Scott P. Herrick, PhD22 Robinson Street, #11 | Cambridge, MA 02138

spherrick@mgh.harvard.edu | 301-606-9294Education

Brown University, Providence, RI 2015PhD in NeuroscienceGeorgetown University, Washington, DC 2007MS in PharmacologyBowdoin College, Brunswick, ME 2004AB in Neuroscience and Chemistry (minor)Research ExperienceMassachusetts General Hospital (MGH) and Harvard Medical School, Boston, MA

2015-PresentDepartment of Neurology, MGH Institute for Neurodegenerative Diseases (MIND)Research Fellow with Dr. Mark Albers Leading an investigation into the association between Alzheimer’s disease and traumatic brain

injury, using the mouse olfactory system as a model of acute axonal injury. Also leading an investigation sponsored by Merck on the ability of a proprietary

pharmaceutical compound to ameliorate a neuronal loss following an acute axonal injury. Collaborated with two distinct labs on Down syndrome and ataxia-related projects. Tested the ability of two compounds directly label targets, one via PET and one fluorescent. Developed a FACS assay to screen damaged neurons following pharmacological treatment.Brown University, Providence, RI 2008-2015Doctoral research with Dr. Gilad Barnea I conducted research into receptors of the main olfactory and vomeronasal sensory systems.

After making specific antibodies I utilized immunoprecipitation assays and mass spectrometry based proteomic analysis to study the interactions between two families of class II vomeronasal sensory receptors.

Additionally, I analyzed several lines of transgenic mice, where the olfactory sensory neurons were forced to express two olfactory receptors in the same neuron, breaking with the archetypal mono-allelic expression of olfactory receptors. I found that neurons expressing two receptors have unique projection patterns in the olfactory bulb, indicating that the receptors play a direct role in axon guidance and glomerular formation.

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Georgetown University, Washington, DC2006-2007

Graduate Student/Research Assistant with Dr. Dan Pak Upon completion of the M.S. degree, I was invited to continue my thesis topic, studying the

role of enigma homologue in dendritic spine maturation. This research resulted in a first author publication.Rockefeller University, Laboratory of Neuroendocrinology, New York, NY

2004-2006Weill Medical College of Cornell University, Department of Neurology and Neuroscience, NY, NYResearch Assistant (Joint Research Appointment) Served as a research assistant to Dr. Bruce McEwen (Rockefeller) and Dr. Teri Milner (Cornell). Utilized neuroendocrinology, immunohistochemistry and transmission electron microscopy.Selected Service and LeadershipGraduate Council Representative at Brown University, Providence, RI

2011-2013Life Science RepresentativeSelected to serve as one of four graduate students on the governing body of graduate school, where I helped to write policies, approve courses, and review departments, alongside the graduate school deans, senior faculty, and administrators.Consultant, Advancing Rhode Island Science Education, Providence, RI

2009-2011Assisted Science teachers to introduce modern molecular biology techniques into the classroom.Teaching Assistant at Brown University, Providence, RI

2009-2011Selected as a co-instructor for the Experimental Physiology class taught by Dr. John Stein.

Preparedneurophysiological experiments, facilitated instruction, graded manuscripts, and delivered

lectures.

Research Skills Animal Research:

I have over ten years of experience working with mice and rats in a laboratory setting. Have genotyped and maintained a colony of 30 lines of mice. Experience with survival surgery, perfusion techniques for immunohistochemistry, and collection of tissue samples for biochemical analysis.

Molecular Biology:

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I am proficient with molecular biology techniques including: cloning, PCR, transfection, transformation, and construct design. In addition I use fluorescence-associated cell sorting (FACS) and flow cytometry to analyze neurons from transgenic animals.

Pharmacology:In addition to a master’s degree in pharmacology, I am currently leading an investigation of a proprietary pharmaceutical compound and analyzing its efficacy in different tissues.

Confocal and Electron Microscopy:I have experience with both confocal and transmission electron microscopy including: tissue preparation, immunohistochemistry, and imaging.Biochemistry:I have experience with membrane biochemistry including: western blots, immunoprecipitation assays, sample fractionation, ultracentrifugation, and mass spectrometry proteomic analysis.

Immunohistochemistry:I have experience using immunohistochemistry techniques including: sample preparation, immuno-fluorescence and immuno-gold labeling, imaging, analysis, antibody production, and antibody conjugation.

Cell Culture:I am experienced with maintaining and experimenting with heterologous cells, specifically HEK and COS cells used for transfection based experiments as well as stable cell lines.

PublicationsCao, L., Herrick, S.P., Lu, L., Cosantino, I., Reitz, S., Nee, A., Folkerths, R., Edlow, B., Albers, M.W.

(In Preparation) Role of BACE1 and its substrate APLP2 in neuronal loss after traumatic axonal injury in mice and humans.

William, C.M., Saqran, L., Stern, M.A., Chiang, C.L., Herrick, S., Rangwala, A., Albers, M.W., Frosch, M.P. Hyman, B.T. (In Preparation) Activity-dependent dysfunction in visual and olfactory sensory systems in mouse models of Down syndrome.

Van de Bittner, G., Riley, M., Cao, L., Ehses, J., Herrick, S., Ricq, E., Wey, H., O’Neill, M., Ahmed, Z., Murray, T., Smith, J., Wang, C., Schroeder, F., Albers, M., Hooker, J. (Accepted) Nasal neuron PET imaging: Quantification of neuron generation and degeneration. Journal of Clinical Investigation.

Herrick, S., Evers, D.M., Lee, J.Y., Udagawa, N., Pak, D.T. (2010) Postsynaptic PDLIM5/Enigma Homolog binds SPAR and causes dendritic spine shrinkage. Mol. Cell. Neurosci. 43(2):188-200.

Milner, T.A., Hernandez, F.J., Herrick, S.P., Pierce, J.P., Iadecola, C., Drake, C.T. (2007) Cellular and subcellular localization of androgen receptor immunoreactivity relative to C1 adrenergic neurons in the rostral ventrolateral medulla of male and female rats. Synapse, 61(5): 268-278.

Herrick, S.P., Waters, E.M., Drake, C.T., McEwen, B.S., Milner, T.A. (2006) Extranuclear estrogen receptor beta immunoreactivity is on doublcortin-containing cells in the adult and neonatal rat dentate gyrus. Brain Research, 1121(1): 46-58.

Wang, G., Drake, C.T., Rozenblit, M., Zhou, P., Alves, S.E., Herrick, S.P., Hayashi, S., Warrier, S., Iadecola, C., Milner, T.A. (2006) Evidence that estrogen directly and indirectly modulates C1 adrenergic bulbospinal neurons in the rostral ventrolateral medulla. Brain Reserch, 1094(1): 163-178.

Milner, T.A., Ayoola, K., Drake, C.T., Herrick, S.P., Tabori, N.E., McEwen, B.S., Warrier, S., Alves, S.E. (2005) Ultrastructural localization of estrogen receptor β immunoreactivity in the rat hippocampal formation. Journal of Comparative Neurology, 491(2): 81-95.

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