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AD-A122 551 COMPUTER-ASSISTED SYSTEM FOR DIGITAL DATA ACQUISITION 1/IOF RESPIRATORY FUNC.. (U) NAVAL MEDICAL RESEARCH INST

BETHESDA MD R P LAYTON ET AL. APR 82 NMRI-82-2UNCLASSIFIED F/G 6/5 NLlilllllllllll

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UNCLASSIFIEDSECURITY CLASSIFICATION OF THIS PAGE MSI&M D06 ftuem0_______________

REPORT DOCUMENTATION4 PAGE .zvrom opxuoyr1. REPORT "NMUER 2GOTACCESSION NO ISRCIP1IEMTS CATALOG NUMBER1

82-2

4. TITLE (mod Subhite) L. TYPE OF REPORT G PERfIOD COVERED

COMNPUTER-ASSISTED SYSTEM FOR DIGITAL DATA MEDICAL RESEARCH PROGRESSACQUISITION OF RESPIRATORY FUNCTION TESTS REPORT,______Final__

AND ANALYSIS OF ISOVOLUME RESISTANCE S. PURFORMINGO DOw REZPORT NGMER

7. AU)THOR(*) &. CONTRACT OR GRANT IOU0990CI

R.P. Layton, P.11. Catron, and S.H. Prince

S. PERFORMING ORGANIZATION NAME AMC ADDRSS 10. PROGRAM ELEMENT PROECT. TASKAREA A WONRK UNIT Nt=ER

Naval Medical Research Institute 500".u5a2. 13Bethesda, Maryland 2081.4 *umat ft6* 2 C3

11. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT OATS

April 1982Naval Medical Research & Development Command Is. NUNUERf P0 EBethesda. Mryland 20814

14. MONITORING AGNYNAME a AODRESS(If diffeel &GIN COR.a&*# Ofiep) IS. SECURITY CLASS. (of &We ,.peee

Bureau of Medicine & Surgery UNCLASSIFIEDDepartment of the Navy fk IAIN01"RINWashington, DC 20372 Ia U%

IS. DISTRIBUTION STATEMENT (of etle RePWc)

APPROVED FOR PUBLIC RELEASE AND SALE. DISTRIBUTION UJNLIMITED.

17. OISTRISUTION STATEMENT (of the abactW tom Stoc ite d.ifferent ftes ROMa

1S. SUPPLEMENTARY NOTES

MINIz 13901?. APRIL 1982. 8099.

It. K EY WORDS (Cetuue an tevoe.e fie. fiaeeety am I*.tIr by' bleek Raa)

pulmonary function, computer, isovolume resistance, human, airways

omputerized methods for collection and transfer of data from pulmonaryfunction tests and for analysis of isovolume resistance data are described.Detailed user instructions are provided for the programs, which are writtenfor a desktop computer.

DO 1473 CDITION oF I NOV5 Is is 0OLETE NLSSFES/N 0102-L-014-6601 i UNCLASSI--OWAM FIeDWmo

TABLE OF CONTENTS

Page Number

Acknowledgments ......... ....................... on back of front page

Abstract ........... ................................. I

I. Introduction ............ .......................... 1

II. Data Acquisition and Transfer ........ .................. 3

A. Program "NDATA .......... ....................... 31. Introduction ....... ....................... 32. User Instructions ......... .................... 6

B. Program "PDPtfr" ............. .................... 111. Introduction .......... ...................... 112. User Instructions ..... .................... 153. User Instructions for PDP Program to be used with

"PDPtfr".. ........................ 16

C. Program "Nictfr" User Instructions ...... ............. 17

D. Program "ERASE" User Instructions .... .............. ... 18

III. Isovolume Resistance .......... ...................... 19

A. Program "ISOR" ....................... 191. Introduction .......... ...................... 192. User Instructions ..... .................... 273. User Instructions for PDP Program to be used with

SOtfr" . . .36

B. Program "ISOtfr" ............ .................... 371. Introduction ....... ....................... 372. User Instructions ...... ..................... 39

C. Program "ISORED ................. .. ....... 401. Introduction ................... 402. User Instructions ................... . 41

List of Figures

Fig. 1. Flowchart for program"NDATA" . . . . . . . . . . . . 4Fig. 2. Flow chart for program "PDPtfr" . . . . ........... 13Fig. 3. Typical transducer signals for isovolume resistance

measurements . . . . . . 0 * , , . . . . . : ...... . 20Fig. 4. Flow chart for program " 1" . . . .... .. . . 21Fig. 5. Flow chart for program "TSOtfr" . . . ..... . . . 38

K

t List of Appendices

Page Number

Appendix 1. "NDATA"a. Equipment List ....................... 43b. Program Listing ......................... 44c. Variable Assignments ........ .................... 49d. Details of Header and Time String Variables .. ........ . 50

Appendix 2. "PDPtfr"a. Program Listing............ ...... . ............ 51b. Listing for PDP Program "LFSRECTB"............... 53

Appendix 3. "Nictfr"a. Equipment List ........ ....................... .... 55b. Program Listing ......... ...................... .. 56

Appendix 4. "ERASE" Program Listing .......... ....... 57

Appendix 5. "ISOR"a. Equipment List ........ ....................... .... 58b. Program Listing ......... ...................... .. 59c. Variable Assignments ....... .................... .. 67

Appendix 6. "ISOtfr"a. Program Listing.. . ......... ... ........... .. 69b. Listing for PDP Program "LFSRC21B" .............. 71

Appendix 7. "ISO1FD"a. Equipment List ........ ....................... ... 73b. Program Listing ......... ...................... .. 74

Appendix 8. Identification of Files of Program Tape .. ......... ... 75

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OTIS

I. Introduction

The computer programs described in this report were developed to improve

the speed and accuracy with which pulmonary function measurements can be made.

Two main systems are discussed. The first makes use of a digital storage

oscilloscope to acquire the output signals of transducers on a body

plethysmograph. These signals are used to obtain pressure-volume curves,

flow-volume loops, and FRC determinations. Multiple measurements can be made

with the oscilloscope only if data previously acquired are transferred to a

permanent storage medium. This function is performed by a desktop computer

which uses the program "NDATA," (programs are described in section II) to

record the data onto magnetic tape. Later, when sufficient information has

been collected, the data are transferred to a computer system which has the

large memory capacity, high computational speed, and sophisticated peripheral

devices needed to properly perform the analysis. The program "PDPtfr" directs

this second data transmission. An experiment in which flow-volume loops were

recorded and subsequently analyzed using this system has been reported

previously (1). Details also are given for two additional programs: "Nictfr"

and "ERASE." The former allows data previously recorded to be displayed again

on the Nicolet oscilloscope; the latter completely erases program or data tapes

whose contents are no longer needed and thus permits them to be reused.

The second system measures isovolume resistance. This determination

cannot be made using the digital oscilloscope since three signals (pressure,

volume, and flow) must be recorded simultaneously. The traces, which are put

on a three-channel strip chart recorder, are analyzed using the desktop

computer, its digitizer, and program "ISOR" (described in section III). The

computer-assisted system for handling isovolume resistance data greatly

increases the speed and accuracy with which this measurement can be made when

|, 1

I

compared to the standard method of measuring distances on the chart paper with

a ruler and calculating values by hand.

In the following sections of this report are given detailed user

Instructions for all the programs required for digital data acquisition and

transfer, and for analysis of £sovolue resistance data. Proram listns,

variable assignment lists, and required equipment are given in the appendices.

The programs for the desktop computer are written in HPL, a language developed

by Hewlett-Packard for its 9825 series computers. The remaining software is

written in FORTRAN IV for Digital Equipment Corporation PDP-11/34 and PDP-11/70

computers using the RSX-11M operating system.

2

00 J_

It. Data Acquisition .and Transfer

A. Program "DA"

1. 'Introduction

The program "NDATA" is used to transfer data stored in a Nicolet

digital oscilloscope (model 2090) to the magnetic tape cassette of the desktop

computer. The transfer is effected using an IEEE-488 interface bus between the

two instruments. The program is written for a Hewlett-Packard 9825 computer

with an external printer, a real-time clock, and the appropriate ROM's (see

Appendix 1). Each cassette can store up to 32 data transfers from the Nicolet.

The system is designed to acquire and store data with as little

operator interaction as possible. The interaction that is required is

accomplished by the use of step-by-step prompts on the LED alphanumeric display

of the computer. User instructions, which follow, describe in detail how to

run the program. A flow chart is show in Fig. 1. Complete program and

variable assignment lists are provided in Appendix 1.

When the program is run, "YES" is assigned to special function key

fO; "NO" is assigned to key f6" Before any data can be recorded the cassette

first must be "marked" into files. It is advisable to use the tape marking

portion of program "UDATA" to prepare a number of tapes before an experiment

instead of waiting until the last minute. Up to 32 data transfers from the

Nicolet can be stored on a single cassette; however, once some data Is stored

on a tape and then the program subsequently is stopped or the tape is remved,

no further data can be transferred to that particular tape. This feature is

designed to prevent loss of data by recording new data over old.

