2011 IEEE Biomedical Circuits

and Systems Conference

(BioCAS 2011)

San Diego, California, USA

10 - 12 November 2011

4 IEEE IEEE Catalog Number: CFP11837-PRT

ISBN: 978-1-4577-1469-6

Table of Contents

Friday, November 11, 2011

A1L-A Circuits for Biomedical Systems I

Chair(s): Timothy Constandinou, Imperial College LondonNitish Thakor, Johns Hopkins University

A1L-A.1 A 4 |jW/Ch Analog Front-End Module with Moderate Inversion and Power-Scalable

Sampling Operation for 3-D Neural Microsystems 1

Khaled Al-Ashmouny, University ofMichiganSun-U Chang, University ofMichiganEuisik Yoon, University ofMichigan, Ann Arbor

A1L-A.2 A Highly-Accurate Low-Power CMOS Potentiostat for Implantable Biosensors 5

Milad Razzaghpour, KTH Royal Institute of TechnologySaul Rodriguez, KTH Royal Institute of TechnologyEduard Alarcon, Universitat Politecnica de CatalunyaAna Rusu, KTH Royal Institute of Technology

A1L-A.3 A 16-Channel 220 Neural Recording IC with Embedded Delta Compression 9

Vahid Majidzadeh, Ecole Polytechnique Federale de Lausanne

Alexandre Sclunid, Ecole Polytechnique Federale de Lausanne

Yusuf Leblebici, Ecole Polytechnique Federale de Lausanne

A1L-A.4 Low-Power Energy-Based CMOS Digital Detector for Neural Recording Arrays 13

Jonathan Drolet, Ecole Polytechnique de Montreal

Hicham Semmaoui, Ecole Polytechnique de Montreal

Mohamad Sawan, Ecole Polytechnique de Montreal

A1L-A.5 Signal Integrity Analysis of a 2-D and 3-D Integrated Potentiostat for

Neurotransmitter Sensing 17

Emre Salman, Stony Brook UniversityMohammad H. Asgari, Stony Brook University

Milutin Stanacevic, Stony Brook University

A1L-A.6 Implementation of Functional Components of the Locomotion Processing Unit 21

Kevin A. Mazurek, Johns Hopkins University

Ralph Etienne-Cummings, Johns Hopkins University

A2P-B Circuits for Biomedical Systems II

Chair(s): Pedram Mohseni, Case Western Reserve University

Guoxing Wang, Shanghai Jiao Tong University

A2P-B.1 A Hardware Implementation of Real-Time Epileptic Seizure Detector on FPGA 25

Tsan-Jieh Chen, National Chiao Tung UniversityChi Jeng, National Chiao Tung University

Shun-Ting Chang, National Chiao Tung University

Herming Chiueh, National Chiao Tung University

Sheng-Fu Liang, National Cheng Kung University

Yu-Cheng Hsu, National Cheng Kung UniversityTzu-Chieh Chien, National Cheng Kung University

A2P-B.2 A Sub-lpW Neural Spike-Peak Detection and Spike-Count Rate Encoding Circuit 29

Sivylla E. Paraskevopoulou, Imperial College London

Timothy G. Constandinou, Imperial College London

A2P-B.3 A Nano Power CMOS Tinnitus Detector for a Fully Implantable Closed-Loop Neurodevice ....

33

Senad Hiseni, Delft University of TechnologyChutham Sawigun, Delft University ofTechnologySven Vanneste, University Hospital AntwerpEddy van der Velden, University Hospital AntwerpDirk De Ridder, University Hospital AntwerpWouter A. Serdijn, Delft University ofTechnology

A2P-B.4 ElectroCorticoGraphy (ECoG) Acquisition Exploiting SignalCharacteristics for Reduced Power 37

Apurva Mishra, University of WashingtonFan Zhang, University of WashingtonBrian P. Otis, University of Washington

A2P-B.5 Real-Time Multi-Channel Seizure Detection and Analysis Hardware 41

Darin Chandler Jr., University ofMaryland, Baltimore CountyJordan Bisasky, University ofMaryland, Baltimore CountyJerome L.V.M. Stanislaus, University ofMaryland, Baltimore CountyTinoosh Mohsenin, University ofMaiyland, Baltimore County

A2P-B.6 Efficient Speech Edge Detection for Mobile Health Applications 45

Dingkun Du, Dartmouth CollegeKofi Odame, Dartmouth College

A2P-C Circuits for Biomedical Systems III

Chair(s): Pedram Mohseni, Case Western Reserve University

Guoxing Wang, Shanghai Jiao Tong University

A2P-C.1 FPGA implementation of an IIR Temporal Filtering Technique for

Real-Time Stimulus Artifact Rejection 49

Kanokwan Limnuson, Case Western Reserve UniversityHui Lu, Case Western Reserve UniversityHillel J. Chiel, Case Western Reserve UniversityPedram Mohseni, Case Western Reserve University

A2P-C.2 Wide Bandwidth Cell Impedance Spectroscopy based on

Digital Auto Balancing Bridge Method 53

Nan Li, National University ofDefense Technology / University ofSussexHui Xu, National University ofDefense TechnologyZhou Zhou, National University ofDefense TechnologyZhaolin Sun, National University ofDefense TechnologyXin Xu, National University ofDefense TechnologyWei Wang, University ofSussex

