100 essential drugs1
DESCRIPTION
USMLE, High-Yield Drugs - Step 1TRANSCRIPT
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Generic Name Common Clinical Utility Mechanism of action Unique Toxicity
Acetaminophen Tylenol
Allopurinol anti-hyperuricemic drug
Alprazolam Xanax GABA receptor agonist
Amino(theo)phylline Tx of bronchial asthma "narrow therapeutic window"
Amiodarone
Amoxicillin hypersensitivity reactions
Amphotericin B nephrotoxicity
Aspirin NSAID, inhibits COX
Atropine
Azidothymidine (AZT) bone marrow suppression
Azithromycin rash in mono (like ampicllin)
Bleomycin pulmonary fibrosis
Bromocriptine
ACE inhibitor
Trade "common" name
antipyretic/analgesic, no anti-inflammatory activity, DOC for children with viral infx
inhibits PG synthesis in CNS (post. Hypothalamus)
centrilobular hepatic necrosis (can be countered with N-acetyl cysteine)
inhibits xanthine oxidasehypersensitivity reaction, skin rash
benzo of choice for panic disorders, Tx of agoraphobia
addiction (with protracted withdrawl)
PDE inhibitor, results in higher conc of intracellular cAMP
Tx of life-threatening supraventricular and ventricular tachyarrhythmias
Class III antiarrhythmic, increases AP duration and refractory period
pulmonary fibrosis, pts may see halos in periphery d/t corneal deposits
for non-penicillinase producing strains of Strep, Staph, H. flu, E. coli, P. mirabilis, uncomplicated GC infx, otitis media
beta lactam antibiotic which inhibits bacterial cell wall synthesis
DOC for systemic mycosespolyene antifungal, binds to membrane ergosterol to induce pore formation
Acdetylsalicylic Acid (ASA)
anti-inflammatory/antipyretic, DOC for RA
GI bleeding, Reye's syndrome
to increase HR and for Tx of cholinesteraase inhibitor-induced toxicity
competitive muscarinic receptor blocker
insufficient dose may cause paradoxical slowing of HR
Zidovudine, Retrovir
part of highly active antiretroviral therapy (HAART), Tx of HIV/AIDS
nucleoside inhibitor (T analog) or reverse transcriptase, terminates viral DNA synthesis
antibacterial, DOC or C. trachomatis urethritis, Tx of legionella, Neisseria and Mycoplasma infx
macrolide antibiotic, bacteriostatic, binds 50s ribosomal subunit, blocks translocation
antineoplastic agent, expecially for Tx of testicular tumors
attacks phosphodiester bonds of DNA, causing strand breakage
anti-Parkinsonism drug, Tx of hyperprolactinemia
dopamine receptor agonist exacerbates psychiatric ilness
Captopril/enalapril/lisinopril
anti-hypertensive, Tx of CHF, post MI therapy
dry cough, angioedema, fetal damage
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Ceftriaxone
Chloroquine
Chlorothiazide hypokalemia
Chlorpromazine
Cholestyramine Questran
Cimetidine/ranitidine Tagamet PUD, GERD, Z-E syndrome
Ciprofloxacin
Clindamycin, lincosamide
Clonidine alpha 2 adrenergic agonist sexual dysfunction
Clozapine agranulocytosis
Cocaine topical anesthetic in the nose and throat
Colchicine antineoplastic agent, gout
Cromolyn sodium only minimal systemic toxicity
active against G- infx (nosocomial, Lyme, N. gonorrhoeae) and bacterial meningitis
3rd gen. cephalosporin, beta-lactam inhibitor of cell wall, blocks terminal cross-linking of bacterial cell wall peptidoglycan ad activates cell wall autolytic enzymes
can cause a positive Coombs' test
DOC against flaciparum malaria, Tx of extraintestinal amebiasis (esp hepatic amebiasis)
antimalarial drug, inhibits breakdown of heme in the plasmodial digestive tract
antihypertensive, used for CHF, nephrotic syndrome, hypercalciuria
prototype thiazide diuretic, binds Cl- channel in DCT, inhibits NaCl reabsorption
low potency drug for Tx of schizophrenia or psychiotic symptomatology