Before it is recorded on tape, each data transfer has attached to

it a descriptive header, a portion of which is common to all files on a given

tape and a segment which is unique to each transfer. The following items are

f 3

"#NDATA"t

Checm*Tape

Yet N

No TIPOOK, TAMPNoTape yesHv- 1 4Y

-

Fig.~~Va 1.Fomhetfrpora NAA

InputHMAI

requested by the program and make up the fixed part of the header: subject

identification number, subject age, code number for subject sex, code number

for subject race, subject height, subject weight, barometric pressure, room

temperature, and a comment line of up to 47 characters. The unique portion of

the header is entered just before each transfer of data from the Nicolet. This

section consists of an experimental type number (1 digit), a four-character

(alphanumeric) record type code, and an event time. The first two items are

chosen by the user to identify the experiment; the event time defaults to a

value of "1 -l" until a specific time is entered. This value can be the tine

at which some treatment or procedure important to the experiment occurs.

Additionally, the time (month:day:hour:mln:sec format) at which a transfer

occurs is read from the computer clock and recorded as part of the header.

5

r

2. User Instructions

1. Insert: Tape cassette with program recorded

2. Press: ERASEType : aPress: EXECUTE

3. Press: LOAD

Type : 1Press: EXECUTE

4. Wait for end of line mark (I-) to be displayed.

5. Press: RUN

6. When "REMOVE PROGRAM CASSETTE" is displayed;a. Remove tapeb. Press: CONTINUE

7. When "Do you want to mark tapes?" is displayed;a. If no,

1) Press "NO" (key f6)2) Go to step 10

b. If yes,1) Press "YES" (key f0 )2) Go to step 8

8. When "Number of tapes to be marked?" is displayed;a. Type: number of tapesb. Press: CONTINUE

9. When "INSERT TAPE CASSETTE" is displayed;a. Insert blank unmarked tapeb. Press: CONTINUEc. If "Tape is not blank--use new tape" is displayed;

1) Remove current tape2) Replace with blank unmarked tape3) Press: CONTINUE

d. If "INSERT TAPE CASSETTE" is displayed again, either tape is notproperly seated in tape drive or no tape is present;1) Properly insert tape2) Press: CONTINUE

e. If "CASSETTE IS WRITE PROTECTED" is displayed;1) Remove cassette2) Slide tab on cassette to "RECORD" position3) R-insert cassette4) Press: CONTINUE

f. If "SYSTEM MALFUNCTION**GET HELPI" is displayed;1) Error number (ern) and error line (erl) are printed on built-in

printer2) A serious software or hardware problem exists and must be

corrected3) Once problem is solved, start over at step 1

6

g. If "MAMKING CASSETTE" is displayed;1) Tape is being properly marked2) Program will return to step 9 until the number of tapes specified

in step 8 are marked3) When last cassette is marked, program will proceed to step 10

10. When "3-digit Subject number - ?" is displayed;a. ype: number wanted (maximum of three digits allowed)b. Press: CONTINUE

11. When "2-digit Subject age - ?" is displayed;a. Type: age (maximum of two digits)b. Press: CONTINUE

12. When "Sex code (1-M, 2-F) - ?" is displayed;a. Type: number wantedb. Press: CONTINUE

13. When "l-digit race code - ?" is displayed;a. Type: number wanted (maximum of one digit)b. Press: CONTINUE

14. When "2-digit Ht. in inches - ?" is displayed;a. Type: number wanted for heightb. Press: CONTINUE

15. When "3-digit Wt. in pounds - ?" is displayed;a. Type: number wanted for weightb. Press: CONTINUE

16. When "Enter Barometric Pressure (im Hg)" is displayed;a. Type: number for pressure in mm of mercuryb. Press: CONTINUE

17. When "2-digit Room Temperature - V" is disalayedSa. Type: number for temperature (Either C or F can be used since this

number is not used for any computations)b. Press: CONTINUE

18. When "Enter heading line" is displayed;a. Type: up to 47 charactersb. Press: CONTINUE

19. When "Do you want to change heading?" is displayed;a. If yes,

1) Press: YES2) Go to step 10

b. If no,1) Press: NO2) Go to step 20

7

20. When "Clock reads: <time>" is displayed;a. Time is displayed as voath:day:hour:min:secb. Press: CONTINUE

21. When "Do you want to reset clock?" is displayed;a. If yes,



22. "Enter time as two-digit number" is displayed for three seconds:a. When "Month?" is displayed;

1) Type: 2-digit month number2) Press: CONTINUE

b. When "Day?" is displayed;1) Type: 2-digit day number2) Press: CONTINUE

c. When "Hour?" is displayed;1) Type: 2-digit hour using 24 hour clock2) Press: CONTINUE

d. When "Minute?" is displayed;1) Type: 2-digit minute2) Press: CONTINUE

e. When "Second?" is displayed;1) Type: 2-digit second2) Press: CONTINUE

f. As clock is internally reset, "Resetting Clock (Be patientl)" isdisplayed. This process may take two minutes.

g. "CLOCK NOW READS: <time>" is displayed;Press: CONTINUE

h. When "DO YOU WANT TO RESET CLOCK?" is displayed;1) If yes,

a) Press: YESb) Go to step 22

2) If no,a) Press: NOb) Go to step 23

23. When "ID number of first data tape - ?" is displayed;a. Type: number to be assigned to first tape (N)b. Press: CONTINUE

24. When "INSERT MARKED TAPE # <N>" is displayed;a. Insert tape on which data is to be recorded (Note: tape must be

previously marked but cannot have any data recorded on it).b. Press: CONTINUEc. If "Tape not marked--use marked tape" is displayed;

1) Remove tape2) Insert a tape which has been marked

8

3) Press: CONTINUE4) Go to step 23

d. If "Tape not blank--use new tape" is displayed;1) Remove tape2) Insert a tape on which no data has been previously recorded3) Press: CONTINUE4) Go to step 23

e. If "SYSTEM MALFUNCTION**GET HELPI" is displayed;1) A serious hardware or software problem exists which must be

corrected2) Program can be started without re-entering header by the following

procedure:a) Type: cont 37b) Press: EXECUTE

25. When "l-digit experimental type # = ?" is displayed;a. Type: number to identify type of experiment for which this data

has been recordedb. Press: CONTINUE

26. When "4-character record type code - "is displayed;a. Type: 4 characters to identify the type of respiratory

maneuver for which this data was takenb. Press: CONTINUE

27. When "Do you have event time yet?" is displayed;a. If yes,

1) Press: YES2) When "4-digit event time - ?" is displayed;

a) Type: time wanted in 24-hour clock notationb) Press: CONTINUE

3) Go to step 28b. If no,

1) Press: NO2) Go to step 28

28. When "Do you want to change data?" is displayed;a. If yes,



29. When "Hit CONTINUE to read data" is displayed;a. Wait until data wanted is stored in Nicolet oscilloscopeb. Press: CONTINUEc. During transfer, "Data is being recorded" is displayedd. If fewer then 32 data transfers have ben recorded on the current

tape, so to step 25a. If 32 data transfers have been recorded, tape Is full; go to step 30

30. ["REWINDING TAPE CASSETTE" is displayed.]

-- __9

31. When tape has been removed;a. N is incremented by 1b. Go to step 24

32. To stop program at any time;a. Press: STOPb. Press: REWINDC. When tape stops rewinding, remove itd. Program is finished

10

B. Program "PDptfr"

1. Introduction

The limited memory sie sad cumputational speed of the HP 9825 desktop

computer make it unsuitable for analysis of the large volume of data which

rapidly can be accmAlated with program "IDATA." Various analysis routines

have been successfully developed for the PDP-11 series computers available at

this facility (1). Thus, once the HP 9825 system has performed its job as a

portable data acquisition device it must be able to transfer the data stored on

its tape cassettes to the larger computer. The software to accomplish this

task consists of program "PDPtfr" for the UP 9825 and program '"FSRECIB" for

the PDP-11/34 computer. User instructions are given in the next section.

Program listings appear in Appendix 2.

The PDP-11/34 must be equipped with a General Instruments GPIB-11

interface. This hardware is connected to the UP-IB interface of the HP-9825

which enables the two computers to communicate using the hand-shake conventions

of the IEEE-488 standard. The program listed in Appendix 2 for the PDP

requires the RSX-11M operating system with the addition of the GPIB driver

supplied by General Instruments.

Once the data transfer has started, it is automatic and only requires

the operator to remove and insert data tapes when the appropriate prompts are

displayed on the UP 9825. Since the data from a single experiment may fill

several tapes, the user must enter the number of tapes that are to be stored in

a single data file in the PDP computer. The tapes themselves need not be

completely full for the transfer to proceed properly. Each file stored on the

larger system is organixed into groups of three records. All three are written

onto the PDI disk in unformatted binary form just as they are received. The

first record contains parameters describing the data and is Identical to the

11

/

- - - -. - - - -------------

header detailed in Appendix 1. Similarly, the second record contains the time

at which the data was acquired and has the format of the time variable

explained in Appendix 1. The third record contains the actual data as

originally transmitted by the Nicolet oscilloscope. It should be noted that

the binary data are byte-reversed relative to the standard PDP-11/34 word and

must be inverted before any analysis programs can be run. once all the data

tapes that constitute one file have been transcribed to the disk of the

PDP-ll/34, both programs end. To transfer another file, the programs must be

started over.

12

Fig. 2. Flow chart for program "PDPtfr"

"PDPttr"

START

\*FTAES

J-1 trki--I

- ISET TAPE

N=L

N 13 E r

L-L+I L<32?

