42 Tubercle and Lung Disease: Supplement 2

The results show significant difference in average number of HRCs between two samples with decreased number in the Pts group, total cumulative 32 difference (p < 0.001) and in the frequency distribution (p < 0.001). We could conclude that analysed groups are two different samples according to their population-genetic structure. It means that they may give a different re- sponse to similar environmental agents. Significantly decreased number of HRCs in the Pts group could be manifestation of their decreased degree of homozygosity and indicate dominant factor influence in predisposition to LTB. It is possible that individuals with such genetic and physiological constitution are more liable to infec- tion by Mycobacterium tuberculosis. The results of ABO blood type frequency analysis speak in favour of genetic predisposition/resistance to LTB as well as to the form of the disease.

* Archive Biol. Sci 42: 3, 11

078-PA10 Tuberculin screening at a hostel for homeless men

Jamieson, S., Williams, C., Davies, P. Tuberculosis Research Unit, Fazakerley Hospital, Liverpool

All staff and residents at a men's hostel for the homeless were screened for tuberculosis. A total of 65 (including 11 staff members) were identified, age range 17-65 (mean 39). A total of 13 did not return for tuberculin test reading; of the remaining 52, 42 had Heaf grade 0-HI, 6 had grade II and 9 Heaf grade IV. The two men with Heaf grade III test who had a cough and all who had a grade IV test were screened at the chest clinic with interview and chest X-ray. No cases of tuberculosis were identified.

There was no significant difference between staff and residents for Heaf grade. The mean age of those with grade IV test was significantly higher (44) than those with grade 0-III (36).

Tuberculin screening is easy to carry out and consid- erably cheaper than chest radiography. It may have a role in tuberculin screening of residents of hostels. Males in hostel accommodation in the City of Liverpool do not appear to be at increased risk of infection from tuberculosis compared with the rest of the population.

092-PAl0 Studies of the anthraco-silicosis with tuberculosis in 122 cases

Lang Wenfang, Chinese Academy of Preventive Medicine, Beijing, China

One hundred and twenty-two anthraco-silicosis with tuberculosis (AST) were all male miners, aged 36-75 (mean 50.3) years with duration of exposure to rack and coal dust for 6--40 (mean 20.3) years. There were several stages of silicosis. The duration of TB was 1-20 (mean 6.4) years. All patients had had combination of chemo- therapy of first and second line antituberculous drugs for a long time. The clinical symptoms of 122 cases included cough (99%), sputum (97%), short of breath

(72%), dyspnea (81%), hemoptysis (46%), night sweat (12%), fever (6%), positive sputum (53%). The roentge- nologic characteristics of the AST: large conglomerate lesions (3-13 cm, mean 10.2 cm) and irregular opacities occurred in three to six of the lung fields. The cavitation (largest 10.5 cm, mean 4.3 cm) in the conglomerate le- sion of AST was found in 58 cases (47.5%). Twenty-two cases of the AST were treated with RFF and EMB for one year. After the treatment of the symptoms and the chest X-ray examination (except for fibrocavernous lesions), all the lesion showed some improvement. Spu- tum conversion rate was 77.3%. Conclusion: The rate of TB in coal miners' pneumoconiosis (12.49%) is higher than general population, the effect of antituberculosis chemotherapy was lower, the TB enhances the progress of lesions of silicosis and silicosis increases suscep- tibility for TB, the conglomerate lesions and the cavita- tions were large and multiple. All active cases of AST should receive chemotherapy as early as possible in the stage of TB lesions.

109-PAl0 Evolution des tuberculoses extrarespiratoires et son retentissement dans le programme national de contr61e de la tuberculose

Didilescu, C. Jalbft, M., Marica, C. Institut National de Pneumophtisiologie, Buearest, Roumanie

Chaque ann6e 1000 personnes attrapent une tuberculose extrarespiratoire en Roumanie; il y a une tendance minime d'augmentation ~t l 'heure actuelle.

On a effectu6 une analyse de la dynamique et de la structure des tuberculoses respiratoires et de ses implica- tions pour le Programme National de Contr61e de la Tuberculose selon les donndes du Registre National de Tuberculose.

Pendant l'intervalle 1965-1994, les tuberculoses extrarespiratoires ont present6 une baisse de l'incidence de 84.6% (de 31.2%ooo en 1965 h 4.8%ooo en 1994 avec des intensit6s diffdrentes d'une localisation h l'autre) et de leur poids sp6cifique dans la tuberculose de 18.5% (1965) ~t 5.1% (1994). Les principales localisations out 6t6 en 1994: la tuberculose ganglionnaire (1.38%ooo), ost6o-articulaire (0.99%ooo), urog6nitale (0.82%ooo) et la tuberculose du m6ninge et du syst~me nerveux central (0.66%ooo). La pr6valence a diminu6 de 164.7%ooo 7t 16.9%ooo et la mortalit6 de 1.9%ooo h 0.088%ooo.

Grace au nivean 61ev6 de l'end6mie tuberculeuse on ne peut pas n6gliger le probl~me des tuberculoses extrarespiratoires. Le Programme National de Contr61e de la Tuberculose (1995-1996) pr6voit des mesures pour optimiser le diagnostique, les sch6mas th6rapeutiques utilis6s et la notification.

l l6 -PA10 La tuberculose pulmonaire chez les vaccin6s par le BCG

Megdiche, M.L., Hamzaoui, A., Chabbou, A., Gharbi, B.EI. H@ital de l'Ariana, Tunisie

I1 s'agit d'une 6tude comparative des diff6rents aspects