1985shutarok/img/file16.pdfantidepressants and methamphetamine in rats. al-khatib imh, fujiwara m,...

１

研究業績（論文発表）

1985 年

1) Amantadineの行動薬理学的研究

藤原道弘、桜井康子、清田義弘、島添隆雄、太田尚、柴田重信、植木昭和

日本薬理学雑誌 85, 259-274 (1985)

2) Δ9-Tetrahydrocannabinol elicited ipsilateral circling behavior in rats with unilateral nigral lesion.

Sakurai Y, Ohta H, Shimazoe T, Kataoka Y, Fujiwara M, Ueki S.

Life Sci. 37, 2181-2185 (1985)

3) Lormetazepamの行動薬理学的・脳波学的研究

植木昭和、渡辺繁紀、藤原道弘、山本経之、柴田重信、柴田和彦、太田尚、桜井康子、岩崎克典、劉世玉、

山下樹三裕、島添隆雄、山路隆之

日本薬理学雑誌 86,145-163 (1985)

1986 年

4) Changes in brain catecholamine levels following olfactory bulbectomy and the effect of acute and chronic

administration of desipramine in rats.

Iwasaki K, Fujiwara M, Shibata S, Ueki S.

Pharmacol Biochem Behav. 24, 1715-1719 (1986)

5) Activity of some atypical antidepressants on five models of muricide in rat.

Al-Khatib IMH, Fujiwara M, Shibata S, Ueki S.

Asia Pacific J Pharmacol. 1, 79-85 (1986)

6) The effect of neurotransmitters on cataleptic behavior induced by PG D2 in rats.

Saito R, Fujiwara M, Kamiya H, Ono N.


7) Optic nerve stimulation-induced increase of release of 3H-glutamate and 3H-aspartate but not 3H-GABA

from the suprachiasmatic nucleus in slices of rat hypothalamus.

Liu S, Shibata S, Iwasaki K, Fujiwra M, Ueki S

Brain Res Bull, 16,527-531(1986)

8) 大黄の向精神作用

植木昭和、西岡五夫、藤原道弘、野中源一郎

現代東洋医学 3, 98-103 (1986)

9) CysteinProtease阻害剤 ESTの中枢作用

２

植木昭和、渡辺繁紀、藤原道弘、柴田重信、劉世玉、岩崎克典、太田尚、島添隆雄、天沼二三雄、奥山茂、

大関正弘

薬理と治療,14,261-271 (1986)

1987 年

10) The role of brain catecholamines in the exhibition of muricide induced by nucleus accumbens lesions and the

effect of antidepressants in rats.

Al-Khatib IMH, Fujiwara M, Iwasaki K, Kataoka Y, Ueki S.


11) Spatial memory disturbance in hydocephalus and the effect of drugs modifying neurotransmitters.

Takakura K, Iwasaki Y, Shitara N, Iwasaki K, Fujiwara M.

Neurotransmitters and Neuroreceptors. 6, 56-65 (1987)

12) Noradrenergic involvement in catalepsy induced by △9-tetrahydrocannabinol.

Kataoka Y, Ohata H, Fujiwara M, Oishi R, Ueki S.

Neuropharmacology. 26, 55-60 (1987)

13) The involvement of neuropeptide Y in the antimuricide action of noradrenaline injected into the medial

amygdala of olfactory bulbectomized rats.

Kataoka Y, Sakurai Y, Mine K, Yamashita K, Fujiwara M, Ueki S.


14) 中枢神経作用薬

藤原道弘

臨床薬物治療学大系 93-128 (1987)

15) うつ病と脳内アミンーラットの muricideについての研究

植木昭和、藤原道弘、山本経之、柴田重信、岩崎克典

続「脳の生体警告系」 115-128 (1987)

16) 大麻の薬理作用

藤原道弘

依存性薬物情報シリーズ No. 1 大麻 43-59 (1987)

1988 年

17) Changes in [3H]-imipramine binding sites in relation to muricide following olfactory bulbectomy and the

effect of nomifensine in brain of rats.

Al-Khatib IMH, Kataoka Y, Fujiwara M, Ueki S.

Archieves Internationals de Pharmacodynamie Therapie. 296, 282-292 (1988)

18) Effect of microinjection of nomifensine into brain on muricide of olfactory bulbectomized rats.

３

Al-khatib IMH, Fujiwara M, Ueki S.

Asia Pacific J Pharmacol. 3, 125-129 (1988)

19) 実験水頭症における空間記憶障害 −放射状迷路を用いた研究−

岩崎康夫、信楽信行、斎藤勇、高倉公朋、八重徹司、岩崎克典、藤原道弘

小児の脳神経 13, 367-372 (1988)

1989 年

20) In vivo changes in brain catecholamine release from rat hypothalamus following olfactory bulbectomy

Iwasaki K, Fujiwara M, Ueki S.


21) Δ9-tetrahydrocannabinol facilitates striatal dopaminergic transmission.

Sakurai-Yamashita Y, Kataoka Y, Fujiwara M, Mine K, Ueki S.


22) Relative importance of the dopaminergic system in haloperidol-catalepsy and the anticataleptic effect of

antidepressants and methamphetamine in rats.

Al-Khatib IMH, Fujiwara M, Ueki S.


23) Is the augmentation of K+-evoked intrasynaptosomal Ca2+ concentration due to the influx of Ca2+ in rat brain

synaptosomes?

Okada M, Mine K, Iwasaki K, Fujiwara M.

J Neurochem. 52, 1837-1842 (1989)

24) Relationship of calcium and adenylate cyclase messenger systems in rat brain synaptosomes.

Okada M, Mine K, Fujiwara M.

Brain Res. 501, 23-31 (1989)

25) Ascorbic acid suppresses the deconjugation of noradrenaline but not dopamine in plasma.


Analytical Biochem. 182, 262-265 (1989)

26) Behavioral pharmacological properties of the novel antidepressant paroxetine, a selective 5-HT uptake

inhibitor

Iwasaki K, Fujiwara M.

Folia Pharmacologica Japomica. 94, 189-206 (1988)

27) アセチルコリン仮設と抗痴呆薬候補

藤原道弘、岩崎克典

神経精神薬理 11, 793-805 (1989)

28) 大黄の行動薬理作用

４

藤原道弘、西岡五夫、野中源一郎、植木昭和

医薬品の開発 2, 薬理活性物質 5, 543-551 (1989)

1990 年

29) The Na+-dependent release of endogenous dopamine and noradrenaline from rat brain synaptosomes.


J Pharmacol Exp Ther. 252, 1283-1288 (1990)

30) Differential calcium dependent between the release of endogenous dopamine and noradrenaline from rat

brain synaptosomes.


J Neurochem. 54, 1947-1952 (1990)

31) Effect of TJ-23 on the learning and memory disturbance following cerebral ischemia in rats.

Fujiwara M, Iwasaki K.

Patient Benefit and Japanese Kampo Product 1, 15-20 (1990)

32) 実験的記憶障害と和漢薬

藤原道弘

和漢医薬学会誌 6, 234-237 (1990)

33) 実験的記憶障害に対する当帰芍薬散の改善作用

藤原道弘

神経精神薬理 12, 217-226 (1990)

34) 高次処理

藤原道弘

脳卒中実験ハンドブック 756-782 (1990)

35) ラットの空間認知獲得に関する基礎的検討

岩崎克典、松本禎明、藤原道弘

動物の学習・記憶試験－その実際と問題点－ 19-34 (1990)

36) 中枢神経作用の探索抗躁うつ病薬

藤原道弘、岩崎克典

医薬品の開発 9, 医薬品の探索 I, 177-200 (1990)

1991 年

37) Effect of Toki-syakuyaku-san on scopolamine-induced deficit of learning and memory in rats.

Fujiwra M, Iwasaki K, Ogata T.

