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ESDE

European Society forDiseases of the EsophagusBologna November 20-22, 2014Royal Hotel Carlton

European Society forXII Congress of the

Finalprogram

XII Congress of the European Society for Diseases of the Esophagus

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Thanks to

Bologna November 20-22, 2014 | Royal Hotel Carlton

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Endorsed by

European Association for Endoscopic Surgery European Society of Neurogastroenterology and Motility

Italian Group for the Study of Gastroenterology and Motility International Society for Diseases of the Esophagus


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CHAIR OF THE CONGRESSSandro MattioliDepartment of Medical and Surgical Sciences (DIMEC)Alma Mater Studiorum - University of Bologna, ItalyThoracic Surgery Maria Cecilia Hospital, Cotignola

SCIENTIFIC SECRETARIATLeda Manara, M. Luisa LugaresiDepartment of Medical and Surgical Sciences (DIMEC)Alma Mater Studiorum - University of Bologna, Italy

ORGANIZING SECRETARIAT I&C srl Via Andrea Costa, 202/6 40134 Bologna, Italy Tel: +39 051.6144004 - Fax: +39 051.6142772E-mail: [email protected]

Via Andrea Costa, 202/6 40134 Bologna, Italy


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ESDE STEERING COMMITTEEManuel Pera, Barcelona (ES) - President Peter Siersema, Utrecht (NL) - General Secretary Christophe Mariette, Lille (FR) - Treasurer

ESDE CONGRESS SCIENTIFIC COMMITTEE Michael S. Griffi n, Newcastle upon Tyne (UK)Christophe Mariette, Lille (FR)Sandro Mattioli, Bologna (I)Manuel Pera, Barcelona (ES)Peter Siersema, Utrecht (NL)J. Jan Van Lanschot, Rotterdam (NL)

ESDE CONGRESS LOCAL COMMITTEE Fabio Baldi, Bologna (I)Giovanni Barbara, Bologna (I)Francesco Bassi, Bologna (I)Franco Bazzoli, Bologna (I)Stefano Brusori, Bologna (I)Carlo Calabrese, Bologna (I)Niccolò Daddi, Bologna (I)Roberto De Giorgio, Bologna (I) Massimo Di Simone, Bologna (I)Luca Ferruzzi, Cotignola (I)Marzio Frazzoni, Modena (I)Nico Pagano, Bologna (I)Vladimiro Pilotti, Cotignola (I)Vincenzo Stanghellini, Bologna (I)Francesco Torresan, Bologna (I)Rocco Maurizio Zagari, Bologna (I)


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FACULTY

Derek Alderson, Bristol (UK)

Vito Annese, Florence (Italy)

Mario Anselmino, Pisa (Italy)

Stephen Attwood, Norfolk (UK)

Qasim Aziz, London (UK)

Fabio Baldi, Bologna (Italy)

Giovanni Barbara, Bologna (Italy)

Franco Bazzoli, Bologna (Italy)

Rosario Bellini, Pisa (Italy)

Mario Bernardi, Bologna (Italy)

Guy Boeckxstaens, Leuven (Belgium)

Luigi Bolondi, Bologna (Italy)

Luigi Bonavina, Milan (Italy)

Albert J. Bredenoord, Amsterdam (The Netherlands)

Carlo Castoro, Padua (Italy)

Vanna Chiarion Sileni, Padua (Italy)

Mario Costantini, Padua (Italy)

Roberto De Giorgio, Bologna (Italy)

Tom R. DeMeester, Los Angeles CA (USA)

Natale Di Martino, Caserta (Italy)

Matteo Fassan, Padua (Italy)

Karl H. Fuchs, Frankfurt (Germany)

Michael S. Griffi n, Newcastle upon Tyne (UK)

Arnulf Hölscher, Cologne (Germany)

Peter J. Kahrilas, Chicago IL (USA)

Sheila K. Krishnadath, Amsterdam (The Netherlands)

Toni Lerut, Leuven (Belgium)

Christophe Mariette, Lille (France)

Sandro Mattioli, Bologna (Italy)

Gianluigi Melotti, Modena (Italy)

Mario Morino, Turin (Italy)

Philippe Nafteux, Leuven (Belgium)

Francesca Negri, Parma (Italy)

Magnus Nilsson, Stockholm (Sweden)

Roberto Penagini, Milan (Italy)

