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MARSEILLE, FRANCEFaculté de Médecine de la TIMONEAmphithéâtre TOGA

February 26 to 29 www.ecmrn2020.com

2020

ORGANISATION GÉNÉRALE : MCO CongrèsVilla Gaby - 285 Corniche JF. Kennedy - 13007 MARSEILLEPhone: + 33 (0)4 95 09 38 00

15th MEETING

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Dear Colleagues

Welcome to Marseille for the 2020 meeting of the European Congress of Magnetic Resonance in Neuropediatrics (ECMRN) formely known as European Society of Magnetic Resonance in Neuropediatrics. (ESMRN). As in previous meetings, the day before the main event will be a precongress day dedicated to fetal, neonatal and infant brain. This educational day adresses basic and advanced topics in this peculiar field.The congress is intended to provide review and discussion of diseases involving the pediatric brain as well as new trends and clinical applications. The congress is designed for practicing radiologists whose work includes pediatric neuroradiology and those involved in neurosciences, neurology and/or related fields.

The congress venue is at the Medical School (Faculté de Médecine), 5 stops by subway from downtown Vieux Port.

Pr Nadine GirardCongress President

Congress Organization Office

Villa Gaby - 285 Corniche Kennedy - 13007 MarseilleTel: 0033 4 95 09 38 00

Sponsors & exhibition - Céline Burel celine.burel@mcocongres.comRegistrations - Audrey Martin Bayon audrey.martin@mcocongres.com

EDITO

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Scientific board

Organizing Commitee

Faculty

James BARKOVICHNuno CANTO MOREIRASerena COUNSELLNadine GIRARDGregor KASPRIANIngeborg KRÄGELOH-MANN

Milan RADOSCharles RAYBAUDAndrea ROSSIDonald TOURNIERMarjo VAN DER KNAAPJeroen VERMEULEN

Guillaume AUZIASBrigitte CHABROLChristine DERUELLE Nadine GIRARD

Julien LEFEVREMathieu MILHAngèle VIOLA

Guillaume AUZIAS Jim BARKOVICHManon BENDERS Odile BOESPFLUG Joseph BOUCRAUT Gregoire BOULOUIS Gianluca BRUGNARA Nuno CANTO MOREIRA Martin CATALA Massimo CAULO Isabella CECCHERINI Mathilde CHEVIGNARD Thomas CHRISTENDaan CHRISTIAENSSerena COUNSELL

Sylvain CUSSAT-BLANC Linda DE VRIES Jessica DUBOIS Dominique FIGARELLA-BRANGER David GERMANAUD Renzo GUERRINI Robert HEVNERJill HUNTER Andras JAKAB Victor JIRSA Gregor KASPRIAN Shannon KOLIND Ingeborg KRÄGELOH-MANN Roland KREIS

Julien LEFEVREGiovani MORANA Zoltan PATAY Milan RADOSAndrea RIGHINI Stefan ROOSENDAAL François ROUSSEAU Mariasavina SEVERINO Maja STEINLIN Pia SUNDGREN Domenico TORTORA Fabio TRIULZI Marjo VAN DER KNAAP Angèle VIOLA Nicole WOLF

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07:50 - 08:00 WELCOME MESSAGE

08:00 - 12:30 THE FETAL BRAIN

• Clinical imaging. A. Righini (Milan, Italy) • DTI : clinical imaging. G. Kasprian (Vienna, Austria) • MRS at 3T. N. Girard (Marseille, France), A. Viola (Marseille, France) • Postmortem. F. Triulzi (Milan, Italy) • Discussion.

10:15 - 10:45 COFFEE BREAK

3D IMAGING • Preprocessing. F. Rousseau (Brest, France) • Sulcation. G. Auzias (Marseille, France), J. Lefevre (Marseille, France) • Human fetal connectome: micro- to macro-scale imaging. A. Jakab (Zurich, Switzerland) • Discussion.

12:30 - 13:30 LUNCH

13:30 - 19:00 THE NEONATAL AND INFANT BRAIN

• The premature: clinical imaging and vulnerability. M. Benders (Utrecht, The Netherlands) • The term infant: clinical imaging and vulnerability. L. De Vries, M. Lequin (Utrecht, The Netherlands) • Congenital heart defect and brain development. M. Benders (Utrecht, The Netherlands) • Perfusion: techniques and clinical applications. D. Tortora (Genova, Italy) • Discussion.

15:30 - 16:00 COFFEE BREAK

3D IMAGING • Methodology of 1H MR spectroscopy: recent consensus efforts and beyond. R. Kreis (Bern, Switzerland) • Folding and maturation. J. Dubois (Paris, France) • Volumetrics. S. Counsell (London, UK) • Imaging structural connectivity in the developing brain. D.Christiaens(London,UK) • FMRI: what can we learn from resting state. M.Caulo(Chieti,Italy) • Discussion.