NO

YESO

14


1. Insert program tapePress: LOADType: 2Press: EXECUTE

2. When end of line (H) mark is displayed,Press: RUN

3. When "Remove Program Tape" is displayed;a. Remove tapeb. Press: CONTINUE

4. When "Start PDP computer program" is displayed;a. Start programb. Press: CONTINUE

5. When "Press CONTINUE to start transfer" is displayed,Press: CONTINUE

6. When "Enter # of cassettes to be read" is displayed;a. Type: number of cassettes whose data are to be stored in a single

data file on the PDP computer.b. Press: CONTINUE

7. When "ID number of first cassette - "is displayed;-' a. Type: number (This Is used for operator prompts only)

b. Press: CONTINUE

8. When "INSERT TAPE # <N>" is displayed;a. Insert tape with ID INb. Press: CONTINUE

9. "File being transferred # <n>" is displayed (The number ni is incrementedas all the files on the tape are automatically transferred.)

10. "REWINDING TAPE" is displayed after last file on a tape has beentransferred.

11. Have the number of tapes specified in step 6 been transferred?a. If no,

1) N is incremented by 12) Go to step 8

b. If yes,1) End-of-file character is sent to PDP computer2) "DATA TRANSFER COMPLETED" is displayed

____ 15__

3. User Instructions for PDP Program to be Used with "PDPtfr"

It is assumed that the operator has properly logged onto the PDP computer

and that the transfer program, named "LFSRECIB," is accessible to him.

1. On the PDP computer terminal;Type: RUN LFSRECIBPress: RETURN

2. When "DATA FILE NAME [NAME.EXT]:" is displayed;a. Type: name wanted for PDP data fileb. Press: RETURN

3. [PDP program is now ready for transfer to start.]

4. When data transfer is completed, "STOP-TTnn" is displayed, where nn isthe number of the terminal being used.

16•i + f

C. Program "Nictfr" User Instructions

This program, called "Hctfr," allows the user to transumit data which has

been stored on a cassette back to the Nicolet oscilloscope for display.

Appendix 3 contains the program listing.

1. Insert: Tape cassette with program

2. Press: ERASEType: aPress: EXECUTE

3. Press: LOADType: 3Press: EXECUTE

4. Wait for end of line mark (1-) to be displayed.

S. Press: REWINDRemove: program tapeInsert: data tapePress: RUN

6. When "Enter number of data dump wanted" is displayed;a. Type: number (between 1 and 32, inclusive)b. Press: CONTINUE

7. Data is displayed on Nicolet screen.Header is printed on external printer.Go to step 6 for another transfer.(Press: STOP to end program)

17

OMNI"I Il

D. Program "ERASE" User Instructions

Program "ERASE" can be used to erase completely any data or program tape

whose contents are no longer wanted. The only equipment needed is a

Hewlett-Packard 9825 computer. Appendix 4 contains the program listing.

1. Insert: tape cassette with program



4. Wait for end of line mark (i-) to be displayed.

5. Press: RUN


7. When "Insert tape to be erased" is displayed;a. Slide tab on tape cassette to "RECORD" position.b. Insert: tapec. Press: CONTINUEd. If "***TAPE IS BEING ERASED**" is displayed;

1) Program is functioning2) When tape is erased, go to step 7

e. If "ERROR OCCURRED" is displayed;1) rom and ern values are printed2) Problem must be corrected3) Start over with step 5

18

Ar1

III. Isovolume Resistance

A. Program "SO"

1. Introduction

Program "ISOR" computes the value of isovolume resistance from

volume, pressure, and flow data obtained for individual breaths during quiet

breathing. Signals from the three types of transducers are recorded

concurrently on a three-channel recorder so that each trace has the same time

base. Two points of equal volume are selected on the volume trace for a single

breath. The two pressure and flow values corresponding in time to these

volumes are taken from the appropriate curves, as depicted in Fig. 3. The

isovolume resistance is computed from the expression: RIS0 - F1 F 2

The program is written for a Hewlett-Packard 9825 desktop

computer with an external printer, a digitizer, and the appropriate ROM's

(read-only-memory modules). A flow chart is given in Fig. 4; a program

listing, variable allocations, and required equipment list are provided in

Appendix 5.

When the program is run, "ISOR" automatically assigns "YES" to

special function key f0 and "NO" to key f6 " These keys should be used as

responses to the appropriate operator prompts that are displayed on the

internal LED display of the computer. Before any analyzed results can be

stored on a cassette, the tape must be "marked" into files with the marking

routine of this program. Up to 400 groups of data (with a maximam of 10

breaths in each group) can be stored on each of the two tracks of a single

cassette. The same tape can be used repeatedly for different analysis

sessions. Unlike "NDATA," program "11SOR" finds the first available empty file

on which to record data even if the tape has been removed from the computer or

the program has been stopped and subsequently restarted.

L 19

" * . --- * - - -*-- - *..--..---".-- ----

V, V2

P1P2

C/)C,,uLJcc

F2

U-

aF,

ttz t 2 TIME

Fig. 3. Typical transduLd, signals for isovolume resistance measurement. V1 andV2 are points of uqual volume which occur at times tj and t2 , respectively.

Pl is the value of transpulmonary pressure at time ti and Fl thecorresponding flow. Similarly, P2 and F2 represent the pressure and flowmeasurements at time t2.

20

Fig. 4. Flow chart f or program "ISOR"

yesMark Tapes? Nark Tapes

No

YRecord

Ye

In ut Oriiae aW K

\Time/

No

No Recalibrate? No It Breath? CmTre Proton

yet Yes

\ForIVFio~WCaI.

R e p e a t

Y "

I o

FParI

21

-14

Reea Ye

Re p di

yes

Me

Scage Yeas

Valuaes?

No

Int DamieSaeFact

Dalaue.

22

I _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

~-ior

DWdw 2pf"SweDate Pon.

RweW Van

R = I&PII& Fj

It"m YM

Axw? set Diodow

No

yes momareadw?

No

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onputs NowMam6 Min R

Prhw Vahm

ltwwd V40 TOW No cArrmt

ON OK? P,

No y4m

yes Mwe ReewdNOWO

t4o

STOP

23

r

The analyzed data is organized as follows: A maxim- of 10

separate breaths may be analyzed for a given single period of data collection;

the isovolume resistances calculated for these breaths are printed and also

stored on tape as a group. Before being recorded, the data for a one-hour

group have appended to them a header which is identical in format to that

previously described for "NDATA" (See Appendix 1). The individual terms are

also similar, with the following exceptions:

a. The experimental type digit is called the C/E code

(control/experiment) in the printout.

b. The four-character record type code is automatically chosen

to be "ISOR."

c. The event time section of the header is not used; it is

filled with four blank spaces.

d. The actual time at which the data was originally recorded

must be manually entered for each hour group.

Each file recorded has the format: 80-character header; 14-character date and

time; hour number (data collection period number); 4-digit time in 24-hour

clock notation; 10 values of isovolume resistance corresponding to each of the

10 breaths analyzed. If fewer than 10 breaths are measured, the unused

variables are assigned the value zero.

The HP 9864A digitizer is easy to use, but a few precautionary

comments are in order. This device consists of a flat bed, to which the chart

paper must be firmly taped, and a cursor with cross-hairs to electronically

select the point of interest on the tracing. Although the cursor has four

buttons, only two need concern the user of this program. The "0" is pressed to

denote the origin of an axes pair; "S" is used for all other points. The red

24

sample light on the digitizer cursor indicates when the origin has been

properly set. Once the origin is set, the cursor may be moved anywhere on the

digitizer bed, but it must not be lifted from the surface until the origin is

to be reset. If the cursor is moved improperly, the digitizer beeps and the

sample light goes out to indicate the origin has been lost. The origin must be

re-established before any further entries can be made. Note that the exact

positioning of the origin is not critical since all computations are performed

by taking the difference between various points. The origin merely provides a

point of reference for the digitizer; however, to facilitate the determination

of the X-axis direction, it should be placed on one of the horizontal (i.e.,

time axis) lines of the chart paper. Since the paper most likely is not

perfectly aligned on the digitizer bed, the program must measure the angle of

rotation between the axes of the chart record and the internal, fixed coordinate

system of the digitizer. Each time the origin is set, "ISOR" determines this

angle by instructing the operator to read five points along the X-axis. The

actual values of these points are immaterial and they need not be equally

spaced. The requirements are:

a. The points should span a significant distance on the chart

record to make possible on accurate determination of the

angle.

b. The line chosen for these five points must parallel the time

axis of the chart record and must contain the point chosen as

the origin.

c. The origin itself must not be used as one of these five

points or an error will occur that aborts the program.

In order to calculate a scale factor, two flow and two pressure

calibration signals must be recorded. When the program instructs the user to

25

OrF

read the flow calibration levels, it assumes the first point corresponds to a

condition of zero flow and the second to a level that spans5 the range of

Interest. The pressure signals are treated similarly.

Once the calibration is completed, the calibration chart record

is removed, the data tracing is placed on the digitizer, and the origin and

axes are again fixed. Data from several breaths can now be read. It is not

necessary to reset the origin unless the chart paper is moved or replaced or

the cursor is lifted off the digitizer surface.

The only remaining information required by the program to

calculate isovolume resistance are the full-scale and scale-multiplier settings

of the chart recorder amplifiers. The program prompts the operator for these

values in a way that permits the pressure and flow channels to have different

settings and allows these settings to be varied between calibration and data

runs.