Basic, Clinical, and Therapeutic Aspects of Alzheimer's and Parkinson's Disease. 2, 379-382 (1991)

38) Effect of Toki-syakuyaku-san on scopolamine-induced deficit of learning and memory in rats

５

Iwasaki K, Ogata T, Fujiwra M

Basic, Clinical, and Therapeutic Aspects of Alzheimer's and Parkinson's Disease. 2, 379-382 (1991)

39) 学習障害モデルとしての実験的正常圧水頭症 −抗痴呆薬候補としての漢方方剤−

藤原道弘

脳と神経 43, 63-66（1991）

40) 電撃ショックならびに scopolamineによるラットの学習記憶障害に及ぼす minaprineの作用

川島数明、荒木博陽、奥山茂、小友進、相原弘和、山本経之、植木昭和、藤原道弘

基礎と臨床 24, 383-388 (1991)

41) 動物からみた大麻の危険性

藤原道弘

こころの臨床 10, 9-12（1991）

42) 老人性痴呆シリーズ/高齢者の疾患の治療ー医療用漢方製剤を用いてー

藤原道弘

漢方医学 15, 1-5 (1991)

43) カオリン水頭症ラットの免疫応答について

上野光一、武田裕夫、佐藤哲男、藤原道弘

Neuroimmunological Res. 4, 35-40 (1991)

1992 年

44) Effect of nebracetam on the disruption of spatial cognition in rats.

Iwasaki K, Matsumoto Y, Fujiwara M.

Jpn J Pharmacol. 58, 117-126 (1992)

45) The facilitating and suppressing effects of Δ9-tetrahydrocannabinol on the rise in intrasynaptosomal Ca2+

concentration in rats.

Okada M, Urae A, Mine K, Shoyama Y, Iwasaki K, Fujiwara M.

Neurosci Lett. 140, 55-58 (1992)

46) Effects of the N-methyl-D-aspartate antagonists on the rise in [Ca2+]i following depolarization in aged rat

brain synaptosomes.

Okada M, Urae A, Iwasaki K, Mine K, Fujiwara M.

Brain Res. 583, 227-236 (1992)

47) 実験的空間認知障害に対する黄連解毒湯ならびに釣藤散の作用

岩崎克典、大神祐輔、植木昭和、藤原道弘

和漢医薬学会誌 8, 476-478 (1992)

48) ラットの空間の手がかりと認知

松本禎明、岩崎克典、藤原道弘

６

九州女子大学紀要 28, 93-106 (1992)

49) 痴呆症

藤原道弘

代謝臨時増刊号漢方薬 29, 130-143 (1992)

50) 第 4章脳・脊髄

藤原道弘

機能形態学（藤原道弘他編）廣川書店 61-112 (1992)

51) 第 9章心血管系

藤原道弘

機能形態学（藤原道弘他編）廣川書店 235-260 (1992)

52) 漢方薬その医学的研究の最先端「痴呆症」

藤原道弘

代謝－臨時増刊号－ 29, 130-143 (1992)

1993 年

53) Toki-Syakuyaku-San and Oren-Gedoku-To improve the disruption of spatial cognition induced by cerebral

ischaemia and dcentral cholinergic dysfunction in rats.


Phytother Res. 7, 60-62 (1993)

54) Plasma-free and sulfoconjugated MHPG in major depressive disorders: differences between responders to

treatment and nonresponders.

Mine K, Okada M, Mishima N, Fujiwara M, Nakagawa T.

Biol Psychiatry. 34, 654-660 (1993)

55) 釣藤散ならびに抑肝散加陳皮半夏の空間認知障害改善作用

江頭伸昭、岩崎克典、植木昭和、藏内浩二、藤原道弘

和漢医薬学会誌 10, 190−194 (1993)

56) 大麻依存

植木昭和、藤原道弘、岩崎克典

精神医学シリーズ 5, 薬物依存 209-218 (1993)

1994 年

57) 抗うつ薬

藤原道弘、片岡泰文

薬局 45, 97-101 (1994)

58) ステップスルー型受動的回避実験

７

岩崎克典

生体の科学 45, 動物の行動機能テスト－個体レベルと分子レベルを結ぶ－ 496-497 (1994)

59) ステップダウン型受動的回避実験

岩崎克典


60) Morris水迷路実験

藤原道弘、三島健一


61) Biel型水迷路実験



62) 8方向放射状迷路実験



63) 老齢ラットの空間認知獲得に及ぼす当帰芍薬散および当帰の影響

岩崎貴代、岩崎克典、藏内浩二、藤原道弘

和漢医薬学雑誌 11, 366-367 (1994)

1995 年

64) Differential role of nucleus accumbens and caudate-putamen in mediating the effect of nomifensine and

methamphetamine on ambulation and rearing of rats in the open-field test.

Al-Khatib IM, Dokmeci I, Fujiwara M.

Jpn J Pharmacol. 67, 69-77 (1995)

65) Long-term spatial cognitive impairment after middle cerebral artery occlusion in rats: no involvement of the

hippocampus.

Okada M, Nakanishi H, Tamura A, Urae A, Mine K, Yamamoto K, Fujiwara M.

J Cereb Blood Flow Metab. 15, 1012-1021 (1995)

66) Long-term spatial cognitive impairment following middle cerebral artery occlusion in rats -A behavioral

study-

Okada M,Tamura A, Urae A, Nakagomi T, Kirino T, Mine K, Fujiwara M

J Cereb Blood Flow Metab. 15, 505-512 (1995)

67) Effect of Toki-Shakuyaku-San and Toki on the acquisition task of spatial cognition in aged-rat.

Iwasaki K, Matsumnoto Y, Fujiwara M.

J Traditional Medicines. 11, 366-367 (1995)

68) 情動と記憶

８


Clinical Neuroscience 13, 1044-1047 (1995)

69) マウスのオキソトレモリン誘発振戦に及ぼすモノアミン関連薬物の影響

松本禎明、三島健一、岩崎克典、藤原道弘

九州女子大学紀要 32, 1-7 (1995)

1996 年

70) The disruption of spatial cognition and changes in brain amino acid, monoamine and acetylcholine in rats

with transient cerebral ischemia.

Iwasaki K, Kitamura Y, Ohgami Y, Mishima K, Fujiwara M.

Brain Res. 709, 163-172 (1996)

71) Changes in gene transcription during Aβ-mediated cell death.

Iwasaki K, Sunderland T, Kusiak J, Wolozin B.

Mol Psychiatry. 1, 65-71 (1996)

72) Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3.

Vito P, Wolozin B, Iwasaki K, Ganjei JK, Lacan E, D'Adamio L.

J Biol Chem. 271, 31025-31028 (1996)

73) Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation.

Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacan E, Sunderland T, Zhao B, Kusiak JW, Wasco W, D'Adamio L

Science. 274, 1710-1713 (1996)

74) The chronic administration of docosahexaenoic acid reduced the spatial cognitive deficit following transient

forebrain ischemia in rats.

Okada M, Amamoto T, Tomonaga M, Kawachi A, Yazawa K, Mine K, Fujiwara M.

Neuroscience. 71, 17-25 (1996)

75) Protective effect of MK-801 on the anoxia-aglycemia induced damage in the fluorocitrate-treated

hippocumpal slice of the rat.

Nakanishi H, Kawachi A, Okada M, Fujiwara M, Yamamoto K.

Brain Res. 732, 232-236 (1996)

76) Transient upregulation of the AT2 receptor mRNA level after global ischemia in the rat brain.

Makino I, Shibata K, Ohgami Y, Fujiwara M, Furukawa T.

Neuropeptides 30, 596-601 (1996)

77) 痴呆の実験モデルと Neurotoransmitter

藤原道弘

最新脳と神経科学シリーズ 2, 痴呆解明への新しい展開 61-80 (1996)

９

1997 年

78) Rolipram and its optical isomers, phosphodiesterase 4 inhibitors, attenuated the scopolamine-induced

impairments of learning and memory in rats.

Egawa T, Mishima K, Matsumoto Y, Iwasaki K, Iwasaki K, Fujiwara M.

Jpn J Pharmacol. 75, 275-281 (1997)

79) Effects of the isocarbacyclin methyl ester clinprost incorporated into lipid microspheres, in focal ischemia of

stroke-prone spontaneously hypertensive rats.

Yae T, Araki H, O-ogami Y, Iwasaki K, Tanabe H, Fujiwara M.