Manuel Pera, Barcelona (Spain)

Loris Pironi, Bologna (Italy)

Bernhard Polzer, Regensburg (Germany)

Shaun Preston, Newcastle upon Tyne (UK)

John V. Reynolds, Dublin (Ireland)

Riccardo Rosati, Milan (Italy)

Massimo Rugge, Padua (Italy)

Alberto Ruol, Padua (Italy)

Jarmo Salo, Helsinki (Finland)

Stefano Santi, Pisa (Italy)

Edoardo V. Savarino, Padua (Italy)

Paul M. Schneider, Zurich (Switzerland)

Peter Siersema, Utrecht (The Netherlands)

Andreas Smout, Utrecht (The Netherlands)

Eduardo M. Targarona, Barcelona (Spain)

Richard Van Hillegersberg, Utrecht (The Netherlands)

Jan J. Van Lanschot, Rotterdam (The Netherlands)

Thomas N. Walsh, Dublin (Ireland)

Kenneth Wang, Rochester MN (USA)

Giovanni Zaninotto, London (UK)


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PRE-CONGRESS COURSES

11.30 SURGERY - SATURNO A HALL Meet the surgeon-video session: a row of surgical procedures Discussion on indications, surgical strategy, how I do it (comparison among different ways to do the same operation) and details of techniques among attendees and presenting surgeons. Chairs: A. Hölscher (D), T. Lerut (BE), S. Mattioli (I)

Esophageal diverticula• Transoral diverticulo-esophagostomy for treatment of Zenker’s diverticulum, R. Rosati (I)• Trans axillary robotic Zenker’s diverticulectomy, G. Melotti (I)• Treatment of large epiphrenic diverticula, S. Santi (I)

GERD and Hiatus Hernias• Laparoscopic Nissen funduplication, P. Nafteux (BE)• Laparoscopic Collis-Nissen in patients with short esophagus and large paraesophageal hernia, M. Pera (ES)• Surgical therapy for short esophagus: the intra operative assessment of the length of the esophagus and

the laparoscopic-left thoracoscopic Collis-Nissen, S. Mattioli (I) Achalasia

• A technical detail to improve surgery for sigmoid achalasia, S. Mattioli (I)• Laparoscopic assisted esophagectomy for end stage achalasia, N. Di Martino (I)

THURSDAY, NOVEMBER 20

15.30


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13.30 GASTROENTEROLOGY - SATURNO B HALL Advances in understanding and management of esophageal diseases with the use of modern functional testing motility devices Chairs: F. Baldi (I), P. J. Kahrilas (USA)

• High resolution manometry (HRM), P. J. Kahrilas (USA)• Adding impedance to HRM: is it clinically relevant? A. Smout (NL)• pH impedance monitoring: how useful for the management of patients? E. V. Savarino (I)• Wireless pH monitoring (Bravo): the added value of prolonged pH monitoring, R. Penagini (I)

15.30

Esophageal cancer• Open transhiatal esophagectomy for adenocarcinoma of the (distal) esophagus and cardia,

J.J. Van Lanschot (NL)• Prone thoracoscopic esophagectomy, L. Bonavina (I)• A Game-Changer In Oesophago-Gastric Surgery, T. N. Walsh (IRL)• Hybrid esophagectomy for adenocarcinoma - Laparoscopic gastrolysis and transthoracic esophagectomy,

A. Hölscher (D)• How to perform the lymphadenectomy at oesophagectomy, D. Alderson (UK)• Robot-assisted thoraco-laparoscopic esophagectomy (RAMIE) in Esophageal Cancer Surgery,

R. Van Hillegersberg (NL)


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16.00 OPENING CEREMONY AND WELCOME S. Mattioli, Chair of the Congress (I) L. Bolondi, President of the School of Medicine, Alma Mater Studiorum, University of Bologna (I) E. Sansavini, President of Gruppo Villa Maria