26


1. Insert: Tape cassette with programa. Press: ERASEb. Type: ac. Press: EXECUTE


3. Wait for end of line mark (-) to be displayed

4. Press: RUN


6. When "Do you want to mark tapes?" is displayed;a. If yes,

1) Press: YES (key f0)2) Go to step 6.c.

b. If no,1) Press: No (key f6)2) Go to step 7

c. When "Number of tapes to be marked?" is displayed;1) Type: number2) Press: CONTINUE

d. When "INSERT TAPE CASSETTE" is displayed;1) Insert: blank tape2) Press: CONTINUE

e. If "Tape is not blank--use new tape" is displayed;1) Remove tape2) Insert: new blank tape3) Press: CONTINUE4) Go to step 6.e.

f. Go to "HELP"1) If a problem was found by "HELP" go to step 6.d.2) If no problem was found by "HELP" go to step 6.g.

g. When 'ARKING CASSETTE" is displayed, tape is being marked.h. Programs returns to step 6.d. until the number of tapes specified in

6.c. are marked. When all are marked it proceeds to step 7.

7. When "TURN ON DIGITIZER! t" is displayed;a. Turn on digitizerb. Press: CONTINUE

8. When "Results to be recorded on tape?" is displayed;a. If yes,

1) Press: YES (key f0)2) Go to stop 9

27


9. When "Track to be recorded?" is displayed;a. Type: 0 or 1 to choose tape track to be usedb. Press: CONTINUE

10. When "3-digit subject number = ?" is displayed;a. Type: numberb. Press: CONTINUE

11. When "2-digit subject age - ?" is displayed;a. Type: numberb. Press : CONTINUE

12. When "Sex Code (l-M, 2-F) - ?" is displayed;a. Type: number (single digit)b. Press: CONTINUE

13. When "l-digit race code = ?" is displayed;a. Type: numberb. Press: CONTINUE

14. When "2-digit Ht. in inches - ?" is displayed;a. Type: number for heightb. Press: CONTINUE

15. When "3-digit Wt. in pounds - ?" is displayed;a. Type: number for weightb. Press: CONTINUE

16. When "l-digit experimental type - ?" is displayed;a. Type: numberb. Press: CONTINUE

17. When "Enter Barometric pressure (mn Rg)" is displayed;a. Type: number for pressure in millimeters of mercuryb. Press: CONTINUE

18. When "2-digit room temperature is displayed;a. Type: number (may be in 0C or 0F)b. Press: CONTINUE

19. When "Enter heading line" is displayed;a. Type: alphanumeric header (47 characters maximum)b. Press: CONTINUE

20. When "Do you want to change heading?" is displayed;a. If yes,



21. When "How many hours of data?" is displayed;a. Type: number (10 breaths can be analyzed for each hour group)b. Press% CONTINUE

22. When "'Number of first hour of data = ?" is displayed;a. Type: numberb. Press: CONTINUE

23. Is data to be put on tape?a. If you answered NO in step 8, go to step 24.b. If you answered YES in step 8,

1) Go to "HELP"; return to next line.2) If "HELP" found a problem go to step 23.b.3) If "HELP" found no problem go to step 24.

24. When "ENTER TIME AS 2-DIGIT NUMBER" is displayed;a. Wait three seconds, enter time of original data as requested in the

following lines:b. When "Month?" is displayed;

1) Type: 2-digit month number of original data2) Press: CONTINUE

c. When "Day?" is displayed;1) Type: 2-digit day2) Press: CONTINUE

d. When "Hour?" is displayed;1) Type: 2-digit hour (24-hour clock notation)2) Press: CONTINUE

e. When "Minute?" is displayed;1) Type: 2-digit minute2) Press: CONTINUE

f. When "Second?" is displayed;1) Type: 2-digit second2) Press: CONTINUE

g. When "Time entered: <time>" is displayed;Press: CONTINUE to proceed

h. When "Re-enter time?" is displayed;1) If yes,

a) Press: YESb) Go to step 24


25. If "Do you want to RECLIBRATE?" is displayed;a. If yes,



29I _________________________________

26. When "Set origin for Flow cal." is displayed;a. Set digitizer origin using cursorb. Press: CONTINUEc. Go to "DIGSET," then proceed to step 27

27. When "Hit COT to read 2 Flow cal. pts." is displayed;a. Press: CONTINUEb. Go to "DATA" to read first point (must be a 0 flow signal); return

to next linec. Go to "DATA" to read second point (must be a non-zero flow); return

to next lined. When "Reread Flow cal. points?" is displayed;

1) If yes,a) Press: YESb) Go to step 27

2) If no,a) Press: NOb) Gc to step 28

28. When "Hit COT to read 2 P cal. pts." is displayed;a. Press: CONTINUEb. Go to "DATA" to read first point (must be zero pressure); return to

next linec. Go to "DATA" to read second point (must be non-zero pressure); return

to next lined. When "Reread Pressure cal. points?" is displayed;

1) If yes,a) Press: YESb) Go to step 28


29. When "Calibration Flow (liters/sec) = ?" is displayed;a. Type: numberb. Press: CONTINUEc. Value is printed

30. When "Volts Full Scale (Cal. Flow) i ?" is displayed;a. Type: number that represents chart recorder full scale (in volts)

when flow calibration signals were recordedb. Press: CONTINUE

31. When "Scale Multiplier (Cal. Flow) - ?" is displayed;a. Type: number that represents scale multiplier on chart recorder

when flow calibration signals were recordedb. Press: CONTINUEc. Values for volts full scale and scale multiplier are printed

32. When "Calibration prescure (cm H2 0) - ?" is displayed;a. Type: numberb. Press: CONTINUEc. Value is printed

30

-. *!*.•*!

33. When "Volts Full Scale (Cal. Press) = ?" is displayed;a. Type: number that represents chart recorder full scale (in

volts) when pressure calibration signals were recordedb. Press: CONTINUE

34. When "Scale Multiplier (Cal. Press) = ?" is displayed;a. Type: number that represents scale multiplier on chart recorder

when flow calibration signals were recordedb. Press: CONTINUEc. Values for volts full scale and scale multiplier are printed

35. When "Change Calibration values?" is displayed;a. If yes,



36. When "Volts Full Scale (Data Flow) = ?" is displayed;a. Type: number that represents chart recorder full scale (in

volts) when the flow data points that are to be digitized wereoriginally recorded

b. Press: CONTINUE

37. When "Scale Multiplier (Data Flow) - ?" is displayed;a. Type: number that represents scale multiplier on chart recorder

when flow data that are to be digitized were originally recordedb. Press: CONTINUEc. Full-scale and multiplier values are printed

38. When "Volts Full Scale (Data Press) - ?" is displayed;a. Type: number that represents chart recorder scale multiplier

setting when pressure data points that are to be digitized wererecorded

b. Press: CONTINUE

39. When "Scale Multiplier (Data Press) - ?" is displayed;a. Type: number that represents chart recorder scale multiplier

setting when pressure data points that are to be digitized wererecorded

b. Press: CONTINUEc. Full-scale and multiplier values are printed

40. When "Change data scale values?" is displayed;a. If yes,



31

4741. When "Set origin for Data axes" is displayed;

a. Set digitizer origin using cursor

b. Press: CONTINUEc. Go to "DIGSET," return to step 42

42. When "Number of breaths this hour - ?" is displayed;

a. Type: number of individual breaths for this hour that are to beanalyzed (maximum of 10 allowed)

b. Press: CONTINUE

43. When "Hit CONT*Read 2 Flow pts. B-<n>" is displayed (note: <n> represents

the number of the breath which currently is being digitized);a. Press: CONTINUEb. When "Read Flow point Fl" is displayed;

1) Go to "DATA"2) Return to next line

c. When "Read Flow point F2" is displayed;

1) Go to "DATA2) Return to step 44

44. When "Reread 2 Flow data points?" is displayed;a. If yes,

1) Press: YES

2) Go to step 43b. If no,

1) Press: NO2) Go to step 45

45. When "Hit CONT*Read 2 Pres. pts. B-<n>" is displayed;a. Press: CONTINUE when ready to digitize pressure data pointsb. When "Read Pressure data point P" is displayed;

1) Go to "DATA"2) Go to next line

c. When "Read Pressure data point P2" is displayed;1) Go to "DATA"2) Go to step 46

46. When "Reread 2 Pressure data points?" is displayed;a. If yes,



47. When "Do you want to reset axes?" is displayed;a. If tracing for next breath is on another chart paper or if the

current paper must be moved to accommodate the next tracing,1) Press: YES

2) When "Set origin for axes," is displayed;a) Press: CONTINUEb) Go to "DIGSET"c) Go to step 48

b. If tracing for next breath is already positioned on digitizer so that

32

nothing needs to be changed,1) Press: NO2) Go to step 48

48. Have the number of breaths entered in step 42 been analyzed for this hour?a. If no, go to step 43b. If yes, go to step 49

49. Data for each breath of this hour as well as mean, maximum, and variationof isovolume resistance are printed.a. If data is not to be recorded (you answered NO in step 8), go to step 55.b. If data is to be recorded (you answered YES in step 8), go to step 50.