Arzneimittelforschung. 47, 1200-1203 (1997)

80) Up-regulation of ganglioside biosynthesis, functional synapse formation, and memory retention by a

synthetic ceramide analog (L-PDMP).

Inokuchi J, Mizutani A, Jimbo M, Usuki S, Yamagishi K, Mochizuki H, Muramoto K, Kobayashi K, Kuroda Y, Iwasaki K,

Ohgami Y, Fujiwara M.

Biochem Biophys Res. Commun. 237, 595-600 (1997)

81) Effect of active fragments of arginine-vasopressin on the disturbance of spatial cognition in rats.

Fujiwara M, Ohgami Y, Inada K, Iwasaki K.

Behav Brain Res. 83, 91-96 (1997)

82) Physiological level of beta-amyloid peptide stimulate protein kinase C in PC12 cells.

Luo Y, Iwasaki K, Hawver DB, Sunderland T, Roth GS, Wolozin B.

Brain Res. 769, 287-295 (1997)

83) Behavioral changes after cerebral infarction in the rat: Long-term spatial cognitive impairment and cerebral

acetylcholine levels.

Tamura A, Nagashima H, Hirakawa M, Narita K, Nagashima Y, Nakayama H, Yonemori F, Okada M, Fujiwara M, Sano

K.

Maturation Phenomenon in Cerebral Ischemia II. 1, 171-175 (1997)

84) 第 7章中枢神経系ならびに神経障害に用いる薬物

藤原道弘

薬物治療学藤原道弘他編南山堂 181-258 (1997)

85) 家族性アルツハイマー病遺伝子「プレセニリン」とアポトーシス

岩崎克典

日本神経精神薬理学雑誌 17, 183-184 (1997)

86) 大麻の精神毒性

藤原道弘，三島健一

神経精神薬理 19, 1059-1067 (1997)

１０

1998 年

87) L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol stimulates ganglioside biosynthesis, neurite

outgrowth and synapse formation in cultured cortical neurons, and ameliorates memory deficit in ischemic rats.

Inokuchi J, Kuroda Y, Kosaka S, Fujiwara M.

Acta Biochimica Polonica. 45, 479-492 (1998)

88) A synthetic ceramide analog (L-PDMP) up-regulates neuronal function.

Inokuchi J, Mizutani A, Jimbo M, Usuki S, Yamagishi K, Mochizuki H, Muramoto K, Kobayashi K, Kuroda Y, Iwasaki K,

Ohgami Y, Fujiwara M.

Ann NY Acad Sci. 845, 219-224 (1998)

89) Repeated ischemia induced impairment of spatial cognition and cellular apoptosis in the hippocampus CA1

area in the rat.

Iwasaki K, Chung E-H, Ohgami Y, Fujiwara M.

J Neurochem. 70, 28-29 (1998)

90) Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia

induced by 6-hydoroxydopamine.

Takai N, Nakanishi H, Tanabe K, Nishioku T, Fujiwara M, Yamamoto K.

J Neurosci Res. 54, 214-222 (1998)

91) A new muscarinic partial agonist, SB202026A, improved the deficit of spatial copgnition induced by

scopolamine, pirenzepine and repeated ischemia in rats.

Iwasaki K, Mishima K, Chung E-H, Ohgami Y, Ishibashi M, Fujiwara M.

Naunyn Schniedeberg's Archives of Pharmacology. 358, 35-38 (1998)

92) Extracellular presence of IL-8 in the astrocyte-rich cultured cerebellar granule cells under acidosis.

Watanabe Y, Miura I, Ohgami Y, Fujiwara M.

Life Sci. 63, 1037-1046 (1998)

93) Role of nerve terminal L-type Ca2+ channel in the brain.

Watanabe Y, Lawlor GF, Fujiwara M.

Life Sci. 62, 1671-1675 (1998)

94) Brain-derived neurotrophic factor stimulates neurite outgrowth in a calretinin-enriched neuronal culture

system.

Iwasaki K, Isaacs K, Jacobowitz D.

Int J Dev Neurosci. 16, 135-145 (1998)

95) Apoptosis in the repeated cerebral ischemia--behavioral & histochemical study.

Iwasaki K, Chung E-H, Fujiwara M.

Nippon Yakurigaku Zasshi 112, 88P-92P (1998)

96) 実験的記憶障害に対する当帰芍薬散の改善効果

１１

藤原道弘

神経精神薬理 12, 217-226 (1998)

97) 大麻によって発現する動物の異常行動

藤原道弘

依存性薬物情報シリーズ 9, 大麻乱用による健康障害 67-82 (1998)

98) 第 5章脳・脊髄

藤原道弘

機能形態学第 2版（藤原道弘他編）廣川書店 121-172 (1998)

99) 第 9章心血管系

高野行夫，藤原道弘

機能形態学第 2版（藤原道弘他編）廣川書店 199-225 (1998)

1999 年

100) Inhibition of GABA system involved in cyclosporine-induced convulsions.

Shuto H, Kataoka Y, Fujisaki K, Nakao T, Sueyasu M, Miura I, Watanabe Y, Fujiwara M, Oishi R.

Life Sci. 65, 879-887 (1999)

101) Cerebral acetylcholine levels and long-term spatial cognitive impairment following middle cerebral artery

occlusion in rats.

Urae A, Okada M, Tamura A, Nakagomi T, Kanemitsu H, Mine K, Fujiwara M, Tomonaga M.

Japan J Psychopharmacol. 19, 267-272 (1999)

102) 老齢ラット海馬における不飽和脂肪酸と LTP形成の関連-ドコサヘキサエン酸慢性投与の影響-

天本敏昭、岡田三津子、河内明夫、中西博、矢澤一良、藤原道弘、朝長正道

日本神経精神薬理学雑誌 19, 273-278 (1999)

103) 大麻


薬物依存研究の最前線 57-81 (1999)

2000 年

104) Nimodipine improves thedisruption of spatial cognition induced by cerebral ischemia.

Taya K, Watanabe Y, Kobayashi H, Fujiwara M.

Physiol Behav. 70, 19-25 (2000)

105) The scopolamine-induced impairment of spatial cognition parallels the acetylcholine release in the ventral

hippocampus in rats.

Mishima K, Iwasaki K, Tsukikawa H, Matsumoto Y, Egashira N, Abe K, Egawa T, Fujiwara M.

Jpn J Pharmacol. 84, 163-173 (2000)

１２

106) Cerebral acetylcholine levels and long-term spatial cognitive impairment following middle cerebral artery

occlusion in rats.

Urae A, Okada M, Tamura A, Nakagomi T, Kanemitsu H, Mine K, Fujiwara M, Tomonaga M.

Jpn J Psychopharmacol. 19, 267-272 (2000)

107) Aβ potentiates pro-apoptotic NGF signaling.

Petrucelli L, Manteuffel M, Iwasaki K, Fujiwara M, Lee J, Wolozin B.

J Neurochem. 72, 221-230 (2000)

108) 大麻による空間認知記憶障害


精神医学レビュー 34, 28-35 (2000)

109) 第 7章中枢神経系ならびに神経障害に用いる薬物

藤原道弘

薬物治療学第 2版藤原道弘他編南山堂 149-228 (2000)

2001 年

110) Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by

dizocilpine.

Hatip-Al-Khatib I, Mishima K, Iwasaki K, Fujiwara M.

Brain Res. 902, 108-118 (2001)

111) Cholinergic involvement in the improving effects of Yoku-kan-san-ka-chimpi-hange

(Yi-Gan-San-Jia-Chen-Pi-Ban-Xia) on the disruption of spatial cognition and the electroconvulsive shock-induced

immobilization.

Egashira N, Mishima K, Kurauchi K, Matsumoto Y, Iwasaki K, Fujiwara M.

J Trad Med. 18, 71-80 (2001)

112) Selective and long-term learning impairment following neonatal hypoxic-ischemic brain insult in rats.

Ikeda T, Mishima K, Yoshikawa T, Iwasaki K, Fujiwara M, Xia YX, Ikenoue T.

