PEDRO RUIZ GALLO NATIONAL UNIVERSITYHUMAN MEDICINE FACULT

MALARIA AND BARTONELLOSIS.

MEDICAL ENGLISH

Vera Bances Paul.Paredes Campos ligiaSegura Ríos Patricia.Rodas Regalado Carlota.Pisfil Colchado Carlos.Pintado Coronel Edwin.

BARTONELLOSIS

What is it?

The human Bartonellosis "Peruvian wart" or "Carrion's disease" is an infectious disease caused by a

bacterium Bartonella bacilliformis, which parasitizes red blood cells from human blood.

MALARIA

infectious, serious and to sometimes fatal, produced by aparasite transmitted by the mosquito's Anopheles

What is it?

CAUSES

MALARIA BARTONELLOSIS

of

MALARIA BARTONELLOSIS

Causative parasite: protozoa of the genus Plasmodium 

-four species: Plasmodium vivax, P. Ovale, P. Malariae and P. Falciparum (the most deadly)

Causative parasite: proteobacteria Bartonella bacilliformis

Vector of this disease : female mosquito of the genus Anopheles.

Main vector: female of the mosquito Lutzomyia verrucarum

TRANSMISSION ROUTES-Direct drive through the bite of a mosquito.-Also be transmitted by blood transfusions or by infected syringes.

TRANSMISSION ROUTES - By the bite of the mosquito.� - Transfusion with infected blood.�

COMMON SIGNS AND SYMPTOMS

FIRST STAGEThe classic symptoms

Acute phase: (Carrion's disease

BARTONELLOSISMALARIA

fever

hemolytic anemia

jaundice

DIFFERENT SIGNS AND SYMPTOMS

FIRST STAGE

shivering hemoglobinuria

arthralgia ( joint pain) retinal damagevomiting

MALARIA

convulsions

BARTONELLOSIS

DIFFERENT SIGNS AND SYMPTOMS

FIRST STAGE

Acute phase: (Carrion's disease

nonpainful hepatomegaly

malaisepallor

lymphadeopathy

COMMON SIGNS AND SYMPTOMS

MALARIA BARTONELLOSIS

Severe malaria SECOND STAGEChronic phase (or Peruvian wart

Peruvian Wart)

SplenomegalyHepatomegaly

normal spleen enlarged spleen

DIFFERENT SIGNS AND SYMPTOMS

MALARIA SECOND STAGE

severe headache hypoglycemia

cerebral ischemia renal failure

Chronic phase (or Peruvian wart Peruvian Wart)

DIFFERENT SIGNS AND SYMPTOMS

BARTONELLOSIS

SECOND STAGE

"Peruvian warts" or "Peruvian wart".

arthralgias lymphadeopathy

myalgias

 What are the possible consequences?

The consequences are often fatal, if not treated quickly.

Malaria

If the infection is not treated, the mortality rate can be as high as 85%

Bartonellosis

The rupture of a large number of red blood cells will produce significant anemia.

Complication hematologic recently reported that may occur with evolution favorable.

 What are the possible consequences?

Malaria Bartonellosis

Hemolytic anemia. Purple thrombocytopenic

Cerebral malaria, that usually ends in a box coma.

Complications have been reported neurological

 What are the possible consequences?

Malaria Bartonellosis

Associated with fever

 What are the possible consequences?

Malaria Bartonellosis

Parasitized erythrocytes bartonellosis

Accentuated due to hemolysis, manifested as a decrease in the amount of urine.

Acute renal failure Acute hemolysis

Malaria treatmentChloroquine

tetracycline or clindamycin

500 mg orally 1 time a week

Adults: 500 mg every 8 hours for 3-10 days.Children: 8.2 mg / kg every 8 hours for 3 to 10 days.

Quinine

Alternative treatmentFor travelers going to areas where it is known to occur Falciparum malaria, there are several options for malaria: mefloquine, atovaquone / proguanil and doxycycline.

Bartonellosis treatmentIn general it is recommended to use:

•In addition to another antimicrobial agent as a beta lactam.•For the effective treatment of B. bacilliformis and protect against any secondary bacterial infection

CHLORAMPHENICOL

The rifampin or streptomycin is used to treat chronic bartonellosis

CIPROFLOXACIN, STREPTOMYCIN, TETRACYCLINE OR ERYTHROMYCIN

Malaria diagnosis.

Examination of samples of peripheral blood.

Detection of parasite antigens.

Molecular techniques.Serology.

Bartonellosis Diagnostics.

Reaction Polymerase ChainBlood smears stained with

Giemsa.Agar cultures and Cell

cultures.Identification of the isolates.Indirect fluorescent antibody

testWestern blot