50. If "DATA IS BEING RECORDED" is displayed;a. The data just printed is stored on tapeb. Go to step 52

51. If the program detects an error in trying to record data;a.* Go to "HELP"b. Go to step 50

52. If "Tape is full--remove it" is not displayed, go to step 55

53. If "Tape is full--remove it" is displayed you have two options:a. If the current tape still has one track which has not been used,

you may do the following:1) Leave tape in the computer2) Type: n -~ D, where n, either 0 or 1, is the number of the

unused but properly marked track3) Press: EXECUTE4) Press: CONTINUE5) Go to step 54

b. If you change the tape;1) Insert: new properly marked but blank tape2) Press: CONTINUE3) Go to step 54

54. "INSERT HARKED TAPE" is displayed as a reminder that you must haveperformed step 53.a. or 53.b. by this time. If not, then you now must

insert a new tape.a. Press: CONTINUEb. If "Tape full--replace" is displayed, the new track or new tape has

been filled previously;1) Remove: tape2) Press: CONTINUE3) Go to step 54.b.

c. If "TAPE NOT HARKED-USE HARKED TAPE" is displayed;1) Remove: tape2) Press: CONTINUE3) Go to step 54.b.

d. Go to "HELP"; go to next linee. Return from "HELP"

1) If a problem was found by "HELP" &4 to step 54.b.2) If no problem was found by "HELP" go to step 55.

33

55. Have the number of hour groups entered in step 21 been analyzed?a. If no, go to step 24b. If yes, go to step 56

56. If data was recorded on tape "REWINDING TAPE CASSETTE" is displayed.

57. When "TURN OFF DIGITIZER!!" is displayed do so.

58. When "End of Data Reduction" is displayed;

1) Program has finished2) Turn equipment off3) Remove data tape

3

I JI

. . . . . . . .4l . . . . . . . . i i I 1 1 1. . . . m l . . . . . . z ' - : 'L - . . " . . . . - -

a. If "INSERT TAPE CASSETTE" is displayed the tape is not properlyinserted.1) Correctly insert tape2) Press: CONTINUE3 Return to main program

b. If "CASSETTE IS WRITE PROTECTED" is displayed;1) Remove: cassette2) Slide tab on cassette to "RECORD" position3) Insert tape into computer4) Press: CONTINUE5) Return to main program

c. If "SYSTEM MALFUNCTION**GET HELP" is displayed, there is a serioushardware or software problem which must be remedied. The ROMidentifying character, ern, and erl are printed on the internalcomputer printer.

"DIGSET":

a. When "Read point on X axis" is displayed;1) Slide digitizer cursor to a point along chart paper X-axis2) Press: "S" button on cursor3) When data point is properly read, computer will beep once.4) Go back to step a.l. until 5 points are read.

b. When "Do you want to reread points?" is displayed;1) If yes,

a) Press: "YES"b) Go to step a.

2) If no,a) Press: "NO"b) Return to main program

"DATA":

a. Slide digitizer cursor to point to be read.b. Press: button "S" on cursor to read point.c. Computer will beep when point is properly recorded.d. Return to main program.

35

3. User Instructions for PDP Program to bu used with "ISOtfr"

It is assumed that the operator has properly logged onto the PDP computer

and that the transfer program, named "LFSRC21B" is accessible to him.

1. On the PDP computer terminalType: RUN LFSRC21BPress: RETURN

2. When "DATA FILE NAME [NAME.EXT]:" is displayed,a. Type: name wanted for PDP data fileb. Press: RETURN

3. [PDP program is now ready for transfer to start.]

4. When data transfer is completed, "STOP-TTnn" is displayed where nn isthe number of the terminal being used.

36

i/- /T

B. Program "ISOtfr"

1. Introduction

Program "ISOR" computes the isovolume resistance for individual

breaths and records these results on a tape cassette. Thus it is not necessary

to transfer the raw data to the PDP computer for analysis. However, for the

purpose of making statistical comparisons of isovo'.ume resistance between

subjects and/or experimental conditions, the analyzed values are best

transcribed to files on the PDP disk. The programs that effect this transfer

are "ISOtfr" for the HP 9825 and "LFSRC2IB" for the PDP-11/34. The hardware

requirements are the same as described for "PDPtfr."

Each data file from the tape is stored as three records on the PDP

disk. The first two consist of the descriptive and time headers, respectively,

as previously described for "ISOR." The third file holds the actual data: 12

numbers with format F10.5. The first number is the hour number, the second the

time in 24-hour clock notation, and the remaining 10 are the calculated

isovolume resistances (liters/sec-cm H20). All the data on a given track of

the tape cassette are stored on one file in the PDP computer.

Detailed user instructions follow in the next section; program

listings are given in Appendix 6.

37

P,

ISO*

START

ENTER TRACKTO BE

TRANSFEWD?

N=I

FXE N YES TRF END OF

EMPTY? YES FLE CHAR.TO PDP

N NO0

PDP

FTL

TFR DATAFILE TO REWIND TAPE

IF4

TFR YESN-N+1 ANOTHER

TAPE?

NO

STOP

Fig. 5. Flow chart for program "ISOtfr'l

38


1. Insert program tapePress: LOADTypo: 7Press: EXECUTE

2.* When end of line mark 0V-) is displayed

Press: RUN

3. ("REWINDING TAPE" is displayed.-]


5. When "Insert Data Tape" is displayed;a. Insert: tape containing data files produced by "1501"b. Press: CONTINUE

6. When "Track to be transf erred?" is displayed;a. Type: either 0 or 1 to specify which track on the tape is to be

transferredb. Press: CONTINUE

7.* When "Start PDP computer program" is displayed;a. Start programb. Press: CONTINUE

8.* When "Press CONTINUE to start transfer" is displayedPress: CONTINUE

9. ("DATA IS BEING TRANSFERRED" is displayed until an empty file isencountered on the tape, then the end-of-file character is sent to the PDPcomputer.]

10. ("REWINDING TAPE" is displayed.]

11. When "DATA TRANSFER IS FINISHED" is displayedPress: CONTINUE

12.* When "Another data transfer?" is displayed;a. If yes,

1) Press: YES (key f 0)2) Go to stop 3

b. If no,1) Press: NO (key f)2) Program ends

39

rm

C. Program."ISORED"

1. Introduction

Program "ISORED" reads data tapes containing isovolume resistance

values calculated and recorded by program "ISOR." These values are then

printed on an external printer. A program listing is given in Appendix 7.

The format of the printout is as follows:

Tape Track # Tape File#HeaderTime and Date of Original DataHour # Time of Data10 Values of Isovolume Resistance (1 for each breath analyzed)

40

__!


1. Insert: tape cassette containing program


3. Press: LOADType: 6Press: CONTINUE

4. Wait f or end of line mark Q)to be displayed

5. Press: RUN

6. When "Rmove program tape" is displayed;a. Rmve tapeb. Press: CONTINUE

7. When "Insert data tape" is displayed;a. Insert: data tapeb. Press: CONTINUE

8. When "Tape track (0 or 1) wanted - "is displayed;a. Type: numberb. Press: CONTINUE

9. When "File number to be read - "is displayed;a. Type: file number (between 1 and 400)b. Press: CONTINUE

10. [Data is printed.]

11. Go to step 9 (To end program, Press: STOP)

41

References

1. Catron, P.W.; Layton, R.P.; Krupa, T.A. A compterized method for

acquisition and analysis of flow-volume loops. Bethesda, Md: Naval

Medical Research Institute; [1981]; No. 81-13, Available from: Naval

Medical Research Institute, Hyperbaric Medicine, Bethesda, Md.

4 2

APPENDIX IaF#1DATA"'

EqupMEnt List

1. Nicolet oscilloscope (model 2090)

2. Hewlett-Packard (HP) 9825B Computeror

HP 9825A Computer vith the following ROMl's:a. general I/0b. extended 1/0c. advanced programingd. string variable

3. IEEE-488 (HP-ID) interface bus (HP 98034A)

4. Printer for HP 9825, such as HP 9866 (Note: program assumes select code ofprinter is 6; if not, all "wrt" commands must be changed to reflect actualselect code.)

5. Real-Time Clock (HP 98035A)

43

APPENDIX lb

0 *

CL e'.~0 0-4

(04

41 D.1

S 0 Q34

04.C 144 '

10 4 F U

9 00'1~0 rz3 -4O %

F-4 tO r. to wC- 2 f- ~0 CO -AA- 4%.- Aj nM 40 A 49 C4 ft 0 4 0C, 41 w ON

A- C Wi -r 411 02 .:'-' n~ (L Aj *t1" 00t' C4 III~ V) Mr ) C 0 Al4to41 a%4 *.o 0 )1W N - 0. 00 - 5

P4 02 0 P44 Ai *-t.1 4 - P -Al-mO +

-4 1 - 0 .0 ..- 0 ft'. J 4 a a -041 i a 41 '-4O .Cp :9- V4+A 1 ClodC" 0 112 0'-- - -rT- o 1 ) 4 Aj4

00 b1! *j N m~ -4 - pa *4 0.-4C r- 2 03 - N 4 A ..404 C' ..(f 4f ar4"w m$ 3 $00 - - (DCw IGO

- Q, as. 31%if 0 -4 O C 41w4*1 1 C3 - C. p44 st . .- 0 *. -#4 -@ ( . 0b

&j A) 0P r- -. 4-r4 J04 1 0N E) Cr Go..r 4-

r*3 *0 U4V -Or 0 -P4 -oo w o 3.@4 Q C411w

hi4141 u) 04 W -040 * 0'00O0 UWp#..-t 0.14 to w ; -' CY~ '.4 U'41a.i A A I O O ... '44. 1% 1 4.1

4C 0) (a Afbe il 0 C 414 t- %4 C- C541 -0 C C C 0 C Ao O0e 4b £h4 -A -V4 -P4 0 Us (PC 1 'C 00C- 4) 9MA0)

*. 1 1 C,-0.4 0.4 41114114:11*0900.o G* 061.I~ C' C 1 .a e go S* 0C Co *00 t 0 o00