neuroleptic agent, antagonist at a1-adrenergic, dopamine, 5HT receptors in CNS
contraindicated in pts with seizure disorders
antihyperlipidemic used for type IIa and IIb hyperlipidemias
anion exchange resin which binds negatively charged bile acids and bile salts, dec enterohepatic recirculation and inc their excretion
constipation and impaired absorption of fat-soluble vitamins
prototype H2 receptor antagonist, reversibly binds to gastric parietal cells and inhibits acid secretion
inhibits cyto p450, increased conc of other drugs and may have antiandrogenic effects
G- infx, gonorrhoeae, UTIs, soft tissue infx, diarrheal diseases
inhibition of bacterial DNA gyrase
pediatric Achilles tendon rupture
anaerobic bacterial infx (lung abscesses, intra-abdominal infx, orthopedic infx)
irreversibly binds 50s subunit, interfering with aa transfer
may cause pseudomembranous enterocolitis
HTNj, opiate withdrawla, benzo withdrawal
refractory schizophrenic pts or tardive dyskinesia
neuroleptic agent with high affinity for 5HT2 and D4 recept
inhibits reuptake of catecholamines
strong abuse potential, respiratory depression and coronary spasm
plant alkaloid, binds tubulin, causes depolymerization of microtubules
peripheral neuritis, alopecia
prophylactic anti-inflammatory in asthma
inhibits mast cell degranulation
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Cyclophosphamide hemorrhagic cystitis
Cyclosporine nephrotoxicity
Diazepam Valium GABA receptor agonist
Diethylstilbestrol via steroid hormone mechanism
Digoxin
Diltiazem generally safe
Diphenhydramine Benadryl minor abuse potential
Dobutamine quite safe in lower doses
Doxorubicin antineoplastic agent cardiotoxicity
Edrophonium Tensilon Dx of MG
Epinephrine
Erythromycin
Estrogen via steroid hormone mechanism
autoimmune disorders and bone marrow transplants
alkylating agent, activated by cyto p450 and then alkylates DNA
immunosuppressant, prevents rejection of allergenic transplants, tx of graft vs host disease and selected autoimmune disorders
synthesis IL-2 by activated T-cells
anxiety, skeletal muscle relaxant, preanesthetic med, status epilepticus
addiction (with protracted withdrawl)
morning after pill, can be used to prevent pregnancy when at high doses
rare, clear cell cervical or vaginal adenocarcinoma among daughters of women who took it during early pregnancy
CHF, A-V nodal depression, a-fib and flutter
reversibly binds and inhibits Na/K ATPase, positive inotropy
life-threatening cardiac arrhythmias
angina from vasospasm, Tx of arrhythmias (SVTs) and mild-moderate HTN
Class IV antiarrhythmic drug, Ca channel blocker
DOC for urticaria and allergic rhinitis, Tx of insomnia
1st generation antihistamine (H1 receptor blocker)
CHF, promotes inc cardiac output with little change in myocardial O2 demand
Beta 1 adrenergic receptor agonist
anthracycline antibiotic which intercalates DNA, binds to cell memb and generates O free radicals through lipid peroxidation
competitive inhibitor of acetylcholinesterase
only as may relate to brevity of effect
DOC for anaphylaxis, used in asthama, cardiac arrest, enhances effect of local anesthetics
alpha and beta adrenergic agonist
excessive dosing may precipitate hypertensive crisis
alternative to PCN in allergic pts, 1st choice for Legionella and M. pneumoniae, 2nd choice for Syphilis and Chlamydial
macrolide antibiotic, binds 50s ribosomal subunit interfering with protein synthesis, blocks translocation
sensorineural hearing loss in large doses, inhibition of cyto p450
OCPs, HRT, primary hypogonadism and hypopituitarism, dysmenorrhea, dysfunctional uterine bleeding, palliative Tx for prostatic carcinoma