A2P-C.3 A 12V-500uA Neuron Stimulator with Current Calibration Mechanism in

0.18pm Standard CMOS Process 57

Chien-Chih Chen, National TsingHua University

Kea-Tiong Tang, National Tsing Hua University

A2P-C.4 An Automated Calibration System for In Vivo Neural Network Study 61

Thoa Nguyen, IMEC

Carmen Bartic, Katholieke Universiteit Leuven

Wolfgang Eberle, IMEC

Georges Gielen, Katholieke Universiteit Leuven

A2P-C.5 An Analog Beamformer for Integrated High-Frequency Medical Ultrasound Imaging 65

Gokce Gurun, Georgia Institute of TechnologyJaime Zahorian, Georgia Institute ofTechnologyCoskun Tekes, Georgia Institute ofTechnologyMustafa Karaman, Isik UniversityPaul Hasler, Georgia Institute of TechnologyF. Levent Degertekin, Georgia Institute ofTechnology

A2P-C.6 Modeling Intrinsic Ion-Channel and Synaptic Variability in a

Cortical Neuromorphic Circuit 69

Mohammad Mahvash, University ofSouthern CaliforniaAlice C. Parker, University ofSouthern California

A2P-D Circuits for Biomedical Systems IV

Chair(s): Guoxing Wang, Shanghai Jiao Tong UniversityPedram Mohseni, Case Western Reserve University

A2P-D.1 Comprehensive Analysis and Optimization of CMOS Neural Amplifiers for

Wireless Recording Implants 73

Haitao Li, Michigan State UniversityAndrew J. Mason, Michigan State University

A2P-D.2 A Low-Power, Low-Voltage, User-Programmable, Wireless Interface for

Reliable Neural Recording 77

Amir Borna, University ofMichigan, Ann Arbor

Khalil Najafi, University ofMichigan, Ann Arbor

A2P-D.3 A 16x16 Multi-Electrode Array with Integrated CMOS Amplifiers for

Neural Signal Recording 82

Lu Wang, Boston UniversityDavid S. Freedman, Boston UniversityRonald W. Knepper, Boston UniversityM. Selim Unlii, Boston UniversityMesut Sahin, New Jersey Institute ofTechnology

A2P-D.4 An Analog-to-Time Converter with Positive Feedback for

Amplifying Miniature Neural RecordingsHsin-Chi Chang, National Tsing Hua UniversityYi-Da Wu, National TsingHua UniversityHsin Chen, National Tsing Hua University

A2P-E Medical Information and Telecare Systems I

Chair(s): Guoxing Wang, Shanghai Jiao Tong UniversityPedram Mohseni, Case Western Reserve University

A2P-E.1 Development of Tele-Echography Interface with AR/VR Visualization

System of Internal Organs

Takashi Yoshinaga, Institute ofSystems, Information Technologies and NanotechnologiesDaisaku Arita, Institute ofSystems, Information Technologies and NanotechnologiesWataru Miyazaki, Tokyo University ofAgriculture and Technology

Kohji Masuda, Tokyo University ofAgriculture and Technology

A2P-E.2 A VHDL Implementation of the Biostator II Glucose Control

Algorithm for Critical Care

Ilias Pagkalos, Imperial College London

Pau Herrero, Imperial College London

Mohamed El-Sharkawy, Imperial College LondonPeter Pesl, Imperial College London

Nick Oliver, Imperial College LondonPantelis Georgiou, Imperial College London

A2P-E.3 Simultaneous Neural and Movement Recording in Large-ScaleImmersive Virtual Environments

Joseph Snider, University of California, San DiegoMarkus Plank, University ofCalifornia, San Diego

Dongpyo Lee, University of California, San DiegoHoward Poizner, University ofCalifornia, San Diego

A3L-A Systems Enabling Experimental Neuroscience in Freely-Moving Animals

Chair(s): Mohsen Mollazadeh, Johns Hopkins UniversityKartikeya Murari, Johns Hopkins University

A3L-A.1 Instrumentation Enabling the Chronic Assessment of Neural Activity:

A Novel Case Study of Hibernation in Ursus Americanus

T.G. Laske, Medtronic, Inc.

D.L. Garshelis, Minnesota State Government

P.A. Iaizzo, University ofMinnesotaD. Carlson, Medtronic, Inc.

R. Jensen, Medtronic, Inc.

S. Stanslaski, Medtronic, Inc.

S. Weiss, Medtronic, Inc.

P. Afshar, Medtronic, Inc.

P. Cong, Medtronic, Inc.

T. Denison, Medtronic, Inc.

A3L-A.2 A Wideband RF Link at the 5.8 GHz ISM Band for Multi-Channel Neural Telemetry

for Small Animals 106

Sabyasachi Roy, Johns Hopkins University

Xiaoqin Wang, Johns Hopkins University

Andy Olson, Montana State UniversityRoss K. Snider, Montana State University

A3L-A.3 Functional Neuroimaging by Using an Implantable CMOS

Multimodal Device in a Freely-Moving Mouse 110

Takuma Kobayashi, Nara Institute Science and TechnologyHideki Tamura, Nara Institute Science and TechnologyYumiko Hatanaka, National Institutefor Physiological Sciences