*.......e * .. .. . o .. .. 0 v-44 I" "r 0 r 0 0% 0-4 NM In 41 in %D r%0 M~ 0 4-4 (4

P4 no i of 0 olP4P - 4 - - 4P1P4 C4 NN N 4N N NMMNNC4f lII4

0J

.3 +.u 010

1 0 01

4J4 P1U 4j

-r4 C44

0 ....

r-4.1-4

0* 0 D ft

"1 =

hi. o .; .. - Ut- .. ,

C'. 0. Eu

C'.b~ -! , .4,i • a 0P s -

0M..: .... e

r4 -w 414 4 n .to .U to 4

0.- (0 a 0 4 0-

u) 0 . I I 0. ai ., ( (, * v

to U 0) U -0. fIJUI:

W CJ04* W1. N -r t4 * b4 63 tE4 ~.41 o,> 0 atf JN 4 * a '.M4J 03 4C'C .4 U). go 044 0 00CUMe 34 ,2 W

Ujc 0 Eu I-40 *. Is 0 n ai40 4 2L4 93t t)N0f I -Z0' 0 IA C I-U - -Iu ~

0%%o Ii a a P4M 1 P4 02 0aa 4J%0 4 $4tfl oft E1

A04 4 i F- 6 g. j UA 4j hi 4.-- O 0 A j4 4 1 ro 1 %) E4 906 XP9% 0) EuC a %a 2N v £ i4 1q 1v- )I 4 3 J. 1wr

0O. to 40o ot t 0s * * *U go go go0 o og oo 00 of4~ 0 s f os

0 0 ~ C-U U C'(A0 DaU ~ h~'O n45

474

0 c..41.9 - q -

04A - L

414t 4

.4+0 -41 - - J441 04 (1).-

00'j 1 C

Ai 41 .- 4-4'U Qi -4) zr.

4.. 0 W U

ft C1 An 04 -.A 4 ~ '*

461 X 'U 'Cta 41C 0 41to ft 0 ) *.zr ON4 .

Ai3 40) r7 ~ AJ -.

4 0) .-0 1.4~ .. f 91 u N1

%0I 44 00 1 . t

N N1 '4- b4 o -P, U ~ .3 *.

Go00- 1= -4 (13. a ZwN 0: a oc

%O 4 flAC4 2 E4 0 .0 0u.4 41U A I+ o

%0w 04 gJ 4j %0 w 4 A.4je10

a0-4M 4-4 C C t7% a CPOCO e0 0of -441 0n W *-00 0.03j411 -t.4Uf =

"4 "44 " a4-s 0. tn~u 0 * + II NO0.-4*.4 -4 w P-G-4 .Ad 91-4 v- M Ag to >4 V.EU 4 4 * .C4r4o n 1

0UI w S L -M + ucwb~I~ E NrE-4tfn N 0 P-441s 2 a-48 P-4

0 J 9%. 41" 0. 03" S4 0 F4 44 A31 u it A )41 AjA A 30wa0 M..Ws J1 w w w'

o1 VO4 1~vw0 0 P4* U4 31 1Z41WainOV0VOu *4

** * ** ** ** ** of of 9. go * ** 99*** 99 * .9 so *. 06 ** *e *. es *. *- *. .. 09 * 0 F4 N of4.

46

Ci

0. +

,--l '.0

W. 2, 3:m 4.) 0-.{3 4(11 1 .-

m4

I 41 +1 . J -4. 1

to " x --- 41 41 4

4) N. )

P4 4. 3 0 % q0 '4-

.4 ,)1 -- * -4 *'-- I

at- w 0 t.0f'.140 m4wPi ..

,0 0Ed .-

:0 C t I m7p, fn U). 4 ;~4 4 .0

. 1 ..4.. . "- -' - .... .... ...41 :

.U 0 -. 0 to ft - 0in 39'400 13 41 w 4 LAO Z P-4 xmE

r-4 .0 D 0 A- 0 .. 0

*4 0 .4 W (3 4-a .0 fai a 'o%, w

*-> C *-A 0 (3W 4 saO CA - Oi4 *. a t &S1

MON AO 0 0 U.~ ). :3 0,~4 7r.- = LA (n.04 g3(aU w * w-. At 0J + -0 ..J

Uj 4 j 4) 4JA K 4v4p444 X0 -4 0 44 W 0W J iQ 0 t w0 P.4.4 449 w9 aZ 4 +0 00 4O j0 .444- 0~o E-4 a %4w 0) = 1 o

47

0 04

%00a411 .

o 4'U

'-42 -.4

Oc.4 0 wtlt.4

N 04 .-

W~~ 0%2r-4 0 u)0

N J

+-

0 0)fC4 ( jwA+U +

W40 Owq w w F

~a2 C'4*

APPENDIX lc

"NDATA"

Variable Assignments

A usedF tape file # in which header is recordedG usedH usedI, 3 used as countersK ID # of tapeL used as error flag

N # of tapes to be markedP tape file # in which data is recordedQ usedZ # of data transfer

A$ headerB$ computer clock timeC$ computer clock reset timeD$ character identifying ROM in which error has

occurredE$ usedX$ used for data buffer

rl yes/no indicatorr15 used

49

/

APPENDIX id"IDATA"

Details of Header and TimeStrins Variables

The header is stored in the string variable A$, dimensioned as A$[80].

A$[1,31 3-digit subject number (right-adjusted)A$[4,5] 2-digit subject ageA$[6,6] 1-digit sex codeA$[7,7] 1-digit race codeA$18,8] 0 (used as spacer)A$[9,10] 2-digit height (inches)A$(11,131 3-digit weight (pounds)A$[(14,14] 1-digit experimental type codeA$[15,18] 4-character record type codeA$[19,22] 4-digit event time (default value is

1100-111)A$[23,23] "1space"A$[(24,28] barometric pressure (m Hg)A$[29,29] "1space"A$[C30,31] 2-digit room temperatureA$[32,32] "1space"A$[33,80] free comment section

The value of the real-time clock is stored in string variable 5$, di men sionedas B$[14].

B$[1,21 monthB$[3,3] "fspace"B$[4,5] dayB$16,6] "space"B$[7,8] hourB$[9,9] "1space"B$[10,111 minuteB$[12,121 "space"B$[13,141 second

50

APPENDIX 2a

20: 0t045~0 m L.~~

o ad C)-44

r-4 0 -4 C

0 13

Ai 0 M -0 0

W 0 41U)c lo

45 w -4 to. Li0

U) t 4' Ai

C 0!(a4. ) W 4 0)

S. ) _-4 ri (DU

In In = .. 0,(P 1(0 . C A3 W 0)'C

41U U) U

'44~ ~ ~ 0 4.5 m4 N j 0 ?aD01 to W mm i Aij(a1V .J 0 . ~ 0 CO) W09(go40~a .0 .Ai W~a OU) 0

tf) .n U)) Ow0 AA 5

0.0u~~ 0 to W ej 0 j W(a'- 10~aa fl. 0-4 Ul M1)0

-4) 4 LiiJ -4 002LOQ> C 4J0O - to1. to5%W.- 0.4)0 .L -cJa. %_- z00.0 04 W co . ot L

4j r% to4 .LiUU)4545~ '-400 v-4M f"'14W

r-004 U)VlQID. %0 r. 0. & .fnud 45 1(40 N

w'ic r. 44 -2~4U bd0 'tn 0. 4

f-4 94 CSP . 0- m U 0 u4% - 2 W tU W ~ -Ai: e.-. I .,r- tgo A a Q+ 45 .-. 4

W~a5 0 0 M 0' W 00-wu),4 4JA C 0JWIf0- 4 M (1 XE-43 4-4L s- 0 U"V 3 A0 m

-*04 ~ ~ ~ .ON, ** **o ol r-Ow mo 00 * * * *. ** .. 0 .0" *1 00 * 0.* * * ** ** 00

o 0 0 Q

o 0 0 0 4

6-40 0 0 0 r

dC It Ot U 5ji N a, - - _ tz - ru

~fn) A1 ft1 A 41J 41 fn)

N 4b9 % u. 4fl r- co b vj.

n14 P2a iw j N~. at 4 '(A4 ". ft aJ -4 %4 4 F-*.~ ~ %O 1 .. 4 %.. 4 * -P4 EU **v **04 %

% 44 9. P4. *0 4 *. to AJ b- U) 0I C) A~-A Uq U) 2t.i-.Ie.I'.3 C u4 o!t'

%0 ? .4 0%otlc 44r 4 4' 4 40+

0 Wa2 1 4 t Vt U)1UJ tf1.41 a *eW 9 A41 X O-

01k 2 -A~1 -i4 4 F-42 hi w i 39I tw 411w I U-4 2 Ca 2 a 31 wV 00

52

APPENIX 2b

PDP PROGRAM "LFSRECIB"

CC S.PRINCE 19-FEB-82 CCC TRANSFERS DATA FROM DR. CATRONS EXPERIMENT FROM THE HP-9825C TO THE 11/34 BY WAY OF THE GPIB-11 BUSS. THE HEADERS ANDC THE ACTUAL DATA ARP. TRANSFERED TO A FILE. NO CONVERSIONSC ARE DONE.CC NOTE: THE TRANSFER OF NICOLET DATA CONTAINS VALUES THAT AREC BYTE REVERSED RELATIVE TO THE PDP-11 WORD. IN ORDER TO DOC ANYTHING WORTH WHILE WITH THIS DATA IT WILL BE NECESSARY TOC SWAP THE BYTES IN EACH WORD.C

