Normal Parkinson's Disease ~ n

0~ 1 5 22~nphilin 1 , .atJ0 - P

n Parkin

!

-Synuclein

Misfolded a-Synuclein

Lewy Body

ynphilin 1

~ ~ept~, Cyclin ETubuhn

,,,, Syt 11 • Ataxi n;

Protein Quality Control Oxidative Stress Protection Apoptosis Oxidative Stress

alpha Synuclein antibody ( GTX112799) (!) ,,,

Neuronal Survival

Huntingtin antibody (GTX132433) I[◄

~ tion Support ~ ~◄ KO/KD Validation f ,_ Comparative Abs

I

r f ,, ' I I , P-

, ' 1 • ► ' r , . I ..

•' • '· . ' ' ) ' I

' I \ ;,,

' ,I

' ~(: .. _, . PGP9.5 antibody (GTX109646) 1[◄ LRRK2 antibody [Nl]. N-term

(GTX113065) Tyrosine Hydroxylase antibody [NlCl] (GTX102424)

Parkinson's Disease Affects dopaminergic neurons

Normal Huntington's Disease

~ BDNF

~

Htt ~

E!ipl / AP

Clathrin

Vescular Trafficking

MW , ·/" ,_.,_si), ,"? (kDa) ~ ' cf~ "',,,,_

mo~[ 130 - --- .. + 1IP1

95 -72 -

55-

43 -

Htt QQQ

,, Htt QQQ

~ -

~ Ca2+ Htt :::►.-

Cx II

~ HiJ>pi J ~

AP

Aberrant Vescular Trafficking

~",;,"' MW ,$':4

{kDa) !:,;:;'" 72 -55 -43-34-26-

10 -

t ~◄ KO/KD Val idation

Apoptosis

(!) Protein Overexpression

HIPl antibody (GTX131449) BDNF antibody (GTX132621) ~ PACSINl antibody (GTX108567)

Huntington's Disease Affects the striatum, basal ganglia, cortex and others

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Striatum

entricle/

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Sulcus

Gyrus

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ers Normal Alzheimer's Disease

sAPPa sAPPl3

Neuronal Survival All Aggregation Neurofibrillary Tangles

Cyt C

~~ Apoptosis

'•'Comparative Abs O Orthogonal Validation

130 -95 -12 -

Normal Alzheimer's Disease 55 - --43-

stantia nigra

Hippocampus

International

-~ ·;:. .. NorrML ,

beta amyloid (1-42) antibody­Conformation Specific (GTX134510) f1)

APP antibody [C2C3]. C-term (GTX101336) (!)

Apolipoprotein E antibody (GTX101456)

Alzheimer's Disease

34-+ + - - ~"1-pMp'lo,eplcle - - + + PIK:€it~

Tau (phospho Ser198) antibody (GTX130456) (!) 0

Affects the cortex, hippocampus, basal forebrain and brain stem

Glutamate

O 0 \ 000 00 0

Astrocyte

Motor neuron

EAAT

Normal Amyotrophic Lateral Sclerosis

0

0 O 0

0

02 50D1 H202 Ca 2 + Ca2+ Caz+

Ca2+

Nucleus Misfolded

50D1

i

., c;;c--: , '.__ ____ , ,,, * ,.+ ,

Cyt C Caspase

Nucleus

Neuronal Survival IF inclusion Apoptosis

MW ,,_;;.."'.,:/'P'- ~,,_<;,

(kDa) ..::,"> ef '¥ "'""'

180-130 -95-72 -55- _

43-

34 -

26 -

C9orf72 antibody [GT1553) (GTX634482) @ 1(•~

t ~◄ KO/KO Validation ~ Protein Overexpression

SOD1 antibody (GTX100554) (!) 1[• TDP43 antibody [GT225] (GTX630196) I~•

' . .

Amyotrophic Lateral Sclerosis Affects spinal motor neurons and the motor cortex

USA

C21orf2 antibody [N1C2] (GTX119046) (!)

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