Mayumi Motoyama, Nara Institute Science and TechnologyToshihiko Noda, Nara Institute Science and Technology

Kiyotaka Sasagawa, Nara Institute Science and TechnologyTakashi Tokuda, Nara Institute Science and Technology

Yasuyuki Ishikawa, Nara Institute Science and TechnologySadao Shiosaka, Nara Institute Science and TechnologyJun Ohta, Nara Institute Science and Technology

A3L-A.4 A Head-Mountable Microscope for High-Speed Fluorescence Brain Imaging 114

Ahmad Osman, John B. Pierce LaboratoryJoon Hyuk Park, Yale UniversityDavid Dickensheets, Montana State UniversityJelena Platisa, John B. Pierce Laboratory

Eugenio Culurciello, Yale UniversityVincent A. Pieribone, John B, Pierce Laboratory

A3 LA.5 Design of a Novel Head-Mountable Microscope System for Laser Speckle Imaging 117

J. Senarathna, Johns Hopkins UniversityK. Murari, Johns Hopkins UniversityR. Etienne-Cummings, Johns Hopkins UniversityN.V. Thakor, Johns Hopkins University

A3L-A.6 Towards a Smart Experimental Arena for Long-Term Electrophysiology Experiments 121

Uei-Ming Jow, Georgia Institute of TechnologyMehdi Kiani, Georgia Institute ofTechnologyXueliang Huo, Georgia Institute ofTechnologyMaysam Ghovanloo, Georgia Institute ofTechnology

A4L-A Compressive Sensing for Biosignals:From Algorithms to Circuits and Systems Design

Chair(s): Gianluca Setti, Universita' di Ferrara

Wen Li, Michigan State University

A4L-A.1 Structured Sparsity Models for Compresslvely Sensed

Electrocardiogram Signals: A Comparative Study 125

Hossein Mamaghanian, Ecole Polytechnique Federate de Lausanne

Nadia Khaled, Ecole Polytechnique Federate de Lausanne

David Atienza, Ecole Polytechnique Federate de Lausanne

Pierre Vandergheynst, Ecole Polytechnique Federate de Lausanne

A4L-A.2 System Considerations for the Compressive Sampling of EEG and ECoG Bio-Signals 129

Daibashish Gangopadhyay, University of Washington

Emily G. Allstot, University of WashingtonAnna M.R. Dixon, University of WashingtonDavid J. Allstot, University of Washington

A4L-A.3 Efficient Realization of Random Demodulator-Based Analog to

Information Converters 133

Yehia Massoud, University ofAlabama at BirminghamSami Smaili, University ofAlabama at BirminghamVikas Singal, University ofAlabama at Birmingham

A4L-A.4 An Architecture for 1-Bit Localized Compressive Sensing with Applications to EEG 137

Javier Haboba, University ofBolognaMauro Mangia, University ofBolognaRiccardo Rovatti, University ofBolognaGianluca Setti, University ofFerrara

A4L-A.5 A Scalable Implementation of Sparse Approximation on a

Field Programmable Analog Array 141

Samuel Shapero, Georgia Institute ofTechnology

Cristopher Rozell, Georgia Institute ofTechnologyAurele Balavoine, Georgia Institute ofTechnology'Paul Hasler, Georgia Institute ofTechnology

A4L-A.6 On-Chip Spike Clustering and Classification Using Self Organizing

Map for Neural Recording Implants 145

Yuning Yang, Michigan State UniversityAndrew J. Mason, Michigan State University

A5P-B Wireless, Wearable, and Implantable/Injectable Technology I

Chair(s): Maysam Ghovanloo, Georgia Institute ofTechnology

Yong Lian, National University ofSingapore

A5P-B.1 A Sub-GHz UWB Pulse Generator for Wireless Implantable Medical Devices 149

M. Stoopman, Delft University ofTechnologyW.A. Serdijn, Delft University of Technology

A5P-B.2 A MedRadio-Band Low-Energy-Per-Bit CMOS OOK Transceiver for

Implantable Medical Devices 153

Li-Chen Liu, National Chiao Tung University

Ming-Han Ho, National Chiao Tung University

Chung-Yu Wu, National Chiao Tung University

A5P-B.3 A Low-Power CMOS BFSK Transceiver for Health Monitoring Systems 157

Sungho Kim, Arizona State UniversityWilliam Lepkowski, Arizona State UniversitySeth J. Wilk, Arizona State UniversityTrevor J. Thornton, Arizona State UniversityBertan Bakkaloglu, Arizona State University

A5P-B.4 PPM Coding Schemes for Super-Regenerative Receivers for

Autonomous Wireless BANs 161

Peng Zhang, Eindhoven University of TechnologyLi Huang, IMEC-NLFrans M.J. Willems, Eindhoven University ofTechnology

A5P-B.5 Integrated CMOS Wireless Power Transfer for Neural Implants 165

Meysam Zargham, University ofToronto

P. Glenn Gulak, University of Toronto

A5P-B.6 A Low-Cost COTS UWB Transceiver for Biological ApplicationsAchieves 50 Mb/s with < 10-6 Raw BER 169

Kerron R. Duncan, Johns Hopkins UniversityRalph Etienne-Cummings, Johns Hopkins University