LOG ICAL *1 LB3YTE (8192) .DOLLAREQUIVALENCE (LBYTE(1) FIN)DATA STnP/'STOP'/.IREAD/1/.1D2/'D2V/

CIDATSZ-8192 I SIZE OF 3RD TRANSFER

CC-- GET FILE NAMEC

TYPE 55 FORMAT(' DATA FILE NAME [NAME.EXTJ 'S

READ(5,7) CLBYTE (I) .I-1,40)7 FORMAT (40A1)

CALL ASSqIGN (2,LBYTE)CALL FDBSET(2, 'NEW')

CC-- READ FIRST HEADER LINE (80 CHARS)C10 J-IBUP(IREAD.3.LBYTE.80)

IF(J.EO.-4)GOTO 10 1 TIMEOUT, REPEAT READIF(J.LT.0)GOTO 100IF (FIN.EQ.STOP) STOP

CC-- OUTPUT LINE TO TERMINAL AND FILEC

WRITECS,20) (LBYTE(I),I-1.80)*20 FORMAT (IH ,80A1)

VRITE(2) (LEYTE (I) .1.1,80)CC-- READ SECOND HEADER LINE (14 CHARS)C30 J'IBUP(IREAD.3.LBYTE.14)

IFCJ.EO.-4)GOTO 30 1 TIMEOUT, REPEAT READIFCJ.LT.0)GOTO 100WRITE (5,40) CLBYTE (DI)1-1,14)

40 PFJMAT(1H , 14A1)VRIYPE(2) CLBYTE CI) .1-1,14) I TO OUTPUT FILE

CC-- READ DA"'A BUFFER C'IDATSZ' BYTES)Cs0 J-IBUP(IREAD.3 .LBYTE.IDATSZ) ITMO~,RPA E

IF(J.EQ.-4)0=T 50 1TMOT EETRA

i ________________53

IVCJ.LT.0)GOTO 100YPE 6 0

60 FORXAT(' DATA BUFFER RUCEIVEDI')WRIlYE(2) (LE7TE(I),I11.IDATSZ) I DATA BUFFER TO OUTPUT FILEGOTO 10

C-- WRITE OUT ERROR NES SAGE

100 WRrPEC5.110)J110 FOIATC' J- 1#15)

STOP 'ERROR'END

1 __ ____ ____ ___54

APPEDIX 3a

"Nictfr'

Equipment List

1. Nicolet oscilloscope (Model 2090)

2. HP 9825 B desktop computeror

HP 9825 A computer with following ROM's:a. general I/0b. extended I/0c. advanced prograumingd. string variable

3. IEEE-488 (HP-IB) interface bus for HP 9825 (HP 98034A)

4. Printer for HP 9825, such as HP 9866(Note: program assumes select code of printer is 6; if not, line 8 mst bechanged to reflect actual select code)

55

/*.'EflhZ 3b

a 044

w0 00w

0 03

U jMi4

is 0n. r-= ~ 0 wc

41b

we .0 A

*44j AJ0 " 0

U).0~ -a W 0.4 o '

-.44 CW h

0 ~ ~ E4 0 Po O'- .- : i-a'4j0

WJJ41O 4 *C4 M1 uI in

0 NM 00% 1-0 M P-4 "4 14w4P

w0.J ~ 4 1 1 .a.a *.-4s~56

Wb yp vqRo N Its~

4 APPENDIX 4

.00

tnto0CL4

00 0. c

44C- (.4 .. cc

-~A 0:a.

410.. VIP1

10

S 0a)0 0'oa W0j 4

Ad.- W 0 -4a s 0 C. 9 0 0 A

$a 0 )tA WA 0 *4 AjbC- 0 SOW to 8 WjisWW- r .t

as 0 00o o o 0Ii) to ot0 00OJU) v Owl 0

0 ~ ~ ~ c P4 MM M e -00 4P4#4#4 o4s- -

6'0~ 0U~2Md .,57

hr

APPDIX 5a

"ISOR1,

Eguipient List

1. HP 9825B desktop computeror

HP 9285A desktop computer with following ROM's:a. general I/0b. extended I/0c. advanced programmingd. string variable

2. HP 9864A digitizer

3. Printer for HP 9825, such as HP 9866.(Note: program assumes printer select code is 6; if not, line 12 must bechanged to reflect actual select code.)

58

APPENDIX 5b

-42

O=

0 $4 Wi

-4C'

0 x0

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4 E-4 13

0. +0. A

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UQa to ix 0I r- wi " Sj

to -1 Eu aV 0 E0 cc tew) -4 to M* 41 uO 41 - Cr-4 14 4 >-. W u ~

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W --1 OF s-U 0 A.I 41Wul C r C.. ".4 C . 1OU ) C c c*.4*.4111Eu * 0-4e--moo 0 go-01.I '44 " u4p-A P4 3W-'r4I..r.,-a y ,-1*4 4..4 0- *0 m 3 w-m ,.4 -0 3 '-4 4-r Eu0 4 ' ft f"Xach.41% W N W* ;m 0 ft 0 Z %4 % P4 w -on + -

to 1 c c 4 4M b 0A C) m4 L4e~.Q a0 t 0 80 wW~ ~ ~ ~ " A * N fw %0F4P N* a~f w . 0 .40

W OI-4 C .-4 cor~-..- F41 000 0 ne~ 0 Aj MI4 * j >.~ '0o

(- P-4J*. CO V i#-4 -43 w *p 0 W 0 i-4 ' Na 9-0 aOU 0 -0 m- 0 d in 0-t, % LA4 2 zc "4 41 ue .e 0 1 h

$4 V~ to V m 41 QIA1U 4 4J4 AJ w fn -4 41E-41G 00 .5U- I 4 .4 44 WC4.4 1 .. 400

59

o -

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M C% N0rC

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C44 0r - 'l 'U - -- '0. 41 4 Wo-0M-

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hA U 0 A a fU.J ~ oa 4 4 l -0 r4 0 a -. 01 0 01 A'CUog "1404P C 0V4.01"4 4 U U -0)Us -AP 44 2 r- MP

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P4 0P 0Cu4A 4W0v-44 41C% 2CC-4 W-Ca..C 1U- W %'4 -5C

0 %4 0 '4) -A 0 0 O . W014 010wm 1Q 0-. 0 %"314 0.4 0:0 04 0%000 sa .tos).0 0 .0 o0 ogo0 0o o 4t # 010So ci) JJ0 to0 toi *0-4 .. ha..- 0 Ci) *0 00 $

tnq uDCd~C oI M 0 k~ft CO % p C ) Usr VIA-4G*% 01--, 40M " M40- q 4 w4w- 4 q q n m n m nininini -UI clh U %0% N% 0 DD%

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to 3t 4) uN AII A) 41 Fo4 004-m0. z$4 0 . EU $4 0 aa 4 r) -i z' 4w 040 Ca. m (U Ca- D4 -C .- 4 CCOr c1% t ip . E4 "

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Im3 O-4 ' W7 30 H * V O s . 0 - 4 aH P5 C C) loco -

0% OH4 N M~ 4' inl %Dt- w M% 0 H- N M V' in %0 r'- M0' 0 H- N Mo o'il %0t'-t v 0% 0 0 0 0 0%0r of -r -r -r -C OZ "C 0 2 %0M0Md N0 - - 4rlv

61

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0.~~~~ to .. 0 .0 9* o0 - 0. 00 o0 o00s 0 # .s .* o t0 ot os fLnar-r m0 4,- t q L o - o s 4c4m- n r ej .im v-c.. en ows o -%wa0 00 0P-4P- pl #4 4 4 o4 4 4 P4 NM 4 (4N MC4M ( fl M. ~Jfq "4P-1-4P4.4 4pq.4 4 M 04 4 4 -4P4 4 4 - - . . . - V . 4 N4plP4P4elt4P 4r

62 .OF- ~ K

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0a- > ~ > *~ M+>-* 0 -04. 4 -r - H 1

3N N - M-- M'~ 0 i-i 0

3--- m=0 0!zr 0- w *U.N04 4.4 U nw 9 L 0 u I% S

Ml - .4> w P C) 0)f r64: -4 la 4-ZaU..6 (D 0 -0'. :u (a m ' w t .4 *.-f6 r414C -1 r%.4' 1 --

go IS .(%4 ~ 41M0A 4P U 0P4 ) -- W i an: H0N -w >4 = 0 -U J. 0->

d) 0 16m Iwv4 U- 0-i' IO mflI w M*N0(AE*C A a~ Vl WO -H 0 a %C) f ) ) O PHO -4D-4- 0M *l n >0.04 0 Ii , C J - U -A wA U e 44.Oil -) )04 P4 0,4P- -4H M U)44A40C4M -

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4 04e i naC o(A0 4MV DP-(n M Uu0-4UN -0 ra%0r-to0%0 .4 f o 11%.0 IV ro 0- r. r0LN% I Ak 1 mk 0% 0 %0 % %D %0~ %D %D C% r-.. .. fl I'-H% "

P4#- -4P- 4 - P4 - P 4 N#- r4P- I P-OC-1rI v-4 4P- f-4.H P 4 4P -0: r4~ voolP v4P

H *.4 0 H-I N.. wuIH 4.06-a63

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m N r-4 + +0 .+0 q0; W d%**-4 z 4 0 N o) N 0 as4 4b0

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48 '4* 40 01 (n 4b4~ C4 a)C-4 in- M- 1-- ft. CAC

F-4 f-4 3 41 to c 04 0c l0 4 c

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cc ca04AJO 40 Oo 0! v 0O40 w cdft C N- vc U. W WA1 C.~~ 0

~00C6 P4 4 4* - 0. j0.0(l4) .41J 40 P..4 a w E- Wi~a E-..b14h w Om Cl )Yoc 0v aZ39I 4% Ca r3 W. 4 +~ C) l~4

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24~ w0~ ~,4i-in N P-*.. 4 N.-"Nu " 4jhiw IN N

3 a .. 0 .4 U i0+W4+ *- $4+ 4' NO~ 0li W.A44J J J44. JJ tZ g44 0 W jg.s0- M 4J ra 0Q0.0a a C41

0 6 IC 44 0 U 0 C WiV44j4W4 ~4j 0 44W4jL4 = i4wa. w +c0 44 31 CO404Wh 2 FOO 0 44.0 2 fO Ct4h $4 t~l10 1 W 4) P4 "4 #-4 01

C.* * *C C CC 0 C P4 N C v* wC r C; *** 0C** CC- CCC * * ** o a** * * ** A* 'we **0 %*a, (. *

#- #-48#-4 P4 P-4 ..4 -4 N v44. N N N N N N 4 M M~ M M~ fn M~ M~ V8 4844 V 4I 484848f q

65

0

-4.