16.15 OPENING LECTURE BARRETT’S ESOPHAGUS: FROM BIOMARKERS TO ENDOSCOPIC TISSUE TRANSPLANTION K. Wang (USA)

16.45 PLENARY SESSION 1 ESDE PRIZE - SELECTED ORAL PRESENTATIONS Chairs: M. Pera (ES), P. Siersema (NL)

C1THE IMPACT OF SEVERE ANASTOMOTIC LEAK ON LONG-TERM SURVIVAL AND CANCER RECURRENCE FOLLOWING SURGICAL RESECTION FOR ESOPHAGEAL MALIGNANCYSheraz Markar1, Caroline Gronnier2, 3, 4, Alain Duhamel5, 6, Jean-Yves Mabrut7, Jean-Pierre Bail8, Nicolas Carrere9, Jérémie H Lefevre10, Cécile Brigand11, Jean-Christophe Vaillant12, Mustapha Adham13, Simon Msika14, Nicolas Demartines15, Issam El Nakadi16, Bernard Meunier17, Denis Collet18, Christophe Mariette2, 3, 4, 5 ,, on behalf of the FREGAT working group – FRENCH – AFCDepartment of Surgery & Cancer, Imperial College, London, UK (1), Department of digestive and oncological surgery, Claude Huriez University Hospital, Lille, France (2), North of France University, Lille, France (3), Inserm, UMR837, Team 5 “Mucins, epithelial differentiation and carcinogenesis”, JPARC, Lille, France (4), SIRIC OncoLille, France (5), Department of biostatistics, University Hospital, Lille, France (6), Departments of digestive surgery of Croix-Rousse University Hospital, Lyon, France (7), Cavale Blanche University Hospital, Brest, France (8), Purpan University Hospital, Toulouse, France (9), Saint Antoine University Hospital, Paris, France (10), Hautepierre University Hospital, Strasbourg, France (11), Pitié-Salpétrière University Hospital, Paris, France (12), Edouard Herriot University Hospital, Lyon, France (13), Louis Mourier University Hospital, Colombes, France (14), Vaudois University Hospital, Lausanne, Switzerland (15), ULB-Erasme-Bordet University Hospital, Bruxelles, Belgium (16), Pontchaillou University Hospital, Rennes, France (17), Haut-Levêque University Hospital, Bordeaux, France (18).


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C2 DIAGNOSTIC PERFORMANCE OF 18F FDG PET/(CT) FOR THE DETECTION OF RECURRENT ESOPHAGEAL CANCER AFTER TREATMENT WITH CURATIVE INTENT: A SYSTEMATIC REVIEW AND META-ANALYSISL. Goense1, P.S.N. van Rossum1,2, M.G.E.H. Lam3, M. van Vulpen2, G. J. Meijer2 J. P. Ruurda1, R. van Hillegersberg1

1Department of Surgery, University Medical Center Utrecht, The Netherlands2 Department of Radiotherapy, University Medical Center Utrecht, The Netherlands 3 Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, The Netherlands

C3NEOADJUVANT CHEMORADIOTHERAPY FOR CANCER OF THE ESOPHAGUS OR GE JUNCTION INHIBITS HEART FUNCTIONJon A. Tsai, Mikael Lund, Reidar Winter, Magnus Nilsson, Mats Lindblad, Ioannis Rouvelas, Lars Lundell, Sigridur Kalman Karolinska University Hospital, Centre for Digestive Diseases, Stockholm, Sweden

C4THE NATIONAL PROFICIENCY GAIN CURVE IN ENGLAND FOR MINIMALLY INVASIVE ESOPHAGECTOMYSheraz R. Markar1, Hugh Mackenzie1, Alan Alkasari2, Omar Faiz2, George B Hanna1

1 – Department of Surgery & Cancer, Imperial College, St Mary’s Hospital, London, UK2 – St Mark’s Hospital and Academic Institute, London, UK

C5SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH ESOPHAGEAL ADENOCARCINOMAAnna M.J. van Nistelrooij1,2, Linda Broer3, Katharina Biermann1, Carel J.M. van Noesel4, J. Jan B. van Lanschot2, André G. Uitterlinden3,4,Bas P.L. Wijnhoven2, Winand N.M. Dinjens1

Departments of Pathology1, Surgery2, Internal Medicine3, Erasmus MC Cancer Institute, University Medical Center Rotterdam, The Netherlands. Department of Patholgy4, Academic Medical Center, Amsterdam, The Netherlands.


