02 09 2011 iliceto meeting padova - eurochinahealth 09 2011 iliceto meeting... · 2) prof sabino...
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Quale Medicina 2000
www.qualemedicina2000.bologna.it Via Mascarella 77/5 40126 Bologna, Italy
Mobile Phone +39 335 6281412 Fax: +39 051587 6855, 051 6079848
Roma Ambasciata di Cina 26 07 2011
OBJECT: MEETING FUWAI CARDIOLOGY HOSPITAL BEIJING.
PEOPLE REPUBLIC OF CHINA DELEGATION IN PADOVA
UNIVERSITY
02 09 2011 15.30 17. 30 AULA MAGNA
lead by Prof jiang Lixing
Prof Yin Jun
Scientific Counselor People Repubblic of China Embassy in Roma
AND Prof Sabino Iliceto
Quale Medicina 2000
www.qualemedicina2000.bologna.it Via Mascarella 77/5 40126 Bologna, Italy
Mobile Phone +39 335 6281412 Fax: +39 051587 6855, 051 6079848
First Chair of Cardiology University of Padova
Director Cardiology Department
Prof Domenico Corrado and Prof Gaetano Thiene, Prof Andrea Nava,
Prof giovanni Danieli
Quale Medicina 2000
www.qualemedicina2000.bologna.it Via Mascarella 77/5 40126 Bologna, Italy
Mobile Phone +39 335 6281412 Fax: +39 051587 6855, 051 6079848
Well Know International Padova team for Arrhythmogenic Right
Ventricular Dysplasia. Cardiomyopathy (ARVD)
Genetic screening
And Cardiology And Arrhythmias department of Padova
Dr ssa Sun Lei
Euro China Italy Health Care Research Center
PROGRAM 02 09 2011 15.30 17. 30 AULA MAGNA
Chair Prof Sabino Iliceto and Prof Jiang Lixin
PADOVA UNIVERSITY CARDIOLOGY DEPARTMENT .
DIRECTOR PROF SABINO ILICETO
Quale Medicina 2000
www.qualemedicina2000.bologna.it Via Mascarella 77/5 40126 Bologna, Italy
Mobile Phone +39 335 6281412 Fax: +39 051587 6855, 051 6079848
1) PROF JIANG LIXIN
THE OXFORD FUWAI CLINICAL TRIALS AND OUTCOMES
RESEARCHES INTERNATIONAL CENTER ACTIVITIES,
BEIJING.
COLLABORATION OPPORTUNITIES
2) PROF SABINO ILICETO
ADVANCEMENT IN THE DIAGNOSIS AND TREATMENT OF
CARDIVASCULAR DISEASES FROM PREVENTION TO
ADVANCED CRITICAL CARE. A 2011 OVERIEW
INTERNATIONAL EXCHANGES AND TRAINING
OPPORTUNITIES
Quale Medicina 2000
www.qualemedicina2000.bologna.it Via Mascarella 77/5 40126 Bologna, Italy
Mobile Phone +39 335 6281412 Fax: +39 051587 6855, 051 6079848
3) TECHNOLOGY ADVACEMENTS AND
IMPLEMENTATION IN CARDIOLOGY AND INTERNATIONAL
EXCHANGES
A) CHINESE SPEAKER
B) ITALIAN SPEAKER
4) OTHER ISSUES IN MODERN CARDIOLOGY (INVASIVE
OR NON INVASIVE) ARRHYTHMOGENIC RIGHT
VENTRICULAR DYSPLASIA CARDIOMYOPATHY
AND CARDIAC SURGERY
Quale Medicina 2000
www.qualemedicina2000.bologna.it Via Mascarella 77/5 40126 Bologna, Italy
Mobile Phone +39 335 6281412 Fax: +39 051587 6855, 051 6079848
A) CHINESE SPEAKER
B) ITALIAN SPEAKER
Diagnosis of arrhythmogenic right
ventricular
cardiomyopathy/dysplasia
Proposed Modification of the Task Force
Criteria
Quale Medicina 2000
www.qualemedicina2000.bologna.it Via Mascarella 77/5 40126 Bologna, Italy
Mobile Phone +39 335 6281412 Fax: +39 051587 6855, 051 6079848
1. Frank I. Marcus1,*, Chair, 2. William J. McKenna2, Co-Chair, 3. Duane Sherrill1, 4. Cristina Basso3, 5. Barbara Bauce3, 6. David A. Bluemke4, 7. Hugh Calkins5, 8. Domenico Corrado3, 9. Moniek G.P.J. Cox6, 10. James P. Daubert7, 11. Guy Fontaine10, 12. Kathleen Gear1, 13. Richard Hauer6, 14. Andrea Nava3, 15. Michael H. Picard11, 16. Nikos Protonotarios13, 17. Jeffrey E. Saffitz12, 18. Danita M. Yoerger Sanborn11, 19. Jonathan S. Steinberg9, 20. Harikrishna Tandri5, 21. Gaetano Thiene3, 22. Jeffrey A. Towbin14, 23. Adalena Tsatsopoulou13, 24. Thomas Wichter15 and 25. Wojciech Zareba8
Translational medicine
Molecular biology and clinical management of arrhythmogenic right
ventricular cardiomyopathy/dysplasia
1. Domenico Corrado1,
2. Cristina Basso2,
Quale Medicina 2000
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3. Kalliopi Pilichou 2,
4. Gaetano Thiene2
+ Author Affiliations
1. 1Inherited Arrhythmogenic Cardiomyopathy Unit, Department of
Cardiac, Thoracic and Vascular Sciences, University of Padua
Medical School, Padua, Italy
2. 2Cardiovascular Pathology, Department of Medico-Diagnostic
Sciences and Special Therapies, University of Padua Medical
School, Padua, Italy
1. Correspondence to Domenico Corrado, Department of Cardiac,
Thoracic and Vascular Sciences, Via Giustiniani, 2-35121
Padova, Italy; [email protected]
Accepted 7 July 2010
Published Online First 7 October 2010
Abstract
In the last two decades the extraordinary advances in molecular
biology of arrhythmogenic right ventricular
cardiomyopathy/dysplasia (ARVC/D) have provided significant
insights into our understanding of the disease aetiology by showing
Quale Medicina 2000
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that it is a genetic disorder of the cardiac desmosomes and that
interactions between mechanical disruption of cell–cell adhesion and
defects of desmosomal-mediated intracellular signalling are likely to
be involved in the pathogenesis of the ARVC/D phenotype. The
discovery of the causative genes for ARVC/D offers the possibility of
identifying genetically-affected individuals before potentially
malignant clinical phenotype occurs. Moreover, the evaluation of
abnormal localisation of desmosomal proteins by
immunohistochemical analysis on endomyocardial biopsy samples
represents a promising test for ARVC/D diagnosis. Early detection of
ARVC/D and preventive therapy of young individuals at highest risk
of experiencing sudden cardiac death may be improved by molecular
genetic screening within affected families and may alter the clinical
management of patients. At present, however, the clinical use of
genotyping is limited by the incomplete knowledge of causative
mutations and the complex genetic background of the disease, which
accounts for the incomplete penetrance and the marked variability of
the phenotype expression. This review addresses the advances in the
molecular biology of ARVC/D, with particular reference to the
Quale Medicina 2000
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genetic basis of the disease, and how these advances have impacted
on understanding the disease pathogenesis, on diagnosis and in
establishing management strategies.
QUESTIONS DISCUSSION AND CONCLUSIONS
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