Behav Brain Res. 118, 17-25 (2001)

113) Ameliorative effect of vasopressin-(4-9) through vasopressin V1A receptor on scopolamine-induced

impairments of rat spatial memory in the eight-arm radial maze.

Mishima K, Tsukikawa H, Inada K, Fujii M, Iwasaki K, Matsumoto Y, Abe K, Egawa T, Fujiwara M.

Eur J Pharmacol. 427, 43-52 (2001)

114) Characteristics of learning and memory impairment induced by ∆9-tetrahydrocannabinol in rats.

Mishima K, Egashira N, Hirosawa N, Fujii M, Matsumoto Y, Iwasaki K, Fujiwara M.

Jpn J Pharmacol. 87, 297-308 (2001)

１３

115) Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by

MK-801 in rats: a behavioral and in vivo microdialysis study.

Hatip-Al-Khatib I, Bölükbasi F, Mishima K, Egashira N, Iwasaki K, Fujiwara M.

Jpn J Pharmacol. 87, 277-287 (2001)

116) Presenilin 1 regurates beta-catenin-mediated transcription in a glycogen synthase kinase-3-indipendent

fashion.

Palacino JJ, Murphy MP, Murayama O, Iwasaki K, Fujiwara M, Takashima A, Golde TE, Wolozin B.

J Biol Chem. 276, 38563-38569 (2001)

117) 大麻による薬物依存と異常行動（総説）

藤原道弘

日本薬理学雑誌 117, 35-41 (2001)

2002 年

118) Impairment of spatial memory in kaolin-induced hydrocephalic rats is associated with changes in the

hippocampal cholinergic and noradrenergic contents.

Egawa T, Mishima K, Egashira N, Fukuzawa M, Abe K, Yae T, Iwasaki K, Fujiwara M.

Behav Brain Res. 129, 31-39 (2002)

119) Involvement of 5-hydroxytryptamine neuronal system in Δ9-tetrahydrocannabinol-induced impairment of

spatial memory.

Egashira N, Mishima K, Katsurabayashi S, Yoshitake T, Matsumoto Y, Ishida J, Yamaguchi M, Iwasaki K, Fujiwara M.

Eur J Pharmacol. 445, 221-229 (2002)

120) Intracerebral microinjections of Δ9-tetrahydrocannabinol: search for the impairment of spatial memory in the

8-arm radial maze in rats.

Egashira N, Mishima K, Iwasaki K, Fujiwara M.

Brain Res. 952, 239-245 (2002)

121) Repeated cerebral ischemia induced hippocampal cell death and impairments of spatial cognition in the rat.

Chung E-H, Iwasaki K, Mishima K, Egashira N, Fujiwara M.

Life Sci. 72, 609-619 (2002)

122) Involvement of reduced acetylcholine release in Δ9-tetrahydrocannabinol-induced impairment of spatial

memory in the 8-arm radial maze.

Mishima K, Egashira N, Matsumoto Y, Iwasaki K, Fujiwara M.

Life Sci. 72, 397-407 (2002)

123) Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia.

Irie K, Mishima K, Ishibashi D, Egashira N, Iwasaki K, Fujiwara M.

Life Sci. 72, 621-629 (2002)

１４

124) The pharmacological characterization of attentional processes using a two-lever choice reaction time task in

rats.

Mishima K, Fujii M, Aoo N, Yoshikawa T, Fukue Y, Honda Y, Egashira N, Iwasaki K, Shoyama Y, Fujiwara M.

Biol Pharm Bull. 25, 1570-1576 (2002)

125) Hypoxia enhances β-amyloid-induced apoptosis in rat cultured hippocampal neurons.

Egashira N, Iwasaki K, Ishibashi M, Hatip-Al-Khatib I, Wolozin B, Mishima K, Irie K, Fujiwara M.

Jpn J Pharmacol. 90, 321-327 (2002)

126) Behavioral and histochemical studies in repeated cerebral ischemia in rats.

Iwasaki K, Mishima K, Fujiwara M.

Advances in Behavioral Biology. 53, 265-268 (2002)

127) Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.

Tatebayashi Y, Miyasaka T, Chui DH, Akagi T, Mishima K, Iwasaki K, Fujiwara M, Tanemura K, Murayama M, Ishiguro

K, Planel E, Sato S, Hashikawa T, Takashima A.

Proc Natl Acad Sci USA 99, 13896-13901 (2002)

128) Dexamethasone prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult

in rats.

Ikeda T, Mishima K, Yoshikawa T, Iwasaki K, Fujiwara M, Xia YX, Ikenoue T.

Behav Brain Res. 136, 161-170 (2002)

129) Development of a novel experimental rat model for neonatal pre-ganglionic upper brachial plexus injury.

Ochiai H, Ikeda T, Mishima K, Yoshikawa T, Aoo N, Iwasaki K, Fujiwara M, Ikenoue T, Nakano S, Wakisaka S.

J Neurosci. Methods. 119, 51-57 (2002)

130) Synthesis of sphingomyelin analogues as a sphingomyelinase inhibitor and the application as a blocking

agent of extracellular stress signaling.

Tsuji Y, Soeda S, Ochiai T, Mishima K, Iwasaki K, Fujiwara M, Yokomatsu T, Murano T, Akiyama T, Shibuya S, Shimeno

H.

Nippon Yakurigaku Zasshi. 120, 67P-69P (2002)

131) ラットの筋力評価新システム

松本禎明、大庭優子、三島健一、江川孝，藏内浩二、北村佳久、岩崎克典、藤原道弘

九州女子大学紀要 38, 39-50 (2002)

132) 繰り返し脳虚血による空間記憶障害の発症機序：脳血管性痴呆症の動物モデルとしての応用

岩崎克典、三島健一、江頭伸昭、藤原道弘

脳機能の解明 239-246 (2002)

133) カンナビノイドの治療薬への応用

藤原道弘、三島健一、江頭伸昭

鎮痛・オピオイド研究最前線 89-101 (2002)

１５

2003年

134) Vitamin E isoforms α-tocotrienol and γ-tocopherol prevent cerebral infarction in mice.

Mishima K, Tanaka T, Pu F, Egashira N, Iwasaki K, Hidaka R, Matsunaga K, Takata J, Karube Y, Fujiwara M.

Neurosci Lett. 337, 56-60 (2003)

135) Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice.

Kaifu T, Nakahara J, Inui M, Mishima K, Momiyama T, Kaji M, Sugahara A, Koito H, Ujike-Asai A, Nakamura A,

Kanazawa K, Tan-Takeuchi K, Iwasaki K, Yokoyama WM, Kudo A, Fujiwara M, Asou H, Takai T.

J Clin Invest. 111, 323-332 (2003)

136) Post-ischemic administration but not pre-ischemic administration of NG-nitro-L-arginine prevents spatial

memory impairments and apoptosis by an inhibition of a delayed increase in NOx- in the hippocampus following repeated

cerebral ischemia.

Mishima K, Pu F, Kaneko T, Egashira N, Iwasaki K, Fujiwara M.


137) Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on

scopolamine-induced impairments of spatial memory in the 8-arm radial maze.

Mishima K, Tsukikawa H, Miura I, Inada K, Abe K, Matsumoto Y, Egashira N, Iwasaki K, Fujiwara M.


138) A synthetic ceramide analog ameliorates spatial cognition deficit and stimulates biosynthesis of brain

gangliosides in rats with cerebral ischemia.

Yamagishi K, Mishima K, Ohgami Y, Iwasaki K, Jimbo M, Masuda H, Igarashi Y, Inokuchi J, Fujiwara M.

Eur J Pharmacol. 462, 53-60 (2003)

139) How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the

hippocampus?

Okada M, Nakanishi H, Amamoto T, Urae R, Ando S, Yazawa K, Fujiwara M.

Brain Res. Mol. Brain Res. 111, 175-181 (2003)

140) Local administration of glial cell line-derived neurotrophic factor improves behavioral and histological

deficit of neonatal Erbs palsy in rats.

Ochiai H, Ikeda T, Mishima K, Aoo N, Iwasaki K, Fujiwara M, Nakano S, Ikenoue T, Wakisaka S.