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C6CLINICAL AND HIGH RESOLUTION MANOMETRY DATA SUPPORT THE HYPOTHESIS THAT PROTON PUMP INHIBITOR-RESPONSIVE ESOPHAGEAL EOSINOPHILIA REPRESENT A GERD-RELATED PHENOMENONOttavia Bartolo1, Mario Costantini2, Chiara de Cassan1, Roberta Caccaro1, Francesca Galeazzi1, Loredana Nicoletti2, Tiziana Morbin2, Lisa Zanatta2, Salvatore Tolone1, Renato Salvador 3, Giacomo Carlo Sturniolo1, Stefano Merigliano2, Edoardo V. Savarino1

1 Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy 2 U.O. Clinica Chirurgica 3, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy3 Chirurgia Generale, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy

18.45 HONORARY MEMBERSHIP LECTURE THE CHALLENGE OF PROGRESSIVE DISEASE IN GERD T.R. DeMeester (USA)

19.15 SOCIETAL AFFAIRS M. Pera (ES)

19.30 Welcome Reception


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8.00 ORAL PRESENTATIONS - Session 1 Chairs: P. Nafteux (BE), E. V. Savarino (I)

C7THE PROGNOSTIC IMPACT OF ISOLATED TUMOR CELLS (ITCS) IN LYMPH NODES OF PN0 ESOPHAGEAL CANCERLaura Albertoni, Lavinia Stefanizzi, Alberto Ruol, Carlo Castoro, Luciano Giacomelli, Claudia Mescoli, Giovanni Zaninotto, Massimo RuggeDepartment of Diagnostic Sciences & Special Therapies (Pathology & Cytopathology Section); University of Padua, Padua, Italy.

C8HYBRID MINIMALLY INVASIVE VERSUS OPEN OESOPHAGECTOMY FOR PATIENTS WITH OESOPHAGEAL CANCER: A MULTICENTRE, OPEN-LABEL, RANDOMISED PHASE III CONTROLLED TRIAL, THE MIRO TRIALCaroline Gronnier (1), Bernard Meunier (2), Denis Pezet (3), Cécile Dalban (4), Denis Collet (5), Pascal-Alexandre Thomas (6), Cécile Brigand (7), Thierry Perniceni (8), Nicolas Carrere (9), Christophe Mariette (1)Department of Surgery at the Lille (1), Rennes (2), Clermont Ferrand (3), Bordeaux (5), Marseille (6), Strasbourg (7), Institut Mutualiste Montsouris (8), Toulouse (9) University Hospitals and Department of Biostatistics, Dijon (4)

C9MUCOSAL PERFORATION DURING LAPAROSCOPIC HELLER MYOTOMY DOESN’T INFLUENCE THE FINAL OUTCOME OF THE TREATMENTRenato Salvador MD FACS, Mario Costantini MD, Cristina Longo MD, Lisa Zanatta MD, Loredana Nicoletti, Giovanni Capovilla MD, Francesca Galeazzi MD, Edoardo Savarino MD, PhD, Giovanni Zaninotto MD FACSDepartment of Surgical, Oncological and Gastroenterological Sciences, University of Padua, School of Medicine, Padua, Italy

FRIDAY, NOVEMBER 21


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C10MICROSATELLITE INSTABILITY IN BARRETT ESOPHAGUS; FROM INTESTINAL METAPLASIA TO ESOPHAGEAL ADENOCARCINOMAMarkos Pave1, Brcic Iva2, Brcic Luka2, Jakic-Razumović Jasminka2, Pulanic Roland1

1Division of Gastroenterology and Hepatology, Univesity Hospital Centre Zagreb2Clinical Department for Pathology and Cytology, University Hospital Center Zagreb, Zagreb School of Medicine

C11MULTIPLE RAPID SWALLOWING IS A USEFUL COMPLEMENTARY TEST TO CORRELATE SYMPTOMS TO ESOPHAGEAL MOTILITY ABNORMALITIES Edoardo V. Savarino1, Chiara de Cassan1, Francesca Galeazzi1, Renato Salvador2, Moira Rigato1, Elisa Marabotto3, Manuele Furnari3,Giorgia Bodini3, Patrizia Zentilin3, Nicola de Bortoli4, Santino Marchi4, Romeo Bardini2, Giacomo Carlo Struniolo1, Vincenzo Savarino3

1 Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy 2 General Surgery, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy3 Division of Gastroenterology, Department of Internal Medicine, University of Genoa, Genoa, Italy 4 Division of Gastroenterology, Department of Internal Medicine, University of Pisa, Pisa, Italy

C12LIVER CIRRHOSIS IS NOT AN ABSOLUTE CONTRAINDICATION TO RADICAL SURGERY FOR ESOPHAGEAL CANCER. RESULTS OF A CASE CONTROL STUDY.C. De Pasqual, M. Valmasoni, G. Zanchettin, S. E. Pierobon, A. Caudo, M. Costantini, S. Merigliano, A. RuolClinica Chirurgica 3, University of Padua, Padua, Italy.


