in the blood vessel, fluid is pushed out If BHP < BOP fluid enters in
IFHP & IOP – low & stable because there are fewer proteins in interstitial fluid
Net Filtration Pressure is the difference between the net hydrostatic pressure and the net osmotic pressure: ♦Net filtration = net hydrostatic – net colloid pressure pressure osmotic pressure
If positive fluid moves OUT of capillary If negative fluid moves INTO capillary
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Equilibrium Analogy to filtration experiment
♦Charcoal = cells & proteins♦CuSO4 = nutrients & O2
Cells & Proteins remain in blood vessel H2O, hormones, other chemicals, nutrients, O2,
glucose, ions = pushed out Equilibrium between arterial & venus ends maintains
proper pressure differences Excess fluid expelled into tissues causes an increase
in interstitial fluid – if in excess, causes EDEMA♦Excess fluid buildup, swollen ankles, etc
Read in book and follow handout
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Equilibrium Equilibrium between arterial & venus ends maintains
proper pressure differences Excess fluid expelled into tissues causes an increase
in interstitial fluid – if in excess, causes EDEMA♦Excess fluid buildup, swollen ankles, etc
Read in book and follow handout Different demands for gas and nutrient exchange For proper delivery – the cardiovascular system
depends on:1. Cardiac Output2. Peripheral Resistance3. Blood Pressure
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Equilibrium Different demands for gas and nutrient exchange For proper delivery – the cardiovascular system
depends on:1. Cardiac Output2. Peripheral Resistance3. Blood Pressure
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Equilibrium Need constant control of these factors to maintain
homeostasis= CARDIOVASCULAR REGULATION
Controlled by♦Autoregulation Mechanisms
•Local factors change pattern of blood flow w/in capillary beds•Response to chemical changes in interstitial fluids
♦Neural Mechanisms•Respond to changes in arterial pressure or blood gas levels @
a specific site stimulates cardiovascular centers of ANS♦Endocrine Mechanisms
•Releases hormones that enhance short-term adjustments and direct long-term changes in cardiovascular performance
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Equilibrium
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Auto Regulation Local changes
♦Sphincters near capillaries are adjusted♦Depend on local VASODILATION & VASOCONSTRICTION
chemicals (nitrous oxide) – know examples from text (p 547)•Vasodilator: factor(s) that promote the dilation of precapillary
sphincters•Local vasodilators act at the tissue level & accelerate blood
flow through the tissue of origin
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Neural Mechanisms Neural Mechanisms
♦Sympathetic division controls…•Smooth muscle tone (vasomotor tone)•Increased sympathetic impulses ( vasoconstriction)•Decreased sympathetic impulses ( vasodilation)
♦Receptors
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Capillaries
Fig. 19.5