A5P-B.7 An Ultra Low Power Digital Receiver Architecture for Biomedical Applications 173

F. Goodarzy, University ofMelbourneL. Koushaeian, University ofMelbourneB. Ghafari, University ofMelbourneE. Skafidas, University ofMelbourne

A5P-B.8 An Area and Power Efficient l-UWB Transmitter for Biomedical

Applications Implemented in 65 nm CMOS Technology 177

Ondrej Novak, University of Utah

Cameron Charles, University ofUtahRichard B. Brown, University of Utah

A5P-C Circuits for Biomedical Systems V

Chair(s): Maysam Ghovanloo, Georgia Institute of TechnologyYong Lian, National University ofSingapore

A5P-C.1 Modeling of a Capacitive Link for Data Telemetry to Biomedical Implants 181

Mohammad Takhti, K.N. Toosi University ofTechnologyFarzad Asgarian, K.N. Toosi University ofTechnologyAmirM. Sodagar, K.N. Toosi University ofTechnology

A5P-C.2 Transmitters for Body Sensor Networks: A Comparative Study 185

Karthik Natarajan, University of WashingtonDavid J. Allstot, University of Washington

Jeffrey S. Walling, Rutgers University

A5P-C.3 A Subthreshold Down Converter Optimized for Super-Low-Power

Applications in MICS Band 189

J. Yang, National ICT Australia/The University ofMelbourne

N. Tran, National ICTAustralia/The University ofMelbourneS. Bai, National ICT Australia/The University ofMelbourneM. Fu, National ICTAustralia/The University ofMelbourne

E. Skafidas, National ICTAustralia/The University ofMelbourne

M. Halpern, National ICT Australia/The University ofMelbourne

D.C. Ng, National ICTAustralia/The University ofMelbourneI. Mareels, University ofMelbourne

A5P-C.4 A Wireless Powered Implantable Bio-Sensor Tag System-on-Chlp for

Continuous Glucose Monitoring 193

Shuo Guan, Fudan University

Jingren Gu, Fudan University

Zhonghan Shen, Fudan University

Junyu Wang, Fudan UniversityYue Huang, Michigan State UniversityAndrew Mason, Michigan State University

A5P-C.5 Development of a Telemetry Unit for Bone Strain Monitoring 197

Fahad Moiz, University ofMissouri-Kansas CityWalter Leon-Salas, University ofMissouri-Kansas CityMark Johnson, University ofMissouri-Kansas City

A5P-D Wireless, Wearable, and Implantable/Injectable Technology II

Chair(s): Yong Lian, National University ofSingaporeMaysam Ghovanloo, Georgia Institute ofTechnology

A5P-D.1 Freezing of Gait Detection in Parkinson's Disease Using

Accelerometer based Smart Clothes 201

K. Niazmand, Technische Universitaet Muenchen

K. Tonn, Technische Universitaet Muenchen

Y. Zhao, Technische Universitaet Muenchen

U.M. Fietzek, Schon Klinik Miinchen SchwabingF. Schroeteler, Schon Klinik Miinchen SchwabingK. Ziegler, Schon Klinik Miinchen SchwabingA.O. Ceballos-Baumann, Schon Klinik Miinchen SchwabingT.C. Lueth, Technische Universitaet Muenchen

A5P-D.2 A Wireless ECG Plaster for Real-Time Cardiac Health Monitoring in

Body Sensor Networks 205

Da Ren Zhang, National University ofSingaporeChacko John Deepu, National University ofSingaporeXiao Yuan Xu, National University ofSingapore

Yong Lian, National University ofSingapore

A5P-D.3 Rapid Processor Customization for Design Optimization:A Case Study of ECG R-Peak Detection 209

Mladen Milosevic, University ofAlabama in Huntsville

Emil Jovanov, University ofAlabama in Huntsville

Aleksandar Milenkovic, University ofAlabama in Huntsville

A5P-E Harvesting/Scavenging Energy for Biomedical Devices I

Chair(s): Yong Lian, National University ofSingapore

Maysam Ghovanloo, Georgia Institute of Technology

A5P-E.1 A Power- and Area-Efficient Integrated Power Management System for

Inductively-Powered Biomedical implants 213

Xiwen Zhang, University ofTexas at Dallas

Hoi Lee, University of Texas at Dallas

Song Guo, University ofTexas at Dallas

A5P-E.2 Dual-Input Dual-Output Energy Harvesting DC-DC Boost Converter for

Wireless Body Area Network 217Se-Won Wang, Korea Advanced Institute ofScience and TechnologyJong-Pil Im, Korea Advanced Institute ofScience and TechnologyGyu-Hyeong Cho, Korea Advanced Institute ofScience and Technology

A5P-E.3 An Efficient Wireless Power Transmission System for the

Capsule Endoscopy Applicaton 221Yu Mao, Peking University / SHRIME

Liang Feng, Peking University / SHRIME

Yuhua Cheng, Peking University / SHRIME

A6L-A Wireless, Wearable, and Implantable/Injectable Technology III

Chair(s): Wouter Serdijn, TUDelftRalph Etienne-Cummings, Johns Hopkins University