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9.00 PLENARY SESSION 2 HOT TOPICS IN GERD Chairs: M. Nilsson (SE), A. Smout (NL)

• The acid pocket in health and GERD, G. Boeckxstaens (BE) • Hiatus hernia and cardial incontinence, P. Kahrilas (USA)• Surgery for refractory GERD, M. Nilsson (SE)• Obesity and GERD; pathophysiology and surgical therapy, M. Anselmino (I)

10.30 Coffee break & Posters Visit P1- P15 Chairs: F. Baldi (I), J.J. Van Lanschot (NL)

11.00 PARALLEL SESSIONS 1 SURGERY 1 (JOINT SESSION ESDE/EAES): SURGERY FOR TYPE II-IV HIATUS HERNIA - MAIN HALL Chairs: D. Alderson (UK), M. Morino (I)

• Natural history of type II-IV HH and the indications for surgical therapy, J. Salo (FI)• Surgical therapy: open vs minimally invasive techniques, K. H. Fuchs (D)• Causes and timing of hernia relapse, L. Bonavina (I)• Cruroplasty: pros and cons of bio-prosthetic materials, E. M. Targarona (ES)


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GASTROENTEROLOGY 1 (Joint session ESDE/ ESNM) - GIOVE HALL COMMON PATHOGENETIC MECHANISMS IN FUNCTIONAL GASTRO-INTESTINAL DISORDERS Chairs: G. Boeckxstaens (BE), R. De Giorgio (I)

• Sensory-motor dysfunction, Q. Aziz (UK)• Luminal factors, microbiota and mucosal barrier, G. Barbara (I)• Neuro-immune interactions - New targets for treatment, G. Boeckxstaens (BE)

12.30 Lunch & Posters Visit P16 - P30 Chairs: M. Nilsson (SE), J. Salo (FI)

13.30 GENERAL ASSEMBLY

14.15 ORAL PRESENTATIONS - Session 2 Chairs: N. Di Martino (I), P. Siersema (NL)

C13INSIGHTS IN WORK REHABILITATION AFTER MINIMALLY INVASIVE ESOPHAGECTOMY: A TWO-CENTRE STUDYLuis Carlos Silva Corten1, Misha D.P. Luyer2, Srdjan Rakic1, Grard A.P. Nieuwenhuijzen2, Marc J. van Det1, Ewout A. Kouwenhoven1

1. Department of Surgery, ZGT-Hospital Group Twente, Almelo, The Netherlands2. Department of Surgery, Catherina Hospital, Eindhoven, The Netherlands

C14ESTROGEN RECEPTORS AND ESOPHAGEAL CANCER: A POTENTIAL THERAPEUTIC PATHWAYWaleed Al-Khyatt, Cristina Tufarelli, Raheela Khan, Syed Y IftikharSchool of Graduate Entry Medicine and Health, University of Nottingham, Royal Derby Hospital, Uttoxeter Road, Derby, United Kingdom.


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C15WHOLE-GENOME TRANSCRIPTOME ANALYSIS REVEALS NOVEL GENE EXPRESSION ALTERATIONS IN ACHALASIAElena Bonora1, Francesca Bianco1, Marialuisa Lugaresi1, Ottorino Perrone1,Vincenzo Stanghellini1, Annalisa Astolfi 2, Valentina Indio2, Francesco Torresan1, Alexandros Ioannou1, Fabio Baldi1, Giovanni Barbara1, Alessandra Gori1 and Roberto De Giorgio1

1 Department of Medical and Surgical Sciences, DIMEC, Alma Mater Studiorum University of Bologna, Bologna, Italy2 Interdipartimental Centre for Cancer Research “Giorgio Prodi”, Alma Mater Studiorum University of Bologna, Bologna, Italy

C16SIGNIFICANCE OF NISSEN FUNDOPLICATION AFTER ENDOSCOPIC RADIOFREQUENCY ABLATION OF BARRETT ESOPHAGUSSkrobić O, Simić A, Veličković D, Djurić-Stojanović A, Šljukić V, Ivanović N, Peško P.Department of Esophagogastric Surgery, First Surgical University Hospital, Belgrade, Serbia