Neurosurgery. 53, 973-978 (2003)

141) Magnetic resonance imaging shows delayed ischemic striatal neurodegeneration.

Fujioka M, Taoka T, Matsuo Y, Mishima K, Ogoshi K, Kondo Y, Tsuda M, Fujiwara M, Asano T, Sakaki T, Miyasaki A,

Park D, Siesjo BK.

Ann Neurol. 54, 732-747 (2003)

１６

142) Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal

apoptosis in rats.

Iwasaki K, Mishima K, Egashira N, Hatip Al-khatib I, Ishibashi D, Irie K, Kobayashi H, Egawa T, Fujiwara M.

J Pharmacol. Sci. 93, 188-196 (2003)

143) Theophylline製剤内服中に血清 K+低下がみられた一症例

江川孝、甲木敬二、松本文行、原田秀徳、池堂ゆかり、山内淳史、高比良誠也、江頭伸昭、片岡泰文、藤

原道弘

九州薬学会会報 57, 81-86 (2003)

2004 年

144) Anandamide inhibits the DOI-induced head-twitch response in mice.

Egashira N, Mishima K, Uchida T, Hasebe N, Nagai H, Mizuki A, Iwasaki K, Ishii H, Nishimura R, Shoyama Y, Fujiwara

M.

Psychopharmacology (Berl). 171, 382-389 (2004)

145) V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze.

Egashira N, Tanoue A, Higashihara F, Mishima K, Fukue Y, Takano Y, Tsujimot G, Iwasaki K, Fujiwara M.

Neurosci Lett. 356, 195-198 (2004)

146) Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated

ischemia in rats.

Iwasaki K, Chung E-H, Egashira N, Hatip Al-khatib I, Mishima K, Egawa T, Irie K, Fujiwara M.

Brain Res. 995, 131-139 (2004)

147) Protective effect of buckwheat polyphenols on long-lasting impairment of spatial memory associated with

hippocampal neuronal damage in rats subjected to repeated cerebral ischemia.

Pu F, Mishima K, Egashira N, Iwasaki K, Kaneko T, Uchida T, Irie K, Ishibashi D, Fujii H, Kosuna K, Fujiwara M

J Pharmacol. Sci. 94, 393-402 (2004)

148) Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal

hypoxia-ischemic insult in rats.

Mishima K, Ikeda T, Yoshikawa T, Aoo N, Egashira N, Xia YX, Ikenoue T, Iwasaki K, Fujiwara M.

Behav Brain Res. 151, 209-217 (2004)

149) Neuroprotective effect of γ-glutamylethylamide (theanine) on cerebral infarction in mice.

Egashira N, Hayakawa K, Mishima K, Kimura H, Iwasaki K, Fujiwara M.

Neurosci Lett. 363, 58-61 (2004)

150) Characteristics of behavioral abnormalities in alpha 1d-adrenoceptors deficient mice.

Mishima K, Tanoue A, Tsuda M, Hasebe N, Fukue Y, Egashira N, Takano Y, Kamiya H, Tsujimoto G, Iwasaki K, Fujiwara

M.

１７

Behav Brain Res. 152, 365-373 (2004)

151) Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level

and blood flow in the ventral hippocampus of freely moving rats.

Hatip-Al-Khatib I, Takashi A, Egashira N, Iwasaki K, Fujiwara M.

Brain Res. 1012, 169-176 (2004)

152) Protection by buckwheat polyphenols of cell death induced by glutamate and kainite in cultured hippocampal

neurons.

Pu F, Mishima K, Irie K, Egashira N, Iwasaki K, Ikeda T, Fujii H, Kosuna K, Fujiwara M.

J Trad Med. 21, 143-146 (2004)

153) Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and

improves spatial memory of rats with twice-repeated cerebral ischemia.

Hatip-Al-Khatib I, Iwasaki K, Chung E-H, Egashira N, Mishima K, Fujiwara M.

Life Sci. 75, 1967-1978 (2004)

154) The serotonin1A receptor agonist 8-OH DPAT reverses Δ9-tetrahydrocannabinol-induced impairment of

spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats.

Inui K, Egashira N, Mishima K, Yano A, Matsumoto Y, Hasebe N, Abe K, Hayakawa K, Ikeda T, Iwasaki K, Fujiwara M.

Neurotoxicity Res. 6, 153-158 (2004)

155) Determination of the effectiveness of components of herbal medicine Toki-Shakuyaku-San and fractions of

Angelica acutiloba in improving the Scopolamine-induced impairment of rat's spatial cognition in eight-armed radial

maze test.

Hatip-Al-Khatib I, Egashira N, Mishima K, Iwasaki K, Iwasaki K, Kurauchi K, Inui K, Ikeda T, Fujiwara M.

J Pharmacol. Sci. 96, 33-41 (2004)

156) Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism.

Hayakawa K, Mishima K, Abe K, Hasebe N, Takamatsu F, Yasuda H, Ikeda T, Inui K, Egashira N, Iwasaki K, Fujiwara

M.

Neuroreport. 15, 2381-2385 (2004)

157) Ovariectomy combined with amyloid β-1-42 impairs memory by decreasing acetylcholine release and

a7nAChR expression without induction of apoptosis in the hippocampus CA1 neurons of rats.

Iwasaki K, Hatip-Al-Khatib I, Egashira N, Akiyoshi Y, Arai T, Mishima K, Takagaki Y, Inui K, Fujiwara M

Neurotoxicity Res. 6, 299-310 (2004)

158) Combination treatment of neonatal rats with hypoxia-ischemia and endotoxin induces long-lasting memory

and learning impairment that is associated with extended cerebral damage.

Ikeda T, Mishima K, Aoo N, Egashira N, Iwasaki K, Fujiwara M, Ikenoue T.

Am J Obstet Gynecol. 191, 2132-2141 (2004)

１８

159) New perspectives in the studies on endocannabinoid and cannabis: abnormal behaviors associate with CB1

cannabinoid receptor and development of therapeutic application.

Fujiwara M, Egashira N.

J Pharmacol Sci. 96, 362-366 (2004)

160) Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress.

Soeda S, Tsuji Y, Ochiai T, Mishima K, Iwasaki K, Fujiwara M, Yokomatsu T, Murano T, Shibuya S, Shimeno H.

Neurochem Int. 45, 619-626 (2004)

161) 特集 2：生物学的精神医学研究の現状と展望（4）薬学部との共同による精神行動薬理学的研究-

福岡大学における取り組みを中心に

永井宏、松下満彦、江頭伸昭、尾籠晃司、藤原道弘、西村良二

脳と精神の医学 15, 461-466 (2004)

162) 脳虚血による記憶障害の発生機序と Ca拮抗薬

岩崎克典、藤原道弘

医報フジ特集脳血管障害と血圧管理 125, 23-27 (2004)

163) 脳血管性痴呆症の治療薬としての Ca拮抗薬の可能性について

岩崎克典、三島健一、江頭伸昭、藤原道弘

福岡大学薬学集報 4, 61-67 (2004)

164) 新しい遺伝子ノックダウン法: RNA interference

三島健一

福岡大学薬学集報 4, 69-72 (2004)

2005 年

165) Hypoxia-ischemic insult in neonatal rats induced slowly progressive brain damage related to memory

impairment.

Mishima K, Ikeda T, Aoo N, Takai N, Takahashi S, Egashira N, Ikenoue T, Iwasaki K, Fujiwara M.

Neurosci Lett. 376, 194-199 (2005)

166) Dexamethasone prevents long-lasting learning impairment following a combination of lipopolysaccharide

and hypoxia-ischemia in neonatal rats.

Ikeda T, Mishima K, Aoo N, Liu AX, Egashira N, Iwasaki K, Fujiwara M, Ikenoue T.

Am J Obstet. Gynecol. 192, 719-726 (2005)

167) Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting

learning impairment following neonatal hypoxic-ischemic brain insult in rats.

Katsuragi S, Ikeda T, Date I, Shingo T, Yasuhara T, Mishima K, Aoo N, Harada K, Egashira N, Iwasaki K, Fujiwara M,

Ikenoue T.

Am J Obstet Gynecol. 192, 1028-1037 (2005)

１９

168) Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent

mechanism.