thromboembolic phenomena
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Finasteride BPH and male pattern bladness
Fluoxetine SSRI
Folic acid ~
Furosemide Lasix
Gentamicin ototoxicity and nephrotoxicity
Haloperidol Haldol
Heparin thrombocytopenia
Hydralazine
Ibuprofen Advil analgesic, anti-inflammatory, antipyretic NSAID, inhibits COX nephrotoxicity
Imipramine severe major depression
Indinavir sulfate part of HAART for HIV/AIDS thrombocytopenia
Indomethacin
5-alpha reductase inhibitor, inhibits conversion of testosterone to DHT in target tissues
gynecomastia for Proscar, not Propecia
depression, panic disorder, OCD, PTSD and bulemia nervosa
inhibits cyto p450, potentially fatal 5HT syndrome when combined with MAOIs
folate defic, dietary supplement for women of childbearing age to prevent NTDs
cofactor which participates in 1 carbon transfer for DNA and methionine synthesis
CHF, pulm edema, renal and liver failure, severe HTN, hypercalcemia
protoype loop diuretic, inhibits reabsorption of Na, K and Cl in ascending thick limb by blocking Na/K/Cl cotransporter
hypokalemia, ototoxicity, allergic interstitial nephritis
G- bacteria, for serious infx, topically in burns infected with Pseudomonas and ocular infx
irreversibly binds 30s ribosome, inhibiting the initiation of protein synthesis
psycotic symptoms or schizo, severe manic or agitated episodes, Tourette's
dopamine receptor antagonist (esp D2) in mesolimbic and mesocortical areas
may cause Parkinsonism, akathisia, dystonia, tardive dyskinesia, hyperprolactinemia, neuroleptic malignant syndrome
in pts at high risk for thrombosis and pulm emboli, used to stop ongoing thrombosis, used in acute phase of MI
accelerates antithrombin III binding to thrombin and antithrombin III, inactivates thrombin, Ixa, Xa, XIa, XIIa and kallikrein, inhibits clot formation, does not dissolve clots!
moderate-severe essential HTN, CHF (in combo with oral nitrates)
direct relaxation of vascular smooth muscle, greater effect on arterioles than venules
lupus-like syndrome with +ANA (in slow acetylators)
prototype tricyclic antidepressent, decreases reuptake of NE and 5HT in the CNS
antimuscarinic effects, orthostatic hypotension
inhibits viral protease, preventing formation of functional reverse transcriptase
closure of PDA, moderate-severe RA, OA, ankylosing spondylitis, Bartter's synd, tendinitis, bursitis, acute gout, dysmenorrhea, DOC for Reiter's
NSAID, inhibits PG-forming COX
blood dyscrasias, hepatotoxicity, contraindicated in pregnant women
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Insulin, regular hypoglycemia
Isoniazid (INH) tx and prevention of TB
Isoproteronol bronchial asthma, bradycardia beta agonist sinus tachycardia
Isotretinoin teratogenic
Ketoconazole
Levodopa
Levothyroxine ~
Lidocaine
Lithium mania, depression, bipolar disorder
Losartan K+ HTN fetal damage
Lovastatin Mevacor HMG-CoA reductase inhibitor
Meperidine Demerol analgesic opioid receptor agonist relative mydriasis
IDDM, NIDDM, diabetic ketoacidosis, hyperosmolar hyperglycemic nonketotic coma
binds tyrosine kinase receptors on cell surface, promoting anabolic reactions withing target cells, promotes translocation of GLUT transporters to plasma memb
inhibits mycolic acid synthesis of mycobacterial cell wall
lupus-like syndrome with +ANA (in slow acetylators)
severe cystic acne that is recalcitrant to standard therapy
unknown (may inhibit sebaceous gland size and function)
coccidiomycosis, histo, blasto, paracoccidio, mucocutaneous candidiasis
blocks synthesis of fungal cell membrane ergosterol
suppression of cyto p450 (be careful of any patient taking Warfarin, etc..)