19:00 - 20:00 WELCOME COCKTAIL

Registration opening & posters installation

Wednesday 26th February • PRE-CONGRESS

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08:00 - 08:30 INTRODUCTION

Pr Nadine Girard Pr Georges Leonetti (Dean Medical School)

08:30 - 10:25 EARLY ABNORMAL NEURODEVELOPMENT

Organizer: C. Deruelle (Marseille, France) Moderators: N. Girard (Marseille, France), J. Vermeulen (Maastricht, The Netherlands) • Autism: where are we? R. Toro (Paris, France) • Fetal alcohol spectrum disorders: what can we learn from MRI morphometrics? D. Germanaud (Paris, France) • What is new in cortex embryology? M. Catala (Paris, France) • New concept of hydrocephalus development. M.Rados(Zagreb,Croatia) • Discussion.

10:25 - 10:50 COFFEE BREAK

10:50 - 12:30 FREE PAPERS - Early abnormal neurodevelopment

Moderators: G. Auzias (Marseille, France), G. Kasprian (Vienna, Austria) 1. Quantitative evaluation of the prenatal brainstem by fetal MRI. G. Dovjak (Vienna, Austria) 2. Signal Change in the Mammillary Bodies in neonates and infants. M. Lequin (Utrecht, The Netherlands) 3. Automatic pathological fetal brain segmentation in high resolution images. K.Payette(Zurich,Switzerland) 4. Are subject-specific connectomics the key for understanding clinical outcomes in children with cerebral palsy? J. Blommaert (Leuven, Belgium) 5. Application of morphological magnetic resonance imaging score to four corpus callosum agenesis sub-groups (complete, partial, associated and isolated): correlation with patient outcome. M. Cardoso Diogo (Vienna, Austria) 6. The effect of prenatal chemotherapy exposure on functional neurodevelopment: a prospective case-control functional MRI study. J. Blommaert (Leuven, Belgium) 7. Prognostic value of brain abnormalities for cognitive outcome in cerebral palsy: a prospective cohort study. I.Moll (Maastricht, The Netherlands) 8. Prediction of neurodevelopmental outcome in preterm neonates with cerebral MR spectroscopy and DTI using feed-forward neural networks. T. Janjic (Innsbruck, Austria) 9. A novel fetal magnetic resonance imaging scoring system for isolated corpus callosum agenesis: correlation with neurodevelopmental outcome. S.Glatter(Vienna,Austria) 10. Mapping the developing sensorimotor network in newborns with diffusion MRI. J.Dubois(Gif-sur-Yvette,France)

12:30 - 13:30 LUNCH

Thursday 27th February • CONGRESS

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13:30 - 15:25 NEUROINFLAMMATION / NEURODEGENERATIVE

Moderators: B. Chabrol (Marseille, France), M. Van Der Knaap (Amsterdam, The Netherlands) • Autoimmune encephalitis. M.Caulo(Chieti,Italy) • Neurodegeneration with brain iron accumulation (NBIA). I. Krägeloh-Mann (Tübingen, Germany) • Genetics disorders mimicking white matter inflammatory diseases. O.BoespflugTanguy(Paris,France) • Biomarkers: what do we have to know? J. Boucraut (Marseille, France) • Discussion.

15:25 - 15:55 FREE PAPERS - Neuroinflammation / neurodegenerative

Moderators: B. Chabrol (Marseille, France), M. Van Der Knaap (Amsterdam, The Netherlands) 11. MOG-Ab-associated demyelination in children - UK tertiary paediatric centre experience. R. Sinha (Manchester, UK) 12. The role of brain magnetic resonance imaging in the diagnosis of neuronal ceroid-lipofuscinose type 2. A. Ntorkou (Paris, France) 13. Fetal MRI in Interferonopathies. D. Prayer (Vienna, Austria)

15:55 - 16:20 COFFEE BREAK

16:20 - 18:45 EPILEPSY / MALFORMATION

Organizer: J. Barkovich (San Francisco, USA), R. Guerrini (Florence, Italy) Moderators: C. Raybaud (Toronto, Canada), R. Guerrini (Florence, Italy) • MTORopathies: an enlarging spectrum of brain and systemic disorders. R. Guerrini (Florence, Italy) • Progressive or nonprogressive. M. Severino (Genova, Italy) • Neuropathology in paediatric epilepsy. R. Hevner (San Diego, USA) • Malformation of cortical development: a 2020 update. M. Severino (Genova, Italy) • Discussion.