A6L-A.1 Optimized R Peak Detection Algorithm for Ultra Low Power ECG Systems 225

Sachin Shrestha, IMEC

Tom Torfs, IMEC

Hyejung Kim, IMECRefet Firat Yazicioglu, IMECInaki Romero, IMEC-NL

Dilpreet Buxi, IMEC-NL

Torfinn Berset, IMEC-NL

Marco Altini, IMEC-NL

A6L-A.2 A Battery-Free Multi-Channel Digital Neural/EMG TelemetrySystem for Flying Insects 229

Stewart J. Thomas, Duke UniversityReid R. Harrison, Intan Technologies LLC

Anthony Leonardo, Howard Hughes Medical Institute

Matthew S. Reynolds, Duke University

A6L-A.3 Portable Hardware for Real-Time Channel Estimation on

Wireless Body Area Networks 233

Seunghyun Oh, University ofMichiganDavid D. Wentzloff, University ofMichigan

A6L-A.4 Wireless Micro-ECoG Recording in Primates During Reach-to-Grasp Movements 237

Mohsen Mollazadeh, Johns Hopkins UniversityElliot Greenwald, Johns Hopkins UniversityNitish Thakor, Johns Hopkins UniversityMarc Schieber, University ofRochester Medical Center

Gert Cauwenberghs, University ofCalifornia, San Diego

A6L-A.5 New Subdural Electrode Contacts for Intracerebral ElectroencephalographicRecordings: Comparative Studies on Neural Signal Recording In Vivo 241

Muhammad T. Salam, Polystim Neurotechnologies Laboratory /Ecole Polytechnique de Montreal

Sebastien Desgent, Sainte- Justine University Hospital Center

Sandra Duss, Sainte- Justine University Hospital Center

Lionel Carmant, Sainte- Justine University Hospital Center

Dang K. Nguyen, Notre-Dame HospitalMohamad Sawan, Polystim Neurotechnologies Laboratoiy /Ecole Polytechnique de Montreal

A6L-A.6 Achieving Electric Field Steering in Deep Brain Stimulation 245

Kenneth Tong, University College London

Virgilio Valente, University College London

Andreas Demosthenous, University College LondonRichard Bayford, Middlesex University

Saturday, November 11, 2011

B1L-A Bio-Inspired and Biomolecular Circuits and Systems I

Chair(s): Philipp Hafliger, University ofOslo

Pantelis Georgiou, Imperial College London

B1L-A.1 Dynamical Systems: A Tool for Analysis and Design of Silicon Half Center Oscillators 249

Fei Li, Nanyang Technological UniversityArindam Basu, Nanyang Technological University

Chip-Hong Chang, Nanyang Technological UniversityAvis H. Cohen, University ofMaryland

B1L-A.2 Bio-Inspired Asynchronous Pixel Event Tri-Color Vision Sensor 253

Juan A, Lenero-Bardallo, University ofOslo

D.H. Bryn, University ofOsloP. Hafliger, University ofOslo

B1L-A.3 Analysis and Reduction of Mismatch in Silicon Neurons 257

Shuo Sun, Nanyang Technological UniversityArindam Basu, Nanyang Technological University

B1L-A.4 A CMOS Pancreatic Islet of Langerhans for Automatic Glycemic Regulation 261

Dylan Banks, Imperial College London

Christina Morris, Imperial College London

Joan Omeru, Imperial College London

Wang Wei, Imperial College LondonPantelis Georgiou, Imperial College London

Christofer Toumazou, Imperial College London

B1L-A.5 CMOS Low Current Measurement System for Nanopore Sensing Applications 265

Brian Goldstein, Yale University

Dongsoo Kim, Yale University

Malgorzata Magoch, Instituto de Tecnologia Qulmica e BiologicaYann Astier, Instituto de Tecnologia Qulmica e Biologica

Eugenio Culurciello, Purdue University

B1L-A.6 Speaker-Independent Isolated Digit Recognition Using an AER Silicon Cochlea

Mohammad Abdollahi, ETH Zurich and University ofZurich I Institute ofNeuroinformaticsShih-Chii Liu, ETH Zurich and University ofZurich /Institute ofNeuroinformatics

269

B2P-B Bio-Inspired and Biomolecular Circuits and Systems II

Chair(s): George Yuan, Hong Kong University ofScience and TechnologyThemistoklis Prodromakis, Imperial College London

B2P-B.1 A Silicon Pancreatic Beta Cell based on the Phantom Bursting Model 273

Harkanwal Deep, Imperial College LondonPantelis Georgiou, Imperial College LondonChristofer Toumazou, Imperial College London

B2P-B.2 A VLSI Network of Spiking Neurons with an Asynchronous Static

Random Access Memory 277

Saber Moradi, University ofZurich and ETH Zurich

Giacomo Indiveri, University ofZurich andETH Zurich

B2P-B.3 HMM Classifier Using Biophysically based CMOS Dendrites for Wordspotting 281

Suma George, Georgia Institute of TechnologyPaul Hasler, Georgia Institute ofTechnology

B2P-B.4 A 60-90 MHz Cochlear-Based Channelizer 285

Alex Grichener, Agilent Technologies Inc.

Yu-Chin Ou, Qualcomm Inc.