for Parkinson's disease (usually with carbidopa)
dopamine precursor (converted by dopa decarboxylase)
hyperkinetic movement disorders, psychotic behavior
DOC for hypothyroidism
activation of nuclear non-histone protein receptors attached to DNA, increasing trnascription of mRNA
primary therapy for ventricular arrhythmias, local anesthetic
decreases automaticity in Purkinje fibers and vent tissue by blockin inactivated Na+ channels, favoring phase III repolarization
cimetidine and propranolol increase its toxicity
antidepressent effect - may decrease supersensitivity of dopamine receptors, increase Ach, enhance 5HT activity for depression; antimania effect - it may prevent recycling of phosphoinositides, causing depletion of IP3 and DAG, diminishes excess catecholamines and 5HT
teratogenic, interstitial nephritis, nephrogenic DI
angiotensin II receptor blocker
Type Iia and Iib hyperlipoproteinemia and secondary hyperlipoproteinemia
elevated liver enzymes, rhabdomyolysis
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Methotrexate
Methylphenidate
Metoprolol/lopressor HTN, tachyarrhythmias, heart disease ~
Metronidazole
Morphine sever pain
Nafcillin penicillin-resistant Staph and Strep infx
Naloxone acute opioid overdose ~
Nifedipine Ca channel blocker Raynaud's phenomenon
Nitroglycerine
Nitroprusside thiocyanate poisoning
Octreotide somatostatin analog ~
Omeprazole GERD, PUD, Z-E syndrome ~
Phentolamine hypertensive crisis associated with pheo orthostatic hypotension
Phenoxybenzamine
anti-neoplastic agent, RA, abortion, ectopic pregnancy, psoriasis
folic acid analogue, blocks DHF reductase, results in decreased dTMP -> decreased DNA and protein synthesis
pneumonitis, fatty liver, myelosuppression
CNS simulant, stimulates mood and alertness and depresses apetite, Tx of ADHD
stimulates release of catecholamines (cross the BBB)
significant abuse potential in non-ADHD subjects
Beta 1 adrenergic receptor blocker
amebic infx, DOC for trichomoniasis and giardiasis, Bacteroides fragilis, C. diff, Gardnerella vaginalis
entry into cells of infectious organism, chemically reduced and products cause death by interaction with DNA and interfering with cell division
disulfiram-like reaction with alcohol consumption, avoid in pregnant women
primary activity at opioid mu receptors
contraindicated with sedative hypnotics, MAOIs and antipsychotics
beta-lactam antibiotic, inhibits bacterial synthesis by preventing peptidoglycan cross-linking, penicillinase resistant
acute tubulo-interstitial nephropathy (ATIN), though much less than methicillin
opioid receptor antagonist with very high affinity at mu receptors, can also block kappa and delta
mild-moderate HTN, coronary vasospasm
angina, coronary vasospasm, Prinzmetal's angina, CHF, short term management of HTN
coronary vasodilation and systemic venous pooling to reduce preload and vasodilation, d/t metabolism to NO -> activate guanylate cyclase -> cGMP
postural hypotension, reflex tachycardia
hypertensive emergencies, acute CHF, sever mitral regurgitation with pulmonary congestion
directly relxes vascular smooth muscle via NO, relaxes both arterioles and venules
controls excessive horomone secretion in acromegaly, glucagonemia, insulinoma
irreversibly inhibits the gastric parietal cell H+/K+ ATPase
competitive and reversibly blocks alpha adrenergic receptors
pheo, hypertensive crisis secondary to MAO OD, prophylaxis for Raynaud's
irreversibly blocks alpha adrenergic receptors by covalent attachment
inhibits ejaculation, may cause orthostatic hypotension
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Phenylephrine tissue necrosis
Phenytoin
Physostigmine glaucoma cholinesterase inhibitor ~
Pilocarpine ~
KCL antiarrhythmic Tx of hypoalemia
Praziquantel eosinophilia
Prednisone
Procainamide
Propranolol HTN, angina, arrhythmias post-MI
Propylthiouracil (PTU) thyrotoxicosis
Quinidine
Sildenafil citrate ED inhibits phosphodiesterase
Spironolactone gynecomastia
nasal decongestant, hypotension, to prolong local anesthetic, to terminate paroxysmal atrial tachycardias, mydriatic
alpha 1 adrenergic receptor agonist
for epilepsy except absence seizures, trigeminal neuralgia, limited use as an antiarrhythmic