Mishima K, Hayakawa K, Abe K, Ikeda T, Egashira N, Iwasaki K, Fujiwara M.

Stroke. 36, 1071-1076 (2005)

169) Post-ischemic treatment with Toki-shakuyaku-san (Tang-Gui-Shao-Yao-San) prevents the impairment of

spatial memory induced by repeated cerebral ischemia in rats.

Pu F, Mishima K, Egashira N, Akiyoshi Y, Liu A-X, Sano K, Irie K, Ishibashi D, Hatip-Al-Khatib I, Iwasaki K, Kurauchi

K, Iwasaki K, Fujiwara M.

Am J Chinese Med. 33, 475-490 (2005)

170) Protective effect of Toki-shakuyaku-san on amyloid β25-35-induced neuronal damage in cultured rat cortical

neurons.

Egashira N, Iwasaki K, Akiyoshi Y, Takagaki Y, Hatip-Al-Khatib I, Mishima K, Kurauchi K, Ikeda T, Fujiwara M.

Phytother Res. 19, 450-453 (2005)

171) Effect of oral administration of zanapezil (TAK-147) 2 mg/kg for 21 days on acetylcholine and monoamines

levels in the ventral hippocampus of freely moving rats.

Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M.

Br J Pharmacol. 145, 1035-1044 (2005)

172) Disruption of the prepulse inhibition of the startle reflex in vasopressin V1b receptor knockout mice: reversal

by antipsychotic drugs.

Egashira N, Tanoue A, Higashihara F, Fuchigami H, Sano K, Mishima K, Fukue Y, Nagai H, Takano Y, Tsujimoto G,

Stemmelin J, Griebel G, Iwasaki K, Ikeda T, Nishimura R, Fujiwara M.

Neuropsychopharmacology. 30, 1996-2005 (2005)

173) Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term

administration for the treatment of neonatal hypoxic-ischemic encephalopathy.

Jasmin I. NOOR, Tomoaki IKEDA, Kenichi MISHIMA, Naoya AOO, Sumie OHTA, Nobuaki EGASHIRA, Katsunori

IWASAKI, Michihiro FUJIWARA, Tsuyomu IKENOUE

Stroke. 36, 2468-2474 (2005)

174) Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W

human tau transgenic mice.

Nobuaki EGASHIRA, Katsunori IWASAKI, Akihiko TAKASHIMA, Takuya WATANABE, Hideyuki KAWABE,

Tomomi MATSUDA, Kenichi MISHIMA, Shozo CHIDORI, Ryoji NISHIMURA, Michihiro FUJIWARA

Brain Res. 1059, 7-12 (2005)

175) Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice:

implications for obsessive-compulsive disorder.

２０

Michihiko MATSUSHITA, Nobuaki EGASHIRA, Satoko HARADA, Ryoko OKUNO, Kenichi MISHIMA, Katsunori

IWASAKI, Ryoji NISHIMURA, Michihiro FUJIWARA

J. Pharmacol. Sci. 99, 154-159 (2005)

176) 脳虚血と β-アミロイド投与による新しいアルツハイマー病モデル動物の作成とニルバジピンの有

効性

岩崎克典、江頭伸昭、秋吉祐樹、高垣祐紀、新井隆、三島健一、藤原道弘

Pharma Medica. 23, 143-155 (2005)

177) 軽度脳虚血による遅発性神経細胞死と進行性認知障害

藤岡政行、田岡俊昭、松尾嘉之、三島健一、御輿久美子、近藤洋一、津田聖一、吉川哲也、藤原道弘、浅野

孝雄、榊寿右、宮嵜章宏、Darren Park、Bo K. Siesjo

脳循環代謝 17, 53-60 (2005)

178) カンナビノイドの臨床応用

藤原道弘、江頭伸昭、三島健一

Anesthesia 21 Century. 7, 35-40 (2005)

179) 強迫性障害の動物モデルである Marble-burying行動の基礎的研究

松下満彦，江頭伸昭，原田聡子，奥野良子，永井宏，千鳥正三，三島健一，岩崎克典，藤原道弘，西村良

二

福岡大学医学紀要 32, 159-165( 2005)

2006 年

180) Rehabilitative training tasks improve spatial learning impairment in the water maze following

hypoxic-ischemic insult in neonatal rats.

Tomoaki Ikeda, Kenichi Mishima, Naoya Aoo, Kazuhiko Harada, An-Xin Liu, Nobuaki Egashira, Katsunori Iwasaki,

Michihiro Fujiwara, Tsuyomu Ikenoue

Pediatr Res. 59, 61-65 (2006)

181) Differential effects of buckwheat and kudingcha extract on neuronal damage in cultured hippocampal neurons

and spatial memory impairment induced by scopolamine in an eight-arm radial maze.

Fengling Pu, Kenichi Mishima, Keiichi Irie, Nobuaki Egashira, Daisuku Ishibashi, Yoshiaki Matsumoto, Tomoaki Ikeda,

Katsunori Iwasaki, Hajime Fujii, Kenichi Kosuna, Michihiro Fujiwara

J Health Science 51, 636-644 (2006)

182) Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory: Involvement of

5-HT1A receptors in the dorsal hippocampus in rats.

Nobuaki Egashira, Akiko Yano, Noriko Ishigami, Kenichi Mishima, Katsunori Iwasaki, Masayuki Fujioka, Michihiko

Matsushita, Ryoji Nishimura, Michihiro Fujiwara

Brain Res. 1069, 54-62 (2006)

２１

183) Antagonistic effects of methanolic extract of Polygala telephioides on morphine responses in mice.

Nobuaki Egashira, Jian-Chen Li, Ai Mizuki, Keita Yamauchi, Tomomi Matsuda, Megumi Osajima, Michihiko Matsushita,

Kenichi Mishima, Katsunori Iwasaki, Shuji Hara, Nobufumi Ono, Ryoji Nishimura, Toshihiro Nohara, Michihiro

Fujiwara

J Ethnopharmacol. 104, 193-198 (2006)

184) Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization.

Nobuaki Egashira, Yoshiaki Matsumoto, Kenichi Mishima, Katsunori Iwasaki, Masayuki Fujioka, Michihiko Matsushita,

Yukihiro Shoyama, Ryoji Nishimura, Michihiro Fujiwara


185) Cerebral ischemia combined with ß-amyloid impairs spatial memory in the eight-arm radial maze task in rats.

Katsunori Iwasaki, Nobuaki Egashira, Izzettin Hatip-Al-Khatib, Yuki Akiyoshi, Takashi Arai, Yuki Takagaki, Takuya

Watanabe, Kenichi Mishima, Michihiro Fujiwara

Brain Res. 1097, 216-223 (2006)

186) Antipsychotics improve ∆9-tetrahydrocannabinol-induced impairment of the prepulse inhibition of the startle

reflex in mice.

Hiroshi Nagai, Nobuaki Egashira, Kazunori Sano, Ami Ogata, Ai Mizuki, Kenichi Mishima, Katsunori Iwasaki, Yukihiro

Shoyama, Ryoji Nishimura, Michihiro Fujiwara


187) Elevated anxiety-like and depressive behavior in Desert hedgehog knockout male mice.

Fujio Umehara, Kenichi Mishima, Nobuaki Egashira, Ami Ogata, Katsunori Iwasaki, Michihiro Fujiwara

Behav Brain Res. 174, 167-173 (2006)

188) Cortical neuronal and glial pathology in TgtauP301L transgenic mice: neuronal degeneration, memory

disturbance, and phenotypic variation.

Tetsuro Murakami, Erwan Paitel, Takeshi Kawarabayashi, Masaki Ikeda, M. Azhar Chishti, Christopher Janus, Etsuro

Matsubara, Atsushi Sasaki, Toshitaka Kawarai, Amie L Phinney, Yasuo Harigaya, Patrick Horne, Nobuaki Egashira,

Kenichi Mishima, Amanda Hanna, Jing Yang, Katsunori Iwasaki, Mitsuo Takahashi, Michihiro Fujiwara, Koichi Ishiguro,

Catherine Bergeron, George A Carlson, Koji Abe, David Westaway, Peter St. George-Hyslop, Mikio Shoji

Am J Pathol. 169, 1365-1375 (2006)

189) Involvement of 5-hydroxytryptamine1A receptors in ∆9-tetrahydrocannabinol-induced catalepsy-like

immobilization in mice.