Gabriel M. Rebeiz, University of California, San Diego

B2P-B.5 A Bio-Inspired Ultra-Low-Power Spike Encoding Circuit for Speech Edge Detection 289

Dingkun Du, Dartmouth CollegeKofi Odame, Dartmouth College

B2P-C Integrated Biomedical Systems, BioMEMS,

Bio-Sensors/Actuators and Lab-on-Chip I

Chair(s): George Yuan, Hong Kong University ofScience and TechnologyThemistoklis Prodromakis, Imperial College London

B2P-C.2 A Wearable Electronic Nose SoC for Healthier Living 293

Kea-Tiong Tang, National Tsing Hua UniversityShih-Wen Chiu, National Tsing Hua UniversityMeng-Fan Chang, National Tsing Hua University

Chih-Cheng Hsieh, National Tsing Hua University

Jyuo-Min Shyu, National Tsing Hua University

B2P-C.3 On-Chip Biochemical Sample Preparation Using Digital Microfluidics 297

Yi-Ling Hsieh, National Cheng Kung University

Tsung-Yi Ho, National Cheng Kung UniversityKrishnendu Chakrabarty, Duke University

B2P-C.4 An Integrated LOC Hydrodynamic Focuser with a CNN-Based Camera System for

Cell Counting Application 301

Andras Laki, Politecnico di Torino

Ismael Rattalino, Politecnico di Torino

Fernando Corinto, Politecnico di Torino

Kristof Ivan, Pdzmdny Peter Catholic UniversityDanilo Demarchi, Politecnico di Torino

Pierluigi Civera, Politecnico di Torino

B2P-C.5 Biosensor Array Microsystem on a CMOS Amperometric Readout Chip 305

X. Liu, Michigan State UniversityL. Li, Michigan State UniversityB. Awate, Michigan State UniversityR.M. Worden, Michigan State UniversityG. Reguera, Michigan State UniversityA.J. Mason, Michigan State University

B2P-C.6 A High Sensitive SPR Biosensor System Utilizing Gold Nanorods 309

Santosh Koppa, University ofTexas at San Antonio

Youngjoong Joo, University ofTexas at San Antonio

B2P-D Integrated Biomedical Systems, BioMEMS,Bio-Sensors/Actuators and Lab-on-Chip II

Chair(s): Themistoklis Prodromakis, Imperial College London

George Yuan, Hong Kong University ofScience and Technology

B2P-D.1 A 10-Bit Resolution Wide Dynamic Range Detector for Cell Recording with

Microelectrode Arrays 313

Jing Guo, Hong Kong University ofScience & Technology

Jiageng Huang, Hong Kong University ofScience & TechnologyJie Yuan, Hong Kong University ofScience & Technology

B2P-D.2 Fully Integrated CMOS Avalanche Photodlode and

Distributed-Sain TIA for CW-fNIRS 317

Ehsan Kamrani, Polystim Neurotechnologies Laboratory / Ecole Polytechnique de Montreal

Mohamad Sawan, Polystim Neurotechnologies Laboratory / Ecole Polytechnique de Montreal

B2P-D.3 VHDL-AMS Model of an Electrochemical Cell to Design VLSI Bio-Chips 321

Marialaura Beltrandi, Ecole Polytechnique Federate de Lausanne

Alain Vachoux, Ecole Polytechnique Federate de Lausanne

Sandro Carrara, Ecole Polytechnique Federate de Lausanne

Yusuf Leblebici, Ecole Polytechnique Federate de Lausanne

Giovanni De Micheli, Ecole Polytechnique Federate de Lausanne

B2P-D.4 A 15uW 16 Channel Exg Processor with Data Transition Memory-QuadLevel Vector for Wearable Healthcare Platform 325

Taehwan Ron, Korea AdvancedInstitute ofScience and TechnologySeulki Lee, Korea AdvancedInstitute ofScience and TechnologyHoi-Jun Yoo, Korea AdvancedInstitute ofScience and Technology

B2P-D.5 Individually Addressable Optoelectronic Arrays for Optogenetlc Neural Stimulation 329

Brian McGovern, Imperial College London

Emmanuel Drakakis, Imperial College London

Mark Neil, Imperial College London

Peter 0' Brian, Tyndall Institute

Brian Corbett, Tyndall Institute

Rolando Berlinguer-Palmini, Newcastle UniversityPatrick Degenaar, Newcastle University

B3L-A

Chair(s):

Cells, Circuits and ComputationRahul Sarpeshkar, MITGeorge Yuan

B3L-A.1 Analog Transistor Models of Bacterial Genetic Circuits 333Ramiz Daniel, Massachusetts Institute ofTechnologySung Sik Woo, Massachusetts Institute of TechnologyLorenzo Turicchia, Massachusetts Institute ofTechnolog)'Rahul Sarpeshkar, Massachusetts Institute ofTechnology

B3L-A.2 Reprogrammable Biological Logic Gate that Exploits Noise 337

Anna Dari, Arizona State UniversityAdi R. Bulsara, SPA WAR Systems Center PacificWilliam L. Ditto, Arizona State UniversityXiao Wang, Arizona State University

B3L-A.3 Engineering Insulation from Retroactivity of the Frequency Response of

Covalent Modification Cycles 341

Domitilla Del Vecchio, Massachusetts Institute of Technology

B3L-A.4 Analysis and Design of a Synthetic Transcriptional Network for Exact Adaptation 345

Jongmin Kim, California Institute of TechnologyRichard M. Murray, California Institute of Technology

