$462 Thursday, November 10, 2005 Poster Abstracts

Subjects and Methods: Total number of patients was 100. Mean age of patients were 55.3 ± 12.4 yr, duration of D M was 11.5 yrs (.9-40 yrs). Mean height was 1.58 ± .09 meter. Male patient was 63 and female was 37. NCV of limbs, fasting (FBS), 2hr. After breakfast blood sugar (2HABF) was done. Results: FBS and 2HABF was 10.2 ± 4.9, 13.7 ± 5.1 mmrol/1. Comparing with own lab s tandard all patients had neuropathic changes. Both lower limb motor and sensory nerves showed negative correlation with height. R t Peroneal nerve conduction velodty (NC.V) - .338/.002, Lt Peroneal NC V -.365/.001, Rt Tibial NCV-.251/.025, Lt Tibial NCV -.379/.001, Rt Sural NOV-.277/.012, Lt Sural NOV - .328/.003. Both Sural ncv showed negative correlation with FBS and 2HABF. Rt Sural NCV-.245/.033, Lt Sural NC V -.365/.001; Rt Sural NCV-.246/.030, Lt Sural NC V -.246/.030 for FBS and 2HABF respectively. 27% and 24% of neuropatlffc patients has absence of any conduction paranreters for right and left Peroneal nerve respectively. 67% and 66% of neuropathic patients has absent conduction parameters for right and left Sural nerve respectively. Conclusion: Result of this study suggests that taller patients have more motor and sensory conduction abnormalities. Electrophysiologicaly sensory functions were found to be more affected than motor parameters and hyperglycaenffa seems to affect sensory conduction parameters.

1424 Clinical and Electroptlysiologieal studies in Diabetic polyneuropathy

Ispekova, B ~, Alexandrov, A ~, Muradyan, N ~. 1 University Hospital "Tzaritza Joanna", Sofia, Bulgaria; ~Institute o/Biophysics, Bulgarian Academy of Sciences, Bulgaria

Background: The clinical signs and symptoms of diabetic polyneuro- pathy (DPN) range and vary fl'om syimnetrical to asyimnetrical, from mononeuriris to mononeuropa thy multiplex and polyneuritis, and from almost purely sensory to almost purely motor fiber involvement. Methods: Motor conduction studies of median, ulnar, peroneal, and tibial nerves were performed using s tandard techniques with surface electrode stimulation. 167 patients with D P N were evaluated with electrophysiological studies. There were 90 female and 77 male investigated patients, ages 20-80 years, durat ion of diabetes - between 1 and 38 years. Results: The patients were divided into three groups based on the motor and sensory conduction velocity and sympathetic skin response (SSR): patients with sensory motor neuropathy (59.8%), patients with purely sensory (18%) and patients with sensory and autonomic neuropathy (121.6%). Ten patients had type I diabetes; 133 had type II diabetes. The juvenile patients, those with the longest duration of the disease had the highest incidence of abnormalities. Conduct ion abnormalities were developed diffusely, but more often in distal segments than in proximal segments. Abnormalit ies were found predominantly at the common sites o f compression, across tire carpal tunnel for the median nerves (128%). Most of the patients with sensory motor neuropathy showed abnormalities of SSR. Conclusion: Motor fibers are less affected than sensory and the upper limbs appear to become less involved than the lower. Peripheral neuropathy is a common complication of diabetes. Nerve conduction studies are well established and are considered to be the most sensitive and objective means for investigation and diagnosis of DPN.

1425 Prolonged F-Wave Latency: an early parameter of nerve involvement in young Diabetic subjects

Islam RM ~, Bhowmik N B 2, R a h m a n ZH 1, Haque A ~, Haque S ~, Haque A 1. 1Department of Neurology, Bangubandhu Sheikh ~ujib Medical University, Dhaka, Bangladedt; 2Department of Neurology, BIRDEM Hospital, Dhaka, Bangladesh

Background: Measurement of F-wave latency is a sensitive and early parameter in diabetic, neuropathy than other parameters of nerve conduction study. Subject and method: A total nmnber o f 62 subjects of which 32 newly diagnosed young diabetic patients (age below 30 years); and 30 age and sex matched control were included in this study. The diagnosis of diabetic neuropathy was based on clinical symptoms, objective neurological signs and electrodiagnostic confirmation. For upper limb ulnar (motor and sensory) conduction study with F-wave latencies and for lower limb peroneal motor conduction with F-wave latencies, sural sensory conduction were measured in both diabetic and control groups. Results: Out of the 32 diabetic patients, 13 were male and 19 were female. The mean age was 24.09 ± 3.94 years. In control group 23 were male and 7 were female with a mean age o f 23.43 ± 2.73 years. The mean ( ± SD) sermn fasting glucose level was 4.80 ± 0.55 mmrol/L in control and was 18.65 ± 6.73 rrmtol/L in the diabetic groups. In diabetic subjects ulnar motor nerve conduction velocity was delayed in 6 (18.757/;) and normal in 26 (181.25%) but the ulnar F-wave latendes were prolonged in 16 (50%). Out of 32 diabetic subjects 28 (187.5%) showed normal peroneal nerve conduction velocity and 17 (53.12%) showed prolonged F-wave latencies. Conclusion: Tiffs study suggests that prolonged F-wave latency is an early indicator of nerve involvement in newly diagnosed young diabetic subjects.

1426 Changes in excitability of Motor Axons with age

Jaltkelowitz, SK 1'2 , Howells, j1, McNulty, PA 1, Burke, D 1'2. 1College of Health Sciences, University of Sydney, Sydney, Australia," 2Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia

Background: Threshold tracking is a novel technique that permits exanffnation of the excitability of hmnan axons in vivo. Protocols have been validated for both motor and sensory axons but changes in axonal excitability with age have not been explored systenratically. This s tudy aims to determine the changes in mxonal exdtability of motor mxons from the third to the eighth decade. Method: Subjects were studied using the T R O N D X M 4 protocol to assess motor axon function. Tire median nerve was stinmlated at the va-ist and tire compound muscle action potential was recorded from the thenar muscles. Results: Stimulus response curves demonstrated a progressive increase in threshold with age. The current-threshold relationship was similar across all decades for depolarizing subthreshold pulses. In the hyperpoladzing direction, the slope of tire current-threshold relation- ship was significantly steeper tire older tire subjects, especially beyond tire first 100 ms of the subthreshold hyperpolarizing pulse. Conclusion: The current required to stimulate mxons percutaneously increases with age. There is also an increase in inward rectification in motor mxons with increasing age, perhaps due to increasing activity of "IN", tire hyperpolatization-activated cation conductance.

1427 Evaluation of Carpal Tunnel Syndrome in patients with Diabetes MeUitus: derivation of Disease control data

Venkateswarlu. K l, Butchi Raju. G ~, Satya Rao. K 1, Dileep Kumar . K ~, Subramanyanr. KAV 2, Mythili. A 2. 1Dept of Neurology, Andhra Medical College, Iqsakhapatnam, India; 2Dept of Endocrinology, Andhra Medical College, I/~sakhapatnam, India

Background: As asymptomatie focal conduction abnormalities across the carpal tunnel are common in patients with diabetes mellitus (DM), interpretation o f symptoms of Carpal Tunnel Syndrome (CTS) needs derivation of disease control data. Methods: Tiffs s tudy included 75 consecutive patients with Type 2 D M with symptoms of polyneuropathy referred for electrophysiological