XXII Swiss NMR Symposium

Tuesday, 16th January 2018

ETH Zürich

Location: ETH Zürich, Hönggerberg, HCI G3, Vladimir-Prelog-Weg 1, CH-8093 Zürich The Symposium is made possible by generous donations from the following companies. Main sponsor:

Further sponsors:

XXII Swiss NMR Symposium 2018

Program 8:30-9:00 Welcome coffee, registration

9:00-9:10 Opening remarks

Session 1: Biological Solution-State NMR - Chair: Matthias Ernst (ETH Zürich) 9:10-9:20 Stephan Grzesiek (Biozentrum Universität Basel)

Deciphering Aallosteric Signaling by NMR 9:25-9:35 Yaroslav Nikolaev (ETH Zürich)

NMR and Computational / Systems Biology 9:40-9:50 Roland Riek (ETH Zürich)

Exact NOEs: Protein Allostery and Enzyme Function at Atomic Resolution

9:55-10:05 Oliver Zerbe (Universität Zürich) NMR of Heptahelical Membrane and Repeat Proteins at UZH

10:10-10:20 Sebastian Hiller (Biozentrum Universität Basel) The Dynamic Dimer the Chaperone Trigger Factor

10:25-10:35 Silke Johannsen (Universität Zürich) New Insights into the Structure of the CPEB3 Ribozyme

10:40-10:50 Alvar Gossert (ETH Zürich) A Combined NOESY Experiment for Efficient Data Collection of Protein-Ligand Complexes

10:50-11:15 Coffee break

XXII Swiss NMR Symposium 2018

Session 2: MRI and in Vivo NMR - Chair: Beat H. Meier (ETH Zürich) 11:15-11:25 Rolf Gruetter (EPFL)

Windows on Metabolism in the Living Brain at Ultra-High Fields 11:30-11:40 Klaas Prüssmann (ETH Zürich, Universität Zürich)

tba 11:45-11:55 Roland Kreis (Universität Bern)

Multiple Benefits from the Water Signal in Clinical MR Spectroscopy 12:00-12:10 Lothar Helm (EPFL)

MRI Contrast Agents - When Fundamental Research Meets Application 12:15-12:25 Peter Vermathen (Universität Bern)

Ex Vivo HR-MAS NMR of Tissues and Cell Cultures and Potential Benefit for in Vivo MRS

12:30-12:40 Sebastian Kozerke (ETH Zürich, Universität Zürich) Hyperpolarized MR Imaging

12:45-14:00 Lunch break

Lunch will be served free of charge to all attendants in the cafeteria on the F floor of the HCI building. Please show your badge at the cash register.

Session 3: DNP, Solid-State NMR and MRFM - Chair: Roland Riek (ETH Zürich) 14:00-14:10 Jean-Philippe Ansermet (EPFL)

High-Field DNP in Liquids at the Microliter Scale 14:15-14:25 Christophe Copéret (ETH Zürich)

Coordination Environment and Electronic Structure of Active Sites from Solid-State NMR Spectroscopy and DNP SENS

14:30-14:40 Christian Degen (ETH Zürich) News from the world of nano-NMR

14:45-15:55 Beat H. Meier (ETH Zürich) Solid State NMR @ Physical Chemistry ETH

15:00-15:10 Martino Poggio (Universität Basel) Nanomagnetic Sensing and NMR

15:15-15:25 Lyndon Emsley (EPFL) New Methods in Solid-State NMR

XXII Swiss NMR Symposium 2018

15:30-16:00 Coffee break

Session 4: Solution-State NMR: Small molecules and methods development Chair: Oliver Zerbe (Universität Zürich) 16:00-16:10 Damien Jeannerat (Université de Genève)

Combining Pulse-Sequence Development with Processing Techniques to Reach Top Resolution in 2D Spectra of Small Molecules

16:15-16:25 Wolfgang Jahnke (Novartis Pharma AG) Protein NMR in Drug Discovery at Novartis

16:30-16:40 Julien Furrer (Universität Bern) Heteronuclear Long-Range Correlation Experiments: HMBC or LR-HSQC?

16:45-16:55 Daniel Häussinger (Universität Basel) A New Approach in Lanthanide Chelating Tags for PCS NMR Spectroscopy

17:00-17:10 Alfred Ross (Hoffmann LaRoche AG) Liquids and Solids: NMR at Roche Basel

17:15-17:25 Marcel J.J. Blommers (Saverna Therapeutics) NMR Guided Drug Discovery of Small Molecules Targeting RNA

There will be an Apero offered in front of the lecture hall HCI G3. Everybody is welcome to join.