C17COMPUTED TOMOGRAPHY FOR STAGING OF OESOPHAGEAL AND JUNCTIONAL CANCER: DO WE NEED A DEDICATED REPORTING TEMPLATE?Mathieu Messager1,3, Gina Brown2, William H Allum1

1. Department of Surgery, Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom2. Radiology Department, Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom3. Department of Digestive and Oncological Surgery, Claude Huriez University Hospital, Lille, France


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C18AN ENHANCED RECOVERY PROGRAM WITH THE EARLY INTRODUCTION OF ORAL FEEDING FOLLOWING MINIMALLY INVASIVE OESOPHAGECTOMY IS WELL TOLERATED AND IS ASSOCIATED WITH LOW MORBIDITY AND EXCELLENT NUTRITIONAL AND PATIENT-REPORTED OUTCOMEST. Murphy#, S. Cushen*, A. Griffi ths^, A. Ryan* *Department of Nutrition, University College Cork^Department of Anaesthetics, Mercy University Hospital, Cork#Department of Surgery, Mercy University Hospital, Cork

15.15 PLENARY SESSION 3 MANAGEMENT OF NON ACHALASIA ESOPHAGEAL MOTOR DISORDERS (Joint Session ESDE/GISMAD) Chairs: R. Penagini (I), R. Van Hillegersberg (NL)

• Clinical and patho-physiologic patterns, A. Smout (NL)• Pharmacological and dilation treatment, V. Annese (I)• Surgical options, G. Zaninotto (UK)

16:30 LECTURE SURGICAL AND NON SURGICAL THERAPY FOR ESOPHAGEAL ACHALASIA. MAY THE OLD HELP THE NEW? S. Mattioli (I)

17.00 Coffee break & Posters Visit P31 - P50 Chairs: G. Boeckxstaens (BE), C. Mariette (FR)


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17.30 LECTURES CANCER OF THE ESOPHAGUS Chairs: J.J. Van Lanschot (NL), T. N. Walsh (IRL)

• Adenocarcinoma of the esophagus: genetic markers and biomarkers for the clinical use, S. K. Krishnadath (NL)• Molecular characterization of disseminated and circulating esophageal cancer cells:

insights into metastasis and diagnostic consequences, B. Polzer (D)• Target therapy: how and when, F. Negri (I)

18.15 PLENARY SESSION 4 THE SEQUENCE METAPLASIA/DYSPLASIA/ADENOCARCINOMA OF THE ESOPHAGUS AND CARDIA Chairs: C. Mariette (FR), P. M. Schneider (CH)

• The pathogenesis of conversion from squamous to columnar epithelium in the esophagus, M. Pera (ES)• The presence/absence of goblet cells in the sequence metaplasia/dysplasia/cancer, M. Fassan (I), M. Rugge (I) • The relationship between tumor’s biology and lymphatic metastases, A. Ruol (I)• A standard or a tailored surgery for adenocarcinoma of the esophagus and cardia? A. Hölscher (D)

19.15 Conclusion

20.30 Faculty dinner


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8.30 ORAL PRESENTATIONS - Session 3 Chairs: A. J. Bredenoord (NL), M. Costantini (I)

C19PROTON PUMP INHIBITOR RESPONSIVE VS. NON-RESPONSIVE FUNCTIONAL HEARTBURN: THE DIFFERENCE LIES IN THE IMPEDANCE BASELINEde Bortoli N1, Martinucci I1, Savarino E2, Tutuian R3, Frazzoni M4, Bertani L 1, Laino G1, Russo S1, Furnari M5, Bellini M1, Savarino V5, Marchi S1.1 Division of Gastroenterology, Department of Traslational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy2 Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy 3 Gastroenterology Unit, Hospital of Bern, Switzerland

4 Gastroenterology Unit, Hospital of Modena, Italy5 Division of Gastroenterology, Department of Internal Medicine, University of Genoa, Genoa, Italy

C20ESOPHAGEAL PERFORATION FOLLOWING ANTERIOR CERVICAL SPINE FIXATION (ACDF). MANAGEMENT AND RESULTS Perrone O., Lugaresi M., Borghesi I., Belloni GP., Uneddu MDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy

C21IN-FIELD CONTROL OF MULTIMODAL THERAPY IN LOCALLY ADVANCED ESOPHAGEAL CANCERH. Thoen1, W. Ceelen1, T. Boterberg2, E. Van Daele1, P. Pattyn1

1Ghent University – Department of Surgery, Belgium2Ghent University – Department of Radiation Oncology, Belgium

SATURDAY, NOVEMBER 22


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C22IMPACT OF NEO-ADJUVANT CHEMOTHERAPY ON CARDIORESPIRATORY RESERVE IN OESOPHAGOGASTRIC ADENOCARCINOMAM. Navidi, K. Sumpter, S.M. Griffi n, R.C.F. SinclairNorthern Oesophagogastric Cancer Unit, Royal Victoria Infi rmary, Newcastle Upon Tyne, UK

C23GASTRO-ESOPHAGEAL REFLUX AND ANTISECRETORY DRUGS USE AMONG PATIENTS WITH CHRONIC AUTOIMMUNE ATROPHIC GASTRITIS: A STUDY WITH PH-IMPEDANCE MONITORINGTenca A1, Pugliese D1, Massironi S1, Consonni D2, Franchina M1, Spampatti M1, Conte D1, Penagini R11. Gastroenterology and Endoscopy Unit - Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico and Department of Pathophysiology and Transplantation University of Milan, Milan, Italy.2. Epidemiology Unit - Department of Preventive Medicine - Fondazione IRCCSCa’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

C24DOES OMENTOPLASTY REDUCE ANASTOMOTIC LEAK FOLLOWING ESOPHAGECTOMY? – META-ANALYSISWiggins T., Markar S.R., Arya S., Hanna G.B.Division of Surgery, Imperial College, London UK


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9.30 PARALLEL SESSIONS 2 SURGERY 2 - MAIN HALL SAFE AND FAST TRACK ESOPHAGECTOMY Chairs: J. V. Reynolds (IRL), R. Rosati (I)

• The ERAS protocol in esophageal surgery, S. Preston (UK)• Is albumin administration benefi cial in the early stage of postoperative hypoalbuminemia following

esophagectomy? M. Bernardi (I)• Peri operative nutrition, L. Pironi (I) • The management of anastomotic leaks, C. Mariette (FR)

GASTROENTEROLOGY 2 - GIOVE HALL EOSINOPHILIC ESOPHAGITIS Chairs: S. Attwood (UK), F. Bazzoli (I)

• Epidemiology in adults, S. Attwood (UK)• Advances in pathogenesis, S. Attwood (UK)• Relationship with GERD and indications of PPIs, R. Penagini (I)• Current management and guidelines, A. J. Bredenoord (NL)

11.00 Coffee break


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11.30 PLENARY SESSION 5 PALLIATION OF DYSPHAGIA IN ADVANCED ESOPHAGEAL CANCER Chairs: S.M. Griffi n (UK), P. Siersema (NL)

• Techniques, results and complications of chemo-radiotherapy, V. Chiarion Sileni (I)• Esophageal stenting: when, how and new developments, P. Siersema (NL)• Indications and techniques of salvage esophagectomy, C. Castoro (I)

12.45 Prizes and closing remarks

13.00 CME-EACCME Questionnarie


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CONGRESS VENUE Royal Hotel CarltonVia Montebello, 8Bologna, ItalyTel: +39 051 249361Fax: +39 051 249724www.monrifhotels.it/RoyalCarltonHotel

How to reach the venue The Royal Hotel Carlton is located in the centre of Bologna, walking distance from the Railway Station and Piazza Maggiore.

By car: From the highway, exit n. 7/City Centre - Fair, following the indications for the Railway Station - Set the navigation system for Via Milazzo 6 to avoid the restricted traffi c zone.

By plane: Guglielmo Marconi International Airport is 15 minutes from the Hotel. Airbus shuttle services depart every 20 minutes from the Airport to the Station.