18:45 - 19:05 FREE PAPERS - Epilepsy / Malformation

Moderators: C. Raybaud (Toronto, Canada), R. Guerrini (Florence, Italy) 14. MRI guided laser ablation for hypothalamic hamartoma in children: initial experience, safety and short follow-up in 5 patients. J. Muchart (Esplugues De Llobregat, Spain) 15. Detecting childhood epileptogenic tissue as outliers of typical brain development. J. O’Muircheartaigh (Denmark Hill, UK)

19:05 - 19:35 POSTER TOUR - Posters 1 to 7

Moderators: S. Counsell (London, UK), N. Canto Moreira (Stockholm, Sweden)

Thursday 27th February • CONGRESS

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08:00 - 09:45 WHITE MATTER: METABOLIC

Organizer: M. Van Der Knaap (Amsterdam, The Netherlands) Moderators: M. Van Der Knaap (Amsterdam, The Netherlands), I. Krägeloh-Mann (Tübingen, Germany) • MR methods to monitor therapy in leukodystrophies. S. Kolind (Vancouver, Canada) • Insights gained from MRI: the tRNA synthetase defects. M. Van Der Knaap (Amsterdam, The Netherlands) • MRI pattern recognition in mitochondrial leukodystrophies. S. Roosendaal (Amsterdam, The Netherlands) • Hypomyelination and the growing list of genes. N. Wolf (Amsterdam, The Netherlands) • Discussion.

09:45 - 10:35 FREE PAPERS - Write matter: metabolic

Moderators: M. Van Der Knaap (Amsterdam, The Netherlands), I. Krägeloh-Mann (Tübingen, Germany) 16. A magnetic resonance imaging and pathology study of hemato poietic stem cell transplantation effects in metachromatic leukodys trophy patients: donor macrophages support oligodendrocytes, thereby enabling remyelination. S. Beerepoot (Amsterdam, The Netherlands) 17. Mucolipidosis IV: new insights from fetal brain imaging and pathology. A. Zerem Sheinman (Tel Aviv, Israel) 18. Analyzing radiological progression in 252 cases of Vanishing White Matter. M.Stellingwerff(Amsterdam,TheNetherlands) 19. Longitudinal analysis of brain atrophy in metachromatic leukodystrophy. M. Al-Saady (Amsterdam, The Netherlands) 20. The Neuroimaging Spectrum of Patients Confirmed to have Organic Acidurias in the Kingdom of Bahrain: An Eighteen Years’ Experience. H. Alhashimi (Manama, Bahrain)

10:35 - 10:55 COFFEE BREAK

10:55 - 12:40 VASCULAR DISEASES

Moderators: N. Canto Moreira (Stockholm, Sweden), N. Girard (Marseille, France) • Clinics: pathomechanism of arterial ischemic stroke. M. Steinlin (Bern, Switzerland) • Genetic insights into vascular diseases. I. Ceccherini (Genova, Italy) • Imaging of pediatric vascular diseases. G. Boulouis (Paris, France) • Discussion.

12:40 - 13:30 LUNCH

Friday 28th February • CONGRESS

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13:30 - 13:50 FREE PAPERS - Vascular diseases

Moderators: N. Canto Moreira (Stockholm, Sweden), N. Girard (Marseille, France) 21. Value of high-resolution vessel wall MRI in pediatric CNS vasculitis. A. Kashgari (Riyadh, Saudi Arabia) 22. Phase contrast MRI suggests an internal carotid vascular tone alteration in migraines. J. Deverdun (Montpellier, France)

13:55 - 15:40 TUMORS

Organizer: Z. Patay (Memphis, USA) Moderators: Z.Patay(Memphis,USA),M.Rados(Zagreb,Croatia) • “2020 update” of the 2016 update of the WHO Classification of Tumours of the CNS. D. Figarella-Branger (Marseille, France) • Radiomics & Deep-Learning for Brain Tumor Imaging and Biomarker Discovery. G. Brugnara (Heidelberg, Germany) • Pediatric postoperative cerebellar mutism syndrome. Z. Patay (Memphis, USA) • Discussion.

15:40 - 15:50 FREE PAPERS

Moderators: Z.Patay(Memphis,USA),M.Rados(Zagreb,Croatia) 23. Postoperative paediatric cerebellar mutism syndrome- Identifying quantitative biomarkers on longitudinal follow-up MRI. S. Avula (Liverpool, UK)

15:50 - 16:20 COFFEE BREAK

16:20 - 18:15 TRAUMA: MILD TBI IN CHILDREN

Moderators: A. Viola (Marseille, France), N. Girard (Marseille, France) • When is a mild TBI imaged? N. Canto Moreira (Stockholm, Sweden) • Clinical presentation and Follow up. M. Chevignard (St Maurice, France) • What can we learn from DTI, MRS, fMRI? J. Hunter (Houston, USA) • Discussion.