S0+ r 0. 40(

.b44 J

*f30 Gi40 n .4 &J

4.J od S. U(:w 4 0 0 0*- 111)0

ba t .4 bd

fAj 7x 4 0. 0.CP-4 4 .lt 0 0

N 4. 0. C "o 4 4 So - %b 1 j04A

%IJ AT Ad M~0 ...- 3kF*o44 d3 A 14

So0 0g 4' 0'. 0 t f o tog to0 $0som%.. Os %D w n 1o

UN.. .%a. %0 %4 (% 0 %Dw%

1.41 0 .Oh66

APPERDIX Sc

Varible Assinumts

A hour numberB I of breaths for a given hourC flag for recording data on tapeD track of tape on which data is recordedE usedF calibration flow valueG usedH # of hours of dataI used as counterJ used as counterK usedL used as counterM used as counterN used as counter0 # of first hour of dataP usedQ usedt # of tapes to be markedS time of dataT usedW calibration pressure valueY usedZ used as flag

B[*] used

C[*]: used for calibration informationC[1] recorder volts full scale, calibration flowC[2] recorder scale multiplier, calibration flowC[3] recorder volts full scale, calibration pressureC[4] recorder scale multiplier, calibration pressureC[5] recorder volts full scale, data flowC16] recorder scale multiplier, data flowC[7] recorder volts full scale, data pressureC[8] recorder scale multiplier, data pressure

D[*] D[I] is average isovolume resistance for data of hour I IF[*]: flow data

F1l] digitizer value for data flow point FlF[2] digitizer value for data flow point F2F[6] scale factor for flow

I*] I[L] is isovolume resistance for breath #LP[*]: pressure data

P111 digitizer value for data pressure point PIP[2] digitizer value for data pressure point P2P[5] scale factor for pressure

67i °,

QN: resistance valuesQ11] max. isovolume resistanceQ(21 min. isovolume resistanceQ(31 variation in isovolume resistance

X(*] usedY[*] used

A$ header stringB$ clock time stringE$ usedF$ used

ri yes/no indicatorr12 printer select code

j 68

APPENDIX 6a

41ON

V. ab) C)0 m

41 G i

4-44. w t

WO a

w0 E-4 1

'414-4j 0 1 ) bC) U-3 NOwa

N f7 0 Oa En 4 60nJ

1 a *.4 4A

h C 0~ n4 0 1' 0) U- 0"AM%0 0aWr-4 '- o0 %-A + - v-On ~ ~ 04 a at A.w -. 0 r-w

wU 1W00 w 0% 04tCV .4j wq P3 cc r4q 4). V. of U -

1.0 E haA x4 ~- 0- 4 4- a E4~w0. -M a "4 0 - 0: 9 r 104 Zz Ct-r-P4.9 4 0 A A M" 4a r. Ag r4 06% S40UMai

E -4 00 0. a 4 % S 3i # 1b

a$ 0* so .e .L es0 o* 9f o0 n *s 00 0s O 4*00 so .. of go0 *0 "Ne Vi~ %co ~ 40 %Nor.4 vblC'i4E0aJe V 00 %iM 1%WMr 4 4P4o -448~ P4'. mP4i M *

~o 'ia. * - 2 O 0'~daW~(~d e~.69~

-4 F

.0 &

0 41

P4 0 ."AVs

O 4 c - 0 c

0t 39 0.A# w

,f- 0 P4 M ~ M f0 OI- C 4M Wim ~ ~ ~ ~~~~~~~~d f"4 4o 4 04 v 0 r ino 4 oI

41,-i 00

[ 7 1 APP ENIX 6 b

PDP PRtOGRAM ILFSRC2IBN

* CC S-aPRINCE 19-FEB-82 ACtC

* C TRANSFERS DhMA FROM DR* CATROES EXEIMENNT FROM THE EP-9825C TO THE 11/34 BY WAY OF THE GPIB-11 BUSS. THE HEADERS ANDC THE ACTUAL DATA AiR TRANSFERED TO A FILE. NO CONVERSIONSC AIR DONE.CC NOTE: THE TRANSFER OF HICOLET DATA CONTAINS VALUES THAT AREC BYTE REVERSED RELATIVE TO THE PDP-11 WORD. IN ORDER TO DOC AN YTH ING WORTH WHILE WITH THIS DATA IT WILL BE NECESSARY TOC SWAP THE BYTES IN EACH WORD.C

LOGICAL*1 LBYTE (8192) .DOLLAREQUIVALENCE ([BYTE Cl) .FIN)DATA STfP/'STOP/.IREAD//PID2/ 'D2'/

CIDATSZ-120 I SIZE OF 3RD TRANSFER

CC-- GET FILE NAMEC

TYPE 55 FOIATC' DATA FILE NAME CNANE.EXTl It$

READC5r7) (LBYTECI),I-1,40)7 POINAT (40A1)

CALL ASrIGN (2oWYTB)CALL PDBSETC2,'NEW')

CC-- READ FIRST HEADER LINE (S0 CHARS)C10 J-IBUP (IREAD -3 -LBYTE -80)

IF(J.EO.-4)GOTO 10 1 TIMEOUTP REPEAT READIF(j.LT.0)GOTO 100

* IF(FIN.EQ.STOP)STOPCC-- OUTPUT LINE Tn TERMINAL AND FILEC

WRITE(5v20) CLBYTE(I) .1.1.80)* 20 POEIATC1H v 80A1

READ (2(LBYTE(I) .Iilv80)

C-- EADSECOND HEADER LINE (14 CHARX)C30 J-IBUPCIREAD.3.LBYTE.14)

IFCJ.EQ.-4)GOT0 30 1 TIMEOUT* REPEAT READIF(J.LT.0)GOTO 100

4 WRITE(5,,40)(LBYTE(I).Iu1.14)40 PFNIT(1E #14A1)

VRI'P3(2)(LBYTECI).I.1.14) I TO OUTPUT FILE*C

C-- READ DATA BUFFER C'IDATSZ' BYTES)C50 J-IBUP(IR9AD.3.LBYT2.IDATSZ)

IVCJ.9Q.-4)GOT0 50 1 TIMEOUT# REPEAT READ

71

IFCJ.LT.0)GOTO 100WPPE 6 0

60 FONIAT(' DATA BUFPER RECEIVBDI )VRIYrE(2) CLBYT(I) .I-1IDATSS) I DATA BUFFER TO OUTPUT FILEGOTO 10

cC-- WRITE OUT SUROR MESSAGEC

*100 VRI'EZ(5,110)J11a FOIAT(' J- I5)

STOP 'ERROR'END

j 72

APPEM)IX 7a

"ISOED"

-u:lpment List

1. UP 9825 B desktop computeror

UP 9825 A computer with following ROM's:a. general I/0b. extended I/0t. advanced programmingd. string variable

2. Printer for HP 9825, such as HP 9866.(Note: program assumes printer select code is 6; if not, all "wrt"statements must be modified to reflect actual select code.)

73

IE

APPENDTX 7b

00

0cto 0

410(d hi

:0'

4 Aj

00

-2 fl ~ 0

U l fl) *. -. LM A0 . O s- 4.-4 4) %A

v)to f .0 0t0-4CG q 0- EnJ~. U3.

-- 4CL % 0 i- 4 fe i

4 w .-- a~ a .44 P4

Ajeu A * f4 A w X ft SA *3 a V) 0 W.W $4.4 eqr4

0 4 f-W fto%0 4

to %4 . -0~ m . *t~m q 0 *-u 4c~U. r- L3Cq a-~~ th00Q--4 a 4 Q 4-4 e

0 3c, t I -f 1,4 Q,4.4 P4VJ -4t Ow J4% #4P, -4-414 D -4P

0~~~ U ~ %A- 0AJ-A0WW JXA

APPENDIX 8

Identification of Files of Proaram Tae

Tape File # File Size Program Name

0 1.00 (special function keys)1 5000 "UDATA"2 2000 "PDPtf r"3 1000 "Nictfr"4 1000 "ERASEff5 8000 "ITSOR"l6 1000 "ISORED"7 2000 "ISOtfr"

75

1/i unclassified lilllllllllll bethesda md r …naval medical research institute 500".u5a2. 13...

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