EACCME ACCREDITATIONEuropean cme credits

The “XII CONGRESS OF THE EUROPEAN SOCIETY FOR DISEASES OF THE ESOPHAGUS-ESDE” is accredited by the European Accreditation Council for

Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists. The EACCME is an institution of the European Union of Medical Specialists (UEMS), www.uems.net.The “XII CONGRESS OF THE EUROPEAN SOCIETY FOR DISEASES OF THE ESOPHAGUS-ESDE” is designated for a maximum of 12 hours of European external CME credits. Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity. Through an agreement between the European Union of Medical Specialists and the American Medical Association, physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits™.Information on the process to convert EACCME credit

GENERAL INFORMATION


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to AMA credit can be found at www.ama-assn.org/go/internationalcme. Live educational activities, occurring outside of Canada, recognized by the UEMS-EACCME for ECMEC credits are deemed to be Accredited Group Learning Activities (Section 1) as defi ned by the Maintenance of Certifi cation Program of The Royal College of Physicians and Surgeons of Canada.Event code: 11336N. 12 European CME credits (ECMEC) granted by the European Accreditation Council for Continuing Medical Education (EACCME). Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity. The EACCME credit system is based on 1 ECMEC per hour with a maximum of 3 ECMECs for half a day and 6 ECMECs for a full-day event.

Italian cme creditsESDE 2014 is accredited for Physicians (Specialties: Gastroenterology, General Surgery, Internal Medicine, Oncology, Thoracic Surgery, Radiation Oncology, Radiology, Vascular Surgery, Pathological Anatomy).The Physicians belonging to other disciplines will not get the credits.

Provider: I&C srl n. 1740-108049CME credits: 7,5Pre Congress Courses are not accredited.

Checking MethodAn effective presence to all meeting sessions as well as a correct answer to the at least 75% of the CME questionnaire are needed to get the CME credits. No exception will be considered.


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ESDE PRIZE AND SELECTED ORAL PRESENTATIONSThis prize has been created in the attempt to promote research and interest of young surgeons and gastroenterologists in the area of esophageal diseases. Abstracts submitted to the congress will be evaluated blindly by a panel composed of surgeons and gastroenterologists. The six abstracts scored with the highest marks will participate in the ESDE competition.The Scientifi c Committee will elect the ESDE prize winner on the base of the scientifi c content of the presentation, the quality of exposition and discussion. The best presentation shall be rewarded with a prize of € 1000,00; presenters in the ESDE prize shall be recognized with a parchment.

Abstracts selected for oral presentation will be considered for pubblication in Diseases of the Esophagus,“after peers review”.

POSTERSPoster exposure is scheduled on November 21 at the following time:

• 10.30-11.00 Coffee Break and Poster Visit - P1- P15• 12.30-13.30 Lunch and Poster Visit - P16 - P30• 17.00-17.30 Coffee Break and Poster Visit - P31 - P50

Mounting Time: you must fi x your poster compulsorily from 08.00 to 19.00 of November 21 2014. Dismounting Time: you are requested to dismount your poster on November 21 from 19.00 to 19.30.

At 19.30 of November 21 our Organization will remove and eliminate all posters not dismounted by presenters.The exposed posters will compete in the “posters’ prize” and shall be rewarded with a prize of € 500,00.A parchment will be given to the fi rst, the second and the third one classifi ed.


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REGISTRATION FEE

Costs including VAT 22% On site registrations

□ MEMBER ESDE € 300,00□ NON MEMBER ESDE € 400,00□ RESIDENT/TRAINEE € 150,00□ PRE-CONGRESS COURSE € 120,00

The registration fee covers:• Admission to scientifi c sessions• Congress kit• Coffee breaks and lunch • Welcome cocktail• Abstracts of the Congress on USB memory

CANCELLATION POLICY• 100% refund for request sent to the Organizing Secretariat before September 30 2014 • After September 30 no refund for the registration fee will be possible

OFFICIAL LANGUAGEEnglish is the offi cial language of the Meeting.Simultaneous translation is not provided.


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TECHNICAL FACILITIESFacilities will be available for computer presentations.The Slide Center with PC will be available in the main hall for check and preview the presentations.It is essential that speakers deliver their presentation to the slide center at least one hour before the session starts.

CERTIFICATE OF ATTENDANCEThe certifi cate of attendance will be available, on request, at the end of the Congress at the Secretariat.

ORGANIZING SECRETARIAT I&C srl Via Andrea Costa, 202/6 40134 Bologna, Italy Tel: +39 051.6144004 - Fax: +39 051.6142772E-mail: [email protected]

The Organizing Secretariat will be open during conference time.

Via Andrea Costa, 202/6 40134 Bologna, Italy


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The Scientifi c Committee wish to thank the following companies for the unrestricted contribution to the ESDE Congress:


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EXHIBITION AREA


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NOTES


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NOTES

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