Nobuaki Egashira, Tomomi Matsuda, Emi Koushi, Kenichi Mishima, Katsunori Iwasaki, Yukihiro Shoyama, Michihiro

Fujiwara

Eur J Pharmacol. 550, 117-122 (2006)

190) Effects of mood stabilizers on the disruption of prepulse inhibition induced by apomorphine or dizocilpine in

mice.

２２

Umeda K, Suemaru K, Todo N, Egashira N, Mishima K, Iwasaki K, Fujiwara M, Araki H.

Eur J Pharmacol. 553, 157-162 (2006)

191) 強迫性障害の動物モデルである Marble-burying行動の基礎的研究

松下満彦、江頭伸昭、原田聡子、奥野良子、永井宏、千鳥正三、三島健一、岩崎克典、藤原道弘、西村良

二

福岡大学医学紀要 32, 159-165 (2006)

192) 若齢期における大麻成分慢性投与による情報処理障害の発現—若齢マウスを用いた Prepulse

inhibitionの検討—

永井宏、江頭伸昭、佐野和憲、緒方歩、水木愛、三島健一、岩崎克典、藤原道弘、西村良二

福岡大学医学紀要 33, 53-61 (2006)

193) 自然発症 2型糖尿病モデルラットに対するココナッツ酵素製剤の抗糖尿病作用

江頭伸昭，淵上裕子，高垣裕紀，西田翔，吉田都，藤岡稔大，三島健一，岩崎克典，中村陽介，持田肇，

藤原道弘

機能性食品と薬理栄養 3, 285-290 (2006)

194) 強迫性障害の動物モデル Marble-burying行動におけるセロトニン１A受容体の関与

松下満彦、江頭伸昭、原田聡子、奥野良子、永井宏、千鳥正三、内田直樹、三島健一、岩崎克典、藤原道

弘、西村良二

福岡大学医学紀要 33, 191-195 (2006)

195) 強制水泳試験における大麻成分 THCの不動時間延長作用に関する研究：カンナビノイド CB1受容

体の関与

千鳥正三、江頭伸昭、松田智美、合志英美、永井宏、松下満彦、内田直樹、三島健一、岩崎克典、藤原道

弘、西村良二

福岡大学医学紀要 33, 197-201 (2006)

196) バソプレシン受容体欠損マウスの精神疾患モデルとしての解析

江頭伸昭，田上昭人，辻本豪三，三島健一，高野行夫，岩崎克典，藤原道弘．

日本神経精神薬理学雑誌 26, 101-105 (2006)

197) バソプレッシン受容体欠損マウスの統合失調症モデルとしての可能性

江頭伸昭，三島健一，岩崎克典，西村良二，藤原道弘

脳と精神の医学 17, 163-168 (2006)

198) 若齢期における大麻成分慢性投与による情報処理障害の発現－若齢マウスを用いた Prepulse

inhibitionの検討－

永井宏，江頭伸昭，佐野和憲，緒方歩，水木愛，三島健一，岩崎克典，藤原道弘，西村良二

福岡大学医学紀要 33, 53-61 (2006)

2007 年

２３

199) Kamikihi-to, a Kampo medicine, Ameliorates impairment of spatial memory in rats

Egashira N, Manome N, Kurauchi K, Matsumoto Y, Iwasaki K, Mishima K, Shoyama Y, Fujiwara M.

Phytother Res. 21, 126-129 (2007)

200) Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo.

Ochiai T, Shimeno H, Mishima K, Iwasaki K, Fujiwara M, Tanaka H, Shoyama Y, Toda A, Eyanagi R, Soeda S.

Biochim Biophys Acta. 1770, 578-584 (2007)

201) High-cholesterol feeding aggravates cerebral infarction via decreasing the CB(1) receptor.

Hayakawa K, Mishima K, Nozako M, Hazekawa M, Aoyama Y, Ogata A, Harada K, Fujioka M, Abe K, Egashira N,


Neurosci Lett. 414, 183-187 (2007)

202) Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice.

Egashira N, Tanoue A, Matsuda T, Koushi E, Harada S, Takano Y, Tsujimoto G, Mishima K, Iwasaki K, Fujiwara M.

Behav Brain Res. 78, 123-127 (2007)

203) Comparison of Single- and Repeated-Ischemia-Induced Changes in Expression of Flip and Flop Splice

Variants of AMPA Receptor Subtypes GluR1 and GluR2 in the Rats Hippocampus CA1 Subregion.

Hatip-Al-Khatib I, Iwasaki K, Egashira N, Ishibashi D, Mishima K, Fujiwara M.

J Pharmacol Sci. 103, 83-91 (2007)

204) Delta(9)-tetrahydrocannabinol (Delta(9)-THC) prevents cerebral infarction via hypothalamic-independent

hypothermia.

Hayakawa K, Mishima K, Nozako M, Hazekawa M, Ogata A, Fujioka M, Harada K, Mishima S, Orito K, Egashira N,


Life Sci. 80, 1466-1471 (2007)

205) Repeated treatment with cannabidiol but not Delta(9)-tetrahydrocannabinol has a neuroprotective effect

without the development of tolerance.

Hayakawa K, Mishima K, Nozako M, Ogata A, Hazekawa M, Liu AX, Fujioka M, Abe K, Hasebe N, Egashira N, Iwasaki

K, Fujiwara M.


206) Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior:

Comparison with paroxetine.

Egashira N, Harada S, Okuno R, Matsushita M, Nishimura R, Mishima K, Iwasaki K, Orito K, Fujiwara M.

Eur J Pharmacol. 563, 149-154 (2007)

207) Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with

be-ta-anyloid in rats.

Iwasaki K., Egashira N., Takagaki Y., Yoshimitsu Y., Hatip-Al-Khatib I., Mishima K., Fujiwara M.

Biol Pharm Bull. 30, 698-701 (2007)

２４

208) Effect of Toki-shakuyaku-san on acetylcholine level and blood flow in dorsal hippocampus of intact and

twice-repeated ischemic rats.

Hatip-Al-Khatib I, Hatip FB, Yoshimitsu Y, Iwasaki K, Egashira N, Liu AX, Mishima K, Fujiwara M.

Phytother Res. 21, 291-294 (2007)

209) Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent

myeloperoxidase-inhibiting mechanism.

Hayakawa K, Mishima K, Nozako M, Hazekawa M, Irie K, Fujioka M, Orito K, Abe K, Hasebe N, Egashira N, Iwasaki K,

Fujiwara M.

J Neurochem. 102, 1488-1496 (2007)

210) Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo.

Ochiai T, Shimeno H, Mishima K, Iwasaki K, Fujiwara M, Tanaka H, Shoyama Y, Toda A, Eyanagi R, Soeda S.

Biochim Biophys Acta. 1770, 578-584 (2007)

211) Neuroprotective Effects of Quercetin and Rutin on Spatial Memory Impairment in an 8-Arm Radial Maze

Task and Neuronal Death Induced by Repeated Cerebral Ischemia in Rats.

Pu F, Mishima K, Irie K, Motohashi K, Tanaka Y, Orito K, Egawa T, Kitamura Y, Egashira N, Iwasaki K, Fujiwara M.

J Pharmacol Sci. 104, 329-334 (2007)

212) Involvement of GABAA receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice.

Egashira N, Hayakawa K, Osajima M, Mishima K, Iwasaki K, Oishi R, Fujiwara M.

J Pharmacol Sci. 105, 211-214 (2007)

213) Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1)

receptor-dependent mechanism.

Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Kitamura Y, Uchida N, Nishimura R, Egashira

N, Iwasaki K, Fujiwara M.

Brain Res. 1188, 157-164 (2007)

214) Delta9-Tetrahydrocannabinol-induced cognitive deficits are reversed by olanzapine but not haloperidol in

rats.

Egashira N, Ishigami N, Mishima K, Iwasaki K, Oishi R, Fujiwara M.