18:15 - 19:45 POSTER TOUR - Posters 8 to 17

Moderators:M.Rados(Zagreb,Croatia),I.Krägeloh-Mann(Tübingen,Germany)

20:30 GALA DINER

Friday 28th February • CONGRESS

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08:00 - 10:25 TRANSLATIONAL RESEARCH

Organizer: A. Viola (Marseille, France) Moderators: A. Viola (Marseille, France), N. Girard (Marseille, France) • History of Artificial intelligence. S. Cussat-Blanc (Toulouse, France) • Finger printing. T. Christen (Grenoble, France) • Building personalized virtual brains with TVB: The impact of spatio-temporal structure. S. Petkoski (Marseille, France) • Clinical applications of multimodal PET/MR imaging. G. Morana (Genova, Italy) • Amide proton transfer imaging (APTw). P. Sundgren (Lund, Sweden) • Discussion.

10:25 - 11:00 COFFEE BREAK

11:00 - 12:00 FREE PAPERS - Translational research and miscellaneous

Moderators: A. Viola (Marseille, France), N. Girard (Marseille, France) 24. Normative Values of Brain MRS Metabolites in Early Childhood. F. Goncalves (Philadelphia, USA) 25. SyMRI for the assessment of the neonatal Brain. V. Schmidbauer (Vienna, Austria) 26. Normative brain volume growth: pooling data across magnetic resonance field strengths. B. Maréchal (Lausanne, Switzerland) 27. Retro-geniculate injuries in children with spastic cerebral palsy are revealed by the retinal ganglion cell topography. F. Lennartsson (Lund, Sweden) 28. Grade IV germinal matrix hemorrhages in late preterm or term neonates: the prenatal hypothesis. A. Barbosa (Sao Paulo, Brazil) 29. Cannabis exposure effects among children and teenagers aged 7 to 18 years brain cognitive development study. H. Ait Belcaid (Marrakech, Morocco)

12:30 FAREWELL

Saturday 29th February • CONGRESS

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Posters1. Necrotic-hemorrhagic demyelinating myelitis mimicking spinal cord tumour in a child.F. Mohd Zaki (Kuala Lumpur, Malaysia)

2. Volumetric, anatomical and relaxometry evaluation with a single MR sequence for brain maturation assessment. B. Morel (Tours, France)

3. Griscelli Syndrome Type 2: A rare genetic disease in a partially blonde toddler with recurrent febrile illness and seizures. The clinical, neuroradiological and histopathological tools that can aid the diagnosis. H. Alhashimi (Manama, Bahrain)

4. Fetal brain biometrics: comparison of 2D T2-weighted and 3D volumetric super-resolution magnetic resonance imaging. P. de Dumast (Lausanne, Switzerland)

5. Translating fetal brain magnetic resonance image super-resolution reconstruction into the clini-cal environment. P. de Dumast (Lausanne, Switzerland)

6. Longitudinal changes of N-acetyl-aspartyl-glutamate (NAAG) in the white matter observed on MR spectroscopy J-I. Takanashi (Yachiyo, Japan)

7. Mitochondrial CNS Disorders in Children: A Pictorial Review of MR Imaging Features. F. Goncalves (Philadelphia, USA)

8. Automated fetal brain segmentation of 2D magnetic resonance image series: transfer learning and 3D topology correction. H. Kebiri (Lausanne, Switzerland)

9. Thalamo-Cortical Functional Connectivity Development in the Fetus. M. Canini (Segrate, Italy)

10. Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) asso-ciated with acute focal bacterial nephritis (AFBN). H. Tada (Chiba, Japan)

11. Evaluation of retrospective motion corrected high resolution volumetric brain MRI in a pedia-tric setting. K. Vecchiato (London, UK)

12. Failure to demonstrate the septal leaflets in the fetus: algorithmic approach to diagnosis. S. Goergen (Melbourne, Australia)

13. Cortical volume in posterior fossa tumor survivors. C. Sleurs (Leuven, Belgium)

14. Application of the Optimized Censoring Toolbox to increase data quality in clinically-indi-cated functional MRI in children. Z. Mercan (Tübingen, Germany)

15. Successful treatment with cyclophosphamide in a child with fulminant acute disseminated encephalomyelitis. F. Valevski Aviva (Tel Aviv, Israel)

16. MRI findings and epilepsy in LAMA2-related muscular dystrophy: an electro-clinico-radiological characterization. J. Muchart (Barcelona, Spain)

17. Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) : local expe-rience in pediatric population. X. Carle (Marseille, France)

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Sponsors 2020PLATINUM SPONSOR

SILVER SPONSORS

SPONSORS

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