inhibits voltage-gated Na channels
gingival hyperplasia, hirsutism
topically for narrow and open-angle glaucoma to reduce IOP
direct-acting muscarinic receptor agonist
involved in maintenance of cellular membrane potential
death if given too quickly as bolus, arrhythmias
DOC for ALL trematode infx, active in cestode infx
antihelminthic, increases memb permeability of susceptible worms to Ca -> paralysis of parasite
anti-inflammatory and immunosuppressant agent, when lon-term therapy is needed
enters target cells and binds to cytosolic receptor, complex is translocated to nucleus, regulates protein synthesis
exogenous Cushing's syndrome
atrial and ventricular arrhythmias, including ventricular ectopic beats
Class IA antiarrhythmic, blocks Na+ channels, thereby slowing rate of phase O depolarization and conduction
lupus-like syndrome with +ANA
beta adrenergic receptor antagonist
use with caution in diabetics, may cause impotence
inhibits thyroid peroxidase-catalyzed reactions, also inhibits peripheral deiodination of T4->T3
maculopapular pruritic rash, agranulocytosis
atrial and ventricular arrhythmias, including ventricular ectopic beats
Class IA antiarrhythmic, blocks Na+ channels, thereby slowing rate of phase O depolarization and conduction, also blocks muscarinic and alpha 1 receptors
patient must be pretreated with b-blocker, digitalis or Ca channel blockers to avoid possible increase in vent response to atrial flutter, may cause Torsades and cinchonism
affects color vision causing difficulty in blue/green discrimination
in combo with K+ losing diuretics to maintain proper K+ balance, useful in presence of high aldosteone levels, used in Dx and Tx of primary hyperaldosteronism, used in Tx of PCOD and female hirsutism
blocks aldosterone action by competitively binding to its receptor
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Streptokinase hemorrhagic stroke
Tamoxifen ~
Terfenadine
Thalidomide unknown teratogenic, causes phcomelia
Tranylcypromine monoamine oxidase inhibitor
Vancomycin
Vasopressin central DI ~
Verapamil Ca channel blocker significant negative inotrope
Warfarin Coumadin warfarin skin necrosis
Zafirlukast asthma hepatotoxicity
Zileuton asthma
Tx of DVTs, PE, unclogging of catheters and shunts, acute MI, hypersensitivity reactions, anaphylaxis
no enzymatic action, forms complexes with plasminogen, which can then cleave free plasminogen into plasmin
reduce recurrence of estrogen-receptor-positive breast cancer, particularly in postmenopausal women
competative antagonist to estrogen at receptors in the breast, partial agonist at other estrogen receptors
prevent or Tx symptoms or allergic reactions, without causing drowsiness
H1 receptor blocker (2nd generation antihistomine)
metabolism is easily inhibited by many hepatic microsomal enzyme inhibitors, high conc can cause Torsades
sedative, immunomodulatory actions, recently reintroduced for Leprosy, skin manifestations of lupus
depression, phobias, narcolepsy, panic attacks
avoid tyramine-containing foods
Trimethoprime/ Sulfamethoxazole
UTIs, shigellosis, salmonellosis, H.flu resp infx, Strep pneumo, PCP, typhoid and paratyphoid fevers, Isospora belli
acts as inhibitor of two sequential steps in synthesis of folic acid, sulfa inhibits PABA incorporation into folic acid, triemth inhibits the reduction of DHF to THF
Steven-Johnson syndrome, blood dyscrasias
G+ only, for C. diff psudomembranous colitis, MRSA, enterococcal infx in PCN allergic pts, PCN-resistant pneumococci, w/ gentamicin for S. faecalis and S. viridans endocarditis
inhibits cell wall synthesis by binding to D-Ala-D-Ala, thus preventin its incorporation into peptidoglycan
rapid infusion may cause facial and neck erythema ("red man syndrome"), ototoxicity, nephrotoxicity
increases water reabsorption in the collecting ducts of the kidney by binding to ADH receptor
mild-moderate Htn, SVTs, migraine headache prophylaxis
simialr to heparin, but not useful for rapid anticoagulation
derivative of Coumarin, interferes with synthesis of vitamin K-dependent clotting factors (II, VII, IX, X, protein C, protein S)
leukotriene receptor antagonist (LTD4)
5-lipoxygenase inhibitor, blocks arachidonic acid -> leukotrienes