Prog Neuropsychopharmacol Biol Psychiatry. 32, 499-506 (2007)

215) 2,5-Dimethoxy-4-iodoamphetamine (DOI) inhibits Delta9-tetrahydrocannabinol-induced catalepsy-like

immobilization in mice.

Egashira N, Koushi E, Mishima K, Iwasaki K, Oishi R, Fujiwara M.

J Pharmacol Sci. 105, 361-366 (2007)

2008 年

216) Calcium-channel antagonists inhibit marble-burying behavior in mice.

２５

Egashira N, Okuno R, Abe M, Matsushita M, Mishima K, Iwasaki K, Oishi R, Nishimura R, Matsumoto Y, Fujiwara M.

J Pharmacol Sci. 108, 140-143 (2008)

217) Allogeneic injection of fetal membrane-derived mesenchymal stem cells induces therapeutic angiogenesis in

a rat model of hind limb ischemia.

Ishikane S, Ohnishi S, Yamahara K, Sada M, Harada K, Mishima K, Iwasaki K, Fujiwara M, Kitamura S, Nagaya N,

Ikeda T.

Stem Cells. 26, 2625-2633 (2008)

218) Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent

mechanisms.

Egashira N, Okuno R, Matsushita M, Abe M, Mishima K, Iwasaki K, Nishimura R, Oishi R, Fujiwara M.

Eur J Pharmacol. 592, 103-108 (2008)

219) Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility

group box1-inhibiting mechanism.

Hayakawa K, Mishima K, Irie K, Hazekawa M, Mishima S, Fujioka M, Orito K, Egashira N, Katsurabayashi S, Takasaki

K, Iwasaki K, Fujiwara M.


220) Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of

cannabinoid CB(1) receptor and serotonergic system.

Egashira N, Matsuda T, Koushi E, Higashihara F, Mishima K, Chidori S, Hasebe N, Iwasaki K, Nishimura R, Oishi R,

Fujiwara M.

Eur J Pharmacol. 589, 117-121 (2008)

221) Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression

of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex.

Egashira N, Iwasaki K, Ishibashi A, Hayakawa K, Okuno R, Abe M, Uchida N, Mishima K, Takasaki K, Nishimura R,

Oishi R, Fujiwara M.

Prog Neuropsychopharmacol Biol Psychiatry. 32, 1516-1520 (2008)

222) Pharmacokinetics of zonisamide and drug interaction with phenobarbital in dogs.

Orito K, Saito M, Fukunaga K, Matsuo E, Takikawa S, Muto M, Mishima K, Egashira N, Fujiwara M.

J Vet Pharmacol Ther. 31, 259-264 (2008)

223) Effects of glutamate-related drugs on marble-burying behavior in mice: implications for

obsessive-compulsive disorder.

Egashira N, Okuno R, Harada S, Matsushita M, Mishima K, Iwasaki K, Nishimura R, Oishi R, Fujiwara M.

Eur J Pharmacol. 586, 164-170 (2008)

224) Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and

cerebral ischemia is related to decreased acetylcholine release in rats.

２６

Watanabe T, Iwasaki K, Ishikane S, Naitou T, Yoshimitsu Y, Yamagata N, Ozdemir MB, Takasaki K, Egashira N,

Mishima K, Fujiwara M.

J Pharmacol Sci. 106, 84-91 (2008)

225) Schizandrin reverses memory impairment in rats.

Egashira N, Kurauchi K, Iwasaki K, Mishima K, Orito K, Oishi R, Fujiwara M.

Phytother Res. 22, 49-52 (2008)

226) Theanine prevents memory impairment induced by repeated cerebral ischemia in rats.

Egashira N, Ishigami N, Pu F, Mishima K, Iwasaki K, Orito K, Oishi R, Fujiwara M.

Phytother Res. 22, 65-68 (2008)

227) Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia

expressing a high-mobility group box1-inhibiting mechanism.

Hayakawa K, Mishima K, Nozako M, Hazekawa M, Mishima S, Fujioka M, Orito K, Egashira N, Iwasaki K, Fujiwara M.

Stroke. 39, 951-958 (2008)

2009 年

228) Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced

swim-stress.

Sano K, Koushi E, Irie K, Higuchi S, Tsuchihashi R, Kinjo J, Egashira N, Oishi R, Uchida N, Nagai H, Nishimura R,

Tanaka H, Morimoto S, Mishima K, Iwasaki K, Fujiwara M.

Biol Pharm Bull. 32, 2065-2067 (2009)

229) Role of vasopressin receptor in psychological and cognitive functions,Egashira N, Mishima K, Iwasaki K,

Nakanishi H, Oishi R, Fujiwara M.

Nippon Yakurigaku Zasshi. 134, 3-7 (2009)

230) Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the

organ of Corti.

Yoshikawa M, Go S, Takasaki K, Kakazu Y, Ohashi M, Nagafuku M, Kabayama K, Sekimoto J, Suzuki S, Takaiwa K,

Kimitsuki T, Matsumoto N, Komune S, Kamei D, Saito M, Fujiwara M, Iwasaki K, Inokuchi J.

Proc Natl Acad Sci U S A. 106, 9483-9488 (2009)

231) Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a

peroxisome proliferator-activated receptor gamma-dependent mechanism.

Haraguchi T, Takasaki K, Naito T, Hayakawa K, Katsurabayashi S, Mishima K, Iwasaki K, Fujiwara M.

Neurosci Lett. 464, 151-155 (2009)

232) Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group

box1-inhibiting mechanism.

２７

Hayakawa K, Irie K, Sano K, Watanabe T, Higuchi S, Enoki M, Nakano T, Harada K, Ishikane S, Ikeda T, Fujioka M,

Orito K, Iwasaki K, Mishima K,Fujiwara M.

Biol Pharm Bull. 32, 1538-1544 (2009)

233) Neuroprotective effects of Kangen-karyu on spatial memory impairment in an 8-arm radial maze and

neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia in rats.

Pu F, Motohashi K, Kaneko T, Tanaka Y, Manome N, Irie K, Takata J,Egashira N, Oishi R, Okamoto T, Sei Y, Yokozawa

T, Mishima K, Iwasaki K, Fujiwara M.

J Pharmacol Sci. 109, 424-430 (2009)

234) Yokukansan inhibits social isolation-induced aggression and methamphetamine-induced hyperlocomotion in

rodents.

Uchida N, Egashira N, Iwasaki K, Ishibashi A, Tashiro R, Nogami A, Manome N, Abe M, Takasaki K, Mishima K,

Takata J, Oishi R, Nishimura R, Fujiwara M.

Biol Pharm Bull. 32, 372-375 (2009)

235) New topics in vasopressin receptors and approach to novel drugs: role of the vasopressin receptor in

psychological and cognitive functions.

Egashira N, Mishima K, Iwasaki K, Oishi R, Fujiwara M.

J Pharmacol Sci. 109, 44-49 (2009)

236) Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage

of life and exacerbation with aging.

Tajima O, Egashira N, Ohmi Y, Fukue Y, Mishima K, Iwasaki K, Fujiwara M, Inokuchi J, Sugiura Y, Furukawa K,

Furukawa K.

Behav Brain Res. 198, 74-82 (2009)

237) Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model

of Alzheimer's disease.

Watanabe T, Yamagata N, Takasaki K, Sano K, Hayakawa K, Katsurabayashi S, Egashira N, Mishima K, Iwasaki K,

Fujiwara M.

Brain Res. 1249, 222-228 (2009)

238) Characteristic behavioral anomalies in rats prenatally exposed to 5-bromo-2'-deoxyuridine.

Orito K, Morishima A, Ogawa T, Muneoka K, Kuwagata M, Takata J, Mishima K, Fujiwara M.

Int J Dev Neurosci. 27, 81-86 (2009)

239) 抑肝散のセロトニン 2A受容体を介した作用

野上愛、高崎浩太郎、岩崎克典、藤原道弘

脳 21, 12, 30-34 (2009)

1985shutarok/img/file16.pdfantidepressants and methamphetamine in rats. al-khatib imh, fujiwara m,...

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