B3L-A.5 Designing Extensible Protein-DNA Interactions for Synthetic Biology 349

Kristjan E. Kaseniit, Massachusetts Institute ofTechnolog)'Samuel D. Perli, Massachusetts Institute ofTechnologyTimothy K. Lu, Massachusetts Institute ofTechnolog)'

B4L-A Integrated Biomedical Systems, BioMEMS,

Bio-Sensors/Actuators and Lab-on-Chip III

Chair(s): Andrew Mason, Michigan State UniversityJennifer Blain Christen, Arizona State University

B4L-A.1 Feasibility of an Electro-Optic Link for Bondpad-Less CMOS Lab-on-Chlps 353

Alexandra Serb, Imperial College London

Konstantin Nikolic, Imperial College London

Timothy G. Constandinou, Imperial College London

B4L-A.2 New Technologies for Nanobiosensing and their Applications to Real-Time Monitoring 357

Cristina Boero, Ecole Polytechnique Federate de Lausanne

Sandro Carrara, Ecole Polytechnique Federale de Lausanne

Giovanni De Micheli, Ecole Polytechnique Federale de Lausanne

B4L-A.3 CMOS Impedance Spectrum Analyzer with Dual-Slope Multiplying ADC 361

Hamed Mazhab Jafari, University ofTorontoRoman Genov, University of Toronto

B4L-A.4 An ISFET based Chemical Gilbert Cell 365

Melpomeni Kalofonou, Imperial College LondonPantelis Georgiou, Imperial College London

Christofer Toumazou, Imperial College London

B4L-A.5 A Novel Design Approach for Developing Chemical Sensing Platforms

Using Inexpensive Technologies 369

T. Prodromakis, Imperial College London

Y. Liu, Imperial College LondonJ. Yang, Imperial College LondonD. Hollinghurst, Imperial College LondonC. Toumazou, Imperial College London

B4L-A.6 An AC Electrokinetic Device for the Rapid Separation and Detection of

Cancer Related DNA Nanoparticulate Biomarkers 373

Rajaram Krishnan, Biological Dynamics, Inc.

David Chariot, Biological Dynamics, Inc.

Lucas Kumosa, Biological Dynamics, Inc.

William Hanna, Biological Dynamics, Inc.

Jerry Lu, Biological Dynamics, Inc.

Avery Sonnenberg, University of California, San DiegoMichael Heller, University ofCalifornia, San Diego

B5P-B Circuits for Biomedical Systems VI

Chair(s): Julio Georgiou, University of CyprusTor Sverre Lande, University of Oslo

B5P-B.1 Sensor Interface with Single-Line Quasi-Digital Output for LigamentBalance Measuring System 377

Xu Zhang, Tsinghua UniversityHong Chen, Tsinghua University

Ming Liu, Tsinghua UniversityChun Zhang, Tsinghua UniversityZhihua Wang, Tsinghua University

B5P-B.2 A 0.5V Signal-Specific Continuous-Time Level-Crossing ADC with Charge Sharing 381

Yongjia Li, Delft University ofTechnologyDuan Zhao, Delft University of TechnologyMarijn N. van Dongen, Delft University ofTechnologyWouter A. Serdijn, Delft University of Technology

B5P-B.3 An 8-Channel Readout Front-End for Long-Term Sleep Quality Monitoring 385

Xiaofei Pu, Fudan UniversityHui Zhang, Fudan University

Yajie Qin, Fudan University

Zhiliang Hong, Fudan University

B5P-B.4 A CMOS Circuit for Precise Reading of Matrix Addressed Magnetoresistive Biosensors 389

Tiago Costa, Instituto Superior Tecnico

Moises S. Piedade, Instituto Superior Tecnico

Jorge R. Femandes, Instituto Superior Tecnico

B5P-B.5 A High-Sensitivity Power-Efficient Limiting Amplifier for

Bioimpedance Phase Angle Detectors 393

Jose L. Ausin, University ofExtremaduraJ. Ramos, University ofExtremaduraJ.F. Duque-Carrillo, University ofExtremaduraGuido Torelli, University ofPavia

B5P-B.6 A CMUT Read-Out Circuit with Improved Receive Sensitivity Using an

Adaptive Biasing Technique 397

Parisa Behnamfar, University ofBritish Columbia

Shahriar Mirabbasi, University ofBritish Columbia

B5P-B.7 A Low Voltage, Energy Efficient Supply Boosted SAR ADC for Biomedical Applications 401

Ali Mesgarani, University ofIdahoSuat U. Ay, University ofIdaho

B5P-B.8 ESD Protection and Biomedical Integrated Circuit Co-Design Techniques 405

Jian Liu, University ofCalifornia, Riverside

Xin Wang, Fairchild Semiconductor, Inc.

Hui Zhao, University of California, Riverside

Qiang Fang, University of California, Riverside

Zitao Shi, University ofCalifornia, Riverside

Li Wang, University of California, Riverside

Chen Zhang, University of California, Riverside

Albert Wang, University ofCalifornia, Riverside

Yuhua Cheng, Peking University / SHRIME

Bin Zhao, Fairchild Semiconductor, Inc.

