預防醫學辦公室防疫醫師 蘇迎士

Zika 病毒臨床表現與流行病學

Virology• Mosquito-transmitted flavivirus• Non-segmented, single-stranded, positive

sense RNA virus• 10,794 nucleotides encoding 3,419 amino

acids

Vol. 14, No. 8, August 2008

http://www.bunyavirus.org/?page_id=293

Emerging Infectious Diseases • February 2012

主要症狀• Maculopapular rash• Fever• Arthritis and arthralgia

0 5 10

發病日

有症狀期約 4~7 日

( 日數 )

潛伏期約 3~7日

病媒蚊 ( 斑蚊屬 )- 靈長類動物形成病毒傳播循環，但詳細病毒循環過程仍待研究 ( 囓齒動物 ?)

5 天後測得 IgMThe Illness

血中可測得病毒時間

N Engl J Med 2009

Human to human

transmission?

Zika Fever in French Polynesia

台灣黃病毒病媒蚊

Midguts

Salivary glans

August 28, 2012Aedes aegypti

August 01, 2013Aedes albopictus

Zika Virus• History of temporary urbanization (O)• History of permanent urbanization(X)• Human viremia suitable for vector (O)• Experimental competence of urban vector (O)

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