zdv ppt - final
TRANSCRIPT
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Correlation of Mean Corpuscular Volume and H
toZidovudine-induced Anemia in Patients UndHighly Active Antiretroviral Therapy at the
!nstitute for Tropical Medicine
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"ac#ground of the $tudy
Zidovudine (ZDV) is a frst-line drug used in antiretroviral therapy (ART
One o the most severe side eets o ZDV inta!e is anemia
A"out #-$% o patients ta!ing ZDV develop anemia
&atients 'ith ZDV in their therapy are at more ris! o developing anem
patients 'ithout ZDV in their therapy
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emoglo"in is the only parameter onsidered or ZDV initia
&revious studies have suggested that a lo' *V may "e mprediting the ris! o ZDV-indued anemia
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%eneral &b'ective
To determine i the hemoglo"in and *V is orrelated "eore and ater treatment o ZDV+
$peci(c &b'ectives To determine i hemoglo"in and *V o patient "eore treatment is orrel
hemoglo"in and *V o those 'hih developed anemia
To determine i hemoglo"in and *V o patient "eore treatment is orrelhemoglo"in and *V o those 'hih did not develop anemia
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$igni(cance of the $tudy
&reventing anemia in ,V patients is espeially important to high survival rate+
ethods to replenish "lood is epensive+
Additional relevant parameters or saely reommending ZDpatients are needed+
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$cope and )imitation
$cope This study oused on the *V o the ,V patients undergoin
ZDV inta!e+
)imitations
All data is gathered rom the Researh ,nstitute or Tropial The data o"tained spanned rom .anuary $/#0 to .anuary $/
2u"3ets had ZDV inluded in their therapy
2u"3ets have at least one ollo' up 'ithin the si months a
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Methodology
,nlusion *riteria
#4 years old and a"ove
ale and emale
Treatment na5ve 6ndergoing AART or the frst time
as used ZDV
as at least one ollo' up 'ithin 1months o treatment
Alive 'ithin 1 months o treatment
.anuary $/#0 7 .anuary $/#1
8lusion *riteria
Aged "elo
Did not have at least one ollo'ithin 1 months o treatm
Already undergone A 6ndergone "lood transusion $ '
"eore start o the
Ta!ing o
Ta!ing o drugs that may indue an
Died 'ithin 1 months o A
;ot reorded 'ithin 1 months rom
start o A
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Methodology
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$tatistical Tests
,
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esults
Before Treatment After Treatment
HGB MCV HGB MCV
Before
Treatment
HGB - - 0.199 0.665 0.227
MCV -0.199 - 0.065 0.858*
After
Treatment HGB 0.665 0.065 - 0.415
MCV 0.227 0.858* 0.415 -
Table *+ *orrelation o hemoglo"in and *V "eore andater treatment o ZDV o patients 'ho did not developanemia>r ? /+404@ p , +.
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esults
Before
Treatment
After Treatment
HGB MCV HGB MCV
Before
Treatment
HGB - 0.004 0.774* -0.177
MCV 0.004 - -0.311 0.774*
After Treatment
HGB 0.774* -0.311 - -0.417
MCV -0.177 0.774* -0.417 -
Table /+ *orrelation o hemoglo"in and *V "eore andater treatment o ZDV o patients 'ho developedanemia>r ? /+404@ p , +*
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Conclusion
emoglo"in and *V are not aurate in assessing ZDV-inin ,V patients undergoing AART involving ZDV+
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ecommendations
arger sample siBe
onger period duration period or sampling
*onsider other parameters andCor tests to orrelate 'ith the ourro ZDV-indued anemia in ,V patients undergoing treatment 'ith Z
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TA; EO6
Antio3o@ Reno .ohn RenBy
*hua@ Tyhius
*hua@ VannesBa endri!e
*ollado@ .ohn .oe"ert
.usto@ .an artin
ateos@ a+ 8loisa *arla
&angan@ eryl ouis
2y@ 2amantha ope
F*T
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Reerenes
Adediran@ A+@ Osun!alu@ V+@ Ga!ama@ T+@ .ohn-Ola"ode@ 2+@ A!in"ami@ A+@ 6he@ 8+@ H
A!anmu@ 2+ ($/#1)+ ,mpat o ,V ,netion and Zidovudine Therapy on R
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Reerenes
*laster@ 2+ ($//$)+
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Reerenes 8poetin ala (R)
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Reerenes 2harma@ 2+ ($/#/)+ Zidovudine-indued anaemia in ,VCA,D2+ ,ndian .ournal o
edial Researh@ #N$@ N0-N1#+ Retrieved :e"ruary #0@ $/#1+
2uma@ +@ 2esan!@ R+@ Vidyasagar@ +@ H 2atyanarayana@ + ($/#0)+ ematologial parameters in ,V su"3ets on Zidovudine Therapy+ &erspetives in edial
Researh@ N($)@ ##-#F+ Retrieved :e"ruary #0@ $/#1+
Tadele@ A+@ edir@ A+@ 8na'ga'@