Gary Zhang, Skyworks

B5P-C Biometrics, Biomedical Signal Processing and Bioimaging Technology I

Chair(s): Julio Georgiou, University ofCyprusTor Sverre Lande, University ofOslo

B5P-C.1 A Predictor for Ventricular Tachycardia based on Heart Rate Variability Analysis 409

Segyeong Joo, University of Ulsan College ofMedicine / Asan Medical Center

Soo-Jin Huh, University of Ulsan College ofMedicine/Asan Medical Center

Kee-Joon Choi, University of Ulsan College ofMedicine /Asan Medical Center

B5P-C.2 DWT and RT-Based Approach for Feature Extraction and

Classification of Mammograms with SVM 412

Salim Lahmiri, University ofQuebec at Montreal

Mounir Boukadoum, University ofQuebec at Montreal

B5P-C.4 Cross-Recurrence Rate for Discriminating 'Concious' and 'Unconcious'

State in Propofol General Anesthesia 416

Nicoletta Nicolaou, University ofCyprusJulius Georgiou, University ofCyprusSaverios Hourris, Nicosia General HospitalPandelitsa Alexandrou, Nicosia General Hospital

B5P-C.5 On-Line Empirical Mode Decomposition Biomedical Microprocessor for

Hilbert Huang Transform 420

Nai-Fu Chang, National Taiwan University

Tung-Chien Chen, National Taiwan University

Cheng-Yi Chiang, National Taiwan UniversityLiang-Gee Chen, National Taiwan University

B5P-C.6 Rakeness-Based Approach to Compressed Sensing of ECGs 424

Mauro Mangia, University ofBolognaJavier Haboba, University ofBolognaRiccardo Rovalti, University ofBolognaGianluca Setti, University ofFerrara

B5P-D Biometrics, Biomedical Signal Processing and Bioimaging Technology II

Chair(s): Tor Sverre Lande, University ofOslo

Julio Georgiou, University ofCyprus

B5P-D.1 Tracking and Control for Handheld Surgery Tools 428

Gontje C. Claasen, Mines ParisTech

Philippe Martin, Mines ParisTech

Frederic Picard, Golden Jubilee National Hospital

B5P-D.2 Scene Optimization for Optogenetic Retinal Prosthesis 432

Walid Al-Atabany, Newcastle UniversityPatrick Degenaar, Newcastle University

B5P-D.3 Detection of Upper Limb Activities Using Multimode Sensor Fusion 436

Yan Wang, University of California, Los AngelesXiaoyu Xu, University ofCalifornia, Los AngelesMaxim Batalin, University ofCalifornia, Los AngelesWilliam Kaiser, University ofCalifornia, Los Angeles

B5P-D.4 Custom Annular Photodetector Arrays for Breast Cancer Margin Assessment

Using Diffuse Reflectance Spectroscopy 440

Sulochana Dhar, Duke UniversityJustin Y. Lo, Duke UniversityBing Yu, Duke UniversityMartin A. Brooke, Duke UniversityNimmi Ramanujam, Duke UniversityNan M. Jokerst, Duke University

B6L-A Biomedical Signal Processing III and Circuits for Biomedical Systems VII

Chair(s): Sandro Carrara, EPFL

Gert Cauwenberghs, UC San Diego

B6L-A.1 Gait-Based Person and Gender Recognition Using Micro-Doppler Signatures 444

Guillaume Garreau, University ofCyprusCharalambos M. Andreou, University ofCyprusAndreas G. Andreou, University ofCyprusJulius Georgiou, University ofCyprusSalvador Dura-Bemal, University ofPlymouthThomas Wennekers, University ofPlymouthSue Denham, University ofPlymouth

B6L-A.2 Automatic Stage Scoring of Single-Channel Sleep EEG based on

Multiscale Permutation Entropy 448

Chih-En Kuo, National Cheng Kung UniversitySheng-Fu Liang, National Cheng Kung University

B6L-A.3 Chest Movement Estimation from Radar Modulation Caused by Heartbeats 452

0yvind Aardal, ForsvaretsforskningsinstituttSvein-Erik Hamran, ForsvaretsforskningsinstituttTor Berger, Forsvarets forskningsinstituttYoann Paichard, ForsvaretsforskningsinstituttTor Sverre Lande, University of Oslo

B6L-A.4 Integrated Ultra-High Impedance Front-End for Non-Contact Biopotential Sensing 456

Yu M. Chi, University of California, San DiegoChristoph Maier, University of California, San DiegoGert Cauwenberghs, University of California, San Diego

B6L-A.5 Circuit Design for Human Metabolites Biochlp 460

S. Sara Ghoreishizadeh, Ecole Polytechnique Federale de Lausanne

Sandro Carrara, Ecole Polytechnique Federale de Lausanne

Giovanni De Micheli, Ecole Polytechnique Federale de Lausanne

B6L-A.6 A Self-Calibration Circuit for a Neural Spike Recording Channel 464

Alberto Rodriguez-Perez, IMSE-CNMand University ofSevilleJesus Ruiz-Amaya, IMSE-CNM and University ofSeville

Manuel Delgado-Restituto, IMSE-CNMand University ofSeville

Mohamad Sawan, Polystim Neurotechnologies Laboratory /Ecole Polytechnique de Montreal

Angel Rodriguez-Vazquez, IMSE-CNMand University ofSeville